Signaling downstream of RAS mutants

Pathway network for the Signaling downstream of RAS mutants SuperPath

Sources:

Reactome

Pathways in the Signaling downstream of RAS mutants SuperPath

#	Name	Source	Genes
1	Signaling downstream of RAS mutants	Reactome	ACTB ACTG1 APBB1IP ARAF ARRB1 ARRB2 BRAF BRAP CALM1 CALM2 CALM3 CAMK2A CAMK2B CAMK2D CAMK2G CNKSR1 CNKSR2 CSK FGA FGB FGG FN1 HRAS IQGAP1 ITGA2B ITGB3 JAK2 KRAS KSR1 KSR2 MAP2K1 MAP2K2 MAP3K11 MAPK1 MAPK3 MARK3 NRAS PEBP1 PHB1 RAF1 RAP1A RAP1B SRC TLN1 VCL VWF YWHAB (see all 47) (see less)
2	Signaling by RAS mutants	Reactome	ACTB ACTG1 APBB1IP ARAF ARRB1 ARRB2 BRAF BRAP CALM1 CALM2 CALM3 CAMK2A CAMK2B CAMK2D CAMK2G CNKSR1 CNKSR2 CSK FGA FGB FGG FN1 HRAS IQGAP1 ITGA2B ITGB3 JAK2 KRAS KSR1 KSR2 MAP2K1 MAP2K2 MAP3K11 MAPK1 MAPK3 MARK3 NRAS PEBP1 PHB1 RAF1 RAP1A RAP1B SRC TLN1 VCL VWF YWHAB (see all 47) (see less)
3	Signaling by moderate kinase activity BRAF mutants	Reactome	ACTB ACTG1 APBB1IP ARAF ARRB1 ARRB2 BRAF BRAP CALM1 CALM2 CALM3 CAMK2A CAMK2B CAMK2D CAMK2G CNKSR1 CNKSR2 CSK FGA FGB FGG FN1 HRAS IQGAP1 ITGA2B ITGB3 JAK2 KRAS KSR1 KSR2 MAP2K1 MAP2K2 MAP3K11 MAPK1 MAPK3 MARK3 NRAS PEBP1 PHB1 RAF1 RAP1A RAP1B SRC TLN1 VCL VWF YWHAB (see all 47) (see less)
4	Paradoxical activation of RAF signaling by kinase inactive BRAF	Reactome	ACTB ACTG1 APBB1IP ARAF ARRB1 ARRB2 BRAF BRAP CALM1 CALM2 CALM3 CAMK2A CAMK2B CAMK2D CAMK2G CNKSR1 CNKSR2 CSK FGA FGB FGG FN1 HRAS IQGAP1 ITGA2B ITGB3 JAK2 KRAS KSR1 KSR2 MAP2K1 MAP2K2 MAP3K11 MAPK1 MAPK3 MARK3 NRAS PEBP1 PHB1 RAF1 RAP1A RAP1B SRC TLN1 VCL VWF YWHAB (see all 47) (see less)
5	Signaling by RAF1 mutants	Reactome	ACTB ACTG1 APBB1IP ARAF ARRB1 ARRB2 BRAF CALM1 CALM2 CALM3 CAMK2A CAMK2B CAMK2D CAMK2G CNKSR1 CNKSR2 CSK FGA FGB FGG FN1 HRAS IQGAP1 ITGA2B ITGB3 JAK2 KRAS KSR1 KSR2 MAP2K1 MAP2K2 MAPK1 MAPK3 MARK3 NRAS RAF1 RAP1A RAP1B SRC TLN1 VCL VWF YWHAB (see all 43) (see less)
6	Negative regulation of MAPK pathway	Reactome	ARAF BRAF BRAP DUSP1 DUSP10 DUSP16 DUSP2 DUSP4 DUSP5 DUSP6 DUSP7 DUSP8 DUSP9 HRAS KRAS KSR1 MAP2K1 MAP2K2 MAPK1 MAPK12 MAPK3 MARK3 NRAS PAQR3 PEBP1 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E PPP5C PTPN3 PTPN7 RAF1 RPS27A UBA52 UBB UBC YWHAB (see all 43) (see less)
7	MAP2K and MAPK activation	Reactome	ACTB ACTG1 APBB1IP ARAF ARRB1 ARRB2 BRAF CNKSR1 CNKSR2 CSK FGA FGB FGG FN1 HRAS IL17RD IQGAP1 ITGA2B ITGB3 KRAS KSR1 KSR2 LAMTOR2 LAMTOR3 MAP2K1 MAP2K2 MAPK1 MAPK3 MARK3 NRAS PEBP1 RAF1 RAP1A RAP1B SRC TLN1 VCL VWF WDR83 YWHAB (see all 40) (see less)
8	RAF activation	Reactome	ARAF BRAF BRAP CALM1 CALM2 CALM3 CAMK2A CAMK2B CAMK2D CAMK2G HRAS JAK2 KRAS KSR1 MAP2K1 MAP2K2 MAP3K11 MARK3 MRAS NRAS PHB1 PPP1CB PPP1CC PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E RAF1 SHOC2 SRC YWHAB (see all 36) (see less)
9	Signaling by high-kinase activity BRAF mutants	Reactome	ACTB ACTG1 APBB1IP ARAF ARRB1 ARRB2 BRAF CNKSR1 CNKSR2 CSK FGA FGB FGG FN1 HRAS IQGAP1 ITGA2B ITGB3 KRAS KSR1 KSR2 MAP2K1 MAP2K2 MAPK1 MAPK3 MARK3 NRAS PEBP1 RAF1 RAP1A RAP1B SRC TLN1 VCL VWF YWHAB (see all 36) (see less)

Gene overlap in member pathways for Signaling downstream of RAS mutants SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	9
2	ARAF	A-Raf Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	9
3	KRAS	KRAS Proto-Oncogene, GTPase	Protein Coding	9
4	MARK3	Microtubule Affinity Regulating Kinase 3	Protein Coding	9
5	NRAS	NRAS Proto-Oncogene, GTPase	Protein Coding	9
6	MAP2K1	Mitogen-Activated Protein Kinase Kinase 1	Protein Coding	9
7	MAP2K2	Mitogen-Activated Protein Kinase Kinase 2	Protein Coding	9
8	RAF1	Raf-1 Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	9
9	BRAF	B-Raf Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	9
10	YWHAB	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Beta	Protein Coding	9
11	KSR1	Kinase Suppressor Of Ras 1	Protein Coding	9
12	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	8
13	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	8
14	SRC	SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase	Protein Coding	8
15	CNKSR1	Connector Enhancer Of Kinase Suppressor Of Ras 1	Protein Coding	7
16	CSK	C-Terminal Src Kinase	Protein Coding	7
17	FGA	Fibrinogen Alpha Chain	Protein Coding	7
18	FGB	Fibrinogen Beta Chain	Protein Coding	7
19	FGG	Fibrinogen Gamma Chain	Protein Coding	7
20	CNKSR2	Connector Enhancer Of Kinase Suppressor Of Ras 2	Protein Coding	7
21	FN1	Fibronectin 1	Protein Coding	7
22	KSR2	Kinase Suppressor Of Ras 2	Protein Coding	7
23	ITGA2B	Integrin Subunit Alpha 2b	Protein Coding	7
24	ITGB3	Integrin Subunit Beta 3	Protein Coding	7
25	ARRB1	Arrestin Beta 1	Protein Coding	7
26	ARRB2	Arrestin Beta 2	Protein Coding	7
27	PEBP1	Phosphatidylethanolamine Binding Protein 1	Protein Coding	7
28	APBB1IP	Amyloid Beta Precursor Protein Binding Family B Member 1 Interacting Protein	Protein Coding	7
29	RAP1A	RAP1A, Member Of RAS Oncogene Family	Protein Coding	7
30	RAP1B	RAP1B, Member Of RAS Oncogene Family	Protein Coding	7
31	ACTB	Actin Beta	Protein Coding	7
32	TLN1	Talin 1	Protein Coding	7
33	ACTG1	Actin Gamma 1	Protein Coding	7
34	VCL	Vinculin	Protein Coding	7
35	VWF	Von Willebrand Factor	Protein Coding	7
36	IQGAP1	IQ Motif Containing GTPase Activating Protein 1	Protein Coding	7
37	JAK2	Janus Kinase 2	Protein Coding	6
38	CALM1	Calmodulin 1	Protein Coding	6
39	CALM2	Calmodulin 2	Protein Coding	6
40	CALM3	Calmodulin 3	Protein Coding	6
41	CAMK2A	Calcium/Calmodulin Dependent Protein Kinase II Alpha	Protein Coding	6
42	CAMK2B	Calcium/Calmodulin Dependent Protein Kinase II Beta	Protein Coding	6
43	CAMK2D	Calcium/Calmodulin Dependent Protein Kinase II Delta	Protein Coding	6
44	CAMK2G	Calcium/Calmodulin Dependent Protein Kinase II Gamma	Protein Coding	6
45	BRAP	BRCA1 Associated Protein	Protein Coding	6
46	MAP3K11	Mitogen-Activated Protein Kinase Kinase Kinase 11	Protein Coding	5
47	PHB1	Prohibitin 1	Protein Coding	5
48	PPP2CA	Protein Phosphatase 2 Catalytic Subunit Alpha	Protein Coding	2
49	PPP2CB	Protein Phosphatase 2 Catalytic Subunit Beta	Protein Coding	2
50	PPP2R1A	Protein Phosphatase 2 Scaffold Subunit Aalpha	Protein Coding	2
51	PPP2R1B	Protein Phosphatase 2 Scaffold Subunit Abeta	Protein Coding	2
52	PPP2R5A	Protein Phosphatase 2 Regulatory Subunit B''Alpha	Protein Coding	2
53	PPP2R5B	Protein Phosphatase 2 Regulatory Subunit B''Beta	Protein Coding	2
54	PPP2R5C	Protein Phosphatase 2 Regulatory Subunit B''Gamma	Protein Coding	2
55	PPP2R5D	Protein Phosphatase 2 Regulatory Subunit B''Delta	Protein Coding	2
56	PPP2R5E	Protein Phosphatase 2 Regulatory Subunit B''Epsilon	Protein Coding	2
57	DUSP10	Dual Specificity Phosphatase 10	Protein Coding	1
58	PAQR3	Progestin And AdipoQ Receptor Family Member 3	Protein Coding	1
59	DUSP1	Dual Specificity Phosphatase 1	Protein Coding	1
60	DUSP2	Dual Specificity Phosphatase 2	Protein Coding	1
61	DUSP4	Dual Specificity Phosphatase 4	Protein Coding	1
62	DUSP5	Dual Specificity Phosphatase 5	Protein Coding	1
63	DUSP6	Dual Specificity Phosphatase 6	Protein Coding	1
64	DUSP7	Dual Specificity Phosphatase 7	Protein Coding	1
65	DUSP8	Dual Specificity Phosphatase 8	Protein Coding	1
66	DUSP9	Dual Specificity Phosphatase 9	Protein Coding	1
67	PPP5C	Protein Phosphatase 5 Catalytic Subunit	Protein Coding	1
68	PTPN3	Protein Tyrosine Phosphatase Non-Receptor Type 3	Protein Coding	1
69	PTPN7	Protein Tyrosine Phosphatase Non-Receptor Type 7	Protein Coding	1
70	RPS27A	Ribosomal Protein S27a	Protein Coding	1
71	MAPK12	Mitogen-Activated Protein Kinase 12	Protein Coding	1
72	UBA52	Ubiquitin A-52 Residue Ribosomal Protein Fusion Product 1	Protein Coding	1
73	UBB	Ubiquitin B	Protein Coding	1
74	UBC	Ubiquitin C	Protein Coding	1
75	DUSP16	Dual Specificity Phosphatase 16	Protein Coding	1
76	LAMTOR2	Late Endosomal/Lysosomal Adaptor, MAPK And MTOR Activator 2	Protein Coding	1
77	IL17RD	Interleukin 17 Receptor D	Protein Coding	1
78	WDR83	WD Repeat Domain 83	Protein Coding	1
79	LAMTOR3	Late Endosomal/Lysosomal Adaptor, MAPK And MTOR Activator 3	Protein Coding	1
80	MRAS	Muscle RAS Oncogene Homolog	Protein Coding	1
81	PPP1CB	Protein Phosphatase 1 Catalytic Subunit Beta	Protein Coding	1
82	PPP1CC	Protein Phosphatase 1 Catalytic Subunit Gamma	Protein Coding	1
83	SHOC2	SHOC2 Leucine Rich Repeat Scaffold Protein	Protein Coding	1

Disorders associated with Signaling downstream of RAS mutants SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Noonan syndrome 1	Direct
2	Costello syndrome	Direct
3	Noonan syndrome with multiple lentigines	Direct
4	Hypertrophic cardiomyopathy	Direct
5	Rasopathy	Enrichment	BRAF, HRAS, KRAS, MAP2K1, MAP2K2, NRAS, RAF1	16.00
6	Noonan syndrome and noonan-related syndrome	Enrichment	BRAF, HRAS, KRAS, MAP2K1, MAP2K2, NRAS, RAF1	11.21
7	Lung non-small cell carcinoma	Enrichment	BRAF, HRAS, KRAS, MAP2K1, NRAS	10.25
8	Cardiofaciocutaneous syndrome 1	Enrichment	BRAF, KRAS, MAP2K1, MAP2K2	10.13
9	Cardiofaciocutaneous syndrome	Enrichment	BRAF, KRAS, MAP2K1, MAP2K2	10.13
10	Melanocytic nevus syndrome, congenital	Enrichment	BRAF, HRAS, NRAS, RAF1	8.53
11	Langerhans cell histiocytosis	Enrichment	BRAF, MAP2K1, NRAS	7.77
12	Dysfibrinogenemia, congenital	Enrichment	FGA, FGB, FGG	7.77
13	Familial dysfibrinogenemia	Enrichment	FGA, FGB, FGG	7.77
14	Familial hypofibrinogenemia	Enrichment	FGA, FGB, FGG	7.77
15	Schimmelpenning-feuerstein-mims syndrome	Enrichment	HRAS, KRAS, NRAS	7.16
16	Afibrinogenemia, congenital	Enrichment	FGA, FGB, FGG	7.16
17	Thrombocytopenia	Enrichment	FGG, ITGA2B, ITGB3, SRC, VWF	6.81
18	Nevus, epidermal	Enrichment	HRAS, KRAS, NRAS	6.22
19	Thyroid cancer, nonmedullary, 2	Enrichment	BRAF, HRAS, NRAS	6.22
20	Noonan syndrome 3	Enrichment	HRAS, KRAS, RAF1	6.22
21	Pilomyxoid astrocytoma	Enrichment	BRAF, KRAS, RAF1	6.22
22	Follicular thyroid carcinoma	Enrichment	BRAF, HRAS, NRAS	6.22
23	Differentiated thyroid carcinoma	Enrichment	BRAF, HRAS, KRAS, NRAS	6.02
24	Catecholaminergic polymorphic ventricular tachycardia	Enrichment	CALM1, CALM2, CALM3	6.02
25	Ras-associated autoimmune leukoproliferative disorder	Enrichment	KRAS, NRAS	5.16
26	Noonan syndrome-like disorder with loose anagen hair	Enrichment	PPP1CB, SHOC2	5.16
27	Baraitser-winter cerebrofrontofacial syndrome	Enrichment	ACTB, ACTG1	5.16
28	Large congenital melanocytic nevus	Enrichment	HRAS, NRAS	4.69
29	Bleeding disorder, platelet-type, 16	Enrichment	ITGA2B, ITGB3	4.69
30	Arteriovenous malformations of the brain	Enrichment	BRAF, IL17RD, KRAS	4.65
31	Chronic myelogenous leukemia, bcr-abl1 positive	Enrichment	KRAS, NRAS	4.39
32	Long qt syndrome 1	Enrichment	CALM1, CALM2, CALM3	4.18
33	Lung cancer	Enrichment	BRAF, KRAS, PPP2R1B	4.09
34	Fetomaternal alloimmune thrombocytopenia 1	Enrichment	ITGA2B, ITGB3	3.99
35	Myelofibrosis	Enrichment	JAK2, SRC	3.85
36	Capillary malformation-arteriovenous malformation 1	Enrichment	KRAS, MAP2K1	3.85
37	Leukemia, chronic myeloid	Enrichment	KRAS, NRAS	3.85
38	Gallbladder cancer	Enrichment	BRAF, KRAS	3.85
39	Glanzmann thrombasthenia 1	Enrichment	ITGA2B, ITGB3	3.85
40	Leukemia, acute myeloid	Enrichment	JAK2, KRAS, NRAS	3.80
41	Arteriovenous malformation	Enrichment	HRAS, MAP2K1	3.61
42	Myopathy, x-linked, with excessive autophagy	Enrichment	HRAS, MAP2K1	3.52
43	Autosomal dominant macrothrombocytopenia	Enrichment	ITGA2B, ITGB3	3.52
44	Juvenile myelomonocytic leukemia	Enrichment	KRAS, NRAS	3.35
45	Lip and oral cavity carcinoma	Enrichment	BRAF, HRAS	3.35
46	Lung cancer susceptibility 3	Enrichment	BRAF, KRAS	3.21
47	Microcephaly	Enrichment	ACTB, ACTG1, CAMK2B, MAPK1	3.07
48	Dandy-walker syndrome	Enrichment	BRAF, PPP1CB	3.04
49	Dilated cardiomyopathy	Enrichment	BRAF, RAF1, VCL	2.91
50	Colorectal cancer	Enrichment	BRAF, NRAS, SRC	2.81
51	Oculoectodermal syndrome	Enrichment	KRAS	2.58
52	Pallister-killian syndrome	Enrichment	ARAF	2.58
53	Noonan syndrome 5	Enrichment	RAF1	2.58
54	Melorheostosis, isolated	Enrichment	MAP2K1	2.58
55	Noonan syndrome 7	Enrichment	BRAF	2.58
56	Leopard syndrome 3	Enrichment	BRAF	2.58
57	Cardiomyopathy, dilated, 1nn	Enrichment	RAF1	2.58
58	Cardiofaciocutaneous syndrome 3	Enrichment	MAP2K1	2.58
59	Melanosis, neurocutaneous	Enrichment	NRAS	2.58
60	Noonan syndrome 6	Enrichment	NRAS	2.58
61	Noonan syndrome 11	Enrichment	MRAS	2.58
62	Intellectual developmental disorder, autosomal recessive 63	Enrichment	CAMK2A	2.58
63	Intellectual developmental disorder, autosomal dominant 54	Enrichment	CAMK2B	2.58
64	Houge-janssens syndrome 4	Enrichment	PPP2R5C	2.58
65	Cardiofaciocutaneous syndrome 2	Enrichment	KRAS	2.58
66	Houge-janssens syndrome 2	Enrichment	PPP2R1A	2.58
67	Lymphangioma	Enrichment	BRAF	2.58
68	Noonan syndrome-like disorder with loose anagen hair 1	Enrichment	SHOC2	2.58
69	Phace association	Enrichment	BRAF	2.58
70	Melorheostosis	Enrichment	MAP2K1	2.58
71	Leopard syndrome 2	Enrichment	RAF1	2.58
72	Cardiofaciocutaneous syndrome 4	Enrichment	MAP2K2	2.58
73	Long qt syndrome 16	Enrichment	CALM3	2.58
74	Visual impairment and progressive phthisis bulbi	Enrichment	MARK3	2.58
75	Thrombocytopenia 6	Enrichment	SRC	2.58
76	Noonan syndrome-like disorder with loose anagen hair 2	Enrichment	PPP1CB	2.58
77	Intellectual developmental disorder, autosomal dominant 53	Enrichment	CAMK2A	2.58
78	Trigonitis	Enrichment	RAF1	2.58
79	Intellectual developmental disorder, autosomal dominant 59	Enrichment	CAMK2G	2.58
80	Long qt syndrome 15	Enrichment	CALM2	2.58
81	Congenital pulmonary airway malformation	Enrichment	KRAS	2.58
82	Syringocystadenoma papilliferum	Enrichment	BRAF	2.58
83	Ganglioglioma	Enrichment	BRAF	2.58
84	Nongerminomatous germ cell tumor	Enrichment	BRAF	2.58
85	Phace syndrome	Enrichment	BRAF	2.58
86	Phakomatosis pigmentokeratotica	Enrichment	HRAS	2.58
87	Ppp2r1a-related neurodevelopmental disorder	Enrichment	PPP2R1A	2.58
88	Classic hairy cell leukemia	Enrichment	BRAF	2.58
89	Neurocutaneous melanocytosis	Enrichment	NRAS	2.58
90	Von willebrand disease, type 1	Enrichment	VWF	2.58
91	Baraitser-winter syndrome 1	Enrichment	ACTB	2.58
92	Von willebrand disease, type 2	Enrichment	VWF	2.58
93	Noonan syndrome 13	Enrichment	MAPK1	2.58
94	Intellectual developmental disorder, x-linked, syndromic, houge type	Enrichment	CNKSR2	2.58
95	Von willebrand disease, type 3	Enrichment	VWF	2.58
96	Fetomaternal alloimmune thrombocytopenia 2	Enrichment	ITGA2B	2.58
97	Congenital smooth muscle hamartoma, with or without hemihypertrophy	Enrichment	ACTB	2.58
98	Cardiomyopathy, dilated, 1w	Enrichment	VCL	2.58
99	Becker nevus syndrome	Enrichment	ACTB	2.58
100	Dystonia-deafness syndrome 1	Enrichment	ACTB	2.58
101	Cardiomyopathy, familial hypertrophic, 15	Enrichment	VCL	2.58
102	Thrombocytopenia 11 with multiple congenital anomalies and dysmorphic facies	Enrichment	RAP1B	2.58
103	Von willebrand's disease	Enrichment	VWF	2.58
104	Thrombocytopenia 8, with dysmorphic features and developmental delay	Enrichment	ACTB	2.58
105	Baraitser-winter syndrome	Enrichment	ACTB	2.58
106	Congenital fibrinogen deficiency	Enrichment	FGG	2.58
107	Congenital smooth muscle hamartoma	Enrichment	ACTB	2.58
108	Capillary leak syndrome	Enrichment	TLN1	2.58
109	Developmental malformations-deafness-dystonia syndrome	Enrichment	ACTB	2.58
110	Bladder cancer	Enrichment	HRAS, KRAS	2.58
111	Immunodeficiency due to defect in mapbp-interacting protein	Enrichment	LAMTOR2	2.53
112	Hypogonadotropic hypogonadism 18 with or without anosmia	Enrichment	IL17RD	2.53
113	Primary immunodeficiency syndrome due to p14 deficiency	Enrichment	LAMTOR2	2.53
114	Long qt syndrome	Enrichment	CALM1, CALM2	2.52
115	Non-immune hydrops fetalis	Enrichment	HRAS, KRAS	2.52
116	Hypogonadotropic hypogonadism 19 with or without anosmia	Enrichment	DUSP6	2.50
117	Pulmonic stenosis	Enrichment	BRAF	2.28
118	Ventricular tachycardia, catecholaminergic polymorphic, 4	Enrichment	CALM1	2.28
119	Encephalocraniocutaneous lipomatosis	Enrichment	KRAS	2.28
120	Thrombocythemia 3	Enrichment	JAK2	2.28
121	Long qt syndrome 14	Enrichment	CALM1	2.28
122	Houge-janssens syndrome 1	Enrichment	PPP2R5D	2.28
123	Polycythemia	Enrichment	JAK2	2.28
124	Houge-janssens syndrome 3	Enrichment	PPP2CA	2.28
125	Hypereosinophilic syndrome	Enrichment	JAK2	2.28
126	Tafro syndrome	Enrichment	MAP2K2	2.28
127	Wooly hair nevus	Enrichment	HRAS	2.28
128	Spondyloepimetaphyseal dysplasia, strudwick type	Enrichment	FN1	2.28
129	Spondylometaphyseal dysplasia, corner fracture type	Enrichment	FN1	2.28
130	Deafness, autosomal dominant 20	Enrichment	ACTG1	2.28
131	Baraitser-winter syndrome 2	Enrichment	ACTG1	2.28
132	Neurodevelopmental disorder with variable familial hypercholanemia	Enrichment	WDR83	2.23
133	Submucosal cleft palate	Enrichment	UBB	2.20
134	Cleft hard palate	Enrichment	UBB	2.20
135	Autosomal dominant non-syndromic intellectual disability	Enrichment	CAMK2A, CAMK2B	2.11
136	Ataxia-telangiectasia	Enrichment	BRAF	2.10
137	Polycythemia vera	Enrichment	JAK2	2.10
138	Tethered spinal cord syndrome	Enrichment	BRAF	2.10
139	Breast implant-associated anaplastic large cell lymphoma	Enrichment	JAK2	2.10
140	Polycystic kidney disease 4	Enrichment	SHOC2	2.10
141	Spermatocytoma	Enrichment	HRAS	2.10
142	Hyper-ige syndrome 1, autosomal dominant, with recurrent infections	Enrichment	ITGB3	2.10
143	Periventricular nodular heterotopia 1	Enrichment	VWF	2.10
144	Glomerulopathy with fibronectin deposits 2	Enrichment	FN1	2.10
145	Bleeding disorder, platelet-type, 24	Enrichment	ITGB3	2.10
146	Familial isolated dilated cardiomyopathy	Enrichment	RAF1, VCL	2.06
147	Uvula, bifid	Enrichment	UBB	2.02
148	Cleft soft palate	Enrichment	UBB	2.02
149	Myeloma, multiple	Enrichment	BRAF, KRAS	2.02
150	Erythrocytosis, familial, 1	Enrichment	JAK2	1.98
151	Diffuse gastric and lobular breast cancer syndrome	Enrichment	KRAS	1.98
152	Thyroid cancer, nonmedullary, 1	Enrichment	BRAF	1.98
153	Budd-chiari syndrome	Enrichment	JAK2	1.98
154	Neurofibromatosis-noonan syndrome	Enrichment	MAP2K2	1.98
155	Lung sarcomatoid carcinoma	Enrichment	KRAS	1.98
156	Craniopharyngioma	Enrichment	BRAF	1.98
157	Pilocytic astrocytoma	Enrichment	KRAS	1.98
158	Newborn respiratory distress syndrome	Enrichment	BRAF	1.98
159	Epidermolytic nevus	Enrichment	HRAS	1.98
160	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	1.98
161	Aminoacylase 1 deficiency	Enrichment	ACTB	1.98
162	Pseudomyogenic hemangioendothelioma	Enrichment	ACTB	1.98
163	Cholangiocarcinoma	Enrichment	PTPN3	1.90
164	Polycystic kidney disease 3 with or without polycystic liver disease	Enrichment	SHOC2	1.88
165	Myeloproliferative neoplasm	Enrichment	JAK2	1.88
166	Amyloidosis, hereditary systemic 2	Enrichment	FGA	1.88
167	Glanzmann thrombasthenia 2	Enrichment	ITGB3	1.88
168	Coloboma of choroid and retina	Enrichment	ACTG1	1.88
169	Wilms tumor 5	Enrichment	BRAF	1.80
170	Ventricular tachycardia, catecholaminergic polymorphic, 1, with or without atrial dysfunction and/or dilated cardiomyopathy	Enrichment	CALM1	1.80
171	Breast adenocarcinoma	Enrichment	KRAS	1.80
172	Lung squamous cell carcinoma	Enrichment	KRAS	1.80
173	Breast cancer	Enrichment	KRAS, PHB1	1.77
174	Familial hypercholanemia	Enrichment	WDR83	1.76
175	Essential thrombocythemia	Enrichment	JAK2	1.73
176	Thrombophilia due to thrombin defect	Enrichment	FGA	1.73
177	Polycystic kidney disease 4 with or without polycystic liver disease	Enrichment	SHOC2	1.68
178	Lymphoma, non-hodgkin, familial	Enrichment	BRAF	1.68
179	Catecholaminergic polymorphic ventricular tachycardia 1	Enrichment	CALM1	1.68
180	Spastic paraplegia 4, autosomal dominant	Enrichment	FGG	1.68
181	Cardiomyopathy, familial hypertrophic, 4	Enrichment	BRAF	1.63
182	Leukemia, acute lymphoblastic 3	Enrichment	JAK2	1.63
183	Primary hyperaldosteronism	Enrichment	BRAF	1.63
184	Ventricular septal defect	Enrichment	BRAF	1.63
185	Melanoma	Enrichment	BRAF	1.58
186	Cat eye syndrome	Enrichment	ACTG1	1.58
187	Pectus excavatum	Enrichment	SHOC2	1.54
188	Specific learning disability	Enrichment	MAPK1	1.54
189	Protein-deficiency anemia	Enrichment	NRAS	1.47
190	Osteoporosis	Enrichment	SRC	1.44
191	Wilms tumor 1	Enrichment	BRAF	1.41
192	Lynch syndrome	Enrichment	KRAS	1.41
193	Rhabdomyosarcoma	Enrichment	HRAS	1.38
194	Melanoma, cutaneous malignant 1	Enrichment	BRAF	1.35
195	Sudden infant death syndrome	Enrichment	CALM2	1.35
196	Heart, malformation of	Enrichment	MAPK1	1.33
197	Diffuse large b-cell lymphoma	Enrichment	BRAF	1.31
198	Lissencephaly	Enrichment	ACTG1	1.27
199	Normosmic congenital hypogonadotropic hypogonadism	Enrichment	DUSP6	1.26
200	Myocardial infarction	Enrichment	ITGB3	1.25
201	Cardiomyopathy, familial hypertrophic, 1	Enrichment	RAF1	1.21
202	Pancreatic cancer	Enrichment	KRAS	1.19
203	Kallmann syndrome	Enrichment	IL17RD	1.18
204	Hydrops fetalis, nonimmune	Enrichment	HRAS	1.18
205	Familial hypertrophic cardiomyopathy	Enrichment	RAF1	1.08
206	Cakut	Enrichment	ACTG1	1.06
207	Left ventricular noncompaction	Enrichment	RAF1	1.05
208	Dystonia	Enrichment	CAMK2B	1.05
209	Non-syndromic x-linked intellectual disability	Enrichment	CNKSR2	1.04
210	Non-syndromic genetic deafness	Enrichment	ACTG1	1.04
211	Nonsyndromic hearing loss	Enrichment	ACTG1	0.98
212	Gastric cancer	Enrichment	KRAS	0.97
213	Nephrotic syndrome	Enrichment	FN1	0.97
214	Hereditary breast carcinoma	Enrichment	KRAS	0.96
215	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	ACTG1	0.89
216	Hereditary breast ovarian cancer syndrome	Enrichment	KRAS	0.87
217	Undetermined early-onset epileptic encephalopathy	Enrichment	CNKSR2	0.86
218	Primary ovarian insufficiency	Enrichment	JAK2	0.84
219	Autism	Enrichment	CAMK2G	0.76
220	Rare genetic deafness	Enrichment	ACTG1	0.72
221	Ovarian cancer	Enrichment	KRAS	0.63
222	Congenital nervous system abnormality	Enrichment	CAMK2B	0.61
223	Nervous system disease	Enrichment	CAMK2B	0.61
224	Autism spectrum disorder	Enrichment	MAP2K1	0.60
225	Complex neurodevelopmental disorder	Enrichment	PPP2CA	0.55

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Signaling downstream of RAS mutants

Pathway Network for Signaling downstream of RAS mutants

Pathway network for the Signaling downstream of RAS mutants SuperPath

Member Pathways for Signaling downstream of RAS mutants

Pathways in the Signaling downstream of RAS mutants SuperPath

Gene overlap in member pathways for Signaling downstream of RAS mutants SuperPath

Associated Genes for Signaling downstream of RAS mutants

Associated Disorders for Signaling downstream of RAS mutants

Disorders associated with Signaling downstream of RAS mutants SuperPath

STRING Interaction Network for Signaling downstream of RAS mutants

Sources for Signaling downstream of RAS mutants