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Signaling downstream of RAS mutants
SuperPath
Pathway network
for
Signaling downstream of RAS mutants
SuperPath
9
Pathways
in the
Signaling downstream of RAS mutants
SuperPath
Signaling by RAF1 mutants
RAF activation
Signaling by moderate kinase activity BRAF mutants
Signaling by high-kinase activity BRAF mutants
Paradoxical activation of RAF signaling by kinase inactive BRAF
Signaling by RAS mutants
Negative regulation of MAPK pathway
Signaling downstream of RAS mutants
MAP2K and MAPK activation
83
Genes
in the
Signaling downstream of RAS mutants
SuperPath
HRAS
ARAF
KRAS
MARK3
NRAS
MAP2K1
MAP2K2
RAF1
BRAF
YWHAB
KSR1
MAPK1
MAPK3
SRC
CNKSR1
CSK
FGA
FGB
FGG
CNKSR2
FN1
KSR2
ITGA2B
ITGB3
ARRB1
ARRB2
APBB1IP
RAP1A
RAP1B
ACTB
TLN1
ACTG1
VCL
VWF
IQGAP1
PEBP1
JAK2
CALM1
CALM2
CALM3
CAMK2A
CAMK2B
CAMK2D
CAMK2G
BRAP
MAP3K11
PHB1
PPP2CA
PPP2CB
PPP2R1A
PPP2R1B
PPP2R5A
PPP2R5B
PPP2R5C
PPP2R5D
PPP2R5E
MRAS
PPP1CB
PPP1CC
SHOC2
DUSP10
PAQR3
DUSP1
DUSP2
DUSP4
DUSP5
DUSP6
DUSP7
DUSP8
DUSP9
PPP5C
PTPN3
PTPN7
RPS27A
MAPK12
UBA52
UBB
UBC
DUSP16
LAMTOR2
IL17RD
WDR83
LAMTOR3
*Darkness represents the genes rank within the SuperPath, via the multiplicity of each gene in the constituent pathways.
STRING interaction network
for
Signaling downstream of RAS mutants
SuperPath