Signaling events mediated by focal adhesion kinase

No Pathway Network information available for Signaling events mediated by focal adhesion kinase

Pathways in the Signaling events mediated by focal adhesion kinase SuperPath

#	Name	Source	Genes
1	Signaling events mediated by focal adhesion kinase	PubChem	ACTA1 ACTN1 ARHGAP26 ARHGAP35 ARHGEF11 ARHGEF28 ARHGEF7 ASAP1 BCAR1 BMX BRAF CAPN2 CCND1 CRK DOCK1 ELMO1 ETS1 GIT2 GRB2 GRB7 ITGA5 ITGAV ITGB1 ITGB5 JUN KLF8 LCK MAP2K1 MAP2K4 MAPK1 MAPK8 MAPK8IP3 MYLK NCK1 PAK1 PIK3CA PIK3R1 PLCG1 PTK2 PTPN21 PXN RAC1 RAF1 RAPGEF1 RASA1 RHOA ROCK2 RRAS SH3GL1 SOS1 SRC TLN1 VCL WASL (see all 54) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	GIT2	GIT ArfGAP 2	Protein Coding	1
2	KLF8	KLF Transcription Factor 8	Protein Coding	1
3	ARHGAP26	Rho GTPase Activating Protein 26	Protein Coding	1
4	PTPN21	Protein Tyrosine Phosphatase Non-Receptor Type 21	Protein Coding	1
5	ROCK2	Rho Associated Coiled-Coil Containing Protein Kinase 2	Protein Coding	1
6	ACTA1	Actin Alpha 1, Skeletal Muscle	Protein Coding	1
7	MAPK8IP3	Mitogen-Activated Protein Kinase 8 Interacting Protein 3	Protein Coding	1
8	ARHGEF11	Rho Guanine Nucleotide Exchange Factor 11	Protein Coding	1
9	CAPN2	Calpain 2	Protein Coding	1
10	ELMO1	Engulfment And Cell Motility 1	Protein Coding	1
11	LCK	LCK Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	1
12	MAP2K4	Mitogen-Activated Protein Kinase Kinase 4	Protein Coding	1
13	ETS1	ETS Proto-Oncogene 1, Transcription Factor	Protein Coding	1
14	MYLK	Myosin Light Chain Kinase	Protein Coding	1
15	CCND1	Cyclin D1	Protein Coding	1
16	DOCK1	Dedicator Of Cytokinesis 1	Protein Coding	1
17	RAPGEF1	Rap Guanine Nucleotide Exchange Factor 1	Protein Coding	1
18	MAPK8	Mitogen-Activated Protein Kinase 8	Protein Coding	1
19	BMX	BMX Non-Receptor Tyrosine Kinase	Protein Coding	1
20	GRB7	Growth Factor Receptor Bound Protein 7	Protein Coding	1
21	BCAR1	BCAR1 Scaffold Protein, Cas Family Member	Protein Coding	1
22	ACTN1	Actinin Alpha 1	Protein Coding	1
23	PXN	Paxillin	Protein Coding	1
24	VCL	Vinculin	Protein Coding	1
25	JUN	Jun Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
26	ARHGEF7	Rho Guanine Nucleotide Exchange Factor 7	Protein Coding	1
27	RASA1	RAS P21 Protein Activator 1	Protein Coding	1
28	ARHGEF28	Rho Guanine Nucleotide Exchange Factor 28	Protein Coding	1
29	ITGA5	Integrin Subunit Alpha 5	Protein Coding	1
30	ITGAV	Integrin Subunit Alpha V	Protein Coding	1
31	MAP2K1	Mitogen-Activated Protein Kinase Kinase 1	Protein Coding	1
32	WASL	WASP Like Actin Nucleation Promoting Factor	Protein Coding	1
33	NCK1	NCK Adaptor Protein 1	Protein Coding	1
34	PLCG1	Phospholipase C Gamma 1	Protein Coding	1
35	PTK2	Protein Tyrosine Kinase 2	Protein Coding	1
36	ITGB1	Integrin Subunit Beta 1	Protein Coding	1
37	PAK1	P21 (RAC1) Activated Kinase 1	Protein Coding	1
38	TLN1	Talin 1	Protein Coding	1
39	RRAS	RAS Related	Protein Coding	1
40	RHOA	Ras Homolog Family Member A	Protein Coding	1
41	ARHGAP35	Rho GTPase Activating Protein 35	Protein Coding	1
42	ASAP1	ArfGAP With SH3 Domain, Ankyrin Repeat And PH Domain 1	Protein Coding	1
43	RAC1	Rac Family Small GTPase 1	Protein Coding	1
44	SH3GL1	SH3 Domain Containing GRB2 Like 1, Endophilin A2	Protein Coding	1
45	GRB2	Growth Factor Receptor Bound Protein 2	Protein Coding	1
46	ITGB5	Integrin Subunit Beta 5	Protein Coding	1
47	CRK	CRK Proto-Oncogene, Adaptor Protein	Protein Coding	1
48	SRC	SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase	Protein Coding	1
49	SOS1	SOS Ras/Rac Guanine Nucleotide Exchange Factor 1	Protein Coding	1
50	BRAF	B-Raf Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	1
51	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	1
52	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	1
53	RAF1	Raf-1 Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	1
54	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	1

Disorders associated with Signaling events mediated by focal adhesion kinase SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Noonan syndrome 1	Enrichment	BRAF, MAP2K1, RAF1, RRAS, SOS1	7.58
2	Noonan syndrome and noonan-related syndrome	Enrichment	BRAF, MAP2K1, RAF1, SOS1	6.53
3	Capillary malformation-arteriovenous malformation 1	Enrichment	MAP2K1, PIK3CA, RASA1	5.69
4	Rasopathy	Enrichment	BRAF, MAP2K1, RAF1, SOS1	5.50
5	Arteriovenous malformation	Enrichment	MAP2K1, PIK3CA, RASA1	5.31
6	Myopathy, x-linked, with excessive autophagy	Enrichment	MAP2K1, PIK3CA, RASA1	5.15
7	Lung non-small cell carcinoma	Enrichment	BRAF, MAP2K1, PIK3CA	5.02
8	Pulmonic stenosis	Enrichment	BRAF, SOS1	4.81
9	Colorectal cancer	Enrichment	BRAF, CCND1, PIK3CA, PIK3R1, SRC	4.62
10	Langerhans cell histiocytosis	Enrichment	BRAF, MAP2K1	4.33
11	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3CA, PIK3R1	4.33
12	Cardiofaciocutaneous syndrome 1	Enrichment	BRAF, MAP2K1	4.03
13	Cardiofaciocutaneous syndrome	Enrichment	BRAF, MAP2K1	4.03
14	Noonan syndrome with multiple lentigines	Enrichment	BRAF, RAF1	4.03
15	Capillary malformations, congenital	Enrichment	PIK3CA, RASA1	3.81
16	Klippel-trenaunay-weber syndrome	Enrichment	PIK3CA, RASA1	3.64
17	Hemihyperplasia, isolated	Enrichment	PIK3CA, RHOA	3.64
18	Dilated cardiomyopathy	Enrichment	ACTA1, BRAF, RAF1, VCL	3.55
19	Noonan syndrome 3	Enrichment	RAF1, SOS1	3.49
20	Gallbladder cancer	Enrichment	BRAF, PIK3CA	3.49
21	Pilomyxoid astrocytoma	Enrichment	BRAF, RAF1	3.49
22	Melanocytic nevus syndrome, congenital	Enrichment	BRAF, RAF1	3.37
23	Juvenile myelomonocytic leukemia	Enrichment	ARHGAP26, RRAS	3.00
24	Lip and oral cavity carcinoma	Enrichment	BRAF, PIK3CA	3.00
25	Macrodactyly	Enrichment	PIK3CA	2.40
26	Cystic angiomatosis of bone, diffuse	Enrichment	RASA1	2.40
27	Noonan syndrome 5	Enrichment	RAF1	2.40
28	Noonan syndrome 4	Enrichment	SOS1	2.40
29	Congenital myopathy 2a, typical, autosomal dominant	Enrichment	ACTA1	2.40
30	Melorheostosis, isolated	Enrichment	MAP2K1	2.40
31	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	2.40
32	Noonan syndrome 7	Enrichment	BRAF	2.40
33	Leopard syndrome 3	Enrichment	BRAF	2.40
34	Cardiomyopathy, dilated, 1nn	Enrichment	RAF1	2.40
35	Cowden syndrome 5	Enrichment	PIK3CA	2.40
36	Cardiofaciocutaneous syndrome 3	Enrichment	MAP2K1	2.40
37	Myopathy, scapulohumeroperoneal	Enrichment	ACTA1	2.40
38	Cerebral cavernous malformations 4	Enrichment	PIK3CA	2.40
39	Noonan syndrome 13	Enrichment	MAPK1	2.40
40	Short syndrome	Enrichment	PIK3R1	2.40
41	Intellectual developmental disorder with macrocephaly, seizures, and speech delay	Enrichment	PAK1	2.40
42	Immune dysregulation, autoimmunity, and autoinflammation	Enrichment	PLCG1	2.40
43	Cardiomyopathy, dilated, 1w	Enrichment	VCL	2.40
44	Lymphangioma	Enrichment	BRAF	2.40
45	Hemifacial myohyperplasia	Enrichment	PIK3CA	2.40
46	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	2.40
47	Phace association	Enrichment	BRAF	2.40
48	Melorheostosis	Enrichment	MAP2K1	2.40
49	Leopard syndrome 2	Enrichment	RAF1	2.40
50	Cardiomyopathy, familial hypertrophic, 15	Enrichment	VCL	2.40
51	Congenital myopathy 2b, severe infantile, autosomal recessive	Enrichment	ACTA1	2.40
52	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	2.40
53	Bleeding disorder, platelet-type, 15	Enrichment	ACTN1	2.40
54	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	2.40
55	Immunodeficiency 22	Enrichment	LCK	2.40
56	Thrombocytopenia 6	Enrichment	SRC	2.40
57	Ectodermal dysplasia with facial dysmorphism and acral, ocular, and brain anomalies	Enrichment	RHOA	2.40
58	Congenital myopathy 2c, severe infantile, autosomal dominant	Enrichment	ACTA1	2.40
59	Linear hypopigmentation and craniofacial asymmetry with acral, ocular and brain anomalies	Enrichment	RHOA	2.40
60	Trigonitis	Enrichment	RAF1	2.40
61	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	2.40
62	Hypospadias	Enrichment	PIK3CA	2.40
63	Rare venous malformation	Enrichment	PIK3CA	2.40
64	Immune dysregulation, neurodevelopmental defects, and colitis	Enrichment	ITGAV	2.40
65	Gorham's disease	Enrichment	RASA1	2.40
66	Zebra body myopathy	Enrichment	ACTA1	2.40
67	Diaphragmatic eventration	Enrichment	PIK3CA	2.40
68	Capillary leak syndrome	Enrichment	TLN1	2.40
69	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	2.40
70	Syringocystadenoma papilliferum	Enrichment	BRAF	2.40
71	Rare combined vascular malformation	Enrichment	PIK3CA	2.40
72	Ganglioglioma	Enrichment	BRAF	2.40
73	Cavernous lymphangioma	Enrichment	PIK3CA	2.40
74	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	2.40
75	Nongerminomatous germ cell tumor	Enrichment	BRAF	2.40
76	Phace syndrome	Enrichment	BRAF	2.40
77	Actin-accumulation myopathy	Enrichment	ACTA1	2.40
78	Microcephaly-corpus callosum and cerebellar vermis hypoplasia-facial dysmorphism-intellectual disability syndrom	Enrichment	RAC1	2.40
79	Classic hairy cell leukemia	Enrichment	BRAF	2.40
80	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	2.40
81	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	2.40
82	Macrodactyly of toe	Enrichment	PIK3CA	2.40
83	Temporomandibular joint anomaly	Enrichment	DOCK1	2.40
84	Lung cancer	Enrichment	BRAF, PIK3CA	2.15
85	Fibromatosis, gingival, 1	Enrichment	SOS1	2.10
86	Keratosis, seborrheic	Enrichment	PIK3CA	2.10
87	Noonan syndrome 8	Enrichment	PIK3CA	2.10
88	Intellectual developmental disorder, autosomal dominant 48	Enrichment	RAC1	2.10
89	Neurodevelopmental disorder with or without variable brain abnormalities	Enrichment	MAPK8IP3	2.10
90	Rosette-forming glioneuronal tumor	Enrichment	PIK3CA	2.10
91	Jacobsen syndrome	Enrichment	ETS1	1.92
92	Ataxia-telangiectasia	Enrichment	BRAF	1.92
93	Pompe disease, infantile-onset	Enrichment	PIK3CA	1.92
94	Nuchal bleb, familial	Enrichment	SOS1	1.92
95	Aortic aneurysm, familial thoracic 7	Enrichment	MYLK	1.92
96	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3R1	1.92
97	Tethered spinal cord syndrome	Enrichment	BRAF	1.92
98	Wieacker-wolff syndrome	Enrichment	RASA1	1.92
99	Immunodeficiency 14	Enrichment	PIK3R1	1.92
100	Keratoacanthoma	Enrichment	PIK3CA	1.92
101	Thrombocytopenia	Enrichment	ACTN1, SRC	1.81
102	Nemaline myopathy 2	Enrichment	ACTA1	1.80
103	Megacystis-microcolon-intestinal hypoperistalsis syndrome 1	Enrichment	MYLK	1.80
104	Thyroid cancer, nonmedullary, 1	Enrichment	BRAF	1.80
105	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	PIK3CA	1.80
106	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	1.80
107	Mantle cell lymphoma	Enrichment	CCND1	1.80
108	Cerebrovascular disease	Enrichment	PIK3CA	1.80
109	Craniopharyngioma	Enrichment	BRAF	1.80
110	Newborn respiratory distress syndrome	Enrichment	BRAF	1.80
111	Familial cerebral cavernous malformations	Enrichment	PIK3CA	1.80
112	Intermediate nemaline myopathy	Enrichment	ACTA1	1.80
113	Gingival fibromatosis	Enrichment	SOS1	1.80
114	Familial isolated dilated cardiomyopathy	Enrichment	RAF1, VCL	1.73
115	Visceral myopathy 1	Enrichment	MYLK	1.70
116	Martsolf syndrome 1	Enrichment	ARHGAP35	1.70
117	Von hippel-lindau syndrome	Enrichment	CCND1	1.70
118	Congenital myopathy 3 with rigid spine	Enrichment	ACTA1	1.70
119	Hemimegalencephaly	Enrichment	PIK3CA	1.70
120	Severe congenital nemaline myopathy	Enrichment	ACTA1	1.70
121	Myeloma, multiple	Enrichment	BRAF, CCND1	1.68
122	Cowden syndrome 1	Enrichment	PIK3CA	1.63
123	Telangiectasia, hereditary hemorrhagic, type 1	Enrichment	RASA1	1.63
124	Wilms tumor 5	Enrichment	BRAF	1.63
125	Hemangioma, capillary infantile	Enrichment	RASA1	1.63
126	Anterior segment dysgenesis 5	Enrichment	ARHGAP35	1.63
127	Basal cell carcinoma 1	Enrichment	RASA1	1.63
128	Breast adenocarcinoma	Enrichment	PIK3CA	1.63
129	Lung squamous cell carcinoma	Enrichment	PIK3CA	1.63
130	Typical nemaline myopathy	Enrichment	ACTA1	1.63
131	Nevus, epidermal	Enrichment	PIK3CA	1.56
132	Thyroid cancer, nonmedullary, 2	Enrichment	BRAF	1.56
133	Myelofibrosis	Enrichment	SRC	1.56
134	Hereditary hemorrhagic telangiectasia	Enrichment	RASA1	1.56
135	Follicular thyroid carcinoma	Enrichment	BRAF	1.56
136	Childhood-onset nemaline myopathy	Enrichment	ACTA1	1.56
137	Overgrowth syndrome	Enrichment	PIK3R1	1.56
138	Lymphoma, non-hodgkin, familial	Enrichment	BRAF	1.50
139	Cardiomyopathy, familial hypertrophic, 4	Enrichment	BRAF	1.45
140	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	RAC1	1.45
141	Adult hepatocellular carcinoma	Enrichment	PIK3CA	1.45
142	Primary hyperaldosteronism	Enrichment	BRAF	1.45
143	Ventricular septal defect	Enrichment	BRAF	1.45
144	Cowden syndrome	Enrichment	PIK3CA	1.45
145	Familial thoracic aortic aneurysm and dissection	Enrichment	MYLK	1.45
146	Breast cancer	Enrichment	JUN, PIK3CA	1.45
147	Leukemia, chronic lymphocytic	Enrichment	CCND1	1.41
148	Peters-plus syndrome	Enrichment	ARHGAP35	1.41
149	Nemaline myopathy	Enrichment	ACTA1	1.41
150	Melanoma	Enrichment	BRAF	1.41
151	Autosomal dominant macrothrombocytopenia	Enrichment	ACTN1	1.41
152	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3R1	1.41
153	Specific learning disability	Enrichment	MAPK1	1.37
154	Meningioma	Enrichment	PIK3CA	1.33
155	Aortic valve disease 1	Enrichment	SOS1	1.30
156	Neural tube defects	Enrichment	ITGB1	1.30
157	Osteoporosis	Enrichment	SRC	1.26
158	Aortic aneurysm, familial thoracic 1	Enrichment	MYLK	1.26
159	Lung cancer susceptibility 3	Enrichment	BRAF	1.26
160	46,xy partial gonadal dysgenesis	Enrichment	SOS1	1.26
161	Wilms tumor 1	Enrichment	BRAF	1.24
162	Congenital myopathy 4a, autosomal dominant	Enrichment	ACTA1	1.24
163	Lynch syndrome	Enrichment	PIK3CA	1.24
164	Melanoma, cutaneous malignant 1	Enrichment	BRAF	1.18
165	Dandy-walker syndrome	Enrichment	BRAF	1.18
166	Heart, malformation of	Enrichment	MAPK1	1.16
167	Neuromuscular disease	Enrichment	ACTA1	1.16
168	Arteriovenous malformations of the brain	Enrichment	BRAF	1.14
169	Diffuse large b-cell lymphoma	Enrichment	BRAF	1.14
170	Congenital myopathy	Enrichment	ACTA1	1.14
171	Endometrial cancer	Enrichment	PIK3CA	1.09
172	Centronuclear myopathy	Enrichment	ACTA1	1.09
173	Hepatocellular carcinoma	Enrichment	PIK3CA	1.08
174	Cardiomyopathy, familial hypertrophic, 1	Enrichment	RAF1	1.04
175	Hydrops fetalis, nonimmune	Enrichment	ACTA1	1.01
176	Bladder cancer	Enrichment	PIK3CA	0.96
177	Prostate cancer	Enrichment	PIK3CA	0.96
178	Severe covid-19	Enrichment	ITGAV	0.96
179	Differentiated thyroid carcinoma	Enrichment	BRAF	0.96
180	Non-immune hydrops fetalis	Enrichment	ACTA1	0.93
181	Familial hypertrophic cardiomyopathy	Enrichment	RAF1	0.91
182	Severe combined immunodeficiency	Enrichment	LCK	0.91
183	Left ventricular noncompaction	Enrichment	RAF1	0.88
184	Fetal akinesia deformation sequence 1	Enrichment	ACTA1	0.86
185	Systemic lupus erythematosus	Enrichment	ETS1	0.84
186	Leukemia, acute myeloid	Enrichment	SH3GL1	0.83
187	Myopathy	Enrichment	ACTA1	0.83
188	Distal arthrogryposis	Enrichment	ACTA1	0.81
189	Gastric cancer	Enrichment	PIK3CA	0.80
190	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	MYLK	0.79
191	Hereditary breast carcinoma	Enrichment	PIK3CA	0.79
192	Hypertelorism	Enrichment	PIK3CA	0.73
193	Hereditary breast ovarian cancer syndrome	Enrichment	BCAR1	0.70
194	Ovarian cancer	Enrichment	PIK3CA	0.48
195	Autism spectrum disorder	Enrichment	MAP2K1	0.45
196	Microcephaly	Enrichment	MAPK1	0.41
197	Complex neurodevelopmental disorder	Enrichment	MAPK8IP3	0.41

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Signaling events mediated by focal adhesion kinase

Pathway Network for Signaling events mediated by focal adhesion kinase

Member Pathways for Signaling events mediated by focal adhesion kinase

Pathways in the Signaling events mediated by focal adhesion kinase SuperPath

Associated Genes for Signaling events mediated by focal adhesion kinase

Associated Disorders for Signaling events mediated by focal adhesion kinase

Disorders associated with Signaling events mediated by focal adhesion kinase SuperPath

STRING Interaction Network for Signaling events mediated by focal adhesion kinase

Sources for Signaling events mediated by focal adhesion kinase