Signaling events mediated by HDAC Class I

Pathway network for the Signaling events mediated by HDAC Class I SuperPath

Sources:

PubChem
GeneGo (Thomson Reuters)

Pathways in the Signaling events mediated by HDAC Class I SuperPath

#	Name	Source	Genes
1	Signaling events mediated by HDAC Class I	PubChem	BTRC CHD3 CHD4 FKBP3 GATA1 GATA2 GATAD2A GATAD2B H2AC20 H2BC21 H3C13 H3C14 H3C15 H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 HDAC1 HDAC2 HDAC3 HDAC8 KAT2B MAX MBD2 MBD3 MBD3L2 MTA2 MXD1 NCOR1 NCOR2 NFKB1 NFKBIA NR2C1 NUP153 NUP210 NUP214 NUP62 PPARG PRKACA PRMT5 RAN RANBP2 RANGAP1 RBBP4 RBBP7 RELA SAP18 SAP30 SIN3A SIN3B SMAD7 SMG5 SMURF1 STAT3 SUMO1 TFCP2 TNF TNFRSF1A UBE2I WDR77 XPO1 YY1 ZFPM1 (see all 73) (see less)
2	Signaling events mediated by HDAC Class II	PubChem	ANKRA2 BCL6 BCOR CAMK2A CAMK4 ESR1 GATA1 GATA2 GNB1 GNG2 GRK2 H2AC20 H2BC21 H3C13 H3C14 H3C15 H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 HDAC10 HDAC11 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC9 HSP90AA1 MEF2C NCOR2 NR3C1 NUP153 NUP210 NUP214 NUP62 RAN RANBP2 RANGAP1 RFXANK SRF SUMO1 TUBA1B TUBB2A UBE2I XPO1 YWHAB YWHAE (see all 58) (see less)
3	Transcription Sin3 and NuRD in transcription regulation	GeneGo (Thomson Reuters)	ARID4A ARID4B CHD3 CHD4 CREBBP EP300 GATAD2A GATAD2B H3-3A H3-3B H3-4 H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 HDAC1 HDAC2 KAT2B MBD2 MBD3 MTA1 MTA2 MTA3 NCOR1 NCOR2 NONO PPARA RARA RARB RBBP4 RBBP7 REST RXRA RXRB SAP130 SAP18 SAP30 SFPQ SIN3A SIN3B SUDS3 THRA (see all 52) (see less)

Gene overlap in member pathways for Signaling events mediated by HDAC Class I SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	H4C2	H4 Clustered Histone 2	Protein Coding	3
2	H4C8	H4 Clustered Histone 8	Protein Coding	3
3	H4C3	H4 Clustered Histone 3	Protein Coding	3
4	H4C4	H4 Clustered Histone 4	Protein Coding	3
5	H4C1	H4 Clustered Histone 1	Protein Coding	3
6	H4C16	H4 Histone 16	Protein Coding	3
7	H4C14	H4 Clustered Histone 14	Protein Coding	3
8	H4C13	H4 Clustered Histone 13	Protein Coding	3
9	H4C5	H4 Clustered Histone 5	Protein Coding	3
10	H4C11	H4 Clustered Histone 11	Protein Coding	3
11	H4C12	H4 Clustered Histone 12	Protein Coding	3
12	H4C6	H4 Clustered Histone 6	Protein Coding	3
13	H4C9	H4 Clustered Histone 9	Protein Coding	3
14	H4C15	H4 Clustered Histone 15	Protein Coding	3
15	NCOR2	Nuclear Receptor Corepressor 2	Protein Coding	3
16	H2AC20	H2A Clustered Histone 20	Protein Coding	2
17	GATAD2B	GATA Zinc Finger Domain Containing 2B	Protein Coding	2
18	H2BC21	H2B Clustered Histone 21	Protein Coding	2
19	GATAD2A	GATA Zinc Finger Domain Containing 2A	Protein Coding	2
20	SIN3B	SIN3 Transcription Regulator Family Member B	Protein Coding	2
21	H3C14	H3 Clustered Histone 14	Protein Coding	2
22	H3C13	H3 Clustered Histone 13	Protein Coding	2
23	H3C15	H3 Clustered Histone 15	Protein Coding	2
24	CHD4	Chromodomain Helicase DNA Binding Protein 4	Protein Coding	2
25	GATA2	GATA Binding Protein 2~Name Same As:- HGNC:18350	Protein Coding	2
26	SAP30	Sin3A Associated Protein 30	Protein Coding	2
27	SAP18	Sin3A Associated Protein 18	Protein Coding	2
28	MTA2	Metastasis Associated 1 Family Member 2	Protein Coding	2
29	GATA1	GATA Binding Protein 1	Protein Coding	2
30	MBD2	Methyl-CpG Binding Domain Protein 2	Protein Coding	2
31	CHD3	Chromodomain Helicase DNA Binding Protein 3	Protein Coding	2
32	KAT2B	Lysine Acetyltransferase 2B	Protein Coding	2
33	RANGAP1	Ran GTPase Activating Protein 1	Protein Coding	2
34	RBBP7	RB Binding Protein 7, Chromatin Remodeling Factor	Protein Coding	2
35	MBD3	Methyl-CpG Binding Domain Protein 3	Protein Coding	2
36	RBBP4	RB Binding Protein 4, Chromatin Remodeling Factor	Protein Coding	2
37	XPO1	Exportin 1	Protein Coding	2
38	SUMO1	Small Ubiquitin Like Modifier 1	Protein Coding	2
39	RAN	RAN, Member RAS Oncogene Family	Protein Coding	2
40	UBE2I	Ubiquitin Conjugating Enzyme E2 I	Protein Coding	2
41	SIN3A	SIN3 Transcription Regulator Family Member A	Protein Coding	2
42	HDAC2	Histone Deacetylase 2	Protein Coding	2
43	NCOR1	Nuclear Receptor Corepressor 1	Protein Coding	2
44	HDAC3	Histone Deacetylase 3	Protein Coding	2
45	NUP210	Nucleoporin 210	Protein Coding	2
46	NUP153	Nucleoporin 153	Protein Coding	2
47	NUP214	Nucleoporin 214	Protein Coding	2
48	NUP62	Nucleoporin 62	Protein Coding	2
49	RANBP2	RAN Binding Protein 2	Protein Coding	2
50	HDAC1	Histone Deacetylase 1	Protein Coding	2
51	TFCP2	Transcription Factor CP2	Protein Coding	1
52	MBD3L2	Methyl-CpG Binding Domain Protein 3 Like 2	Protein Coding	1
53	FKBP3	FKBP Prolyl Isomerase 3	Protein Coding	1
54	MXD1	MAX Dimerization Protein 1	Protein Coding	1
55	SMG5	SMG5 Nonsense Mediated MRNA Decay Factor	Protein Coding	1
56	ZFPM1	Zinc Finger Protein, FOG Family Member 1	Protein Coding	1
57	PRMT5	Protein Arginine Methyltransferase 5	Protein Coding	1
58	WDR77	WD Repeat Domain 77	Protein Coding	1
59	HDAC8	Histone Deacetylase 8	Protein Coding	1
60	NR2C1	Nuclear Receptor Subfamily 2 Group C Member 1	Protein Coding	1
61	MAX	MYC Associated Transcriptional Regulator X	Protein Coding	1
62	NFKBIA	NFKB Inhibitor Alpha	Protein Coding	1
63	TNFRSF1A	TNF Receptor Superfamily Member 1A	Protein Coding	1
64	BTRC	Beta-Transducin Repeat Containing E3 Ubiquitin Protein Ligase	Protein Coding	1
65	SMAD7	SMAD Family Member 7	Protein Coding	1
66	SMURF1	SMAD Specific E3 Ubiquitin Protein Ligase 1	Protein Coding	1
67	YY1	YY1 Transcription Factor	Protein Coding	1
68	STAT3	Signal Transducer And Activator Of Transcription 3	Protein Coding	1
69	RELA	RELA Proto-Oncogene, NF-KB Subunit	Protein Coding	1
70	PPARG	Peroxisome Proliferator Activated Receptor Gamma	Protein Coding	1
71	TNF	Tumor Necrosis Factor	Protein Coding	1
72	PRKACA	Protein Kinase CAMP-Activated Catalytic Subunit Alpha	Protein Coding	1
73	NFKB1	Nuclear Factor Kappa B Subunit 1	Protein Coding	1
74	ANKRA2	Ankyrin Repeat Family A Member 2	Protein Coding	1
75	RFXANK	Regulatory Factor X Associated Ankyrin Containing Protein	Protein Coding	1
76	BCOR	BCL6 Corepressor	Protein Coding	1
77	HDAC11	Histone Deacetylase 11	Protein Coding	1
78	HDAC5	Histone Deacetylase 5	Protein Coding	1
79	TUBB2A	Tubulin Beta 2A Class IIa	Protein Coding	1
80	HDAC7	Histone Deacetylase 7	Protein Coding	1
81	TUBA1B	Tubulin Alpha 1b	Protein Coding	1
82	MEF2C	Myocyte Enhancer Factor 2C	Protein Coding	1
83	HDAC10	Histone Deacetylase 10	Protein Coding	1
84	HDAC4	Histone Deacetylase 4	Protein Coding	1
85	BCL6	BCL6 Transcription Repressor	Protein Coding	1
86	NR3C1	Nuclear Receptor Subfamily 3 Group C Member 1	Protein Coding	1
87	SRF	Serum Response Factor	Protein Coding	1
88	CAMK2A	Calcium/Calmodulin Dependent Protein Kinase II Alpha	Protein Coding	1
89	GRK2	G Protein-Coupled Receptor Kinase 2	Protein Coding	1
90	HDAC6	Histone Deacetylase 6	Protein Coding	1
91	HSP90AA1	Heat Shock Protein 90 Alpha Family Class A Member 1	Protein Coding	1
92	CAMK4	Calcium/Calmodulin Dependent Protein Kinase IV	Protein Coding	1
93	YWHAE	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Epsilon	Protein Coding	1
94	YWHAB	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Beta	Protein Coding	1
95	GNB1	G Protein Subunit Beta 1	Protein Coding	1
96	GNG2	G Protein Subunit Gamma 2	Protein Coding	1
97	HDAC9	Histone Deacetylase 9	Protein Coding	1
98	ESR1	Estrogen Receptor 1	Protein Coding	1
99	CREBBP	CREB Binding Lysine Acetyltransferase	Protein Coding	1
100	EP300	EP300 Lysine Acetyltransferase	Protein Coding	1
101	H3-3A	H3.3 Histone A	Protein Coding	1
102	H3-3B	H3.3 Histone B	Protein Coding	1
103	NONO	Non-POU Domain Containing Octamer Binding	Protein Coding	1
104	PPARA	Peroxisome Proliferator Activated Receptor Alpha	Protein Coding	1
105	RARA	Retinoic Acid Receptor Alpha	Protein Coding	1
106	RARB	Retinoic Acid Receptor Beta	Protein Coding	1
107	ARID4A	AT-Rich Interaction Domain 4A	Protein Coding	1
108	REST	RE1 Silencing Transcription Factor	Protein Coding	1
109	RXRA	Retinoid X Receptor Alpha	Protein Coding	1
110	RXRB	Retinoid X Receptor Beta	Protein Coding	1
111	SFPQ	Splicing Factor Proline And Glutamine Rich	Protein Coding	1
112	THRA	Thyroid Hormone Receptor Alpha	Protein Coding	1
113	H3-4	H3.4 Histone, Cluster Member	Protein Coding	1
114	MTA1	Metastasis Associated 1	Protein Coding	1
115	ARID4B	AT-Rich Interaction Domain 4B	Protein Coding	1
116	MTA3	Metastasis Associated 1 Family Member 3	Protein Coding	1
117	SUDS3	SIN3A Corepressor Complex Component SDS3	Protein Coding	1
118	SAP130	Sin3A Associated Protein 130	Protein Coding	1

Disorders associated with Signaling events mediated by HDAC Class I SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Tessadori-bicknell-van haaften neurodevelopmental syndrome 1	Enrichment	H4C1, H4C3	4.84
2	Tessadori-bicknell-van haaften neurodevelopmental syndrome 2	Enrichment	H4C1, H4C11	4.84
3	Witteveen-kolk syndrome	Enrichment	SIN3A, SIN3B	4.84
4	Bryant-li-bhoj neurodevelopmental syndrome 2	Enrichment	H3-3A, H3-3B	4.84
5	Primary mediastinal large b-cell lymphoma	Enrichment	BCL6, XPO1	4.75
6	Tessadori-bicknell-van haaften neurodevelopmental syndrome 4	Enrichment	H4C1, H4C9	4.37
7	Tessadori-bicknell-van haaften neurodevelopmental syndrome 3	Enrichment	H4C1, H4C5	4.37
8	Myeloma, multiple	Enrichment	ARID4A, CREBBP, NCOR2, RXRA	4.22
9	Rubinstein-taybi syndrome 1	Enrichment	CREBBP, EP300	3.67
10	Chromosome 16p13.3 deletion syndrome, proximal	Enrichment	CREBBP, EP300	3.67
11	Kidney clear cell sarcoma	Enrichment	BCOR, YWHAE	3.57
12	Renal cell carcinoma with mit translocations	Enrichment	NONO, SFPQ	3.52
13	Leukemia, acute myeloid	Enrichment	BCOR, GATA2, NUP214	3.18
14	Myelodysplastic syndrome	Enrichment	GATA2, GNB1	3.02
15	Rare genetic intellectual disability	Enrichment	CREBBP, EP300	2.83
16	Gliosarcoma	Enrichment	NFKBIA, PPARG	2.49
17	Giant cell glioblastoma	Enrichment	NFKBIA, PPARG	2.43
18	Spermatogenic failure, x-linked, 9	Enrichment	RBBP7	2.42
19	Gand syndrome	Enrichment	GATAD2B	2.42
20	Wilms tumor 6	Enrichment	REST	2.42
21	Intellectual developmental disorder, x-linked, syndromic 34	Enrichment	NONO	2.42
22	Deafness, autosomal dominant 27	Enrichment	REST	2.42
23	Microphthalmia, syndromic 12	Enrichment	RARB	2.42
24	Fibromatosis, gingival, 5	Enrichment	REST	2.42
25	Syndromic x-linked intellectual disability 34	Enrichment	NONO	2.42
26	Bryant-li-bhoj neurodevelopmental syndrome 1	Enrichment	H3-3A	2.42
27	Menke-hennekam syndrome 1	Enrichment	CREBBP	2.42
28	Severe intellectual disability-poor language-strabismus-grimacing face-long fingers syndrome	Enrichment	GATAD2B	2.42
29	Rubinstein-taybi syndrome due to 16p13.3 microdeletion	Enrichment	CREBBP	2.42
30	Chromosome 15q24 deletion syndrome	Enrichment	SIN3A	2.42
31	Resistance to thyroid hormone due to a mutation in thyroid hormone receptor alpha	Enrichment	THRA	2.42
32	Menke-hennekam syndrome	Enrichment	CREBBP	2.42
33	Tooth agenesis	Enrichment	RANBP2, SUMO1	2.41
34	Chondrodysplasia with platyspondyly, distinctive brachydactyly, hydrocephaly, and microphthalmia	Enrichment	HDAC6	2.37
35	Anemia, congenital, nonspherocytic hemolytic, 9	Enrichment	GATA1	2.37
36	Thrombocytopenia, x-linked, with or without dyserythropoietic anemia	Enrichment	GATA1	2.37
37	Thrombocytopenia with beta-thalassemia, x-linked	Enrichment	GATA1	2.37
38	Glucocorticoid resistance, generalized	Enrichment	NR3C1	2.37
39	Intellectual developmental disorder, autosomal recessive 63	Enrichment	CAMK2A	2.37
40	Chromosome 2q37 deletion syndrome	Enrichment	HDAC4	2.37
41	Auriculocondylar syndrome 4	Enrichment	HDAC9	2.37
42	Orofacial cleft 10	Enrichment	SUMO1	2.37
43	Anemia, x-linked, with or without neutropenia and/or platelet abnormalities	Enrichment	GATA1	2.37
44	Lymphedema, primary, with myelodysplasia	Enrichment	GATA2	2.37
45	Neurodevelopmental disorder with hypotonia, stereotypic hand movements, and impaired language	Enrichment	MEF2C	2.37
46	Immunodeficiency 21	Enrichment	GATA2	2.37
47	Encephalopathy, acute, infection-induced 9	Enrichment	NUP214	2.37
48	Intellectual developmental disorder, autosomal dominant 42	Enrichment	GNB1	2.37
49	Deafness-lymphedema-leukemia syndrome	Enrichment	GATA2	2.37
50	Neurodevelopmental disorder with central hypotonia and dysmorphic facies	Enrichment	HDAC4	2.37
51	Intellectual developmental disorder, autosomal dominant 53	Enrichment	CAMK2A	2.37
52	Acute megakaryoblastic leukemia in children with down syndrome	Enrichment	GATA1	2.37
53	Thrombocytopenia with congenital dyserythropoietic anemia	Enrichment	GATA1	2.37
54	5q14.3 microdeletion syndrome	Enrichment	MEF2C	2.37
55	Complete atrioventricular septal defect without ventricular hypoplasia	Enrichment	MEF2C	2.37
56	Mhc class ii deficiency 2	Enrichment	RFXANK	2.37
57	Familial acute necrotizing encephalopathy	Enrichment	RANBP2	2.37
58	Mef2c-related disorder	Enrichment	MEF2C	2.37
59	Distal 17p13.3 microdeletion syndrome	Enrichment	YWHAE	2.37
60	Periodic fever, familial, autosomal dominant	Enrichment	TNFRSF1A	2.27
61	Cornelia de lange syndrome 5	Enrichment	HDAC8	2.27
62	T-cell large granular lymphocyte leukemia	Enrichment	STAT3	2.27
63	Multiple sclerosis 5	Enrichment	TNFRSF1A	2.27
64	Polydactyly-macrocephaly syndrome	Enrichment	MAX	2.27
65	Pigmented nodular adrenocortical disease, primary, 4	Enrichment	PRKACA	2.27
66	Colorectal cancer 3	Enrichment	SMAD7	2.27
67	Autoimmune disease, multisystem, infantile-onset, 1	Enrichment	STAT3	2.27
68	Cardioacrofacial dysplasia 1	Enrichment	PRKACA	2.27
69	Tnf receptor-associated periodic fever syndrome	Enrichment	TNFRSF1A	2.27
70	Pparg-associated congenital generalized lipodystrophy	Enrichment	PPARG	2.27
71	Stat3-related early-onset multisystem autoimmune disease	Enrichment	STAT3	2.27
72	Chronic lymphoproliferative disorder of natural killer cells	Enrichment	STAT3	2.27
73	Fibromatosis, gingival, 1	Enrichment	REST	2.12
74	Thumb deformity	Enrichment	CREBBP	2.12
75	Sifrim-hitz-weiss syndrome	Enrichment	CHD4	2.12
76	Hypothyroidism, congenital, nongoitrous, 6	Enrichment	THRA	2.12
77	Intellectual developmental disorder, autosomal dominant 48	Enrichment	RARB	2.12
78	Snijders blok-campeau syndrome	Enrichment	CHD3	2.12
79	Menke-hennekam syndrome 2	Enrichment	EP300	2.12
80	Acute myeloid leukemia with kat6a-crebbp fusion	Enrichment	CREBBP	2.12
81	Myeloproliferative syndrome, transient	Enrichment	GATA1	2.07
82	Galactosemia ii	Enrichment	NR3C1	2.07
83	Microphthalmia, syndromic 1	Enrichment	BCOR	2.07
84	Striatonigral degeneration, infantile	Enrichment	NUP62	2.07
85	Porphyria, congenital erythropoietic	Enrichment	GATA1	2.07
86	Microphthalmia, syndromic 2	Enrichment	BCOR	2.07
87	Nephronophthisis-like nephropathy 1	Enrichment	RANGAP1	2.07
88	Intravascular large b-cell lymphoma	Enrichment	BCL6	2.07
89	Mhc class ii deficiency 3	Enrichment	RFXANK	2.07
90	Acute basophilic leukemia	Enrichment	GATA1	2.07
91	Acute myeloid leukemia with t(6;9) (p23;q34.1)	Enrichment	NUP214	2.07
92	Acute necrotizing encephalopathy of childhood	Enrichment	RANBP2	2.07
93	Cerebral visual impairment	Enrichment	GNB1	2.07
94	Carotid intimal medial thickness 1	Enrichment	PPARG	1.97
95	Ectodermal dysplasia and immunodeficiency 2	Enrichment	NFKBIA	1.97
96	Immunodeficiency, common variable, 12, with autoimmunity	Enrichment	NFKB1	1.97
97	Syndactyly, type iii	Enrichment	HDAC8	1.97
98	Gabriele-de vries syndrome	Enrichment	YY1	1.97
99	Autoinflammatory disease, familial, behcet-like 3	Enrichment	RELA	1.97
100	Wilson-turner syndrome	Enrichment	HDAC8	1.97
101	Immunodeficiency 127	Enrichment	TNF	1.97
102	Rela fusion-positive ependymoma	Enrichment	RELA	1.97
103	Fibrolamellar carcinoma	Enrichment	PRKACA	1.97
104	Ectodermal dysplasia and immune deficiency	Enrichment	NFKBIA	1.97
105	Developmental and epileptic encephalopathy 78	Enrichment	YY1	1.97
106	Insulinoma	Enrichment	YY1	1.97
107	Intermittent hydrarthrosis	Enrichment	TNFRSF1A	1.97
108	Familial partial lipodystrophy	Enrichment	PPARG	1.97
109	Common variable immunodeficiency 12	Enrichment	NFKB1	1.97
110	Tethered spinal cord syndrome	Enrichment	CREBBP	1.94
111	Intraocular pressure quantitative trait locus	Enrichment	CREBBP	1.94
112	Complex neurodevelopmental disorder	Enrichment	H4C3, H4C5, H4C9	1.92
113	Estrogen resistance	Enrichment	ESR1	1.89
114	Ectodermal dysplasia 11b, hypohidrotic/hair/tooth type, autosomal recessive	Enrichment	RANBP2	1.89
115	Miller-dieker lissencephaly syndrome	Enrichment	YWHAE	1.89
116	Chromosome 17p13.3, centromeric, duplication syndrome	Enrichment	YWHAE	1.89
117	Cortical dysplasia, complex, with other brain malformations 5	Enrichment	TUBB2A	1.89
118	High-grade b-cell lymphoma double-hit/triple-hit	Enrichment	BCL6	1.89
119	Migraine without aura	Enrichment	ESR1	1.89
120	Gingival fibromatosis	Enrichment	REST	1.82
121	Hyper-ige syndrome 1, autosomal dominant, with recurrent infections	Enrichment	STAT3	1.79
122	Psoriatic arthritis	Enrichment	TNF	1.79
123	Nasopharyngeal carcinoma	Enrichment	NFKBIA	1.79
124	Breast implant-associated anaplastic large cell lymphoma	Enrichment	STAT3	1.79
125	Hyper ige syndrome	Enrichment	STAT3	1.79
126	Ectodermal dysplasia 10b, hypohidrotic/hair/tooth type, autosomal recessive	Enrichment	RANBP2	1.77
127	Down syndrome	Enrichment	GATA1	1.77
128	Arthrogryposis multiplex congenita 3, myogenic type	Enrichment	ESR1	1.77
129	Tubulinopathy	Enrichment	TUBB2A	1.77
130	Ectodermal dysplasia	Enrichment	RANBP2	1.77
131	Familial infantile bilateral striatal necrosis	Enrichment	NUP62	1.77
132	Rubinstein-taybi syndrome 2	Enrichment	EP300	1.72
133	Autosomal dominant non-syndromic intellectual disability	Enrichment	CAMK2A, GNB1	1.71
134	Ectodermal dysplasia 10a, hypohidrotic/hair/nail type, autosomal dominant	Enrichment	RANBP2	1.67
135	Follicular lymphoma	Enrichment	BCL6	1.67
136	Acute megakaryocytic leukemia	Enrichment	GATA1	1.67
137	Autosomal recessive hypohidrotic ectodermal dysplasia syndrome	Enrichment	RANBP2	1.67
138	Endometrial stromal sarcoma	Enrichment	YWHAE	1.67
139	Lipodystrophy, familial partial, type 3	Enrichment	PPARG	1.67
140	Leptin deficiency or dysfunction	Enrichment	PPARG	1.67
141	Congenital generalized lipodystrophy	Enrichment	PPARG	1.67
142	Cerebral malaria	Enrichment	TNF	1.67
143	Hypertrichosis	Enrichment	CREBBP	1.64
144	Inflammatory myofibroblastic tumor	Enrichment	RANBP2	1.60
145	Vascular dementia	Enrichment	TNF	1.57
146	Mitochondrial dna depletion syndrome 4a	Enrichment	RANBP2	1.53
147	Glioma susceptibility 1	Enrichment	H3-3A	1.52
148	Mitochondrial dna depletion syndrome 4b	Enrichment	RANBP2	1.47
149	Hypothyroidism	Enrichment	GNB1	1.47
150	Charge syndrome	Enrichment	EP300	1.47
151	Common variable immunodeficiency	Enrichment	NFKB1	1.43
152	Primary hyperaldosteronism	Enrichment	NR3C1	1.42
153	Mhc class ii deficiency	Enrichment	RFXANK	1.42
154	Fanconi anemia, complementation group c	Enrichment	HDAC8	1.37
155	Permanent neonatal diabetes mellitus	Enrichment	STAT3	1.37
156	Isolated split hand-split foot malformation	Enrichment	BTRC	1.37
157	Migraine with or without aura 1	Enrichment	ESR1	1.34
158	Mhc class ii deficiency 1	Enrichment	RFXANK	1.34
159	Leukemia, acute lymphoblastic	Enrichment	GNB1	1.34
160	Cornelia de lange syndrome 1	Enrichment	HDAC8	1.32
161	Ellis-van creveld syndrome	Enrichment	PRKACA	1.32
162	Cornelia de lange syndrome	Enrichment	HDAC8	1.32
163	Microphthalmia/coloboma 12	Enrichment	RARB	1.31
164	Acute promyelocytic leukemia	Enrichment	RARA	1.31
165	Heart disease	Enrichment	CREBBP	1.28
166	Ciliary dyskinesia, primary, 3	Enrichment	NFKB1	1.28
167	Protein-deficiency anemia	Enrichment	GATA1	1.27
168	Coloboma of macula	Enrichment	RARB	1.25
169	Polydactyly, postaxial, type a1	Enrichment	EP300	1.25
170	Wilms tumor 1	Enrichment	REST	1.25
171	Corpus callosum, agenesis of	Enrichment	CREBBP	1.25
172	Isolated corpus callosum agenesis	Enrichment	CREBBP	1.25
173	Intellectual disability-hypoplastic corpus callosum-preauricular tag syndrome	Enrichment	CREBBP	1.25
174	Asthma	Enrichment	TNF	1.24
175	Atrial heart septal defect	Enrichment	HDAC8	1.24
176	Interatrial communication	Enrichment	HDAC8	1.24
177	Alzheimer's disease	Enrichment	TNF	1.17
178	Cleft palate, isolated	Enrichment	GNB1	1.15
179	Diffuse large b-cell lymphoma	Enrichment	CREBBP	1.15
180	Multiple sclerosis	Enrichment	TNFRSF1A	1.14
181	Pheochromocytoma	Enrichment	MAX	1.14
182	Autism spectrum disorder	Enrichment	GNB1, MEF2C	1.10
183	Microphthalmia	Enrichment	RARB	1.09
184	Scoliosis	Enrichment	CREBBP	1.05
185	Myocardial infarction	Enrichment	ESR1	1.05
186	Polycystic kidney disease	Enrichment	HDAC8	1.03
187	Diamond-blackfan anemia 1	Enrichment	GATA1	1.03
188	Precursor t-cell acute lymphoblastic leukemia	Enrichment	NUP214	1.03
189	Behcet syndrome	Enrichment	TNFRSF1A	1.01
190	Jeune thoracic dystrophy	Enrichment	GRK2	0.99
191	Hereditary paraganglioma-pheochromocytoma syndromes	Enrichment	MAX	0.97
192	Strabismus	Enrichment	GNB1	0.96
193	Asphyxiating thoracic dystrophy	Enrichment	GRK2	0.95
194	Malaria	Enrichment	TNF	0.93
195	Autoinflammatory disease	Enrichment	TNFRSF1A	0.92
196	Short-rib thoracic dysplasia 1 with or without polydactyly	Enrichment	GRK2	0.88
197	Dystonia	Enrichment	GNB1	0.86
198	Diamond-blackfan anemia	Enrichment	GATA1	0.84
199	Differentiated thyroid carcinoma	Enrichment	PPARG	0.84
200	Cerebral palsy	Enrichment	GNB1	0.81
201	Hereditary breast carcinoma	Enrichment	ESR1	0.76
202	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	REST	0.74
203	Thrombocytopenia	Enrichment	GATA1	0.73
204	Systemic lupus erythematosus	Enrichment	TNF	0.72
205	Type 2 diabetes mellitus	Enrichment	PPARG	0.69
206	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	MEF2C	0.66
207	Body mass index quantitative trait locus 11	Enrichment	PPARG	0.63
208	Autism	Enrichment	CREBBP	0.62
209	Breast cancer	Enrichment	ESR1	0.56
210	Colorectal cancer	Enrichment	EP300	0.55
211	Congenital nervous system abnormality	Enrichment	CREBBP	0.47
212	Nervous system disease	Enrichment	CREBBP	0.47
213	Microcephaly	Enrichment	EP300	0.42
214	Inherited cancer-predisposing syndrome	Enrichment	MAX	0.29

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Signaling events mediated by HDAC Class I

Pathway Network for Signaling events mediated by HDAC Class I

Pathway network for the Signaling events mediated by HDAC Class I SuperPath

Member Pathways for Signaling events mediated by HDAC Class I

Pathways in the Signaling events mediated by HDAC Class I SuperPath

Gene overlap in member pathways for Signaling events mediated by HDAC Class I SuperPath

Associated Genes for Signaling events mediated by HDAC Class I

Associated Disorders for Signaling events mediated by HDAC Class I

Disorders associated with Signaling events mediated by HDAC Class I SuperPath

STRING Interaction Network for Signaling events mediated by HDAC Class I

Sources for Signaling events mediated by HDAC Class I