Signaling events mediated by HDAC Class III

No Pathway Network information available for Signaling events mediated by HDAC Class III

Pathways in the Signaling events mediated by HDAC Class III SuperPath

#	Name	Source	Genes
1	Signaling events mediated by HDAC Class III	PubChem	ACSS1 ACSS2 BAX CDKN1A EP300 FHL2 FOXO1 FOXO3 FOXO4 H1-4 H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 HDAC4 HOXA10 KAT2B MEF2D MYOD1 PPARGC1A SIRT1 SIRT2 SIRT3 SIRT7 TP53 TUBA1B TUBB2A XRCC6 (see all 38) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	HOXA10	Homeobox A10	Protein Coding	1
2	H1-4	H1.4 Linker Histone, Cluster Member	Protein Coding	1
3	MYOD1	Myogenic Differentiation 1	Protein Coding	1
4	SIRT7	Sirtuin 7	Protein Coding	1
5	TUBB2A	Tubulin Beta 2A Class IIa	Protein Coding	1
6	TUBA1B	Tubulin Alpha 1b	Protein Coding	1
7	MEF2D	Myocyte Enhancer Factor 2D	Protein Coding	1
8	HDAC4	Histone Deacetylase 4	Protein Coding	1
9	SIRT2	Sirtuin 2	Protein Coding	1
10	FOXO4	Forkhead Box O4	Protein Coding	1
11	KAT2B	Lysine Acetyltransferase 2B	Protein Coding	1
12	XRCC6	X-Ray Repair Cross Complementing 6	Protein Coding	1
13	ACSS1	Acyl-CoA Synthetase Short Chain Family Member 1	Protein Coding	1
14	ACSS2	Acyl-CoA Synthetase Short Chain Family Member 2	Protein Coding	1
15	FHL2	Four And A Half LIM Domains 2	Protein Coding	1
16	SIRT1	Sirtuin 1	Protein Coding	1
17	H4C2	H4 Clustered Histone 2	Protein Coding	1
18	H4C8	H4 Clustered Histone 8	Protein Coding	1
19	H4C3	H4 Clustered Histone 3	Protein Coding	1
20	H4C4	H4 Clustered Histone 4	Protein Coding	1
21	H4C1	H4 Clustered Histone 1	Protein Coding	1
22	H4C16	H4 Histone 16	Protein Coding	1
23	H4C14	H4 Clustered Histone 14	Protein Coding	1
24	H4C13	H4 Clustered Histone 13	Protein Coding	1
25	H4C5	H4 Clustered Histone 5	Protein Coding	1
26	H4C11	H4 Clustered Histone 11	Protein Coding	1
27	H4C12	H4 Clustered Histone 12	Protein Coding	1
28	H4C6	H4 Clustered Histone 6	Protein Coding	1
29	H4C9	H4 Clustered Histone 9	Protein Coding	1
30	H4C15	H4 Clustered Histone 15	Protein Coding	1
31	FOXO3	Forkhead Box O3	Protein Coding	1
32	FOXO1	Forkhead Box O1	Protein Coding	1
33	EP300	EP300 Lysine Acetyltransferase	Protein Coding	1
34	SIRT3	Sirtuin 3	Protein Coding	1
35	PPARGC1A	PPARG Coactivator 1 Alpha	Protein Coding	1
36	TP53	Tumor Protein P53	Protein Coding	1
37	CDKN1A	Cyclin Dependent Kinase Inhibitor 1A	Protein Coding	1
38	BAX	BCL2 Associated X, Apoptosis Regulator	Protein Coding	1

Disorders associated with Signaling events mediated by HDAC Class III SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Tessadori-bicknell-van haaften neurodevelopmental syndrome 1	Enrichment	H4C1, H4C3	5.12
2	Tessadori-bicknell-van haaften neurodevelopmental syndrome 2	Enrichment	H4C1, H4C11	5.12
3	Tessadori-bicknell-van haaften neurodevelopmental syndrome 4	Enrichment	H4C1, H4C9	4.64
4	Tessadori-bicknell-van haaften neurodevelopmental syndrome 3	Enrichment	H4C1, H4C5	4.64
5	Rhabdomyosarcoma 2	Enrichment	FOXO1, TP53	4.12
6	Myeloma, multiple	Enrichment	H1-4, HDAC4, TP53	3.29
7	Diffuse large b-cell lymphoma	Enrichment	FOXO1, TP53	2.90
8	Colorectal cancer	Enrichment	BAX, EP300, TP53	2.74
9	Chromosome 2q37 deletion syndrome	Enrichment	HDAC4	2.55
10	Bone marrow failure syndrome 5	Enrichment	TP53	2.55
11	Papilloma of choroid plexus	Enrichment	TP53	2.55
12	Basal cell carcinoma 7	Enrichment	TP53	2.55
13	Anaplastic thyroid carcinoma	Enrichment	TP53	2.55
14	Rahman syndrome	Enrichment	H1-4	2.55
15	Congenital myopathy 17	Enrichment	MYOD1	2.55
16	Ductal carcinoma in situ	Enrichment	TP53	2.55
17	Neurodevelopmental disorder with central hypotonia and dysmorphic facies	Enrichment	HDAC4	2.55
18	Thyroid gland undifferentiated carcinoma	Enrichment	TP53	2.55
19	Small-cell carcinoma of the ovary of hypercalcemic type	Enrichment	TP53	2.55
20	Diffuse pediatric-type high-grade glioma, h3-wildtype and idh-wildtype	Enrichment	TP53	2.55
21	Choroid plexus cancer	Enrichment	TP53	2.55
22	Pleomorphic xanthoastrocytoma	Enrichment	TP53	2.55
23	Bladder cancer	Enrichment	CDKN1A, TP53	2.53
24	Complex neurodevelopmental disorder	Enrichment	H4C3, H4C5, H4C9	2.30
25	Adrenocortical carcinoma, hereditary	Enrichment	TP53	2.25
26	Cervical cancer	Enrichment	TP53	2.25
27	Lymphoma, hodgkin, classic	Enrichment	TP53	2.25
28	Menke-hennekam syndrome 2	Enrichment	EP300	2.25
29	Congenital fibrosarcoma	Enrichment	TP53	2.25
30	Li-fraumeni syndrome 1	Enrichment	TP53	2.25
31	Sarcoma	Enrichment	TP53	2.25
32	Cervix carcinoma	Enrichment	TP53	2.25
33	Hodgkin's lymphoma	Enrichment	TP53	2.25
34	Pleomorphic rhabdomyosarcoma	Enrichment	TP53	2.25
35	Osteogenic sarcoma	Enrichment	TP53	2.08
36	Nasopharyngeal carcinoma	Enrichment	TP53	2.08
37	Cortical dysplasia, complex, with other brain malformations 5	Enrichment	TUBB2A	2.08
38	Atypical teratoid rhabdoid tumor	Enrichment	TP53	2.08
39	Anaplastic astrocytoma	Enrichment	TP53	2.08
40	Squamous cell carcinoma	Enrichment	TP53	2.08
41	T-cell acute lymphoblastic leukemia	Enrichment	BAX	2.08
42	Adenocarcinoma	Enrichment	TP53	2.08
43	Bone osteosarcoma	Enrichment	TP53	2.08
44	Small cell cancer of the lung	Enrichment	TP53	1.95
45	Thyroid cancer, nonmedullary, 1	Enrichment	TP53	1.95
46	Lung sarcomatoid carcinoma	Enrichment	TP53	1.95
47	Tubulinopathy	Enrichment	TUBB2A	1.95
48	Embryonal rhabdomyosarcoma	Enrichment	TP53	1.95
49	Rubinstein-taybi syndrome 2	Enrichment	EP300	1.86
50	Lymphoma	Enrichment	TP53	1.86
51	Acute megakaryocytic leukemia	Enrichment	TP53	1.86
52	Li-fraumeni syndrome	Enrichment	TP53	1.78
53	Myopathy, centronuclear, 1	Enrichment	MYOD1	1.78
54	Rubinstein-taybi syndrome 1	Enrichment	EP300	1.78
55	Chromosome 16p13.3 deletion syndrome, proximal	Enrichment	EP300	1.78
56	Adrenocortical carcinoma	Enrichment	TP53	1.78
57	Breast adenocarcinoma	Enrichment	TP53	1.78
58	Esophageal cancer	Enrichment	TP53	1.71
59	Multiple endocrine neoplasia, type i	Enrichment	CDKN1A	1.71
60	Squamous cell carcinoma, head and neck	Enrichment	TP53	1.71
61	Essential thrombocythemia	Enrichment	TP53	1.71
62	Gallbladder cancer	Enrichment	TP53	1.71
63	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	TP53	1.71
64	Glioma susceptibility 1	Enrichment	TP53	1.65
65	Lymphoma, non-hodgkin, familial	Enrichment	TP53	1.65
66	Orofacial cleft 1	Enrichment	ACSS2	1.60
67	Charge syndrome	Enrichment	EP300	1.60
68	Adult hepatocellular carcinoma	Enrichment	TP53	1.60
69	Primary hyperaldosteronism	Enrichment	TP53	1.60
70	Leukemia, chronic lymphocytic	Enrichment	TP53	1.56
71	Familial colorectal cancer	Enrichment	TP53	1.56
72	Myelodysplastic syndrome	Enrichment	TP53	1.52
73	Lip and oral cavity carcinoma	Enrichment	TP53	1.48
74	Lung cancer susceptibility 3	Enrichment	TP53	1.41
75	Polydactyly, postaxial, type a1	Enrichment	EP300	1.38
76	Rare genetic intellectual disability	Enrichment	EP300	1.38
77	Rhabdomyosarcoma	Enrichment	TP53	1.36
78	Gliosarcoma	Enrichment	TP53	1.36
79	Giant cell glioblastoma	Enrichment	TP53	1.33
80	Hepatoblastoma	Enrichment	TP53	1.24
81	Hepatocellular carcinoma	Enrichment	TP53	1.22
82	Diamond-blackfan anemia 1	Enrichment	TP53	1.20
83	Pancreatic cancer	Enrichment	TP53	1.17
84	Auditory neuropathy	Enrichment	H1-4	1.15
85	Prostate cancer	Enrichment	TP53	1.11
86	Diamond-blackfan anemia	Enrichment	TP53	1.02
87	Fetal akinesia deformation sequence 1	Enrichment	MYOD1	1.01
88	Leukemia, acute myeloid	Enrichment	TP53	0.97
89	Distal arthrogryposis	Enrichment	MYOD1	0.95
90	Gastric cancer	Enrichment	TP53	0.94
91	Hereditary breast carcinoma	Enrichment	TP53	0.93
92	Familial isolated dilated cardiomyopathy	Enrichment	FHL2	0.86
93	Hereditary breast ovarian cancer syndrome	Enrichment	TP53	0.84
94	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	PPARGC1A	0.82
95	Breast cancer	Enrichment	TP53	0.72
96	Ovarian cancer	Enrichment	TP53	0.61
97	Microcephaly	Enrichment	EP300	0.53
98	Inherited cancer-predisposing syndrome	Enrichment	TP53	0.51

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Signaling events mediated by HDAC Class III

Pathway Network for Signaling events mediated by HDAC Class III

Member Pathways for Signaling events mediated by HDAC Class III

Pathways in the Signaling events mediated by HDAC Class III SuperPath

Associated Genes for Signaling events mediated by HDAC Class III

Associated Disorders for Signaling events mediated by HDAC Class III

Disorders associated with Signaling events mediated by HDAC Class III SuperPath

STRING Interaction Network for Signaling events mediated by HDAC Class III

Sources for Signaling events mediated by HDAC Class III