Signaling events mediated by PRL

No Pathway Network information available for Signaling events mediated by PRL

#	Name	Source	Genes
1	Signaling events mediated by PRL	PubChem	AGT ATF5 BCAR1 CCNA2 CCNE1 CDK2 CDKN1A EGR1 ITGA1 ITGB1 MAPK3 PTP4A1 PTP4A2 PTP4A3 RABGGTA RABGGTB RAC1 RHOA RHOC ROCK1 SRC TUBA1B (see all 22) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	PTP4A1	Protein Tyrosine Phosphatase 4A1	Protein Coding	1
2	PTP4A3	Protein Tyrosine Phosphatase 4A3	Protein Coding	1
3	TUBA1B	Tubulin Alpha 1b	Protein Coding	1
4	ATF5	Activating Transcription Factor 5	Protein Coding	1
5	RABGGTB	Rab Geranylgeranyltransferase Subunit Beta	Protein Coding	1
6	RABGGTA	Rab Geranylgeranyltransferase Subunit Alpha	Protein Coding	1
7	PTP4A2	Protein Tyrosine Phosphatase 4A2	Protein Coding	1
8	CCNE1	Cyclin E1	Protein Coding	1
9	CCNA2	Cyclin A2	Protein Coding	1
10	RHOC	Ras Homolog Family Member C	Protein Coding	1
11	EGR1	Early Growth Response 1	Protein Coding	1
12	ROCK1	Rho Associated Coiled-Coil Containing Protein Kinase 1	Protein Coding	1
13	AGT	Angiotensinogen	Protein Coding	1
14	CDK2	Cyclin Dependent Kinase 2	Protein Coding	1
15	BCAR1	BCAR1 Scaffold Protein, Cas Family Member	Protein Coding	1
16	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	1
17	ITGB1	Integrin Subunit Beta 1	Protein Coding	1
18	ITGA1	Integrin Subunit Alpha 1	Protein Coding	1
19	RHOA	Ras Homolog Family Member A	Protein Coding	1
20	RAC1	Rac Family Small GTPase 1	Protein Coding	1
21	SRC	SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase	Protein Coding	1
22	CDKN1A	Cyclin Dependent Kinase Inhibitor 1A	Protein Coding	1

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Thrombocytopenia 6	Enrichment	SRC	2.79
2	Ectodermal dysplasia with facial dysmorphism and acral, ocular, and brain anomalies	Enrichment	RHOA	2.79
3	Linear hypopigmentation and craniofacial asymmetry with acral, ocular and brain anomalies	Enrichment	RHOA	2.79
4	Microcephaly-corpus callosum and cerebellar vermis hypoplasia-facial dysmorphism-intellectual disability syndrom	Enrichment	RAC1	2.79
5	Intellectual developmental disorder, autosomal dominant 48	Enrichment	RAC1	2.49
6	Hemihyperplasia, isolated	Enrichment	RHOA	2.01
7	Renal tubular dysgenesis	Enrichment	AGT	2.01
8	Multiple endocrine neoplasia, type i	Enrichment	CDKN1A	1.95
9	Myelofibrosis	Enrichment	SRC	1.95
10	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	RAC1	1.84
11	Neural tube defects	Enrichment	ITGB1	1.68
12	Osteoporosis	Enrichment	SRC	1.65
13	Hypertension, essential	Enrichment	AGT	1.56
14	Bladder cancer	Enrichment	CDKN1A	1.34
15	Thrombocytopenia	Enrichment	SRC	1.12
16	Hereditary breast ovarian cancer syndrome	Enrichment	BCAR1	1.07
17	Colorectal cancer	Enrichment	SRC	0.88

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Pathway Network for Signaling events mediated by PRL