Signaling events mediated by PTP1B

No Pathway Network information available for Signaling events mediated by PTP1B

Pathways in the Signaling events mediated by PTP1B SuperPath

#	Name	Source	Genes
1	Signaling events mediated by PTP1B	PubChem	ABL1 AKT1 BCAR1 CAPN1 CAV1 CDH2 CRK CSF1 CSF1R CSK CSN2 DOK1 EGF EGFR FCGR2A FER GRB2 INS INSR IRS1 ITGA2B ITGB3 JAK2 LAT LEP LEPR NOX4 PDGFB PDGFRB PIK3CA PIK3R1 PRL PRLR PTPN1 RHOA SHC1 SOCS3 SPRY2 SRC STAT3 STAT5A STAT5B TRPV6 TXN TYK2 YBX1 (see all 46) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	TRPV6	Transient Receptor Potential Cation Channel Subfamily V Member 6	Protein Coding	1
2	FER	FER Tyrosine Kinase	Protein Coding	1
3	PRL	Prolactin	Protein Coding	1
4	LEPR	Leptin Receptor	Protein Coding	1
5	STAT5B	Signal Transducer And Activator Of Transcription 5B	Protein Coding	1
6	CDH2	Cadherin 2	Protein Coding	1
7	NOX4	NADPH Oxidase 4	Protein Coding	1
8	PRLR	Prolactin Receptor	Protein Coding	1
9	CSF1	Colony Stimulating Factor 1	Protein Coding	1
10	FCGR2A	Fc Gamma Receptor IIa	Protein Coding	1
11	CSF1R	Colony Stimulating Factor 1 Receptor	Protein Coding	1
12	DOK1	Docking Protein 1	Protein Coding	1
13	YBX1	Y-Box Binding Protein 1	Protein Coding	1
14	CSN2	Casein Beta	Protein Coding	1
15	PDGFB	Platelet Derived Growth Factor Subunit B	Protein Coding	1
16	SPRY2	Sprouty RTK Signaling Antagonist 2	Protein Coding	1
17	EGF	Epidermal Growth Factor	Protein Coding	1
18	TXN	Thioredoxin	Protein Coding	1
19	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	1
20	CAV1	Caveolin 1	Protein Coding	1
21	BCAR1	BCAR1 Scaffold Protein, Cas Family Member	Protein Coding	1
22	CSK	C-Terminal Src Kinase	Protein Coding	1
23	PTPN1	Protein Tyrosine Phosphatase Non-Receptor Type 1	Protein Coding	1
24	LAT	Linker For Activation Of T Cells	Protein Coding	1
25	CAPN1	Calpain 1	Protein Coding	1
26	STAT3	Signal Transducer And Activator Of Transcription 3	Protein Coding	1
27	LEP	Leptin	Protein Coding	1
28	ABL1	ABL Proto-Oncogene 1, Non-Receptor Tyrosine Kinase	Protein Coding	1
29	ITGA2B	Integrin Subunit Alpha 2b	Protein Coding	1
30	RHOA	Ras Homolog Family Member A	Protein Coding	1
31	GRB2	Growth Factor Receptor Bound Protein 2	Protein Coding	1
32	JAK2	Janus Kinase 2	Protein Coding	1
33	STAT5A	Signal Transducer And Activator Of Transcription 5A	Protein Coding	1
34	ITGB3	Integrin Subunit Beta 3	Protein Coding	1
35	CRK	CRK Proto-Oncogene, Adaptor Protein	Protein Coding	1
36	SRC	SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase	Protein Coding	1
37	SOCS3	Suppressor Of Cytokine Signaling 3	Protein Coding	1
38	TYK2	Tyrosine Kinase 2	Protein Coding	1
39	PDGFRB	Platelet Derived Growth Factor Receptor Beta	Protein Coding	1
40	INS	Insulin	Protein Coding	1
41	IRS1	Insulin Receptor Substrate 1	Protein Coding	1
42	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	1
43	INSR	Insulin Receptor	Protein Coding	1
44	SHC1	SHC Adaptor Protein 1	Protein Coding	1
45	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	1
46	EGFR	Epidermal Growth Factor Receptor	Protein Coding	1

Disorders associated with Signaling events mediated by PTP1B SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Meningioma	Enrichment	AKT1, PDGFB, PIK3CA	5.10
2	Lip and oral cavity carcinoma	Enrichment	ABL1, EGFR, PIK3CA	5.10
3	Hyper-ige syndrome 1, autosomal dominant, with recurrent infections	Enrichment	ITGB3, STAT3	4.47
4	Bleeding disorder, platelet-type, 16	Enrichment	ITGA2B, ITGB3	4.47
5	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3CA, PIK3R1	4.47
6	Breast implant-associated anaplastic large cell lymphoma	Enrichment	JAK2, STAT3	4.47
7	Leptin deficiency or dysfunction	Enrichment	LEP, LEPR	4.17
8	Cowden syndrome 1	Enrichment	EGFR, PIK3CA	3.78
9	Hemihyperplasia, isolated	Enrichment	PIK3CA, RHOA	3.78
10	Fetomaternal alloimmune thrombocytopenia 1	Enrichment	ITGA2B, ITGB3	3.78
11	Breast adenocarcinoma	Enrichment	AKT1, PIK3CA	3.78
12	Lung squamous cell carcinoma	Enrichment	EGFR, PIK3CA	3.78
13	Colorectal cancer	Enrichment	AKT1, PIK3CA, PIK3R1, SRC	3.68
14	Myelofibrosis	Enrichment	JAK2, SRC	3.63
15	Glanzmann thrombasthenia 1	Enrichment	ITGA2B, ITGB3	3.63
16	Basal ganglia calcification, idiopathic, 1	Enrichment	PDGFB, PDGFRB	3.51
17	Permanent neonatal diabetes mellitus	Enrichment	INS, STAT3	3.51
18	Type 2 diabetes mellitus	Enrichment	INSR, IRS1, PTPN1	3.42
19	Adult hepatocellular carcinoma	Enrichment	EGF, PIK3CA	3.40
20	Cowden syndrome	Enrichment	AKT1, PIK3CA	3.40
21	Autosomal dominant macrothrombocytopenia	Enrichment	ITGA2B, ITGB3	3.30
22	Thrombocytopenia	Enrichment	ITGA2B, ITGB3, SRC	3.25
23	Lung non-small cell carcinoma	Enrichment	EGFR, PIK3CA	3.22
24	Acute promyelocytic leukemia	Enrichment	STAT3, STAT5B	3.07
25	Arteriovenous malformations of the brain	Enrichment	CDH2, EGFR	2.73
26	Breast cancer	Enrichment	AKT1, PIK3CA, SHC1	2.68
27	Macrodactyly	Enrichment	PIK3CA	2.47
28	Proteus syndrome	Enrichment	AKT1	2.47
29	Donohue syndrome	Enrichment	INSR	2.47
30	Premature aging syndrome, penttinen type	Enrichment	PDGFRB	2.47
31	Hyperinsulinemic hypoglycemia, familial, 5	Enrichment	INSR	2.47
32	Immunodeficiency 35	Enrichment	TYK2	2.47
33	Pineal hyperplasia, insulin-resistant diabetes mellitus, and somatic abnormalities	Enrichment	INSR	2.47
34	Hypomagnesemia 4, renal	Enrichment	EGF	2.47
35	Diabetes mellitus, insulin-resistant, with acanthosis nigricans	Enrichment	INSR	2.47
36	Lipodystrophy, congenital generalized, type 3	Enrichment	CAV1	2.47
37	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	2.47
38	Dermatitis, atopic, 4	Enrichment	SOCS3	2.47
39	Basal ganglia calcification, idiopathic, 5	Enrichment	PDGFB	2.47
40	Cowden syndrome 5	Enrichment	PIK3CA	2.47
41	Myofibromatosis, infantile, 1	Enrichment	PDGFRB	2.47
42	Multiple fibroadenomas of the breast	Enrichment	PRLR	2.47
43	Iga nephropathy 3	Enrichment	SPRY2	2.47
44	Pulmonary hypertension, primary, 3	Enrichment	CAV1	2.47
45	Cerebral cavernous malformations 4	Enrichment	PIK3CA	2.47
46	Growth hormone insensitivity syndrome with immune dysregulation 2, autosomal dominant	Enrichment	STAT5B	2.47
47	Short syndrome	Enrichment	PIK3R1	2.47
48	Fetomaternal alloimmune thrombocytopenia 2	Enrichment	ITGA2B	2.47
49	Agenesis of corpus callosum, cardiac, ocular, and genital syndrome	Enrichment	CDH2	2.47
50	T-cell large granular lymphocyte leukemia	Enrichment	STAT3	2.47
51	Hyperprolactinemia	Enrichment	PRLR	2.47
52	Lipodystrophy, familial partial, type 7	Enrichment	CAV1	2.47
53	Hemifacial myohyperplasia	Enrichment	PIK3CA	2.47
54	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	2.47
55	Arrhythmogenic right ventricular dysplasia, familial, 14	Enrichment	CDH2	2.47
56	Basal ganglia calcification, idiopathic, 4	Enrichment	PDGFRB	2.47
57	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	2.47
58	Cowden syndrome 6	Enrichment	AKT1	2.47
59	Hyperparathyroidism	Enrichment	TRPV6	2.47
60	Myeloid and lymphoid neoplasms associated with pdgfrb rearrangement	Enrichment	PDGFRB	2.47
61	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	2.47
62	Kosaki overgrowth syndrome	Enrichment	PDGFRB	2.47
63	Leptin receptor deficiency	Enrichment	LEPR	2.47
64	Autoimmune disease, multisystem, infantile-onset, 1	Enrichment	STAT3	2.47
65	Thrombocytopenia 6	Enrichment	SRC	2.47
66	Ectodermal dysplasia with facial dysmorphism and acral, ocular, and brain anomalies	Enrichment	RHOA	2.47
67	Brain abnormalities, neurodegeneration, and dysosteosclerosis	Enrichment	CSF1R	2.47
68	Ocular pterygium-digital keloid dysplasia syndrome	Enrichment	PDGFRB	2.47
69	Linear hypopigmentation and craniofacial asymmetry with acral, ocular and brain anomalies	Enrichment	RHOA	2.47
70	Hyperparathyroidism, transient neonatal	Enrichment	TRPV6	2.47
71	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	2.47
72	Attention deficit-hyperactivity disorder 8	Enrichment	CDH2	2.47
73	Csf1r-related disorder	Enrichment	CSF1R	2.47
74	Hypospadias	Enrichment	PIK3CA	2.47
75	Familial hyperprolactinemia	Enrichment	PRLR	2.47
76	Stat3-related early-onset multisystem autoimmune disease	Enrichment	STAT3	2.47
77	Rare venous malformation	Enrichment	PIK3CA	2.47
78	Diaphragmatic eventration	Enrichment	PIK3CA	2.47
79	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	2.47
80	Early-onset calcifying leukoencephalopathy-skeletal dysplasia	Enrichment	CSF1R	2.47
81	Rare combined vascular malformation	Enrichment	PIK3CA	2.47
82	Cavernous lymphangioma	Enrichment	PIK3CA	2.47
83	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	2.47
84	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	2.47
85	Chronic lymphoproliferative disorder of natural killer cells	Enrichment	STAT3	2.47
86	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	2.47
87	Egf-related primary hypomagnesemia with intellectual disability	Enrichment	EGF	2.47
88	Macrodactyly of toe	Enrichment	PIK3CA	2.47
89	Bladder cancer	Enrichment	EGFR, PIK3CA	2.37
90	Ovarian cancer	Enrichment	AKT1, EGFR, PIK3CA	2.32
91	Lung cancer	Enrichment	EGFR, PIK3CA	2.28
92	Myeloproliferative disorder, chronic, with eosinophilia	Enrichment	PDGFRB	2.17
93	Hyperparathyroidism, neonatal severe	Enrichment	TRPV6	2.17
94	Growth hormone insensitivity syndrome with immune dysregulation 1, autosomal recessive	Enrichment	STAT5B	2.17
95	Dermatofibrosarcoma protuberans	Enrichment	PDGFB	2.17
96	Hyperinsulinemic hypoglycemia, familial, 4	Enrichment	INSR	2.17
97	Keratosis, seborrheic	Enrichment	PIK3CA	2.17
98	Maturity-onset diabetes of the young, type 10	Enrichment	INS	2.17
99	Noonan syndrome 8	Enrichment	PIK3CA	2.17
100	Thrombocythemia 3	Enrichment	JAK2	2.17
101	Spastic paraplegia 76, autosomal recessive	Enrichment	CAPN1	2.17
102	Albinism, oculocutaneous, type ia	Enrichment	NOX4	2.17
103	Myopia 28, autosomal recessive	Enrichment	DOK1	2.17
104	Hyperproinsulinemia	Enrichment	INS	2.17
105	Congenital heart defects and skeletal malformations syndrome	Enrichment	ABL1	2.17
106	Infantile myofibromatosis	Enrichment	PDGFRB	2.17
107	Rosette-forming glioneuronal tumor	Enrichment	PIK3CA	2.17
108	Diabetes mellitus, permanent neonatal, 4	Enrichment	INS	2.17
109	Polycythemia	Enrichment	JAK2	2.17
110	Immunodeficiency 52	Enrichment	LAT	2.17
111	Lymphomatoid papulosis	Enrichment	TYK2	2.17
112	Hypereosinophilic syndrome	Enrichment	JAK2	2.17
113	Laron syndrome with immunodeficiency	Enrichment	STAT5B	2.17
114	Primary cutaneous anaplastic large cell lymphoma	Enrichment	TYK2	2.17
115	Hereditary breast carcinoma	Enrichment	AKT1, PIK3CA	2.01
116	Type 1 diabetes mellitus 2	Enrichment	INS	1.99
117	Polycythemia vera	Enrichment	JAK2	1.99
118	Pompe disease, infantile-onset	Enrichment	PIK3CA	1.99
119	Leukoencephalopathy, hereditary diffuse, with spheroids 1	Enrichment	CSF1R	1.99
120	Neonatal nephrocutaneous inflammatory syndrome	Enrichment	EGFR	1.99
121	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3R1	1.99
122	Hyper ige syndrome	Enrichment	STAT3	1.99
123	Immunodeficiency 14	Enrichment	PIK3R1	1.99
124	T-cell acute lymphoblastic leukemia	Enrichment	ABL1	1.99
125	Bleeding disorder, platelet-type, 24	Enrichment	ITGB3	1.99
126	Neonatal inflammatory skin and bowel disease	Enrichment	EGFR	1.99
127	Keratoacanthoma	Enrichment	PIK3CA	1.99
128	Erythrocytosis, familial, 1	Enrichment	JAK2	1.87
129	Budd-chiari syndrome	Enrichment	JAK2	1.87
130	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	PIK3CA	1.87
131	Bone mineral density quantitative trait locus 15	Enrichment	TRPV6	1.87
132	Neonatal diabetes mellitus	Enrichment	INS	1.87
133	Chronic myelogenous leukemia, bcr-abl1 positive	Enrichment	ABL1	1.87
134	Cerebrovascular disease	Enrichment	PIK3CA	1.87
135	Familial cerebral cavernous malformations	Enrichment	PIK3CA	1.87
136	Capillary malformations, congenital	Enrichment	PIK3CA	1.77
137	Glanzmann thrombasthenia 2	Enrichment	ITGB3	1.77
138	Myeloproliferative neoplasm	Enrichment	JAK2	1.77
139	Hemimegalencephaly	Enrichment	PIK3CA	1.77
140	Diffuse cutaneous systemic sclerosis	Enrichment	CAV1	1.77
141	Primary hypereosinophilic syndrome	Enrichment	PDGFRB	1.77
142	Primary ovarian insufficiency	Enrichment	JAK2, PRLR	1.77
143	Klippel-trenaunay-weber syndrome	Enrichment	PIK3CA	1.70
144	Type 1 diabetes mellitus	Enrichment	INS	1.70
145	Limited scleroderma	Enrichment	CAV1	1.70
146	46,xy disorder of sex development	Enrichment	INSR	1.70
147	Nevus, epidermal	Enrichment	PIK3CA	1.63
148	Squamous cell carcinoma, head and neck	Enrichment	EGFR	1.63
149	Capillary malformation-arteriovenous malformation 1	Enrichment	PIK3CA	1.63
150	Leukemia, chronic myeloid	Enrichment	ABL1	1.63
151	Essential thrombocythemia	Enrichment	JAK2	1.63
152	Gallbladder cancer	Enrichment	PIK3CA	1.63
153	Overgrowth syndrome	Enrichment	PIK3R1	1.63
154	Moyamoya angiopathy	Enrichment	ABL1	1.63
155	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	ABL1	1.63
156	Leukemia, acute lymphoblastic 3	Enrichment	JAK2	1.52
157	Arteriovenous malformation	Enrichment	PIK3CA	1.52
158	Myopathy, x-linked, with excessive autophagy	Enrichment	PIK3CA	1.48
159	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3R1	1.48
160	Frontotemporal dementia 1	Enrichment	CSF1R	1.44
161	Meningioma, familial	Enrichment	PDGFB	1.44
162	Diabetes mellitus	Enrichment	INS	1.44
163	Heritable pulmonary arterial hypertension	Enrichment	CAV1	1.44
164	Alzheimer's disease	Enrichment	CSF1R	1.36
165	Osteoporosis	Enrichment	SRC	1.33
166	Lung cancer susceptibility 3	Enrichment	EGFR	1.33
167	Heart disease	Enrichment	ABL1	1.33
168	Inherited isolated arrhythmogenic cardiomyopathy, dominant-right variant	Enrichment	CDH2	1.33
169	Corpus callosum, agenesis of	Enrichment	CDH2	1.30
170	Hydrocephalus	Enrichment	PDGFRB	1.30
171	Lynch syndrome	Enrichment	PIK3CA	1.30
172	Isolated corpus callosum agenesis	Enrichment	CDH2	1.30
173	Intellectual disability-hypoplastic corpus callosum-preauricular tag syndrome	Enrichment	CDH2	1.30
174	Gliosarcoma	Enrichment	EGFR	1.28
175	Alzheimer disease, familial, 1	Enrichment	CSF1R	1.25
176	Pancreatitis, hereditary	Enrichment	TRPV6	1.25
177	Dandy-walker syndrome	Enrichment	PDGFRB	1.25
178	Giant cell glioblastoma	Enrichment	EGFR	1.25
179	Diffuse large b-cell lymphoma	Enrichment	STAT3	1.20
180	Maturity-onset diabetes of the young	Enrichment	INS	1.18
181	Endometrial cancer	Enrichment	PIK3CA	1.16
182	Hepatocellular carcinoma	Enrichment	PIK3CA	1.14
183	Myocardial infarction	Enrichment	ITGB3	1.14
184	Malaria	Enrichment	FCGR2A	1.12
185	Precursor t-cell acute lymphoblastic leukemia	Enrichment	ABL1	1.12
186	Auditory neuropathy	Enrichment	CDH2	1.07
187	Prostate cancer	Enrichment	PIK3CA	1.03
188	Cystic fibrosis	Enrichment	FCGR2A	0.99
189	Systemic lupus erythematosus	Enrichment	FCGR2A	0.91
190	Cerebral palsy	Enrichment	PDGFRB	0.91
191	Leukemia, acute myeloid	Enrichment	JAK2	0.90
192	Gastric cancer	Enrichment	PIK3CA	0.87
193	Body mass index quantitative trait locus 11	Enrichment	LEPR	0.81
194	Hypertelorism	Enrichment	PIK3CA	0.79
195	Hereditary breast ovarian cancer syndrome	Enrichment	BCAR1	0.77
196	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	CSF1R	0.75
197	Microcephaly	Enrichment	ABL1	0.47
198	Inherited cancer-predisposing syndrome	Enrichment	EGFR	0.44

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Signaling events mediated by PTP1B

Pathway Network for Signaling events mediated by PTP1B

Member Pathways for Signaling events mediated by PTP1B

Pathways in the Signaling events mediated by PTP1B SuperPath

Associated Genes for Signaling events mediated by PTP1B

Associated Disorders for Signaling events mediated by PTP1B

Disorders associated with Signaling events mediated by PTP1B SuperPath

STRING Interaction Network for Signaling events mediated by PTP1B

Sources for Signaling events mediated by PTP1B