Signaling events mediated by TCPTP

No Pathway Network information available for Signaling events mediated by TCPTP

Pathways in the Signaling events mediated by TCPTP SuperPath

#	Name	Source	Genes
1	Signaling events mediated by TCPTP	PubChem	ATR CREBBP CSF1 CSF1R EGF EGFR EIF2AK2 GAB1 GRB2 HGF INS INSR ITGA1 ITGB1 JAK1 JAK3 KDR KPNA2 KPNB1 LMAN1 MET PDGFB PDGFRB PIAS1 PIK3CA PIK3CB PIK3R1 PTPN1 PTPN2 RAB4A SHC1 SOS1 SRC STAT1 STAT3 STAT5A STAT5B STAT6 VEGFA (see all 39) (see less)
2	MET activates PI3K/AKT signaling	Reactome	GAB1 GRB2 HGF MET PIK3CA PIK3R1 (see all 6) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	HGF	Hepatocyte Growth Factor	Protein Coding	2
2	GAB1	GRB2 Associated Binding Protein 1	Protein Coding	2
3	MET	MET Proto-Oncogene, Receptor Tyrosine Kinase	Protein Coding	2
4	GRB2	Growth Factor Receptor Bound Protein 2	Protein Coding	2
5	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	2
6	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	2
7	STAT5B	Signal Transducer And Activator Of Transcription 5B	Protein Coding	1
8	PTPN2	Protein Tyrosine Phosphatase Non-Receptor Type 2	Protein Coding	1
9	CSF1	Colony Stimulating Factor 1	Protein Coding	1
10	JAK3	Janus Kinase 3	Protein Coding	1
11	STAT6	Signal Transducer And Activator Of Transcription 6	Protein Coding	1
12	CSF1R	Colony Stimulating Factor 1 Receptor	Protein Coding	1
13	PDGFB	Platelet Derived Growth Factor Subunit B	Protein Coding	1
14	EGF	Epidermal Growth Factor	Protein Coding	1
15	KPNA2	Karyopherin Subunit Alpha 2	Protein Coding	1
16	KPNB1	Karyopherin Subunit Beta 1	Protein Coding	1
17	PTPN1	Protein Tyrosine Phosphatase Non-Receptor Type 1	Protein Coding	1
18	STAT3	Signal Transducer And Activator Of Transcription 3	Protein Coding	1
19	CREBBP	CREB Binding Lysine Acetyltransferase	Protein Coding	1
20	ITGB1	Integrin Subunit Beta 1	Protein Coding	1
21	ITGA1	Integrin Subunit Alpha 1	Protein Coding	1
22	RAB4A	RAB4A, Member RAS Oncogene Family	Protein Coding	1
23	LMAN1	Lectin, Mannose Binding 1	Protein Coding	1
24	STAT5A	Signal Transducer And Activator Of Transcription 5A	Protein Coding	1
25	KDR	Kinase Insert Domain Receptor	Protein Coding	1
26	SRC	SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase	Protein Coding	1
27	PIAS1	Protein Inhibitor Of Activated STAT 1	Protein Coding	1
28	EIF2AK2	Eukaryotic Translation Initiation Factor 2 Alpha Kinase 2	Protein Coding	1
29	ATR	ATR Checkpoint Kinase	Protein Coding	1
30	SOS1	SOS Ras/Rac Guanine Nucleotide Exchange Factor 1	Protein Coding	1
31	PDGFRB	Platelet Derived Growth Factor Receptor Beta	Protein Coding	1
32	INS	Insulin	Protein Coding	1
33	PIK3CB	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Beta	Protein Coding	1
34	INSR	Insulin Receptor	Protein Coding	1
35	SHC1	SHC Adaptor Protein 1	Protein Coding	1
36	STAT1	Signal Transducer And Activator Of Transcription 1	Protein Coding	1
37	JAK1	Janus Kinase 1	Protein Coding	1
38	EGFR	Epidermal Growth Factor Receptor	Protein Coding	1
39	VEGFA	Vascular Endothelial Growth Factor A	Protein Coding	1

Disorders associated with Signaling events mediated by TCPTP SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3CA, PIK3R1	6.31
2	Colorectal cancer	Enrichment	MET, PIK3CA, PIK3R1	5.30
3	Breast implant-associated anaplastic large cell lymphoma	Enrichment	JAK1, STAT3	4.62
4	Hepatocellular carcinoma	Enrichment	MET, PIK3CA	4.43
5	Lung cancer	Enrichment	MET, PIK3CA	4.09
6	Cowden syndrome 1	Enrichment	EGFR, PIK3CA	3.92
7	Lung squamous cell carcinoma	Enrichment	EGFR, PIK3CA	3.92
8	Basal ganglia calcification, idiopathic, 1	Enrichment	PDGFB, PDGFRB	3.65
9	Permanent neonatal diabetes mellitus	Enrichment	INS, STAT3	3.65
10	Adult hepatocellular carcinoma	Enrichment	EGF, PIK3CA	3.54
11	Lung non-small cell carcinoma	Enrichment	EGFR, PIK3CA	3.36
12	Macrodactyly	Enrichment	PIK3CA	3.35
13	Deafness, autosomal recessive 26	Enrichment	GAB1	3.35
14	Deafness, autosomal recessive 39	Enrichment	HGF	3.35
15	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	3.35
16	Cowden syndrome 5	Enrichment	PIK3CA	3.35
17	Cerebral cavernous malformations 4	Enrichment	PIK3CA	3.35
18	Short syndrome	Enrichment	PIK3R1	3.35
19	Osteofibrous dysplasia	Enrichment	MET	3.35
20	Deafness, autosomal recessive 97	Enrichment	MET	3.35
21	Hemifacial myohyperplasia	Enrichment	PIK3CA	3.35
22	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	3.35
23	Autism 9	Enrichment	MET	3.35
24	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	3.35
25	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	3.35
26	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	3.35
27	Arthrogryposis, distal, type 11	Enrichment	MET	3.35
28	Hypospadias	Enrichment	PIK3CA	3.35
29	Rare venous malformation	Enrichment	PIK3CA	3.35
30	Diaphragmatic eventration	Enrichment	PIK3CA	3.35
31	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	3.35
32	Rare combined vascular malformation	Enrichment	PIK3CA	3.35
33	Cavernous lymphangioma	Enrichment	PIK3CA	3.35
34	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	3.35
35	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	3.35
36	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	3.35
37	Macrodactyly of toe	Enrichment	PIK3CA	3.35
38	Meningioma	Enrichment	PDGFB, PIK3CA	3.28
39	Lip and oral cavity carcinoma	Enrichment	EGFR, PIK3CA	3.28
40	Acute promyelocytic leukemia	Enrichment	STAT3, STAT5B	3.21
41	Nk-cell enteropathy	Enrichment	JAK3, PIK3CB	3.21
42	Rare autosomal recessive non-syndromic sensorineural deafness type dfnb	Enrichment	HGF, MET	3.20
43	Ovarian cancer	Enrichment	MET, PIK3CA	3.09
44	Keratosis, seborrheic	Enrichment	PIK3CA	3.05
45	Noonan syndrome 8	Enrichment	PIK3CA	3.05
46	Childhood hepatocellular carcinoma	Enrichment	MET	3.05
47	Rosette-forming glioneuronal tumor	Enrichment	PIK3CA	3.05
48	Papillary renal cell carcinoma	Enrichment	MET	3.05
49	Pompe disease, infantile-onset	Enrichment	PIK3CA	2.88
50	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3R1	2.88
51	Immunodeficiency 14	Enrichment	PIK3R1	2.88
52	Renal cell carcinoma	Enrichment	MET	2.88
53	Keratoacanthoma	Enrichment	PIK3CA	2.88
54	Diffuse large b-cell lymphoma	Enrichment	CREBBP, STAT3	2.87
55	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	PIK3CA	2.75
56	Cerebrovascular disease	Enrichment	PIK3CA	2.75
57	Familial cerebral cavernous malformations	Enrichment	PIK3CA	2.75
58	Capillary malformations, congenital	Enrichment	PIK3CA	2.66
59	Hemimegalencephaly	Enrichment	PIK3CA	2.66
60	Klippel-trenaunay-weber syndrome	Enrichment	PIK3CA	2.58
61	Hemihyperplasia, isolated	Enrichment	PIK3CA	2.58
62	Breast adenocarcinoma	Enrichment	PIK3CA	2.58
63	Donohue syndrome	Enrichment	INSR	2.54
64	Premature aging syndrome, penttinen type	Enrichment	PDGFRB	2.54
65	Hyperinsulinemic hypoglycemia, familial, 5	Enrichment	INSR	2.54
66	Pineal hyperplasia, insulin-resistant diabetes mellitus, and somatic abnormalities	Enrichment	INSR	2.54
67	Hypomagnesemia 4, renal	Enrichment	EGF	2.54
68	Diabetes mellitus, insulin-resistant, with acanthosis nigricans	Enrichment	INSR	2.54
69	Noonan syndrome 4	Enrichment	SOS1	2.54
70	Basal ganglia calcification, idiopathic, 5	Enrichment	PDGFB	2.54
71	Seckel syndrome 1	Enrichment	ATR	2.54
72	Myofibromatosis, infantile, 1	Enrichment	PDGFRB	2.54
73	Growth hormone insensitivity syndrome with immune dysregulation 2, autosomal dominant	Enrichment	STAT5B	2.54
74	Hyper-ige syndrome 6, autosomal dominant, with recurrent infections	Enrichment	STAT6	2.54
75	Leukoencephalopathy, developmental delay, and episodic neurologic regression syndrome	Enrichment	EIF2AK2	2.54
76	T-cell large granular lymphocyte leukemia	Enrichment	STAT3	2.54
77	Microvascular complications of diabetes 1	Enrichment	VEGFA	2.54
78	Cutaneous telangiectasia and cancer syndrome, familial	Enrichment	ATR	2.54
79	Immunodeficiency 31a	Enrichment	STAT1	2.54
80	Basal ganglia calcification, idiopathic, 4	Enrichment	PDGFRB	2.54
81	Myeloid and lymphoid neoplasms associated with pdgfrb rearrangement	Enrichment	PDGFRB	2.54
82	Immunodeficiency 31b	Enrichment	STAT1	2.54
83	Kosaki overgrowth syndrome	Enrichment	PDGFRB	2.54
84	Autoimmune disease, multisystem, infantile-onset, 1	Enrichment	STAT3	2.54
85	Thrombocytopenia 6	Enrichment	SRC	2.54
86	Dystonia 33	Enrichment	EIF2AK2	2.54
87	Menke-hennekam syndrome 1	Enrichment	CREBBP	2.54
88	Brain abnormalities, neurodegeneration, and dysosteosclerosis	Enrichment	CSF1R	2.54
89	Ocular pterygium-digital keloid dysplasia syndrome	Enrichment	PDGFRB	2.54
90	Tufted angioma of skin	Enrichment	KDR	2.54
91	T-b+ severe combined immunodeficiency due to jak3 deficiency	Enrichment	JAK3	2.54
92	Csf1r-related disorder	Enrichment	CSF1R	2.54
93	Rubinstein-taybi syndrome due to 16p13.3 microdeletion	Enrichment	CREBBP	2.54
94	Stat3-related early-onset multisystem autoimmune disease	Enrichment	STAT3	2.54
95	Menke-hennekam syndrome	Enrichment	CREBBP	2.54
96	Early-onset calcifying leukoencephalopathy-skeletal dysplasia	Enrichment	CSF1R	2.54
97	Familial cutaneous telangiectasia and oropharyngeal predisposition cancer syndrome	Enrichment	ATR	2.54
98	Chronic lymphoproliferative disorder of natural killer cells	Enrichment	STAT3	2.54
99	Mendelian susceptibility to mycobacterial diseases due to partial jak1 deficiency	Enrichment	JAK1	2.54
100	Egf-related primary hypomagnesemia with intellectual disability	Enrichment	EGF	2.54
101	Nevus, epidermal	Enrichment	PIK3CA	2.51
102	Capillary malformation-arteriovenous malformation 1	Enrichment	PIK3CA	2.51
103	Renal cell carcinoma, papillary, 1	Enrichment	MET	2.51
104	Gallbladder cancer	Enrichment	PIK3CA	2.51
105	Overgrowth syndrome	Enrichment	PIK3R1	2.51
106	Bladder cancer	Enrichment	EGFR, PIK3CA	2.51
107	Arthrogryposis, distal, type 1a	Enrichment	MET	2.45
108	Arteriovenous malformation	Enrichment	PIK3CA	2.40
109	Cowden syndrome	Enrichment	PIK3CA	2.40
110	Myopathy, x-linked, with excessive autophagy	Enrichment	PIK3CA	2.35
111	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3R1	2.35
112	Myeloproliferative disorder, chronic, with eosinophilia	Enrichment	PDGFRB	2.24
113	Fibromatosis, gingival, 1	Enrichment	SOS1	2.24
114	Hemangiopericytoma, malignant	Enrichment	STAT6	2.24
115	Thumb deformity	Enrichment	CREBBP	2.24
116	Growth hormone insensitivity syndrome with immune dysregulation 1, autosomal recessive	Enrichment	STAT5B	2.24
117	Dermatofibrosarcoma protuberans	Enrichment	PDGFB	2.24
118	Pulmonic stenosis	Enrichment	SOS1	2.24
119	Hyperinsulinemic hypoglycemia, familial, 4	Enrichment	INSR	2.24
120	Angioma, tufted	Enrichment	KDR	2.24
121	Maturity-onset diabetes of the young, type 10	Enrichment	INS	2.24
122	Immunodeficiency 31c	Enrichment	STAT1	2.24
123	Hyperproinsulinemia	Enrichment	INS	2.24
124	Infantile myofibromatosis	Enrichment	PDGFRB	2.24
125	Acute myeloid leukemia with kat6a-crebbp fusion	Enrichment	CREBBP	2.24
126	Diabetes mellitus, permanent neonatal, 4	Enrichment	INS	2.24
127	Autoinflammation, immune dysregulation, and eosinophilia	Enrichment	JAK1	2.24
128	Combined deficiency of factor v and factor viii	Enrichment	LMAN1	2.24
129	Laron syndrome with immunodeficiency	Enrichment	STAT5B	2.24
130	Type 2 diabetes mellitus	Enrichment	INSR, PTPN1	2.19
131	Renal cell carcinoma, nonpapillary	Enrichment	MET	2.18
132	Lynch syndrome	Enrichment	PIK3CA	2.18
133	Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-negative, nk cell-negative, due to adenosine deaminase deficiency	Enrichment	JAK3	2.07
134	Hyper-ige syndrome 1, autosomal dominant, with recurrent infections	Enrichment	STAT3	2.07
135	Type 1 diabetes mellitus 2	Enrichment	INS	2.07
136	Leukoencephalopathy, hereditary diffuse, with spheroids 1	Enrichment	CSF1R	2.07
137	Factor v and factor viii, combined deficiency of, 1	Enrichment	LMAN1	2.07
138	Nuchal bleb, familial	Enrichment	SOS1	2.07
139	Neonatal nephrocutaneous inflammatory syndrome	Enrichment	EGFR	2.07
140	Tethered spinal cord syndrome	Enrichment	CREBBP	2.07
141	Hyper ige syndrome	Enrichment	STAT3	2.07
142	Torsion dystonia 1	Enrichment	EIF2AK2	2.07
143	Intraocular pressure quantitative trait locus	Enrichment	CREBBP	2.07
144	Neonatal inflammatory skin and bowel disease	Enrichment	EGFR	2.07
145	Endometrial cancer	Enrichment	PIK3CA	2.03
146	Neonatal diabetes mellitus	Enrichment	INS	1.94
147	Adenosine deaminase deficiency	Enrichment	JAK3	1.94
148	Gingival fibromatosis	Enrichment	SOS1	1.94
149	Prostate cancer	Enrichment	PIK3CA	1.89
150	Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-negative	Enrichment	JAK3	1.84
151	Primary hypereosinophilic syndrome	Enrichment	PDGFRB	1.84
152	Rubinstein-taybi syndrome 1	Enrichment	CREBBP	1.77
153	Type 1 diabetes mellitus	Enrichment	INS	1.77
154	Hemangioma, capillary infantile	Enrichment	KDR	1.77
155	Chromosome 16p13.3 deletion syndrome, proximal	Enrichment	CREBBP	1.77
156	Chronic mucocutaneous candidiasis	Enrichment	STAT1	1.77
157	Hypertrichosis	Enrichment	CREBBP	1.77
158	46,xy disorder of sex development	Enrichment	INSR	1.77
159	Gastric cancer	Enrichment	PIK3CA	1.72
160	Hereditary breast carcinoma	Enrichment	PIK3CA	1.71
161	Breast cancer	Enrichment	PIK3CA, SHC1	1.71
162	Myelofibrosis	Enrichment	SRC	1.70
163	Squamous cell carcinoma, head and neck	Enrichment	EGFR	1.70
164	Noonan syndrome 3	Enrichment	SOS1	1.70
165	Oligoarticular juvenile idiopathic arthritis	Enrichment	PTPN2	1.70
166	Rheumatoid factor-negative juvenile idiopathic arthritis	Enrichment	PTPN2	1.70
167	Sensorineural hearing loss	Enrichment	HGF	1.68
168	Hypertelorism	Enrichment	PIK3CA	1.64
169	Frontotemporal dementia 1	Enrichment	CSF1R	1.51
170	Meningioma, familial	Enrichment	PDGFB	1.51
171	Diabetes mellitus	Enrichment	INS	1.51
172	Aortic valve disease 1	Enrichment	SOS1	1.43
173	Neural tube defects	Enrichment	ITGB1	1.43
174	Alzheimer's disease	Enrichment	CSF1R	1.43
175	Osteoporosis	Enrichment	SRC	1.40
176	Lung cancer susceptibility 3	Enrichment	EGFR	1.40
177	Seckel syndrome	Enrichment	ATR	1.40
178	Heart disease	Enrichment	CREBBP	1.40
179	46,xy partial gonadal dysgenesis	Enrichment	SOS1	1.40
180	Corpus callosum, agenesis of	Enrichment	CREBBP	1.37
181	Hydrocephalus	Enrichment	PDGFRB	1.37
182	Isolated corpus callosum agenesis	Enrichment	CREBBP	1.37
183	Rare genetic intellectual disability	Enrichment	CREBBP	1.37
184	Intellectual disability-hypoplastic corpus callosum-preauricular tag syndrome	Enrichment	CREBBP	1.37
185	Noonan syndrome and noonan-related syndrome	Enrichment	SOS1	1.37
186	Gliosarcoma	Enrichment	EGFR	1.35
187	Alzheimer disease, familial, 1	Enrichment	CSF1R	1.32
188	Dandy-walker syndrome	Enrichment	PDGFRB	1.32
189	Giant cell glioblastoma	Enrichment	EGFR	1.32
190	Arteriovenous malformations of the brain	Enrichment	EGFR	1.27
191	Inherited cancer-predisposing syndrome	Enrichment	EGFR, MET	1.26
192	Maturity-onset diabetes of the young	Enrichment	INS	1.25
193	Noonan syndrome 1	Enrichment	SOS1	1.19
194	Scoliosis	Enrichment	CREBBP	1.18
195	Tetralogy of fallot	Enrichment	KDR	1.14
196	Rasopathy	Enrichment	SOS1	1.14
197	Severe covid-19	Enrichment	JAK3	1.10
198	Nephronophthisis	Enrichment	PIAS1	1.04
199	Severe combined immunodeficiency	Enrichment	JAK3	1.04
200	Cerebral palsy	Enrichment	PDGFRB	0.97
201	Thrombocytopenia	Enrichment	SRC	0.89
202	Myeloma, multiple	Enrichment	CREBBP	0.83
203	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	CSF1R	0.81
204	Primary ovarian insufficiency	Enrichment	KDR	0.81
205	Autism	Enrichment	CREBBP	0.73
206	Congenital nervous system abnormality	Enrichment	CREBBP	0.58
207	Nervous system disease	Enrichment	CREBBP	0.58

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Signaling events mediated by TCPTP

Pathway Network for Signaling events mediated by TCPTP

Member Pathways for Signaling events mediated by TCPTP

Pathways in the Signaling events mediated by TCPTP SuperPath

Associated Genes for Signaling events mediated by TCPTP

Associated Disorders for Signaling events mediated by TCPTP

Disorders associated with Signaling events mediated by TCPTP SuperPath

STRING Interaction Network for Signaling events mediated by TCPTP

Sources for Signaling events mediated by TCPTP