Signaling events mediated by the Hedgehog family

Pathway network for the Signaling events mediated by the Hedgehog family SuperPath

Sources:

PubChem
Reactome

Pathways in the Signaling events mediated by the Hedgehog family SuperPath

#	Name	Source	Genes
1	Signaling events mediated by the Hedgehog family	PubChem	AKT1 ARRB2 BOC CDON DHH DISP1 GAS1 GLI2 GLI3 GRK2 HHAT HHIP IHH LRP2 LRPAP1 PIK3CA PIK3R1 PTCH1 PTCH2 PTHLH SHH SMO STIL TGFB2 (see all 24) (see less)
2	Ligand-receptor interactions	Reactome	BOC CDON DHH GAS1 HHIP IHH PTCH1 SHH (see all 8) (see less)
3	HHAT G278V doesn't palmitoylate Hh-Np	Reactome	DHH HHAT IHH SHH

Gene overlap in member pathways for Signaling events mediated by the Hedgehog family SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	SHH	Sonic Hedgehog Signaling Molecule	Protein Coding	3
2	DHH	Desert Hedgehog Signaling Molecule	Protein Coding	3
3	IHH	Indian Hedgehog Signaling Molecule	Protein Coding	3
4	HHIP	Hedgehog Interacting Protein	Protein Coding	2
5	GAS1	Growth Arrest Specific 1	Protein Coding	2
6	BOC	BOC Cell Adhesion Associated, Oncogene Regulated	Protein Coding	2
7	PTCH1	Patched 1	Protein Coding	2
8	HHAT	Hedgehog Acyltransferase	Protein Coding	2
9	CDON	Cell Adhesion Associated, Oncogene Regulated	Protein Coding	2
10	STIL	STIL Centriolar Assembly Protein	Protein Coding	1
11	PTHLH	Parathyroid Hormone Like Hormone	Protein Coding	1
12	PTCH2	Patched 2	Protein Coding	1
13	DISP1	Dispatched RND Transporter Family Member 1	Protein Coding	1
14	LRPAP1	LDL Receptor Related Protein Associated Protein 1	Protein Coding	1
15	GLI3	GLI Family Zinc Finger 3	Protein Coding	1
16	GLI2	GLI Family Zinc Finger 2	Protein Coding	1
17	GRK2	G Protein-Coupled Receptor Kinase 2	Protein Coding	1
18	SMO	Smoothened, Frizzled Class Receptor	Protein Coding	1
19	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	1
20	ARRB2	Arrestin Beta 2	Protein Coding	1
21	TGFB2	Transforming Growth Factor Beta 2	Protein Coding	1
22	LRP2	LDL Receptor Related Protein 2	Protein Coding	1
23	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	1
24	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	1

Disorders associated with Signaling events mediated by the Hedgehog family SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	46,xy complete gonadal dysgenesis	Direct
2	Alobar holoprosencephaly	Enrichment	CDON, DISP1, GAS1, GLI2, PTCH1, SHH, STIL	10.74
3	Semilobar holoprosencephaly	Enrichment	CDON, DISP1, GAS1, GLI2, PTCH1, SHH, STIL	10.67
4	Septopreoptic holoprosencephaly	Enrichment	CDON, DISP1, GAS1, GLI2, PTCH1, SHH, STIL	10.38
5	Midline interhemispheric variant of holoprosencephaly	Enrichment	CDON, DISP1, GAS1, GLI2, PTCH1, SHH, STIL	10.38
6	Lobar holoprosencephaly	Enrichment	CDON, DISP1, GAS1, GLI2, PTCH1, SHH, STIL	10.33
7	Microform holoprosencephaly	Enrichment	CDON, DISP1, GAS1, GLI2, PTCH1, SHH	10.33
8	Meningioma	Enrichment	AKT1, PIK3CA, SMO	5.97
9	Polydactyly, preaxial ii	Enrichment	PTCH1, SHH	5.74
10	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3CA, PIK3R1	5.05
11	Hirschsprung disease 1	Enrichment	GLI3, IHH, SMO	4.76
12	Basal cell nevus syndrome 1	Enrichment	PTCH1, PTCH2	4.35
13	Basal cell carcinoma 1	Enrichment	PTCH1, PTCH2	4.35
14	Breast adenocarcinoma	Enrichment	AKT1, PIK3CA	4.35
15	Macs syndrome	Enrichment	PTCH1, SHH	4.24
16	Overgrowth syndrome	Enrichment	PIK3R1, PTCH1	4.20
17	Cowden syndrome	Enrichment	AKT1, PIK3CA	3.97
18	Medulloblastoma	Enrichment	PTCH1, PTCH2	3.57
19	Breast cancer	Enrichment	AKT1, PIK3CA, PTCH2	3.52
20	Polydactyly, postaxial, type a1	Enrichment	GLI3, PTCH1	3.51
21	Colorectal cancer	Enrichment	AKT1, PIK3CA, PIK3R1	3.33
22	Craniosynostosis	Enrichment	GLI2, GLI3	3.25
23	Holoprosencephaly 3	Enrichment	SHH	3.23
24	46,xy sex reversal 7	Enrichment	DHH	3.23
25	Schilbach-rott syndrome	Enrichment	PTCH1	3.23
26	Microphthalmia/coloboma 5	Enrichment	SHH	3.23
27	Acrocapitofemoral dysplasia	Enrichment	IHH	3.23
28	Holoprosencephaly 11	Enrichment	CDON	3.23
29	Turner syndrome	Enrichment	PTCH1	3.23
30	Monosomy 9q22.3	Enrichment	PTCH1	3.23
31	Autosomal dominant preaxial polydactyly-upperback hypertrichosis syndrome	Enrichment	SHH	3.23
32	Ovarian cancer	Enrichment	AKT1, PIK3CA, PTCH1	3.14
33	46,xy gonadal dysgenesis with minifascicular neuropathy	Enrichment	DHH	2.93
34	Solitary median maxillary central incisor	Enrichment	SHH	2.93
35	Isolated radial hemimelia	Enrichment	SHH	2.93
36	Brachydactyly, type a1	Enrichment	IHH	2.75
37	Syndactyly, type iv	Enrichment	SHH	2.75
38	Holoprosencephaly 7	Enrichment	PTCH1	2.75
39	Hypoplastic or aplastic tibia with polydactyly	Enrichment	SHH	2.75
40	Pallister-hall syndrome	Enrichment	GLI3	2.75
41	Macrodactyly	Enrichment	PIK3CA	2.75
42	Proteus syndrome	Enrichment	AKT1	2.75
43	Greig cephalopolysyndactyly syndrome	Enrichment	GLI3	2.75
44	Curry-jones syndrome	Enrichment	SMO	2.75
45	Polydactyly, preaxial iv	Enrichment	GLI3	2.75
46	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	2.75
47	Cowden syndrome 5	Enrichment	PIK3CA	2.75
48	Donnai-barrow syndrome	Enrichment	LRP2	2.75
49	Culler-jones syndrome	Enrichment	GLI2	2.75
50	Microcephaly 7, primary, autosomal recessive	Enrichment	STIL	2.75
51	Cerebral cavernous malformations 4	Enrichment	PIK3CA	2.75
52	Short syndrome	Enrichment	PIK3R1	2.75
53	Nivelon-nivelon-mabille syndrome	Enrichment	HHAT	2.75
54	Camurati-engelmann disease 2	Enrichment	TGFB2	2.75
55	Hemifacial myohyperplasia	Enrichment	PIK3CA	2.75
56	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	2.75
57	Holoprosencephaly 9	Enrichment	GLI2	2.75
58	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	2.75
59	Cowden syndrome 6	Enrichment	AKT1	2.75
60	Brachydactyly, type e2	Enrichment	PTHLH	2.75
61	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	2.75
62	Holoprosencephaly 10	Enrichment	DISP1	2.75
63	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	2.75
64	Prolactin-producing pituitary gland adenoma	Enrichment	LRP2	2.75
65	Hypospadias	Enrichment	PIK3CA	2.75
66	Rare venous malformation	Enrichment	PIK3CA	2.75
67	Diaphragmatic eventration	Enrichment	PIK3CA	2.75
68	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	2.75
69	Rare combined vascular malformation	Enrichment	PIK3CA	2.75
70	Cavernous lymphangioma	Enrichment	PIK3CA	2.75
71	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	2.75
72	Postaxial polydactyly-anterior pituitary anomalies-facial dysmorphism syndrome	Enrichment	GLI2	2.75
73	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	2.75
74	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	2.75
75	Macrodactyly of toe	Enrichment	PIK3CA	2.75
76	Schizencephaly	Enrichment	SHH	2.63
77	Hereditary breast carcinoma	Enrichment	AKT1, PIK3CA	2.57
78	Pallister-hall-like syndrome	Enrichment	SMO	2.45
79	Keratosis, seborrheic	Enrichment	PIK3CA	2.45
80	White-sutton syndrome	Enrichment	GLI2	2.45
81	Noonan syndrome 8	Enrichment	PIK3CA	2.45
82	Tibial hemimelia	Enrichment	GLI3	2.45
83	Rosette-forming glioneuronal tumor	Enrichment	PIK3CA	2.45
84	Synpolydactyly	Enrichment	GLI3	2.45
85	Loeys-dietz syndrome 4	Enrichment	TGFB2	2.45
86	Postaxial polydactyly type b	Enrichment	GLI3	2.45
87	Non-syndromic syndactyly	Enrichment	LRP2	2.45
88	Commissural facial cleft	Enrichment	PTCH2	2.45
89	Congenital hydrocephalus	Enrichment	PTCH1	2.38
90	Brachydactyly, type e1	Enrichment	PTHLH	2.28
91	Acrocallosal syndrome	Enrichment	GLI3	2.28
92	Pompe disease, infantile-onset	Enrichment	PIK3CA	2.28
93	Aarskog-scott syndrome	Enrichment	GLI3	2.28
94	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3R1	2.28
95	Umbilical hernia	Enrichment	GLI3	2.28
96	Myopia 23, autosomal recessive	Enrichment	LRPAP1	2.28
97	Immunodeficiency 14	Enrichment	PIK3R1	2.28
98	Keratoacanthoma	Enrichment	PIK3CA	2.28
99	Septooptic dysplasia	Enrichment	SHH	2.15
100	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	PIK3CA	2.15
101	Cerebrovascular disease	Enrichment	PIK3CA	2.15
102	Prolactinoma	Enrichment	LRP2	2.15
103	Familial cerebral cavernous malformations	Enrichment	PIK3CA	2.15
104	Microphthalmia/coloboma 12	Enrichment	CDON	2.12
105	Pituitary stalk interruption syndrome	Enrichment	CDON	2.08
106	Coloboma of macula	Enrichment	CDON	2.05
107	Capillary malformations, congenital	Enrichment	PIK3CA	2.05
108	Hemimegalencephaly	Enrichment	PIK3CA	2.05
109	Rare isolated myopia	Enrichment	LRPAP1	2.05
110	Rhabdomyosarcoma	Enrichment	PTCH1	2.03
111	Atrial septal defect 1	Enrichment	TGFB2	1.98
112	Klippel-trenaunay-weber syndrome	Enrichment	PIK3CA	1.98
113	Cowden syndrome 1	Enrichment	PIK3CA	1.98
114	Hemihyperplasia, isolated	Enrichment	PIK3CA	1.98
115	Lung squamous cell carcinoma	Enrichment	PIK3CA	1.98
116	Nevus, epidermal	Enrichment	PIK3CA	1.91
117	Capillary malformation-arteriovenous malformation 1	Enrichment	PIK3CA	1.91
118	Gallbladder cancer	Enrichment	PIK3CA	1.91
119	Microphthalmia	Enrichment	PTCH1	1.89
120	Combined pituitary hormone deficiency	Enrichment	GLI2	1.85
121	Loeys-dietz syndrome	Enrichment	TGFB2	1.80
122	Arteriovenous malformation	Enrichment	PIK3CA	1.80
123	Adult hepatocellular carcinoma	Enrichment	PIK3CA	1.80
124	Marfan syndrome	Enrichment	TGFB2	1.76
125	Myopathy, x-linked, with excessive autophagy	Enrichment	PIK3CA	1.76
126	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3R1	1.76
127	Lung non-small cell carcinoma	Enrichment	PIK3CA	1.71
128	Lip and oral cavity carcinoma	Enrichment	PIK3CA	1.68
129	Diaphragmatic hernia, congenital	Enrichment	GLI3	1.64
130	Lynch syndrome	Enrichment	PIK3CA	1.58
131	Hereditary breast ovarian cancer syndrome	Enrichment	PTCH1	1.50
132	Ehlers-danlos syndrome	Enrichment	TGFB2	1.48
133	Endometrial cancer	Enrichment	PIK3CA	1.44
134	Hepatocellular carcinoma	Enrichment	PIK3CA	1.42
135	Precursor t-cell acute lymphoblastic leukemia	Enrichment	STIL	1.40
136	Autism	Enrichment	SHH	1.38
137	Jeune thoracic dystrophy	Enrichment	GRK2	1.36
138	Asphyxiating thoracic dystrophy	Enrichment	GRK2	1.31
139	Bladder cancer	Enrichment	PIK3CA	1.30
140	Prostate cancer	Enrichment	PIK3CA	1.30
141	Lung cancer	Enrichment	PIK3CA	1.26
142	Primary autosomal recessive microcephaly	Enrichment	STIL	1.26
143	Short-rib thoracic dysplasia 1 with or without polydactyly	Enrichment	GRK2	1.25
144	Gastric cancer	Enrichment	PIK3CA	1.13
145	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	TGFB2	1.12
146	Inherited cancer-predisposing syndrome	Enrichment	PTCH1	1.12
147	Hypertelorism	Enrichment	PIK3CA	1.05
148	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	GLI2	1.02
149	Hereditary retinal dystrophy	Enrichment	LRP2	0.39
150	Fundus dystrophy	Enrichment	LRP2	0.39

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Signaling events mediated by the Hedgehog family

Pathway Network for Signaling events mediated by the Hedgehog family

Pathway network for the Signaling events mediated by the Hedgehog family SuperPath

Member Pathways for Signaling events mediated by the Hedgehog family

Pathways in the Signaling events mediated by the Hedgehog family SuperPath

Gene overlap in member pathways for Signaling events mediated by the Hedgehog family SuperPath

Associated Genes for Signaling events mediated by the Hedgehog family

Associated Disorders for Signaling events mediated by the Hedgehog family

Disorders associated with Signaling events mediated by the Hedgehog family SuperPath

STRING Interaction Network for Signaling events mediated by the Hedgehog family

Sources for Signaling events mediated by the Hedgehog family