Signaling mediated by p38-alpha and p38-beta

No Pathway Network information available for Signaling mediated by p38-alpha and p38-beta

Pathways in the Signaling mediated by p38-alpha and p38-beta SuperPath

#	Name	Source	Genes
1	Signaling mediated by p38-alpha and p38-beta	PubChem	ATF1 ATF2 ATF6 CEBPB CREB1 DDIT3 EIF4E EIF4EBP1 ELK4 ESR1 GDI1 HBP1 HSPB1 JUN KRT19 KRT8 MAPK14 MAPKAPK2 MAPKAPK3 MAPKAPK5 MEF2A MEF2C MITF MKNK1 NOS2 PLA2G4A PPARGC1A PTGS2 RAB5A RPS6KA5 SLC9A1 TP53 USF1 (see all 33) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	GDI1	GDP Dissociation Inhibitor 1	Protein Coding	1
2	KRT19	Keratin 19	Protein Coding	1
3	KRT8	Keratin 8	Protein Coding	1
4	MEF2A	Myocyte Enhancer Factor 2A	Protein Coding	1
5	HBP1	HMG-Box Transcription Factor 1	Protein Coding	1
6	ELK4	ETS Transcription Factor ELK4	Protein Coding	1
7	CREB1	CAMP Responsive Element Binding Protein 1	Protein Coding	1
8	MEF2C	Myocyte Enhancer Factor 2C	Protein Coding	1
9	ATF6	Activating Transcription Factor 6	Protein Coding	1
10	MITF	Melanocyte Inducing Transcription Factor	Protein Coding	1
11	MAPKAPK3	MAPK Activated Protein Kinase 3	Protein Coding	1
12	EIF4E	Eukaryotic Translation Initiation Factor 4E	Protein Coding	1
13	EIF4EBP1	Eukaryotic Translation Initiation Factor 4E Binding Protein 1	Protein Coding	1
14	MAPKAPK5	MAPK Activated Protein Kinase 5	Protein Coding	1
15	USF1	Upstream Transcription Factor 1	Protein Coding	1
16	HSPB1	Heat Shock Protein Family B (Small) Member 1	Protein Coding	1
17	ATF1	Activating Transcription Factor 1	Protein Coding	1
18	MKNK1	MAPK Interacting Serine/Threonine Kinase 1	Protein Coding	1
19	MAPKAPK2	MAPK Activated Protein Kinase 2	Protein Coding	1
20	SLC9A1	Solute Carrier Family 9 Member A1	Protein Coding	1
21	RAB5A	RAB5A, Member RAS Oncogene Family	Protein Coding	1
22	MAPK14	Mitogen-Activated Protein Kinase 14	Protein Coding	1
23	JUN	Jun Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
24	CEBPB	CCAAT Enhancer Binding Protein Beta	Protein Coding	1
25	RPS6KA5	Ribosomal Protein S6 Kinase A5	Protein Coding	1
26	ATF2	Activating Transcription Factor 2	Protein Coding	1
27	PPARGC1A	PPARG Coactivator 1 Alpha	Protein Coding	1
28	TP53	Tumor Protein P53	Protein Coding	1
29	NOS2	Nitric Oxide Synthase 2	Protein Coding	1
30	PLA2G4A	Phospholipase A2 Group IVA	Protein Coding	1
31	DDIT3	DNA Damage Inducible Transcript 3	Protein Coding	1
32	PTGS2	Prostaglandin-Endoperoxide Synthase 2	Protein Coding	1
33	ESR1	Estrogen Receptor 1	Protein Coding	1

Disorders associated with Signaling mediated by p38-alpha and p38-beta SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Melanoma of soft tissue	Enrichment	ATF1, CREB1	4.76
2	Breast cancer	Enrichment	ESR1, JUN, TP53	3.10
3	Malaria	Enrichment	MAPKAPK3, NOS2	2.85
4	Hyperlipidemia, familial combined, 1	Enrichment	USF1	2.61
5	Heterochromia iridis	Enrichment	MITF	2.61
6	Tietz albinism-deafness syndrome	Enrichment	MITF	2.61
7	Lichtenstein-knorr syndrome	Enrichment	SLC9A1	2.61
8	Bone marrow failure syndrome 5	Enrichment	TP53	2.61
9	Intellectual developmental disorder, x-linked 41	Enrichment	GDI1	2.61
10	Papilloma of choroid plexus	Enrichment	TP53	2.61
11	Basal cell carcinoma 7	Enrichment	TP53	2.61
12	Autism 19	Enrichment	EIF4E	2.61
13	Anaplastic thyroid carcinoma	Enrichment	TP53	2.61
14	Neurodevelopmental disorder with hypotonia, stereotypic hand movements, and impaired language	Enrichment	MEF2C	2.61
15	Coloboma, osteopetrosis, microphthalmia, macrocephaly, albinism, and deafness	Enrichment	MITF	2.61
16	Coronary artery disease, autosomal dominant, 1	Enrichment	MEF2A	2.61
17	Charcot-marie-tooth disease, axonal, type 2f	Enrichment	HSPB1	2.61
18	Cytosolic phospholipase-a2 alpha deficiency associated bleeding disorder	Enrichment	PLA2G4A	2.61
19	Achromatopsia 7	Enrichment	ATF6	2.61
20	Neurocardiofaciodigital syndrome	Enrichment	MAPKAPK5	2.61
21	Macular dystrophy, patterned, 3	Enrichment	MAPKAPK3	2.61
22	Ductal carcinoma in situ	Enrichment	TP53	2.61
23	Gastrointestinal ulceration, recurrent, with dysfunctional platelets	Enrichment	PLA2G4A	2.61
24	Thyroid gland undifferentiated carcinoma	Enrichment	TP53	2.61
25	Small-cell carcinoma of the ovary of hypercalcemic type	Enrichment	TP53	2.61
26	Diffuse pediatric-type high-grade glioma, h3-wildtype and idh-wildtype	Enrichment	TP53	2.61
27	5q14.3 microdeletion syndrome	Enrichment	MEF2C	2.61
28	Choroid plexus cancer	Enrichment	TP53	2.61
29	Complete atrioventricular septal defect without ventricular hypoplasia	Enrichment	MEF2C	2.61
30	Pleomorphic xanthoastrocytoma	Enrichment	TP53	2.61
31	Cryptogenic multifocal ulcerous stenosing enteritis	Enrichment	PLA2G4A	2.61
32	Mef2c-related disorder	Enrichment	MEF2C	2.61
33	Adrenocortical carcinoma, hereditary	Enrichment	TP53	2.31
34	Cervical cancer	Enrichment	TP53	2.31
35	Histiocytoma, angiomatoid fibrous	Enrichment	CREB1	2.31
36	Neuronopathy, distal hereditary motor, autosomal dominant 3	Enrichment	HSPB1	2.31
37	Lymphoma, hodgkin, classic	Enrichment	TP53	2.31
38	Melanoma, cutaneous malignant 8	Enrichment	MITF	2.31
39	Papillary renal cell carcinoma	Enrichment	MITF	2.31
40	Congenital fibrosarcoma	Enrichment	TP53	2.31
41	Li-fraumeni syndrome 1	Enrichment	TP53	2.31
42	Sarcoma	Enrichment	TP53	2.31
43	Cervix carcinoma	Enrichment	TP53	2.31
44	Hodgkin's lymphoma	Enrichment	TP53	2.31
45	Pleomorphic rhabdomyosarcoma	Enrichment	TP53	2.31
46	Hereditary breast carcinoma	Enrichment	ESR1, TP53	2.29
47	Waardenburg syndrome, type 2a	Enrichment	MITF	2.14
48	Osteogenic sarcoma	Enrichment	TP53	2.14
49	Nasopharyngeal carcinoma	Enrichment	TP53	2.14
50	Estrogen resistance	Enrichment	ESR1	2.14
51	Bacteremia 2	Enrichment	MAPKAPK3	2.14
52	Atypical teratoid rhabdoid tumor	Enrichment	TP53	2.14
53	Anaplastic astrocytoma	Enrichment	TP53	2.14
54	Myxoid liposarcoma	Enrichment	DDIT3	2.14
55	Squamous cell carcinoma	Enrichment	TP53	2.14
56	Adenocarcinoma	Enrichment	TP53	2.14
57	Migraine without aura	Enrichment	ESR1	2.14
58	Bone osteosarcoma	Enrichment	TP53	2.14
59	Cryptogenic cirrhosis	Enrichment	KRT8	2.14
60	Hereditary breast ovarian cancer syndrome	Enrichment	MITF, TP53	2.10
61	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	MEF2C, PPARGC1A	2.06
62	Small cell cancer of the lung	Enrichment	TP53	2.01
63	Thyroid cancer, nonmedullary, 1	Enrichment	TP53	2.01
64	Arthrogryposis multiplex congenita 3, myogenic type	Enrichment	ESR1	2.01
65	Lung sarcomatoid carcinoma	Enrichment	TP53	2.01
66	Embryonal rhabdomyosarcoma	Enrichment	TP53	2.01
67	Tuberculosis	Enrichment	MAPKAPK3	2.01
68	Clear cell papillary renal cell carcinoma	Enrichment	MITF	2.01
69	Hyperlipidemia, familial combined, 3	Enrichment	USF1	1.92
70	Neuronopathy, distal hereditary motor, autosomal dominant 2	Enrichment	HSPB1	1.92
71	Rhabdomyosarcoma 2	Enrichment	TP53	1.92
72	Lymphoma	Enrichment	TP53	1.92
73	Acute megakaryocytic leukemia	Enrichment	TP53	1.92
74	Li-fraumeni syndrome	Enrichment	TP53	1.84
75	Waardenburg syndrome, type 4a	Enrichment	MITF	1.84
76	Adrenocortical carcinoma	Enrichment	TP53	1.84
77	Breast adenocarcinoma	Enrichment	TP53	1.84
78	Waardenburg syndrome	Enrichment	MITF	1.84
79	Esophageal cancer	Enrichment	TP53	1.77
80	Waardenburg syndrome, type 1	Enrichment	MITF	1.77
81	Squamous cell carcinoma, head and neck	Enrichment	TP53	1.77
82	Waardenburg syndrome, type 2e	Enrichment	MITF	1.77
83	Essential thrombocythemia	Enrichment	TP53	1.77
84	Gallbladder cancer	Enrichment	TP53	1.77
85	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	TP53	1.77
86	Glioma susceptibility 1	Enrichment	TP53	1.71
87	Lymphoma, non-hodgkin, familial	Enrichment	TP53	1.71
88	Adult hepatocellular carcinoma	Enrichment	TP53	1.66
89	Primary hyperaldosteronism	Enrichment	TP53	1.66
90	Leukemia, chronic lymphocytic	Enrichment	TP53	1.62
91	Melanoma	Enrichment	MITF	1.62
92	Achromatopsia	Enrichment	ATF6	1.62
93	Familial colorectal cancer	Enrichment	TP53	1.62
94	Migraine with or without aura 1	Enrichment	ESR1	1.58
95	Myelodysplastic syndrome	Enrichment	TP53	1.58
96	Lip and oral cavity carcinoma	Enrichment	TP53	1.54
97	Lung cancer susceptibility 3	Enrichment	TP53	1.47
98	Rhabdomyosarcoma	Enrichment	TP53	1.42
99	Gliosarcoma	Enrichment	TP53	1.42
100	Melanoma, cutaneous malignant 1	Enrichment	MITF	1.39
101	Giant cell glioblastoma	Enrichment	TP53	1.39
102	Inherited cancer-predisposing syndrome	Enrichment	MITF, TP53	1.39
103	Diffuse large b-cell lymphoma	Enrichment	TP53	1.34
104	Hepatoblastoma	Enrichment	TP53	1.30
105	Hepatocellular carcinoma	Enrichment	TP53	1.28
106	Myocardial infarction	Enrichment	ESR1	1.28
107	Diamond-blackfan anemia 1	Enrichment	TP53	1.26
108	Ear malformation	Enrichment	MITF	1.25
109	Pancreatic cancer	Enrichment	TP53	1.23
110	Bladder cancer	Enrichment	TP53	1.17
111	Prostate cancer	Enrichment	TP53	1.17
112	Non-syndromic x-linked intellectual disability	Enrichment	GDI1	1.08
113	Diamond-blackfan anemia	Enrichment	TP53	1.08
114	Non-syndromic genetic deafness	Enrichment	MITF	1.08
115	Leukemia, acute myeloid	Enrichment	TP53	1.03
116	Charcot-marie-tooth disease	Enrichment	HSPB1	1.02
117	Nonsyndromic hearing loss	Enrichment	MITF	1.01
118	Gastric cancer	Enrichment	TP53	1.00
119	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	MITF	0.92
120	Myeloma, multiple	Enrichment	TP53	0.89
121	Cone-rod dystrophy 2	Enrichment	ATF6	0.82
122	Rare genetic deafness	Enrichment	MITF	0.76
123	Colorectal cancer	Enrichment	TP53	0.72
124	Ovarian cancer	Enrichment	TP53	0.66
125	Autism spectrum disorder	Enrichment	MEF2C	0.63
126	Hereditary retinal dystrophy	Enrichment	ATF6	0.29
127	Fundus dystrophy	Enrichment	ATF6	0.29

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Signaling mediated by p38-alpha and p38-beta

Pathway Network for Signaling mediated by p38-alpha and p38-beta

Member Pathways for Signaling mediated by p38-alpha and p38-beta

Pathways in the Signaling mediated by p38-alpha and p38-beta SuperPath

Associated Genes for Signaling mediated by p38-alpha and p38-beta

Associated Disorders for Signaling mediated by p38-alpha and p38-beta

Disorders associated with Signaling mediated by p38-alpha and p38-beta SuperPath

STRING Interaction Network for Signaling mediated by p38-alpha and p38-beta

Sources for Signaling mediated by p38-alpha and p38-beta