Signalling to ERKs

Pathway network for the Signalling to ERKs SuperPath

Sources:

Reactome

Pathways in the Signalling to ERKs SuperPath

#	Name	Source	Genes
1	Signalling to ERKs	Reactome	BRAF CRK CRKL FRS2 GRB2 HRAS KIDINS220 KRAS MAP2K1 MAP2K2 MAPK1 MAPK11 MAPK12 MAPK13 MAPK14 MAPK3 MAPKAPK2 MAPKAPK3 NGF NRAS NTRK1 RALA RALB RALGDS RAP1A RAPGEF1 RIT1 RIT2 SHC1 SHC2 SHC3 SOS1 SRC YWHAB (see all 34) (see less)
2	Signalling to RAS	Reactome	GRB2 HRAS KRAS MAPK11 MAPK12 MAPK13 MAPK14 MAPKAPK2 MAPKAPK3 NGF NRAS NTRK1 RALA RALB RALGDS SHC1 SHC2 SHC3 SOS1 SRC (see all 20) (see less)
3	Prolonged ERK activation events	Reactome	BRAF CRK CRKL FRS2 KIDINS220 MAP2K1 MAP2K2 MAPK1 MAPK3 NGF NTRK1 RAP1A RAPGEF1 YWHAB (see all 14) (see less)
4	p38MAPK events	Reactome	HRAS KRAS MAPK11 MAPK12 MAPK13 MAPK14 MAPKAPK2 MAPKAPK3 NRAS RALA RALB RALGDS SRC (see all 13) (see less)
5	Frs2-mediated activation	Reactome	BRAF CRKL FRS2 MAP2K1 MAP2K2 MAPK1 MAPK3 NGF NTRK1 RAP1A RAPGEF1 YWHAB (see all 12) (see less)
6	ARMS-mediated activation	Reactome	BRAF CRK KIDINS220 NGF NTRK1 RAP1A YWHAB (see all 7) (see less)
7	Signalling to p38 via RIT and RIN	Reactome	BRAF NGF NTRK1 RIT1 RIT2

Gene overlap in member pathways for Signalling to ERKs SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	NGF	Nerve Growth Factor	Protein Coding	6
2	NTRK1	Neurotrophic Receptor Tyrosine Kinase 1	Protein Coding	6
3	BRAF	B-Raf Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	5
4	RAP1A	RAP1A, Member Of RAS Oncogene Family	Protein Coding	4
5	YWHAB	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Beta	Protein Coding	4
6	FRS2	Fibroblast Growth Factor Receptor Substrate 2	Protein Coding	3
7	CRK	CRK Proto-Oncogene, Adaptor Protein	Protein Coding	3
8	CRKL	CRK Like Proto-Oncogene, Adaptor Protein	Protein Coding	3
9	MAPK14	Mitogen-Activated Protein Kinase 14	Protein Coding	3
10	RAPGEF1	Rap Guanine Nucleotide Exchange Factor 1	Protein Coding	3
11	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	3
12	KRAS	KRAS Proto-Oncogene, GTPase	Protein Coding	3
13	NRAS	NRAS Proto-Oncogene, GTPase	Protein Coding	3
14	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	3
15	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	3
16	MAPK11	Mitogen-Activated Protein Kinase 11	Protein Coding	3
17	MAPK13	Mitogen-Activated Protein Kinase 13	Protein Coding	3
18	MAP2K1	Mitogen-Activated Protein Kinase Kinase 1	Protein Coding	3
19	MAP2K2	Mitogen-Activated Protein Kinase Kinase 2	Protein Coding	3
20	KIDINS220	Kinase D Interacting Substrate 220	Protein Coding	3
21	RALA	RAS Like Proto-Oncogene A	Protein Coding	3
22	RALB	RAS Like Proto-Oncogene B	Protein Coding	3
23	RALGDS	Ral Guanine Nucleotide Dissociation Stimulator	Protein Coding	3
24	MAPK12	Mitogen-Activated Protein Kinase 12	Protein Coding	3
25	SRC	SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase	Protein Coding	3
26	MAPKAPK3	MAPK Activated Protein Kinase 3	Protein Coding	3
27	MAPKAPK2	MAPK Activated Protein Kinase 2	Protein Coding	3
28	SHC2	SHC Adaptor Protein 2	Protein Coding	2
29	GRB2	Growth Factor Receptor Bound Protein 2	Protein Coding	2
30	SHC3	SHC Adaptor Protein 3	Protein Coding	2
31	RIT2	Ras Like Without CAAX 2	Protein Coding	2
32	RIT1	Ras Like Without CAAX 1	Protein Coding	2
33	SHC1	SHC Adaptor Protein 1	Protein Coding	2
34	SOS1	SOS Ras/Rac Guanine Nucleotide Exchange Factor 1	Protein Coding	2

Disorders associated with Signalling to ERKs SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Rasopathy	Enrichment	BRAF, HRAS, KRAS, MAP2K1, MAP2K2, NRAS, RIT1, SOS1	16.00
2	Noonan syndrome 1	Enrichment	BRAF, HRAS, KRAS, MAP2K1, MAP2K2, NRAS, RIT1, SOS1	10.96
3	Noonan syndrome and noonan-related syndrome	Enrichment	BRAF, HRAS, KRAS, MAP2K1, MAP2K2, NRAS, RIT1, SOS1	10.80
4	Lung non-small cell carcinoma	Enrichment	BRAF, HRAS, KRAS, MAP2K1, NRAS	10.33
5	Cardiofaciocutaneous syndrome 1	Enrichment	BRAF, KRAS, MAP2K1, MAP2K2	10.26
6	Cardiofaciocutaneous syndrome	Enrichment	BRAF, KRAS, MAP2K1, MAP2K2	10.26
7	Schimmelpenning-feuerstein-mims syndrome	Enrichment	HRAS, KRAS, NRAS	8.55
8	Differentiated thyroid carcinoma	Enrichment	BRAF, HRAS, KRAS, NRAS, NTRK1	8.08
9	Langerhans cell histiocytosis	Enrichment	BRAF, MAP2K1, NRAS	7.84
10	Nevus, epidermal	Enrichment	HRAS, KRAS, NRAS	7.62
11	Noonan syndrome 3	Enrichment	HRAS, KRAS, SOS1	7.02
12	Thyroid cancer, nonmedullary, 2	Enrichment	BRAF, HRAS, NRAS	6.30
13	Follicular thyroid carcinoma	Enrichment	BRAF, HRAS, NRAS	6.30
14	Melanocytic nevus syndrome, congenital	Enrichment	BRAF, HRAS, NRAS	6.10
15	Ras-associated autoimmune leukoproliferative disorder	Enrichment	KRAS, NRAS	6.07
16	Neuropathy, hereditary sensory and autonomic, type v	Enrichment	NGF, NTRK1	5.64
17	Large congenital melanocytic nevus	Enrichment	HRAS, NRAS	5.59
18	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	CRKL, MAPK1	5.37
19	Chronic myelogenous leukemia, bcr-abl1 positive	Enrichment	KRAS, NRAS	5.29
20	Pulmonic stenosis	Enrichment	BRAF, SOS1	5.21
21	Leukemia, chronic myeloid	Enrichment	KRAS, NRAS	4.75
22	Juvenile myelomonocytic leukemia	Enrichment	KRAS, NRAS	4.25
23	Non-immune hydrops fetalis	Enrichment	HRAS, KRAS, RIT1	4.21
24	Capillary malformation-arteriovenous malformation 1	Enrichment	KRAS, MAP2K1	3.90
25	Gallbladder cancer	Enrichment	BRAF, KRAS	3.90
26	Pilomyxoid astrocytoma	Enrichment	BRAF, KRAS	3.90
27	Arteriovenous malformation	Enrichment	HRAS, MAP2K1	3.66
28	Myopathy, x-linked, with excessive autophagy	Enrichment	HRAS, MAP2K1	3.57
29	Bladder cancer	Enrichment	HRAS, KRAS	3.47
30	Noonan syndrome 7	Enrichment	BRAF	3.43
31	Leopard syndrome 3	Enrichment	BRAF	3.43
32	Lymphangioma	Enrichment	BRAF	3.43
33	Phace association	Enrichment	BRAF	3.43
34	Syringocystadenoma papilliferum	Enrichment	BRAF	3.43
35	Ganglioglioma	Enrichment	BRAF	3.43
36	Nongerminomatous germ cell tumor	Enrichment	BRAF	3.43
37	Phace syndrome	Enrichment	BRAF	3.43
38	Classic hairy cell leukemia	Enrichment	BRAF	3.43
39	Lip and oral cavity carcinoma	Enrichment	BRAF, HRAS	3.40
40	Ventriculomegaly and arthrogryposis	Enrichment	KIDINS220	3.29
41	Lung cancer susceptibility 3	Enrichment	BRAF, KRAS	3.26
42	Leukemia, acute myeloid	Enrichment	KRAS, NRAS	3.19
43	Insensitivity to pain, congenital, with anhidrosis	Enrichment	NTRK1	3.13
44	Noonan syndrome 8	Enrichment	RIT1	3.13
45	Pain sensitivity quantitative trait locus 1	Enrichment	NTRK1	3.13
46	Melorheostosis, isolated	Enrichment	MAP2K1	3.05
47	Cardiofaciocutaneous syndrome 3	Enrichment	MAP2K1	3.05
48	Noonan syndrome 13	Enrichment	MAPK1	3.05
49	Melorheostosis	Enrichment	MAP2K1	3.05
50	Cardiofaciocutaneous syndrome 4	Enrichment	MAP2K2	3.05
51	Oculoectodermal syndrome	Enrichment	KRAS	3.02
52	Melanosis, neurocutaneous	Enrichment	NRAS	3.02
53	Noonan syndrome 6	Enrichment	NRAS	3.02
54	Hiatt-neu-cooper neurodevelopmental syndrome	Enrichment	RALA	3.02
55	Cardiofaciocutaneous syndrome 2	Enrichment	KRAS	3.02
56	Macular dystrophy, patterned, 3	Enrichment	MAPKAPK3	3.02
57	Thrombocytopenia 6	Enrichment	SRC	3.02
58	Congenital pulmonary airway malformation	Enrichment	KRAS	3.02
59	Phakomatosis pigmentokeratotica	Enrichment	HRAS	3.02
60	Neurocutaneous melanocytosis	Enrichment	NRAS	3.02
61	Arteriovenous malformations of the brain	Enrichment	BRAF, KRAS	2.99
62	Spastic paraplegia, intellectual disability, nystagmus, and obesity	Enrichment	KIDINS220	2.99
63	Thyroid carcinoma, familial medullary	Enrichment	NTRK1	2.96
64	Ataxia-telangiectasia	Enrichment	BRAF	2.96
65	Tethered spinal cord syndrome	Enrichment	BRAF	2.96
66	Colorectal cancer	Enrichment	BRAF, NRAS, SRC	2.88
67	Thyroid cancer, nonmedullary, 1	Enrichment	BRAF	2.83
68	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	RIT1	2.83
69	Craniopharyngioma	Enrichment	BRAF	2.83
70	Noonan syndrome with multiple lentigines	Enrichment	BRAF	2.83
71	Newborn respiratory distress syndrome	Enrichment	BRAF	2.83
72	Noonan syndrome 4	Enrichment	SOS1	2.83
73	Tafro syndrome	Enrichment	MAP2K2	2.75
74	Hydrops fetalis, nonimmune	Enrichment	HRAS, RIT1	2.72
75	Costello syndrome	Enrichment	HRAS	2.72
76	Encephalocraniocutaneous lipomatosis	Enrichment	KRAS	2.72
77	Wooly hair nevus	Enrichment	HRAS	2.72
78	Wilms tumor 5	Enrichment	BRAF	2.66
79	Bacteremia 2	Enrichment	MAPKAPK3	2.54
80	Spermatocytoma	Enrichment	HRAS	2.54
81	Lung cancer	Enrichment	BRAF, KRAS	2.54
82	Lymphoma, non-hodgkin, familial	Enrichment	BRAF	2.53
83	Fibromatosis, gingival, 1	Enrichment	SOS1	2.53
84	Kabuki syndrome 1	Enrichment	KIDINS220	2.51
85	Cardiomyopathy, familial hypertrophic, 4	Enrichment	BRAF	2.48
86	Primary hyperaldosteronism	Enrichment	BRAF	2.48
87	Ventricular septal defect	Enrichment	BRAF	2.48
88	Neurofibromatosis-noonan syndrome	Enrichment	MAP2K2	2.45
89	Melanoma	Enrichment	BRAF	2.43
90	Diffuse gastric and lobular breast cancer syndrome	Enrichment	KRAS	2.42
91	Lung sarcomatoid carcinoma	Enrichment	KRAS	2.42
92	Tuberculosis	Enrichment	MAPKAPK3	2.42
93	Pilocytic astrocytoma	Enrichment	KRAS	2.42
94	Epidermolytic nevus	Enrichment	HRAS	2.42
95	Nuchal bleb, familial	Enrichment	SOS1	2.35
96	Heart disease	Enrichment	RIT1	2.29
97	Breast cancer	Enrichment	KRAS, SHC1	2.27
98	Wilms tumor 1	Enrichment	BRAF	2.26
99	Breast adenocarcinoma	Enrichment	KRAS	2.24
100	Lung squamous cell carcinoma	Enrichment	KRAS	2.24
101	Gingival fibromatosis	Enrichment	SOS1	2.23
102	Melanoma, cutaneous malignant 1	Enrichment	BRAF	2.20
103	Dandy-walker syndrome	Enrichment	BRAF	2.20
104	Myelofibrosis	Enrichment	SRC	2.17
105	Diffuse large b-cell lymphoma	Enrichment	BRAF	2.16
106	Myeloma, multiple	Enrichment	BRAF, KRAS	2.06
107	Ovarian cancer	Enrichment	KRAS, NTRK1	2.02
108	Specific learning disability	Enrichment	MAPK1	2.01
109	Peripheral nervous system disease	Enrichment	NGF	1.93
110	Neuropathy	Enrichment	NGF	1.93
111	Protein-deficiency anemia	Enrichment	NRAS	1.91
112	Osteoporosis	Enrichment	SRC	1.87
113	Lynch syndrome	Enrichment	KRAS	1.85
114	Rhabdomyosarcoma	Enrichment	HRAS	1.82
115	Heart, malformation of	Enrichment	MAPK1	1.80
116	Aortic valve disease 1	Enrichment	SOS1	1.72
117	Hypertelorism	Enrichment	RIT1	1.72
118	Cerebral palsy	Enrichment	KIDINS220	1.70
119	46,xy partial gonadal dysgenesis	Enrichment	SOS1	1.69
120	Primary ovarian insufficiency	Enrichment	NTRK1	1.67
121	Malaria	Enrichment	MAPKAPK3	1.66
122	Pancreatic cancer	Enrichment	KRAS	1.63
123	Dilated cardiomyopathy	Enrichment	BRAF	1.54
124	Gastric cancer	Enrichment	KRAS	1.39
125	Hereditary breast carcinoma	Enrichment	KRAS	1.38
126	Thrombocytopenia	Enrichment	SRC	1.35
127	Hereditary breast ovarian cancer syndrome	Enrichment	KRAS	1.29
128	Autism spectrum disorder	Enrichment	MAP2K1	1.03
129	Microcephaly	Enrichment	MAPK1	0.98
130	Complex neurodevelopmental disorder	Enrichment	RALA	0.95

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Signalling to ERKs

Pathway Network for Signalling to ERKs

Pathway network for the Signalling to ERKs SuperPath

Member Pathways for Signalling to ERKs

Pathways in the Signalling to ERKs SuperPath

Gene overlap in member pathways for Signalling to ERKs SuperPath

Associated Genes for Signalling to ERKs

Associated Disorders for Signalling to ERKs

Disorders associated with Signalling to ERKs SuperPath

STRING Interaction Network for Signalling to ERKs

Sources for Signalling to ERKs