Sildenafil treatment

No Pathway Network information available for Sildenafil treatment

Pathways in the Sildenafil treatment SuperPath

#	Name	Source	Genes
1	Sildenafil treatment	WikiPathways	AKT1 AKT2 AKT3 GAPDH GSK3B GUCY1A1 GUCY1A2 GUCY1B1 GUCY1B2 NOS1 NOS2 NOS3 NRF1 PDE4A PDE4B PDE5A PPARGC1A PRKG1 PRKN TFAM ZNF746 (see all 21) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	PDE5A	Phosphodiesterase 5A	Protein Coding	1
2	TFAM	Transcription Factor A, Mitochondrial	Protein Coding	1
3	PRKG1	Protein Kinase CGMP-Dependent 1	Protein Coding	1
4	PDE4B	Phosphodiesterase 4B	Protein Coding	1
5	PDE4A	Phosphodiesterase 4A	Protein Coding	1
6	PRKN	Parkin RBR E3 Ubiquitin Protein Ligase	Protein Coding	1
7	NRF1	Nuclear Respiratory Factor 1	Protein Coding	1
8	NOS3	Nitric Oxide Synthase 3	Protein Coding	1
9	NOS2	Nitric Oxide Synthase 2	Protein Coding	1
10	NOS1	Nitric Oxide Synthase 1	Protein Coding	1
11	GUCY1A1	Guanylate Cyclase 1 Soluble Subunit Alpha 1	Protein Coding	1
12	GUCY1A2	Guanylate Cyclase 1 Soluble Subunit Alpha 2	Protein Coding	1
13	GSK3B	Glycogen Synthase Kinase 3 Beta	Protein Coding	1
14	GAPDH	Glyceraldehyde-3-Phosphate Dehydrogenase	Protein Coding	1
15	AKT2	AKT Serine/Threonine Kinase 2	Protein Coding	1
16	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	1
17	PPARGC1A	PPARG Coactivator 1 Alpha	Protein Coding	1
18	AKT3	AKT Serine/Threonine Kinase 3	Protein Coding	1
19	ZNF746	Zinc Finger Protein 746	Protein Coding	1
20	GUCY1B1	Guanylate Cyclase 1 Soluble Subunit Beta 1	Protein Coding	1
21	GUCY1B2	Guanylate Cyclase 1 Soluble Subunit Beta 2 (Pseudogene)	Pseudogene	1

Disorders associated with Sildenafil treatment SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Proteus syndrome	Enrichment	AKT1	2.81
2	Pyloric stenosis, infantile hypertrophic, 1	Enrichment	NOS1	2.81
3	Hypoinsulinemic hypoglycemia with hemihypertrophy	Enrichment	AKT2	2.81
4	Leprosy 2	Enrichment	PRKN	2.81
5	Aortic aneurysm, familial thoracic 8	Enrichment	PRKG1	2.81
6	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 2	Enrichment	AKT3	2.81
7	Moyamoya disease 6 with or without achalasia	Enrichment	GUCY1A1	2.81
8	Cowden syndrome 6	Enrichment	AKT1	2.81
9	Moyamoya disease with early-onset achalasia	Enrichment	GUCY1A1	2.81
10	Capillary hemangioma	Enrichment	AKT3	2.81
11	Akt2-related familial partial lipodystrophy	Enrichment	AKT2	2.81
12	Parkinson disease 12	Enrichment	PRKN	2.51
13	Microcephaly 21, primary, autosomal recessive	Enrichment	GAPDH	2.51
14	Senior-loken syndrome 7	Enrichment	AKT3	2.51
15	Bardet-biedl syndrome 16	Enrichment	AKT3	2.51
16	Mitochondrial dna depletion syndrome 15	Enrichment	TFAM	2.51
17	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	AKT3	2.21
18	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	AKT3	2.21
19	Idiopathic achalasia	Enrichment	NOS1	2.21
20	Complex hereditary spastic paraplegia	Enrichment	PRKN	2.21
21	Alzheimer disease 2	Enrichment	NOS3	2.11
22	Parkinson disease 2, autosomal recessive juvenile	Enrichment	PRKN	2.11
23	Pre-eclampsia	Enrichment	NOS3	2.11
24	Parkin type of early-onset parkinson disease	Enrichment	PRKN	2.11
25	Hemimegalencephaly	Enrichment	AKT3	2.11
26	Moyamoya disease 1	Enrichment	GUCY1A1	2.03
27	Breast adenocarcinoma	Enrichment	AKT1	2.03
28	Ovarian cancer	Enrichment	AKT1, PRKN	1.98
29	Megacolon	Enrichment	AKT3	1.97
30	Cowden syndrome	Enrichment	AKT1	1.86
31	Stroke, ischemic	Enrichment	NOS3	1.81
32	Polymicrogyria	Enrichment	AKT3	1.81
33	Early-onset parkinson's disease	Enrichment	PRKN	1.73
34	Meningioma	Enrichment	AKT1	1.73
35	Lung cancer susceptibility 3	Enrichment	PRKN	1.67
36	Alzheimer disease, familial, 1	Enrichment	NOS3	1.58
37	Hypertension, essential	Enrichment	NOS3	1.58
38	Parkinson's disease	Enrichment	PRKN	1.54
39	Myocardial infarction	Enrichment	GUCY1A1	1.47
40	Malaria	Enrichment	NOS2	1.46
41	Parkinson disease, late-onset	Enrichment	PRKN	1.44
42	Lung cancer	Enrichment	PRKN	1.31
43	Type 2 diabetes mellitus	Enrichment	AKT2	1.20
44	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	PRKG1	1.18
45	Hereditary breast carcinoma	Enrichment	AKT1	1.18
46	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	PPARGC1A	1.06
47	Schizophrenia	Enrichment	PRKN	1.06
48	Primary ovarian insufficiency	Enrichment	NOS3	1.06
49	Autism	Enrichment	PRKN	0.98
50	Breast cancer	Enrichment	AKT1	0.96
51	Colorectal cancer	Enrichment	AKT1	0.90
52	Autism spectrum disorder	Enrichment	PRKN	0.81

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Sildenafil treatment

Pathway Network for Sildenafil treatment

Member Pathways for Sildenafil treatment

Pathways in the Sildenafil treatment SuperPath

Associated Genes for Sildenafil treatment

Associated Disorders for Sildenafil treatment

Disorders associated with Sildenafil treatment SuperPath

STRING Interaction Network for Sildenafil treatment

Sources for Sildenafil treatment