Sirolimus Pathway, Pharmacokinetics/Pharmacodynamics

No Pathway Network information available for Sirolimus Pathway, Pharmacokinetics/Pharmacodynamics

#	Name	Source	Genes
1	Sirolimus Pathway, Pharmacokinetics/Pharmacodynamics	PharmGKB	ABCB1 AKT1S1 CYP2C8 CYP3A4 CYP3A5 DEPTOR FKBP1A HDAC1 MLST8 MTOR PPARGC1A RPS6KB1 RPTOR TCF7L2 YY1 (see all 15) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	RPS6KB1	Ribosomal Protein S6 Kinase B1	Protein Coding	1
2	YY1	YY1 Transcription Factor	Protein Coding	1
3	FKBP1A	FKBP Prolyl Isomerase 1A	Protein Coding	1
4	TCF7L2	Transcription Factor 7 Like 2	Protein Coding	1
5	MTOR	Mechanistic Target Of Rapamycin Kinase	Protein Coding	1
6	HDAC1	Histone Deacetylase 1	Protein Coding	1
7	ABCB1	ATP Binding Cassette Subfamily B Member 1	Protein Coding	1
8	CYP2C8	Cytochrome P450 Family 2 Subfamily C Member 8	Protein Coding	1
9	CYP3A4	Cytochrome P450 Family 3 Subfamily A Member 4	Protein Coding	1
10	CYP3A5	Cytochrome P450 Family 3 Subfamily A Member 5	Protein Coding	1
11	PPARGC1A	PPARG Coactivator 1 Alpha	Protein Coding	1
12	AKT1S1	AKT1 Substrate 1	Protein Coding	1
13	DEPTOR	DEP Domain Containing MTOR Interacting Protein	Protein Coding	1
14	MLST8	MTOR Associated Protein MLST8	Protein Coding	1
15	RPTOR	Regulatory Associated Protein Of MTOR Complex 1	Protein Coding	1

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Colchicine resistance	Enrichment	ABCB1	2.96
2	Drug metabolism, altered, cyp2c8-related	Enrichment	CYP2C8	2.96
3	Encephalopathy, acute transient	Enrichment	ABCB1	2.96
4	Inflammatory bowel disease 13	Enrichment	ABCB1	2.96
5	Vitamin d-dependent rickets, type 3	Enrichment	CYP3A4	2.96
6	Gabriele-de vries syndrome	Enrichment	YY1	2.66
7	Cebalid syndrome	Enrichment	MTOR	2.66
8	Developmental and epileptic encephalopathy 78	Enrichment	YY1	2.66
9	Insulinoma	Enrichment	YY1	2.66
10	Smith-kingsmore syndrome	Enrichment	MTOR	2.66
11	Focal cortical dysplasia, type ii	Enrichment	MTOR	2.35
12	Isolated focal cortical dysplasia type ii	Enrichment	MTOR	2.35
13	Hemimegalencephaly	Enrichment	MTOR	2.26
14	Renal cell carcinoma, papillary, 1	Enrichment	MTOR	2.11
15	Overgrowth syndrome	Enrichment	MTOR	2.11
16	Epilepsy, idiopathic generalized	Enrichment	ABCB1	1.92
17	Renal cell carcinoma, nonpapillary	Enrichment	MTOR	1.78
18	Rare genetic intellectual disability	Enrichment	MTOR	1.78
19	Hypertension, essential	Enrichment	CYP3A5	1.73
20	Type 2 diabetes mellitus	Enrichment	TCF7L2	1.34
21	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	PPARGC1A	1.21
22	Autism	Enrichment	TCF7L2	1.11
23	Complex neurodevelopmental disorder	Enrichment	TCF7L2	0.89

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Pathway Network for Sirolimus Pathway, Pharmacokinetics/Pharmacodynamics