SMAD Signaling Network

No Pathway Network information available for SMAD Signaling Network

Pathways in the SMAD Signaling Network SuperPath

#	Name	Source	Genes
1	SMAD Signaling Network	QIAGEN	ACTA1 ACTA2 ACTB ACTG1 ACTG2 ATF1 ATF2 ATF3 ATF4 ATF5 ATF6 ATF7 AXIN1 BMP1 BMP10 BMP15 BMP2 BMP3 BMP4 BMP5 BMP6 BMP7 BMP8A BMP8B CREBBP CTBP1 CTBP2 DAB2 EP300 FLNA FLNB FLNC FOS FOSB FOSL1 FOSL2 FOXH1 HACE1 HDAC1 HDAC10 HDAC11 HDAC2 HDAC3 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HECW1 HECW2 ITCH JUN JUNB JUND KPNB1 LEFTY2 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB10 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 RAB5A RAB5B RAB5C RAN RNF8 SIN3A SIN3B SKI SKIL SMAD2 SMAD3 SMAD4 SMURF1 SMURF2 SNX6 STUB1 TGFB1 TGFB2 TGFB3 TGFBR1 TGFBR2 TGFBRAP1 TGIF1 TRAF7 UBE3A UBE3B UBE3C UBR1 UBR2 UBR5 WWP1 WWP2 XPO1 ZFYVE9 (see all 120) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	ACTA1	Actin Alpha 1, Skeletal Muscle	Protein Coding	1
2	ACTA2	Actin Alpha 2, Smooth Muscle	Protein Coding	1
3	ACTB	Actin Beta	Protein Coding	1
4	ACTG1	Actin Gamma 1	Protein Coding	1
5	ACTG2	Actin Gamma 2, Smooth Muscle	Protein Coding	1
6	ATF1	Activating Transcription Factor 1	Protein Coding	1
7	ATF2	Activating Transcription Factor 2	Protein Coding	1
8	ATF3	Activating Transcription Factor 3	Protein Coding	1
9	ATF4	Activating Transcription Factor 4	Protein Coding	1
10	ATF5	Activating Transcription Factor 5	Protein Coding	1
11	ATF6	Activating Transcription Factor 6	Protein Coding	1
12	ATF7	Activating Transcription Factor 7	Protein Coding	1
13	AXIN1	Axin 1	Protein Coding	1
14	BMP1	Bone Morphogenetic Protein 1	Protein Coding	1
15	BMP10	Bone Morphogenetic Protein 10	Protein Coding	1
16	BMP15	Bone Morphogenetic Protein 15	Protein Coding	1
17	BMP2	Bone Morphogenetic Protein 2	Protein Coding	1
18	BMP3	Bone Morphogenetic Protein 3	Protein Coding	1
19	BMP4	Bone Morphogenetic Protein 4	Protein Coding	1
20	BMP5	Bone Morphogenetic Protein 5	Protein Coding	1
21	BMP6	Bone Morphogenetic Protein 6	Protein Coding	1
22	BMP7	Bone Morphogenetic Protein 7	Protein Coding	1
23	BMP8B	Bone Morphogenetic Protein 8b	Protein Coding	1
24	BMP8A	Bone Morphogenetic Protein 8a	Protein Coding	1
25	UBR2	Ubiquitin Protein Ligase E3 Component N-Recognin 2	Protein Coding	1
26	CREBBP	CREB Binding Lysine Acetyltransferase	Protein Coding	1
27	CTBP1	C-Terminal Binding Protein 1	Protein Coding	1
28	CTBP2	C-Terminal Binding Protein 2	Protein Coding	1
29	DAB2	DAB Adaptor Protein 2	Protein Coding	1
30	LEFTY2	Left-Right Determination Factor 2	Protein Coding	1
31	UBR5	Ubiquitin Protein Ligase E3 Component N-Recognin 5	Protein Coding	1
32	EP300	EP300 Lysine Acetyltransferase	Protein Coding	1
33	FLNA	Filamin A	Protein Coding	1
34	FLNB	Filamin B	Protein Coding	1
35	FLNC	Filamin C	Protein Coding	1
36	FOS	Fos Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
37	FOSB	FosB Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
38	FOSL1	FOS Like 1, AP-1 Transcription Factor Subunit	Protein Coding	1
39	FOSL2	FOS Like 2, AP-1 Transcription Factor Subunit	Protein Coding	1
40	FOXH1	Forkhead Box H1	Protein Coding	1
41	HACE1	HECT Domain And Ankyrin Repeat Containing E3 Ubiquitin Protein Ligase 1	Protein Coding	1
42	HDAC1	Histone Deacetylase 1	Protein Coding	1
43	HDAC10	Histone Deacetylase 10	Protein Coding	1
44	HDAC11	Histone Deacetylase 11	Protein Coding	1
45	HDAC2	Histone Deacetylase 2	Protein Coding	1
46	HDAC3	Histone Deacetylase 3	Protein Coding	1
47	HDAC5	Histone Deacetylase 5	Protein Coding	1
48	HDAC6	Histone Deacetylase 6	Protein Coding	1
49	HDAC7	Histone Deacetylase 7	Protein Coding	1
50	HDAC8	Histone Deacetylase 8	Protein Coding	1
51	HDAC9	Histone Deacetylase 9	Protein Coding	1
52	HECW2	HECT, C2 And WW Domain Containing E3 Ubiquitin Protein Ligase 2	Protein Coding	1
53	ITCH	Itchy E3 Ubiquitin Protein Ligase	Protein Coding	1
54	JUN	Jun Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
55	JUNB	JunB Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
56	JUND	JunD Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
57	KPNB1	Karyopherin Subunit Beta 1	Protein Coding	1
58	SMAD2	SMAD Family Member 2	Protein Coding	1
59	SMAD3	SMAD Family Member 3	Protein Coding	1
60	SMAD4	SMAD Family Member 4	Protein Coding	1
61	ZFYVE9	Zinc Finger FYVE-Type Containing 9	Protein Coding	1
62	HECW1	HECT, C2 And WW Domain Containing E3 Ubiquitin Protein Ligase 1	Protein Coding	1
63	PSMD6	Proteasome 26S Subunit, Non-ATPase 6	Protein Coding	1
64	PSMA1	Proteasome 20S Subunit Alpha 1	Protein Coding	1
65	PSMA2	Proteasome 20S Subunit Alpha 2	Protein Coding	1
66	PSMA3	Proteasome 20S Subunit Alpha 3	Protein Coding	1
67	PSMA4	Proteasome 20S Subunit Alpha 4	Protein Coding	1
68	PSMA5	Proteasome 20S Subunit Alpha 5	Protein Coding	1
69	PSMA6	Proteasome 20S Subunit Alpha 6	Protein Coding	1
70	PSMA7	Proteasome 20S Subunit Alpha 7	Protein Coding	1
71	PSMB1	Proteasome 20S Subunit Beta 1	Protein Coding	1
72	PSMB10	Proteasome 20S Subunit Beta 10	Protein Coding	1
73	PSMB2	Proteasome 20S Subunit Beta 2	Protein Coding	1
74	PSMB3	Proteasome 20S Subunit Beta 3	Protein Coding	1
75	PSMB4	Proteasome 20S Subunit Beta 4	Protein Coding	1
76	PSMB5	Proteasome 20S Subunit Beta 5	Protein Coding	1
77	PSMB6	Proteasome 20S Subunit Beta 6	Protein Coding	1
78	PSMB7	Proteasome 20S Subunit Beta 7	Protein Coding	1
79	PSMB8	Proteasome 20S Subunit Beta 8	Protein Coding	1
80	PSMB9	Proteasome 20S Subunit Beta 9	Protein Coding	1
81	PSMC1	Proteasome 26S Subunit, ATPase 1	Protein Coding	1
82	PSMC2	Proteasome 26S Subunit, ATPase 2	Protein Coding	1
83	PSMC3	Proteasome 26S Subunit, ATPase 3	Protein Coding	1
84	PSMC4	Proteasome 26S Subunit, ATPase 4	Protein Coding	1
85	PSMC5	Proteasome 26S Subunit, ATPase 5	Protein Coding	1
86	PSMC6	Proteasome 26S Subunit, ATPase 6	Protein Coding	1
87	PSMD1	Proteasome 26S Subunit, Non-ATPase 1	Protein Coding	1
88	PSMD2	Proteasome 26S Subunit Ubiquitin Receptor, Non-ATPase 2	Protein Coding	1
89	PSMD3	Proteasome 26S Subunit, Non-ATPase 3	Protein Coding	1
90	PSMD4	Proteasome 26S Subunit Ubiquitin Receptor, Non-ATPase 4	Protein Coding	1
91	PSMD5	Proteasome 26S Subunit, Non-ATPase 5	Protein Coding	1
92	PSMD7	Proteasome 26S Subunit, Non-ATPase 7	Protein Coding	1
93	RAB5A	RAB5A, Member RAS Oncogene Family	Protein Coding	1
94	RAB5B	RAB5B, Member RAS Oncogene Family	Protein Coding	1
95	RAB5C	RAB5C, Member RAS Oncogene Family	Protein Coding	1
96	RAN	RAN, Member RAS Oncogene Family	Protein Coding	1
97	TRAF7	TNF Receptor Associated Factor 7	Protein Coding	1
98	RNF8	Ring Finger Protein 8	Protein Coding	1
99	SIN3A	SIN3 Transcription Regulator Family Member A	Protein Coding	1
100	SIN3B	SIN3 Transcription Regulator Family Member B	Protein Coding	1
101	SKI	SKI Proto-Oncogene	Protein Coding	1
102	SKIL	SKI Like Proto-Oncogene	Protein Coding	1
103	SMURF1	SMAD Specific E3 Ubiquitin Protein Ligase 1	Protein Coding	1
104	SMURF2	SMAD Specific E3 Ubiquitin Protein Ligase 2	Protein Coding	1
105	SNX6	Sorting Nexin 6	Protein Coding	1
106	STUB1	STIP1 Homology And U-Box Containing Protein 1	Protein Coding	1
107	TGFB1	Transforming Growth Factor Beta 1	Protein Coding	1
108	TGFB2	Transforming Growth Factor Beta 2	Protein Coding	1
109	TGFB3	Transforming Growth Factor Beta 3	Protein Coding	1
110	TGFBR1	Transforming Growth Factor Beta Receptor 1	Protein Coding	1
111	TGFBR2	Transforming Growth Factor Beta Receptor 2	Protein Coding	1
112	TGFBRAP1	Transforming Growth Factor Beta Receptor Associated Protein 1	Protein Coding	1
113	TGIF1	TGFB Induced Factor Homeobox 1	Protein Coding	1
114	UBE3A	Ubiquitin Protein Ligase E3A	Protein Coding	1
115	UBE3B	Ubiquitin Protein Ligase E3B	Protein Coding	1
116	UBE3C	Ubiquitin Protein Ligase E3C	Protein Coding	1
117	UBR1	Ubiquitin Protein Ligase E3 Component N-Recognin 1	Protein Coding	1
118	WWP1	WW Domain Containing E3 Ubiquitin Protein Ligase 1	Protein Coding	1
119	WWP2	WW Domain Containing E3 Ubiquitin Protein Ligase 2	Protein Coding	1
120	XPO1	Exportin 1	Protein Coding	1

Disorders associated with SMAD Signaling Network SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	ACTA2, FLNA, SKI, SMAD2, SMAD3, SMAD4, TGFB2, TGFB3, TGFBR1, TGFBR2	10.38
2	Loeys-dietz syndrome	Enrichment	SMAD2, SMAD3, TGFB2, TGFB3, TGFBR1, TGFBR2	10.19
3	Loeys-dietz syndrome 1	Enrichment	SMAD2, TGFBR1, TGFBR2	6.17
4	Marfan syndrome	Enrichment	TGFB2, TGFBR1, TGFBR2	4.11
5	Loeys-dietz syndrome 2	Enrichment	TGFBR1, TGFBR2	4.11
6	Proteasome-associated autoinflammatory syndrome 3	Enrichment	PSMB4, PSMB9	4.11
7	Witteveen-kolk syndrome	Enrichment	SIN3A, SIN3B	4.11
8	Loeys-dietz syndrome 4	Enrichment	TGFB2, TGFB3	4.11
9	Baraitser-winter cerebrofrontofacial syndrome	Enrichment	ACTB, ACTG1	4.11
10	Connective tissue disease	Enrichment	ACTA2, FLNB, SMAD3, TGFBR2	3.76
11	Proteasome-associated autoinflammatory syndrome 1	Enrichment	PSMB4, PSMB8	3.64
12	Proteosome-associated autoinflammatory syndrome	Enrichment	PSMB4, PSMB8	3.64
13	Aortic aneurysm	Enrichment	SMAD3, TGFBR1	3.34
14	Pseudomyogenic hemangioendothelioma	Enrichment	ACTB, FOSB	3.34
15	Patent foramen ovale	Enrichment	FLNA, FLNC, PSMC3	3.30
16	Ehlers-danlos syndrome	Enrichment	SMAD3, TGFB2, TGFBR2	3.23
17	Ventricular septal defect 1	Enrichment	BMP2, BMP7	3.12
18	Histiocytoid hemangioma	Enrichment	FOS, FOSB	3.12
19	Atrial septal defect 1	Enrichment	BMP2, TGFB2	2.94
20	Rubinstein-taybi syndrome 1	Enrichment	CREBBP, EP300	2.94
21	Chromosome 16p13.3 deletion syndrome, proximal	Enrichment	CREBBP, EP300	2.94
22	Patent ductus arteriosus	Enrichment	FLNA, PSMC3	2.94
23	Hemochromatosis, type 1	Enrichment	BMP2, BMP6	2.68
24	Fanconi anemia, complementation group c	Enrichment	FLNA, HDAC8	2.68
25	Nemaline myopathy	Enrichment	ACTA1, FLNC	2.48
26	Microcephaly	Enrichment	ACTB, ACTG1, EP300, HDAC8, PSMC3	2.33
27	Rare genetic intellectual disability	Enrichment	CREBBP, EP300	2.12
28	Septopreoptic holoprosencephaly	Enrichment	FOXH1, TGIF1	2.12
29	Midline interhemispheric variant of holoprosencephaly	Enrichment	FOXH1, TGIF1	2.12
30	Microform holoprosencephaly	Enrichment	FOXH1, TGIF1	2.07
31	Lobar holoprosencephaly	Enrichment	FOXH1, TGIF1	2.07
32	Boomerang dysplasia	Enrichment	FLNB	2.05
33	Chondrodysplasia with platyspondyly, distinctive brachydactyly, hydrocephaly, and microphthalmia	Enrichment	HDAC6	2.05
34	Baraitser-winter syndrome 1	Enrichment	ACTB	2.05
35	Otopalatodigital syndrome, type i	Enrichment	FLNA	2.05
36	Intestinal pseudoobstruction, neuronal, chronic idiopathic, x-linked	Enrichment	FLNA	2.05
37	Congenital myopathy 2a, typical, autosomal dominant	Enrichment	ACTA1	2.05
38	Atelosteogenesis, type iii	Enrichment	FLNB	2.05
39	Atelosteogenesis, type i	Enrichment	FLNB	2.05
40	Multiple self-healing squamous epithelioma	Enrichment	TGFBR1	2.05
41	Holoprosencephaly 4	Enrichment	TGIF1	2.05
42	Johanson-blizzard syndrome	Enrichment	UBR1	2.05
43	Spastic paraplegia and psychomotor retardation with or without seizures	Enrichment	HACE1	2.05
44	Myopathy, scapulohumeroperoneal	Enrichment	ACTA1	2.05
45	Caudal duplication anomaly	Enrichment	AXIN1	2.05
46	Shprintzen-goldberg craniosynostosis syndrome	Enrichment	SKI	2.05
47	Kaufman oculocerebrofacial syndrome	Enrichment	UBE3B	2.05
48	Megacystis-microcolon-intestinal hypoperistalsis syndrome 5	Enrichment	ACTG2	2.05
49	Neurodevelopmental disorder with microcephaly, hypotonia, and absent language	Enrichment	PSMB1	2.05
50	Auriculocondylar syndrome 4	Enrichment	HDAC9	2.05
51	Terminal osseous dysplasia	Enrichment	FLNA	2.05
52	Cornelia de lange syndrome 5	Enrichment	HDAC8	2.05
53	Ovarian dysgenesis 2	Enrichment	BMP15	2.05
54	Congenital smooth muscle hamartoma, with or without hemihypertrophy	Enrichment	ACTB	2.05
55	Fg syndrome 2	Enrichment	FLNA	2.05
56	Microphthalmia, syndromic 6	Enrichment	BMP4	2.05
57	Orofacial cleft 11	Enrichment	BMP4	2.05
58	Deafness, cataract, impaired intellectual development, and polyneuropathy	Enrichment	PSMC3	2.05
59	Camurati-engelmann disease 2	Enrichment	TGFB2	2.05
60	Otopalatodigital syndrome spectrum disorder	Enrichment	FLNA	2.05
61	Becker nevus syndrome	Enrichment	ACTB	2.05
62	Autoimmune disease, multisystem, with facial dysmorphism	Enrichment	ITCH	2.05
63	Dystonia-deafness syndrome 1	Enrichment	ACTB	2.05
64	Visceral neuropathy, familial, 3, autosomal dominant	Enrichment	ACTG2	2.05
65	Colorectal cancer, hereditary nonpolyposis, type 6	Enrichment	TGFBR2	2.05
66	Iron overload	Enrichment	BMP6	2.05
67	Congenital myopathy 2b, severe infantile, autosomal recessive	Enrichment	ACTA1	2.05
68	Proteasome-associated autoinflammatory syndrome 6	Enrichment	PSMB9	2.05
69	Achromatopsia 7	Enrichment	ATF6	2.05
70	Loeys-dietz syndrome 6	Enrichment	SMAD2	2.05
71	Autosomal dominant familial visceral neuropathy	Enrichment	ACTG2	2.05
72	Loeys-dietz syndrome 5	Enrichment	TGFB3	2.05
73	Cardiac, facial, and digital anomalies with developmental delay	Enrichment	TRAF7	2.05
74	20p12.3 microdeletion syndrome	Enrichment	BMP2	2.05
75	X-linked ehlers-danlos syndrome	Enrichment	FLNA	2.05
76	Neurodevelopmental disorder with absent speech and movement and behavioral abnormalities	Enrichment	UBE3C	2.05
77	Congenital myopathy 2c, severe infantile, autosomal dominant	Enrichment	ACTA1	2.05
78	Short stature, facial dysmorphism, and skeletal anomalies with or without cardiac anomalies 1	Enrichment	BMP2	2.05
79	Thrombocytopenia 8, with dysmorphic features and developmental delay	Enrichment	ACTB	2.05
80	Menke-hennekam syndrome 1	Enrichment	CREBBP	2.05
81	Craniometadiaphyseal osteosclerosis with hip dysplasia	Enrichment	AXIN1	2.05
82	Congenital heart defects, multiple types, 8, with or without heterotaxy	Enrichment	SMAD2	2.05
83	Immature teratoma of ovary	Enrichment	BMP15	2.05
84	Spastic paraplegia-severe developmental delay-epilepsy syndrome	Enrichment	HACE1	2.05
85	Baraitser-winter syndrome	Enrichment	ACTB	2.05
86	Heritable thoracic aortic disease	Enrichment	SMAD4	2.05
87	Rubinstein-taybi syndrome due to 16p13.3 microdeletion	Enrichment	CREBBP	2.05
88	Syndromic multisystem autoimmune disease due to itch deficiency	Enrichment	ITCH	2.05
89	Neurodevelopmental disorder with speech delay and behavioral abnormalities	Enrichment	UBR5	2.05
90	Chromosome 15q24 deletion syndrome	Enrichment	SIN3A	2.05
91	Flnb-related disorders	Enrichment	FLNB	2.05
92	Traf7-associated heart defect-digital anomalies-facial dysmorphism-motor and speech delay syndrome	Enrichment	TRAF7	2.05
93	Zebra body myopathy	Enrichment	ACTA1	2.05
94	Congenital smooth muscle hamartoma	Enrichment	ACTB	2.05
95	Aplasia cutis-enamel dysplasia syndrome	Enrichment	FOSL2	2.05
96	Developmental malformations-deafness-dystonia syndrome	Enrichment	ACTB	2.05
97	Menke-hennekam syndrome	Enrichment	CREBBP	2.05
98	15q11q13 microduplication syndrome	Enrichment	UBE3A	2.05
99	X-linked keloid scarring-reduced joint mobility-increased optic cup-to-disc ratio syndrome	Enrichment	FLNA	2.05
100	Actin-accumulation myopathy	Enrichment	ACTA1	2.05
101	Myopathic intestinal pseudoobstruction	Enrichment	ACTG2	2.05
102	Actg2 visceral myopathy	Enrichment	ACTG2	2.05
103	Alobar holoprosencephaly	Enrichment	FOXH1, TGIF1	2.01
104	Semilobar holoprosencephaly	Enrichment	FOXH1, TGIF1	1.97
105	Myhre syndrome	Enrichment	SMAD4	1.75
106	Camurati-engelmann disease 1	Enrichment	TGFB1	1.75
107	Visceral neuropathy, familial, 1, autosomal recessive	Enrichment	FLNA	1.75
108	Thumb deformity	Enrichment	CREBBP	1.75
109	Otopalatodigital syndrome, type ii	Enrichment	FLNA	1.75
110	Melnick-needles syndrome	Enrichment	FLNA	1.75
111	Frontometaphyseal dysplasia 1	Enrichment	FLNA	1.75
112	Aortic aneurysm, familial thoracic 2	Enrichment	ACTA2	1.75
113	Juvenile polyposis/hereditary hemorrhagic telangiectasia syndrome	Enrichment	SMAD4	1.75
114	Microvascular complications of diabetes 5	Enrichment	TGFBR2	1.75
115	Deafness, autosomal dominant 20	Enrichment	ACTG1	1.75
116	Smooth muscle dysfunction syndrome	Enrichment	ACTA2	1.75
117	Aortic aneurysm, familial thoracic 6	Enrichment	ACTA2	1.75
118	Baraitser-winter syndrome 2	Enrichment	ACTG1	1.75
119	Osteogenesis imperfecta, type xiii	Enrichment	BMP1	1.75
120	Moyamoya disease 5	Enrichment	ACTA2	1.75
121	Syndactyly, type iii	Enrichment	HDAC8	1.75
122	Neurodevelopmental disorder with hypotonia, seizures, and absent language	Enrichment	HECW2	1.75
123	Loeys-dietz syndrome 3	Enrichment	SMAD3	1.75
124	Proteasome-associated autoinflammatory syndrome 5	Enrichment	PSMB10	1.75
125	Immunodeficiency 121 with autoinflammation	Enrichment	PSMB10	1.75
126	Birk-aharoni syndrome	Enrichment	PSMC1	1.75
127	Hypotonia, ataxia, developmental delay, and tooth enamel defect syndrome	Enrichment	CTBP1	1.75
128	Cardiac valvular dysplasia, x-linked	Enrichment	FLNA	1.75
129	Spondyloepiphyseal dysplasia, nishimura type	Enrichment	WWP2	1.75
130	Spinocerebellar ataxia 48	Enrichment	STUB1	1.75
131	Menke-hennekam syndrome 2	Enrichment	EP300	1.75
132	Inflammatory bowel disease, immunodeficiency, and encephalopathy	Enrichment	TGFB1	1.75
133	Wilson-turner syndrome	Enrichment	HDAC8	1.75
134	Acute myeloid leukemia with kat6a-crebbp fusion	Enrichment	CREBBP	1.75
135	Cardiovascular system disease	Enrichment	FLNC	1.75
136	Camurati-engelmann disease	Enrichment	TGFB1	1.75
137	Craniosynostosis 7	Enrichment	BMP2	1.75
138	Blepharophimosis - intellectual disability syndrome	Enrichment	UBE3B	1.75
139	Multifocal pattern dystrophy simulating fundus flavimaculatus	Enrichment	UBR2	1.75
140	Primary mediastinal large b-cell lymphoma	Enrichment	XPO1	1.75
141	Angelman syndrome due to maternal 15q11q13 deletion	Enrichment	UBE3A	1.75
142	Intestinal obstruction	Enrichment	ACTG2	1.75
143	Prune belly syndrome	Enrichment	FLNA	1.58
144	Larsen syndrome	Enrichment	FLNB	1.58
145	Juvenile polyposis syndrome	Enrichment	SMAD4	1.58
146	Arterial tortuosity syndrome	Enrichment	FLNA	1.58
147	Periventricular nodular heterotopia 1	Enrichment	FLNA	1.58
148	Myopathy, myofibrillar, 5	Enrichment	FLNC	1.58
149	Transposition of the great arteries, dextro-looped	Enrichment	BMP2	1.58
150	Spondylocarpotarsal synostosis syndrome	Enrichment	FLNB	1.58
151	Congenital short bowel syndrome	Enrichment	FLNA	1.58
152	Myopathy, distal, 4	Enrichment	FLNC	1.58
153	Tethered spinal cord syndrome	Enrichment	CREBBP	1.58
154	Frontometaphyseal dysplasia	Enrichment	FLNA	1.58
155	Intraocular pressure quantitative trait locus	Enrichment	CREBBP	1.58
156	High bone mass osteogenesis imperfecta	Enrichment	BMP1	1.58
157	Melanoma of soft tissue	Enrichment	ATF1	1.58
158	Thyroid hemiagenesis	Enrichment	PSMD3	1.58
159	Angelman syndrome due to imprinting defect in 15q11-q13	Enrichment	UBE3A	1.58
160	Brachydactyly, type a2	Enrichment	BMP2	1.46
161	Nemaline myopathy 2	Enrichment	ACTA1	1.46
162	Megacystis-microcolon-intestinal hypoperistalsis syndrome 1	Enrichment	ACTG2	1.46
163	Autoimmune lymphoproliferative syndrome	Enrichment	ACTA2	1.46
164	Microtia-anotia	Enrichment	BMP5	1.46
165	Aminoacylase 1 deficiency	Enrichment	ACTB	1.46
166	Cardiomyopathy, familial hypertrophic, 26	Enrichment	FLNC	1.46
167	Congenital generalized lipodystrophy	Enrichment	FOS	1.46
168	Intermediate nemaline myopathy	Enrichment	ACTA1	1.46
169	Hemifacial hyperplasia	Enrichment	FLNC	1.36
170	Arrhythmogenic right ventricular dysplasia, familial, 1	Enrichment	TGFB3	1.36
171	Visceral myopathy 1	Enrichment	ACTG2	1.36
172	Congenital myopathy 3 with rigid spine	Enrichment	ACTA1	1.36
173	Atrioventricular septal defect	Enrichment	BMP5	1.36
174	Goldberg-shprintzen syndrome	Enrichment	SKI	1.36
175	Rubinstein-taybi syndrome 2	Enrichment	EP300	1.36
176	Congenital heart defects, multiple types, 4	Enrichment	BMP7	1.36
177	Heart conduction disease	Enrichment	FLNC	1.36
178	Arrhythmogenic right ventricular dysplasia 1	Enrichment	TGFB3	1.36
179	Coloboma of choroid and retina	Enrichment	ACTG1	1.36
180	Severe congenital nemaline myopathy	Enrichment	ACTA1	1.36
181	Generalized juvenile polyposis/juvenile polyposis coli	Enrichment	SMAD4	1.36
182	Angelman syndrome	Enrichment	UBE3A	1.28
183	Developmental dysplasia of the hip 1	Enrichment	PSMC3	1.28
184	Wolf-hirschhorn syndrome	Enrichment	CTBP1	1.28
185	Moyamoya disease 1	Enrichment	ACTA2	1.28
186	Anterior segment dysgenesis 5	Enrichment	BMP4	1.28
187	Inflammatory bowel disease 25, autosomal recessive	Enrichment	TGFB1	1.28
188	Spinocerebellar ataxia, autosomal recessive 16	Enrichment	STUB1	1.28
189	Intestinal pseudo-obstruction	Enrichment	ACTG2	1.28
190	Il10-related early-onset inflammatory bowel disease	Enrichment	TGFB1	1.28
191	Hypertrichosis	Enrichment	CREBBP	1.28
192	Classic ehlers-danlos syndrome	Enrichment	TGFBR1	1.28
193	Inherited arrhythmogenic cardiomyopathy	Enrichment	FLNC	1.28
194	Typical nemaline myopathy	Enrichment	ACTA1	1.28
195	Esophageal cancer	Enrichment	TGFBR2	1.22
196	Gallbladder cancer	Enrichment	SMAD4	1.22
197	Hereditary hemorrhagic telangiectasia	Enrichment	SMAD4	1.22
198	Myofibrillar myopathy	Enrichment	FLNC	1.22
199	Childhood-onset nemaline myopathy	Enrichment	ACTA1	1.22
200	Familial isolated restrictive cardiomyopathy	Enrichment	FLNC	1.22
201	Neuroblastoma	Enrichment	HACE1	1.16
202	Cornelia de lange syndrome 1	Enrichment	HDAC8	1.11
203	Charge syndrome	Enrichment	EP300	1.11
204	Adult hepatocellular carcinoma	Enrichment	AXIN1	1.11
205	Cornelia de lange syndrome	Enrichment	HDAC8	1.11
206	Familial thoracic aortic aneurysm and dissection	Enrichment	SMAD3	1.11
207	Cat eye syndrome	Enrichment	ACTG1	1.07
208	Peters-plus syndrome	Enrichment	BMP4	1.07
209	Omenn syndrome	Enrichment	PSMB10	1.07
210	Stickler syndrome	Enrichment	BMP4	1.07
211	Polymicrogyria	Enrichment	PSMC3	1.07
212	Achromatopsia	Enrichment	ATF6	1.07
213	Pectus excavatum	Enrichment	TGFBR1	1.03
214	Atrial heart septal defect	Enrichment	HDAC8	1.03
215	Interatrial communication	Enrichment	HDAC8	1.03
216	Cardiac conduction defect	Enrichment	FLNC	0.99
217	Renal hypodysplasia/aplasia 3	Enrichment	BMP4	0.99
218	Meningioma	Enrichment	TRAF7	0.99
219	Restrictive cardiomyopathy	Enrichment	FLNC	0.99
220	46 xx gonadal dysgenesis	Enrichment	BMP15	0.99
221	Inherited isolated arrhythmogenic ventricular dysplasia, biventricular variant	Enrichment	TGFB3	0.99
222	Inherited isolated arrhythmogenic cardiomyopathy, dominant-left variant	Enrichment	TGFB3	0.99
223	Chromosome 1p36 deletion syndrome	Enrichment	SKI	0.96
224	Aortic aneurysm, familial thoracic 1	Enrichment	SMAD3	0.93
225	Lung cancer susceptibility 3	Enrichment	ACTA2	0.93
226	Periventricular nodular heterotopia	Enrichment	FLNA	0.93
227	Heart disease	Enrichment	CREBBP	0.93
228	Cleft lip/palate	Enrichment	BMP4	0.93
229	Inherited isolated arrhythmogenic cardiomyopathy, dominant-right variant	Enrichment	TGFB3	0.93
230	Polydactyly, postaxial, type a1	Enrichment	EP300	0.90
231	Congenital myopathy 4a, autosomal dominant	Enrichment	ACTA1	0.90
232	Corpus callosum, agenesis of	Enrichment	CREBBP	0.90
233	Osteogenesis imperfecta, type iii	Enrichment	BMP1	0.90
234	Lynch syndrome	Enrichment	TGFBR2	0.90
235	Isolated corpus callosum agenesis	Enrichment	CREBBP	0.90
236	Intellectual disability-hypoplastic corpus callosum-preauricular tag syndrome	Enrichment	CREBBP	0.90
237	Arrhythmogenic right ventricular cardiomyopathy	Enrichment	FLNC	0.88
238	Cleft palate, isolated	Enrichment	FLNA	0.85
239	Neuromuscular disease	Enrichment	ACTA1	0.83
240	Polycystic kidney disease	Enrichment	HDAC8	0.83
241	Diffuse large b-cell lymphoma	Enrichment	CREBBP	0.81
242	Congenital myopathy	Enrichment	ACTA1	0.81
243	Dilated cardiomyopathy	Enrichment	ACTA1, FLNC	0.80
244	Cardiomyopathy, dilated, 1a	Enrichment	FLNC	0.77
245	Lissencephaly	Enrichment	ACTG1	0.77
246	Centronuclear myopathy	Enrichment	ACTA1	0.77
247	Hepatocellular carcinoma	Enrichment	AXIN1	0.75
248	Myocardial infarction	Enrichment	PSMA6	0.75
249	Visceral heterotaxy	Enrichment	LEFTY2	0.75
250	Colorectal cancer	Enrichment	EP300, SMAD4	0.75
251	Brittle bone disorder	Enrichment	BMP1	0.73
252	Cardiomyopathy, familial hypertrophic, 1	Enrichment	FLNC	0.72
253	Autoinflammatory disease	Enrichment	PSMB8	0.72
254	Scoliosis	Enrichment	CREBBP	0.72
255	Pancreatic cancer	Enrichment	SMAD4	0.70
256	Tetralogy of fallot	Enrichment	FLNC	0.69
257	Hydrops fetalis, nonimmune	Enrichment	ACTA1	0.69
258	Non-immune hydrops fetalis	Enrichment	ACTA1	0.62
259	Congenital nervous system abnormality	Enrichment	CREBBP, HECW2	0.62
260	Nervous system disease	Enrichment	CREBBP, HECW2	0.62
261	Lung cancer	Enrichment	ACTA2	0.61
262	Cystic fibrosis	Enrichment	TGFB1	0.61
263	Familial hypertrophic cardiomyopathy	Enrichment	FLNC	0.59
264	Cakut	Enrichment	ACTG1	0.58
265	Non-syndromic genetic deafness	Enrichment	ACTG1	0.56
266	Fetal akinesia deformation sequence 1	Enrichment	ACTA1	0.55
267	Myopathy	Enrichment	ACTA1	0.52
268	Distal arthrogryposis	Enrichment	ACTA1	0.51
269	Nonsyndromic hearing loss	Enrichment	ACTG1	0.51
270	Gastric cancer	Enrichment	SMAD4	0.50
271	Thrombocytopenia	Enrichment	SMAD4	0.46
272	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	ACTG1	0.43
273	Spastic ataxia	Enrichment	FLNC	0.42
274	Myeloma, multiple	Enrichment	CREBBP	0.41
275	Primary ovarian insufficiency	Enrichment	BMP6	0.39
276	Cone-rod dystrophy 2	Enrichment	ATF6	0.34
277	Autism	Enrichment	CREBBP	0.32
278	Breast cancer	Enrichment	JUN	0.31
279	Rare genetic deafness	Enrichment	ACTG1	0.30
280	Inherited cancer-predisposing syndrome	Enrichment	SMAD4	0.16
281	Hereditary retinal dystrophy	Enrichment	ATF6, UBR2	0.14
282	Fundus dystrophy	Enrichment	ATF6, UBR2	0.14

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

SMAD Signaling Network

Pathway Network for SMAD Signaling Network

Member Pathways for SMAD Signaling Network

Pathways in the SMAD Signaling Network SuperPath

Associated Genes for SMAD Signaling Network

Associated Disorders for SMAD Signaling Network

Disorders associated with SMAD Signaling Network SuperPath

STRING Interaction Network for SMAD Signaling Network

Sources for SMAD Signaling Network