Small cell lung cancer

No Pathway Network information available for Small cell lung cancer

Pathways in the Small cell lung cancer SuperPath

#	Name	Source	Genes
1	Small cell lung cancer	WikiPathways	AKT1 AKT2 AKT3 APAF1 BAK1 BAX BCL2 BCL2L1 BID BIRC2 BIRC3 BIRC7 BIRC8 CASP3 CASP8 CASP9 CCND1 CCNE1 CCNE2 CDK2 CDK4 CDK6 CDKN1A CDKN1B CDKN1C CDKN2B CHUK CKS1B CKS2 COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL4A6 CYCS DDB2 E2F1 E2F2 E2F3 FHIT FN1 GADD45A GADD45B GADD45G IKBKB IKBKG ITGA2 ITGA2B ITGA3 ITGA6 ITGAV ITGB1 LAMA1 LAMA2 LAMA3 LAMA4 LAMA5 LAMB1 LAMB2 LAMB3 LAMB4 LAMC1 LAMC2 LAMC3 MAX MYC NFKB1 NFKBIA NFKBIB NOS2 PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PIK3R3 POLK PTEN PTGS2 PTK2 RARB RB1 RELA RXRA RXRB RXRG SKP1 TP53 TRAF1 TRAF2 TRAF3 TRAF4 TRAF5 TRAF6 ZBTB17 (see all 96) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	TRAF4	TNF Receptor Associated Factor 4	Protein Coding	1
2	CCNE2	Cyclin E2	Protein Coding	1
3	CCNE1	Cyclin E1	Protein Coding	1
4	IKBKG	Inhibitor Of Nuclear Factor Kappa B Kinase Regulatory Subunit Gamma	Protein Coding	1
5	CASP9	Caspase 9	Protein Coding	1
6	CASP8	Caspase 8	Protein Coding	1
7	CASP3	Caspase 3	Protein Coding	1
8	BIRC7	Baculoviral IAP Repeat Containing 7	Protein Coding	1
9	TRAF6	TNF Receptor Associated Factor 6	Protein Coding	1
10	TRAF3	TNF Receptor Associated Factor 3	Protein Coding	1
11	TRAF1	TNF Receptor Associated Factor 1	Protein Coding	1
12	TP53	Tumor Protein P53	Protein Coding	1
13	BID	BH3 Interacting Domain Death Agonist	Protein Coding	1
14	RXRG	Retinoid X Receptor Gamma	Protein Coding	1
15	RXRB	Retinoid X Receptor Beta	Protein Coding	1
16	RXRA	Retinoid X Receptor Alpha	Protein Coding	1
17	BCL2L1	BCL2 Like 1	Protein Coding	1
18	RELA	RELA Proto-Oncogene, NF-KB Subunit	Protein Coding	1
19	BCL2	BCL2 Apoptosis Regulator	Protein Coding	1
20	CCND1	Cyclin D1	Protein Coding	1
21	RB1	RB Transcriptional Corepressor 1	Protein Coding	1
22	RARB	Retinoic Acid Receptor Beta	Protein Coding	1
23	BAX	BCL2 Associated X, Apoptosis Regulator	Protein Coding	1
24	BAK1	BCL2 Antagonist/Killer 1	Protein Coding	1
25	PTK2	Protein Tyrosine Kinase 2	Protein Coding	1
26	PTGS2	Prostaglandin-Endoperoxide Synthase 2	Protein Coding	1
27	PTEN	Phosphatase And Tensin Homolog	Protein Coding	1
28	CYCS	Cytochrome C, Somatic	Protein Coding	1
29	PIK3R2	Phosphoinositide-3-Kinase Regulatory Subunit 2	Protein Coding	1
30	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	1
31	PIK3CD	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Delta	Protein Coding	1
32	PIK3CB	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Beta	Protein Coding	1
33	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	1
34	POLK	DNA Polymerase Kappa	Protein Coding	1
35	NOS2	Nitric Oxide Synthase 2	Protein Coding	1
36	NFKBIA	NFKB Inhibitor Alpha	Protein Coding	1
37	NFKB1	Nuclear Factor Kappa B Subunit 1	Protein Coding	1
38	GADD45B	Growth Arrest And DNA Damage Inducible Beta	Protein Coding	1
39	MYC	MYC Proto-Oncogene, BHLH Transcription Factor	Protein Coding	1
40	MAX	MYC Associated Transcriptional Regulator X	Protein Coding	1
41	LAMC2	Laminin Subunit Gamma 2	Protein Coding	1
42	LAMC1	Laminin Subunit Gamma 1	Protein Coding	1
43	LAMB3	Laminin Subunit Beta 3	Protein Coding	1
44	LAMB2	Laminin Subunit Beta 2	Protein Coding	1
45	LAMB1	Laminin Subunit Beta 1	Protein Coding	1
46	LAMA4	Laminin Subunit Alpha 4	Protein Coding	1
47	LAMA3	Laminin Subunit Alpha 3	Protein Coding	1
48	LAMA2	Laminin Subunit Alpha 2	Protein Coding	1
49	ITGB1	Integrin Subunit Beta 1	Protein Coding	1
50	ITGAV	Integrin Subunit Alpha V	Protein Coding	1
51	ITGA3	Integrin Subunit Alpha 3	Protein Coding	1
52	ITGA2B	Integrin Subunit Alpha 2b	Protein Coding	1
53	ITGA2	Integrin Subunit Alpha 2	Protein Coding	1
54	ITGA6	Integrin Subunit Alpha 6	Protein Coding	1
55	IKBKB	Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Beta	Protein Coding	1
56	BIRC3	Baculoviral IAP Repeat Containing 3	Protein Coding	1
57	BIRC2	Baculoviral IAP Repeat Containing 2	Protein Coding	1
58	APAF1	Apoptotic Peptidase Activating Factor 1	Protein Coding	1
59	LAMA1	Laminin Subunit Alpha 1	Protein Coding	1
60	FN1	Fibronectin 1	Protein Coding	1
61	FHIT	Fragile Histidine Triad Diadenosine Triphosphatase	Protein Coding	1
62	AKT2	AKT Serine/Threonine Kinase 2	Protein Coding	1
63	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	1
64	E2F3	E2F Transcription Factor 3	Protein Coding	1
65	E2F2	E2F Transcription Factor 2	Protein Coding	1
66	E2F1	E2F Transcription Factor 1	Protein Coding	1
67	GADD45A	Growth Arrest And DNA Damage Inducible Alpha	Protein Coding	1
68	DDB2	Damage Specific DNA Binding Protein 2	Protein Coding	1
69	COL4A6	Collagen Type IV Alpha 6 Chain	Protein Coding	1
70	COL4A5	Collagen Type IV Alpha 5 Chain	Protein Coding	1
71	COL4A4	Collagen Type IV Alpha 4 Chain	Protein Coding	1
72	COL4A3	Collagen Type IV Alpha 3 Chain	Protein Coding	1
73	COL4A2	Collagen Type IV Alpha 2 Chain	Protein Coding	1
74	COL4A1	Collagen Type IV Alpha 1 Chain	Protein Coding	1
75	CKS2	CDC28 Protein Kinase Regulatory Subunit 2	Protein Coding	1
76	CHUK	Component Of Inhibitor Of Nuclear Factor Kappa B Kinase Complex	Protein Coding	1
77	LAMC3	Laminin Subunit Gamma 3	Protein Coding	1
78	CDKN2B	Cyclin Dependent Kinase Inhibitor 2B	Protein Coding	1
79	CDKN1C	Cyclin Dependent Kinase Inhibitor 1C	Protein Coding	1
80	CDKN1B	Cyclin Dependent Kinase Inhibitor 1B	Protein Coding	1
81	CDKN1A	Cyclin Dependent Kinase Inhibitor 1A	Protein Coding	1
82	CDK6	Cyclin Dependent Kinase 6	Protein Coding	1
83	CDK4	Cyclin Dependent Kinase 4	Protein Coding	1
84	CDK2	Cyclin Dependent Kinase 2	Protein Coding	1
85	AKT3	AKT Serine/Threonine Kinase 3	Protein Coding	1
86	PIK3R3	Phosphoinositide-3-Kinase Regulatory Subunit 3	Protein Coding	1
87	CKS1B	CDC28 Protein Kinase Regulatory Subunit 1B	Protein Coding	1
88	BIRC8	Baculoviral IAP Repeat Containing 8	Pseudogene	1
89	GADD45G	Growth Arrest And DNA Damage Inducible Gamma	Protein Coding	1
90	ZBTB17	Zinc Finger And BTB Domain Containing 17	Protein Coding	1
91	TRAF5	TNF Receptor Associated Factor 5	Protein Coding	1
92	TRAF2	TNF Receptor Associated Factor 2	Protein Coding	1
93	SKP1	S-Phase Kinase Associated Protein 1	Protein Coding	1
94	NFKBIB	NFKB Inhibitor Beta	Protein Coding	1
95	LAMA5	Laminin Subunit Alpha 5	Protein Coding	1
96	LAMB4	Laminin Subunit Beta 4	Protein Coding	1

Disorders associated with Small cell lung cancer SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Nephrotic syndrome	Enrichment	COL4A3, COL4A4, COL4A5, FN1, ITGA3, LAMA5, LAMB2	7.73
2	Junctional epidermolysis bullosa	Enrichment	ITGA6, LAMA3, LAMB3, LAMC2	6.54
3	Digenic alport syndrome	Enrichment	COL4A3, COL4A4, COL4A5	6.46
4	Breast cancer	Enrichment	AKT1, CASP8, CDKN2B, CKS1B, PIK3CA, PTEN, TP53	6.02
5	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	AKT3, PIK3CA, PIK3R2	5.86
6	Bladder cancer	Enrichment	CDKN1A, PIK3CA, PTEN, RB1, TP53	5.78
7	Kidney disease	Enrichment	COL4A3, COL4A4, COL4A5, LAMB2	5.52
8	Alport syndrome 3a, autosomal dominant	Enrichment	COL4A3, COL4A4, COL4A5	5.47
9	Autosomal dominant alport syndrome	Enrichment	COL4A3, COL4A4, COL4A5	5.47
10	Hemimegalencephaly	Enrichment	AKT3, PIK3CA, PTEN	5.47
11	Alport syndrome	Enrichment	COL4A3, COL4A4, COL4A5	5.47
12	Epidermolysis bullosa, junctional 1a, intermediate	Enrichment	LAMA3, LAMB3, LAMC2	5.17
13	Epidermolysis bullosa, junctional 1b, severe	Enrichment	LAMA3, LAMB3, LAMC2	5.17
14	Junctional epidermolysis bullosa non-herlitz type	Enrichment	LAMA3, LAMB3, LAMC2	5.17
15	Breast adenocarcinoma	Enrichment	AKT1, PIK3CA, TP53	5.17
16	Multiple endocrine neoplasia, type i	Enrichment	CDKN1A, CDKN1B, CDKN2B	4.93
17	Adult hepatocellular carcinoma	Enrichment	CASP8, PIK3CA, TP53	4.55
18	Cowden syndrome	Enrichment	AKT1, PIK3CA, PTEN	4.55
19	Colorectal cancer	Enrichment	AKT1, BAX, CCND1, PIK3CA, PIK3R1, TP53	4.47
20	Myeloma, multiple	Enrichment	CCND1, PIK3R2, RXRA, TP53, TRAF5	4.34
21	Prostate cancer	Enrichment	PIK3CA, POLK, PTEN, TP53	4.31
22	Ectodermal dysplasia and immune deficiency	Enrichment	IKBKG, NFKBIA	4.30
23	X-linked diffuse leiomyomatosis-alport syndrome	Enrichment	COL4A5, COL4A6	4.30
24	Meningioma	Enrichment	AKT1, PIK3CA, PTEN	4.14
25	Lip and oral cavity carcinoma	Enrichment	PIK3CA, RB1, TP53	4.14
26	Ovarian cancer	Enrichment	AKT1, CDKN1B, PIK3CA, PTEN, RB1, TP53	4.10
27	Hematuria, benign familial, 1	Enrichment	COL4A3, COL4A4	3.83
28	Osteogenic sarcoma	Enrichment	RB1, TP53	3.83
29	Nasopharyngeal carcinoma	Enrichment	NFKBIA, TP53	3.83
30	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3CA, PIK3R1	3.83
31	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3CD, PIK3R1	3.83
32	High-grade b-cell lymphoma double-hit/triple-hit	Enrichment	BCL2, MYC	3.83
33	Immunodeficiency 14	Enrichment	PIK3CD, PIK3R1	3.83
34	Squamous cell carcinoma	Enrichment	RB1, TP53	3.83
35	Bone osteosarcoma	Enrichment	RB1, TP53	3.83
36	Gastric cancer	Enrichment	CDK4, PIK3CA, PTEN, TP53	3.63
37	Hereditary breast carcinoma	Enrichment	AKT1, PIK3CA, PTEN, TP53	3.59
38	Brain small vessel disease 1 with or without ocular anomalies	Enrichment	COL4A1, COL4A2	3.53
39	Small cell cancer of the lung	Enrichment	RB1, TP53	3.53
40	Alport syndrome 2, autosomal recessive	Enrichment	COL4A3, COL4A4	3.53
41	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	AKT3, PIK3R2	3.53
42	Autosomal recessive alport syndrome	Enrichment	COL4A3, COL4A4	3.53
43	Inherited cancer-predisposing syndrome	Enrichment	CDK4, CDKN1B, MAX, PTEN, RB1, TP53	3.46
44	Hepatocellular carcinoma	Enrichment	CASP8, PIK3CA, TP53	3.32
45	Epidermolysis bullosa	Enrichment	ITGA6, LAMB3	3.31
46	Acute megakaryocytic leukemia	Enrichment	PTEN, TP53	3.31
47	Familial porencephaly	Enrichment	COL4A1, COL4A2	3.31
48	Cowden syndrome 1	Enrichment	PIK3CA, PTEN	3.14
49	Hemorrhage, intracerebral	Enrichment	COL4A1, COL4A2	3.14
50	Fetomaternal alloimmune thrombocytopenia 1	Enrichment	ITGA2, ITGA2B	3.14
51	Squamous cell carcinoma, head and neck	Enrichment	PTEN, TP53	2.99
52	Gallbladder cancer	Enrichment	PIK3CA, TP53	2.99
53	Megacolon	Enrichment	AKT3, FHIT	2.99
54	Leukemia, chronic lymphocytic	Enrichment	CCND1, TP53	2.67
55	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3CD, PIK3R1	2.67
56	Chronic kidney disease	Enrichment	COL4A4, COL4A5	2.43
57	Multiple sclerosis	Enrichment	LAMA5, LAMB1	2.37
58	Lung cancer susceptibility 3	Enrichment	RB1, TP53	2.37
59	Hypertension	Enrichment	COL4A4, COL4A5	2.25
60	Rhabdomyosarcoma	Enrichment	PTEN, TP53	2.25
61	Gliosarcoma	Enrichment	NFKBIA, TP53	2.25
62	Melanoma, cutaneous malignant 1	Enrichment	CDK4, CDKN2B	2.20
63	Giant cell glioblastoma	Enrichment	NFKBIA, TP53	2.20
64	Hereditary breast ovarian cancer syndrome	Enrichment	FHIT, PTEN, TP53	2.16
65	Macrodactyly	Enrichment	PIK3CA	2.15
66	Proteus syndrome	Enrichment	AKT1	2.15
67	Hypoinsulinemic hypoglycemia with hemihypertrophy	Enrichment	AKT2	2.15
68	Vacterl association with hydrocephalus	Enrichment	PTEN	2.15
69	Alport syndrome 1, x-linked	Enrichment	COL4A5	2.15
70	Incontinentia pigmenti	Enrichment	IKBKG	2.15
71	Autoinflammatory disease, systemic, x-linked	Enrichment	IKBKG	2.15
72	Caspase 8 deficiency	Enrichment	CASP8	2.15
73	Melanoma, cutaneous malignant 3	Enrichment	CDK4	2.15
74	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	2.15
75	Cardiomyopathy, dilated, 1jj	Enrichment	LAMA4	2.15
76	Cowden syndrome 5	Enrichment	PIK3CA	2.15
77	Microcephaly 12, primary, autosomal recessive	Enrichment	CDK6	2.15
78	Lissencephaly 5	Enrichment	LAMB1	2.15
79	Fetal encasement syndrome	Enrichment	CHUK	2.15
80	Cerebral cavernous malformations 4	Enrichment	PIK3CA	2.15
81	Immunodeficiency 15b	Enrichment	IKBKB	2.15
82	Nephrotic syndrome, type 26	Enrichment	LAMA5	2.15
83	Deafness, x-linked 6	Enrichment	COL4A6	2.15
84	Immunodeficiency 15a	Enrichment	IKBKB	2.15
85	Short syndrome	Enrichment	PIK3R1	2.15
86	Bone marrow failure syndrome 5	Enrichment	TP53	2.15
87	Fetomaternal alloimmune thrombocytopenia 2	Enrichment	ITGA2B	2.15
88	Ectodermal dysplasia and immunodeficiency 1	Enrichment	IKBKG	2.15
89	Papilloma of choroid plexus	Enrichment	TP53	2.15
90	Basal cell carcinoma 7	Enrichment	TP53	2.15
91	Porencephaly	Enrichment	COL4A1	2.15
92	Immunodeficiency 132a	Enrichment	TRAF3	2.15
93	Immunodeficiency 132b	Enrichment	TRAF3	2.15
94	Anaplastic thyroid carcinoma	Enrichment	TP53	2.15
95	Papillary tumor of the pineal region	Enrichment	PTEN	2.15
96	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 2	Enrichment	AKT3	2.15
97	Thrombocytopenia 4	Enrichment	CYCS	2.15
98	Hemifacial myohyperplasia	Enrichment	PIK3CA	2.15
99	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	2.15
100	Neuroendocrine tumor	Enrichment	CDKN1B	2.15
101	Cortical malformations, occipital	Enrichment	LAMC3	2.15
102	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	2.15
103	Polydactyly-macrocephaly syndrome	Enrichment	MAX	2.15
104	Cowden syndrome 6	Enrichment	AKT1	2.15
105	Microphthalmia, syndromic 12	Enrichment	RARB	2.15
106	Immunodeficiency 14b, autosomal recessive	Enrichment	PIK3CD	2.15
107	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	2.15
108	Glioma susceptibility 2	Enrichment	PTEN	2.15
109	Ductal carcinoma in situ	Enrichment	TP53	2.15
110	Bartsocas-papas syndrome 2	Enrichment	CHUK	2.15
111	Bent bone dysplasia syndrome 2	Enrichment	LAMA5	2.15
112	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	2.15
113	Thyroid gland undifferentiated carcinoma	Enrichment	TP53	2.15
114	Trilateral retinoblastoma	Enrichment	RB1	2.15
115	Small-cell carcinoma of the ovary of hypercalcemic type	Enrichment	TP53	2.15
116	Col4a1-related disorders	Enrichment	COL4A1	2.15
117	Occipital pachygyria and polymicrogyria	Enrichment	LAMC3	2.15
118	Hypospadias	Enrichment	PIK3CA	2.15
119	Capillary hemangioma	Enrichment	AKT3	2.15
120	Diffuse pediatric-type high-grade glioma, h3-wildtype and idh-wildtype	Enrichment	TP53	2.15
121	Choroid plexus cancer	Enrichment	TP53	2.15
122	Rare venous malformation	Enrichment	PIK3CA	2.15
123	Fetomaternal alloimmune thrombocytopenia 3	Enrichment	ITGA2	2.15
124	Col4a1 or col4a2-related cerebral small vessel disease	Enrichment	COL4A1	2.15
125	Immune dysregulation, neurodevelopmental defects, and colitis	Enrichment	ITGAV	2.15
126	Diaphragmatic eventration	Enrichment	PIK3CA	2.15
127	X-linked alport syndrome	Enrichment	COL4A5	2.15
128	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	2.15
129	Combined immunodeficiency-hypogammaglobulinemia-skeletal anomalies syndrome due to ikbka deficiency	Enrichment	CHUK	2.15
130	Pleomorphic xanthoastrocytoma	Enrichment	TP53	2.15
131	Rare combined vascular malformation	Enrichment	PIK3CA	2.15
132	Cavernous lymphangioma	Enrichment	PIK3CA	2.15
133	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	2.15
134	Intrauterine growth restriction-short stature-early adult-onset diabetes syndrome	Enrichment	CDKN1C	2.15
135	Segmental outgrowth-lipomatosis-arteriovenous malformation-epidermal nevus syndrome	Enrichment	PTEN	2.15
136	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	2.15
137	Lama5-related multisystemic syndrome	Enrichment	LAMA5	2.15
138	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	2.15
139	Macrodactyly of toe	Enrichment	PIK3CA	2.15
140	Laminin subunit alpha 2-related muscular dystrophy	Enrichment	LAMA2	2.15
141	Akt2-related familial partial lipodystrophy	Enrichment	AKT2	2.15
142	Lung oat cell carcinoma	Enrichment	RB1	2.15
143	Diffuse large b-cell lymphoma	Enrichment	PTEN, TP53	2.11
144	Focal segmental glomerulosclerosis	Enrichment	COL4A4, COL4A5	2.06
145	Endometrial cancer	Enrichment	PIK3CA, PTEN	2.02
146	Skin disease	Enrichment	LAMB3, LAMC2	1.98
147	Malaria	Enrichment	IKBKG, NOS2	1.94
148	Amelogenesis imperfecta, type ia	Enrichment	LAMB3	1.85
149	Burkitt lymphoma	Enrichment	MYC	1.85
150	Adrenocortical carcinoma, hereditary	Enrichment	TP53	1.85
151	Spondyloepimetaphyseal dysplasia, strudwick type	Enrichment	FN1	1.85
152	Spondylometaphyseal dysplasia, corner fracture type	Enrichment	FN1	1.85
153	Epidermolysis bullosa, junctional 2c, laryngoonychocutaneous	Enrichment	LAMA3	1.85
154	Myasthenic syndrome, congenital, 5	Enrichment	LAMB2	1.85
155	Cervical cancer	Enrichment	TP53	1.85
156	Immunodeficiency 33	Enrichment	IKBKG	1.85
157	Xeroderma pigmentosum, complementation group e	Enrichment	DDB2	1.85
158	Ectodermal dysplasia and immunodeficiency 2	Enrichment	NFKBIA	1.85
159	Keratosis, seborrheic	Enrichment	PIK3CA	1.85
160	Lissencephaly 1	Enrichment	LAMB1	1.85
161	Roifman-chitayat syndrome	Enrichment	PIK3CD	1.85
162	Intrauterine growth retardation, metaphyseal dysplasia, adrenal hypoplasia congenita, and genital anomalies	Enrichment	CDKN1C	1.85
163	Neurodevelopmental disorder with hypotonia, speech delay, and dysmorphic facies	Enrichment	POLK	1.85
164	Specific language impairment 5	Enrichment	COL4A4	1.85
165	Chromosome 13q14 deletion syndrome	Enrichment	RB1	1.85
166	Noonan syndrome 8	Enrichment	PIK3CA	1.85
167	Pierson syndrome	Enrichment	LAMB2	1.85
168	Lymphoma, hodgkin, classic	Enrichment	TP53	1.85
169	Immunodeficiency, common variable, 12, with autoimmunity	Enrichment	NFKB1	1.85
170	Multiple endocrine neoplasia, type iv	Enrichment	CDKN1B	1.85
171	Encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy, 1	Enrichment	COL4A2	1.85
172	Epidermolysis bullosa, junctional 3b, severe	Enrichment	LAMC2	1.85
173	Epidermolysis bullosa, junctional 3a, intermediate	Enrichment	LAMC2	1.85
174	Intellectual developmental disorder, autosomal dominant 48	Enrichment	RARB	1.85
175	Epidermolysis bullosa, junctional 2a, intermediate	Enrichment	LAMA3	1.85
176	Autoinflammatory disease, familial, behcet-like 3	Enrichment	RELA	1.85
177	Intravascular large b-cell lymphoma	Enrichment	BCL2	1.85
178	Nephrotic syndrome, type 5, with or without ocular abnormalities	Enrichment	LAMB2	1.85
179	Epidermolysis bullosa, junctional 7, with interstitial lung disease and nephrotic syndrome	Enrichment	ITGA3	1.85
180	Rela fusion-positive ependymoma	Enrichment	RELA	1.85
181	Senior-loken syndrome 7	Enrichment	AKT3	1.85
182	Rosette-forming glioneuronal tumor	Enrichment	PIK3CA	1.85
183	Congenital fibrosarcoma	Enrichment	TP53	1.85
184	Glomerulonephritis	Enrichment	COL4A4	1.85
185	Li-fraumeni syndrome 1	Enrichment	TP53	1.85
186	Sarcoma	Enrichment	TP53	1.85
187	Cervix carcinoma	Enrichment	TP53	1.85
188	Immune system disease	Enrichment	PIK3CD	1.85
189	Hodgkin's lymphoma	Enrichment	TP53	1.85
190	Bardet-biedl syndrome 16	Enrichment	AKT3	1.85
191	Epidermolysis bullosa, junctional 2b, severe	Enrichment	LAMA3	1.85
192	Glucosephosphate dehydrogenase deficiency	Enrichment	IKBKG	1.85
193	Vacterl with hydrocephalus	Enrichment	PTEN	1.85
194	Familial retinoblastoma	Enrichment	RB1	1.85
195	Common variable immunodeficiency 12	Enrichment	NFKB1	1.85
196	Juvenile polyposis of infancy	Enrichment	PTEN	1.85
197	Xeroderma pigmentosum group e	Enrichment	DDB2	1.85
198	Pleomorphic rhabdomyosarcoma	Enrichment	TP53	1.85
199	Retinal arteries, tortuosity of	Enrichment	COL4A1	1.68
200	Retinoblastoma	Enrichment	RB1	1.68
201	Bleeding disorder, platelet-type, 16	Enrichment	ITGA2B	1.68
202	Pompe disease, infantile-onset	Enrichment	PIK3CA	1.68
203	Glomerulopathy with fibronectin deposits 2	Enrichment	FN1	1.68
204	Muscular dystrophy, congenital merosin-deficient, 1a	Enrichment	LAMA2	1.68
205	Brain small vessel disease 2	Enrichment	COL4A2	1.68
206	Woolly hair, autosomal recessive 3	Enrichment	RB1	1.68
207	Microangiopathy and leukoencephalopathy, pontine, autosomal dominant	Enrichment	COL4A1	1.68
208	Epidermolysis bullosa, junctional 6, with pyloric atresia	Enrichment	ITGA6	1.68
209	Pilarowski-bjornsson syndrome	Enrichment	COL4A3	1.68
210	Hypotrichosis 8	Enrichment	RB1	1.68
211	Alport syndrome 3b, autosomal recessive	Enrichment	COL4A3	1.68
212	Dedifferentiated liposarcoma	Enrichment	CDK4	1.68
213	Poretti-boltshauser syndrome	Enrichment	LAMA1	1.68
214	Angiopathy, hereditary, with nephropathy, aneurysms, and muscle cramps	Enrichment	COL4A1	1.68
215	Atypical teratoid rhabdoid tumor	Enrichment	TP53	1.68
216	Anaplastic astrocytoma	Enrichment	TP53	1.68
217	T-cell acute lymphoblastic leukemia	Enrichment	BAX	1.68
218	Adenocarcinoma	Enrichment	TP53	1.68
219	Hematuria, benign familial, 2	Enrichment	COL4A3	1.68
220	Laryngeal squamous cell carcinoma	Enrichment	PTEN	1.68
221	Well-differentiated liposarcoma	Enrichment	CDK4	1.68
222	Keratoacanthoma	Enrichment	PIK3CA	1.68
223	Lama2-related muscular dystrophy	Enrichment	LAMA2	1.68
224	Lung cancer	Enrichment	CASP8, PIK3CA	1.67
225	Genetic steroid-resistant nephrotic syndrome	Enrichment	COL4A3, LAMA5	1.62
226	Schizencephaly	Enrichment	COL4A1	1.55
227	Thyroid cancer, nonmedullary, 1	Enrichment	TP53	1.55
228	Lynch syndrome 4	Enrichment	RB1	1.55
229	Mantle cell lymphoma	Enrichment	CCND1	1.55
230	Lung sarcomatoid carcinoma	Enrichment	TP53	1.55
231	Cerebrovascular disease	Enrichment	PIK3CA	1.55
232	Embryonal rhabdomyosarcoma	Enrichment	TP53	1.55
233	Familial cerebral cavernous malformations	Enrichment	PIK3CA	1.55
234	Silver-russell syndrome due to a point mutation	Enrichment	CDKN1C	1.55
235	Primary hyperparathyroidism	Enrichment	CDKN1B	1.55
236	Glioma	Enrichment	PTEN	1.55
237	Rare x-linked non-syndromic sensorineural deafness type dfn	Enrichment	COL4A6	1.55
238	Cerebral palsy	Enrichment	COL4A1, COL4A2	1.51
239	Ectodermal dysplasia 10a, hypohidrotic/hair/nail type, autosomal dominant	Enrichment	TRAF6	1.46
240	Lymphoma, mucosa-associated lymphoid type	Enrichment	BIRC3	1.46
241	Capillary malformations, congenital	Enrichment	PIK3CA	1.46
242	Von hippel-lindau syndrome	Enrichment	CCND1	1.46
243	Anemia, congenital, nonspherocytic hemolytic, 1	Enrichment	IKBKG	1.46
244	Rhabdomyosarcoma 2	Enrichment	TP53	1.46
245	Macrocephaly/autism syndrome	Enrichment	PTEN	1.46
246	Muscular dystrophy, limb-girdle, autosomal recessive 23	Enrichment	LAMA2	1.46
247	Follicular lymphoma	Enrichment	BCL2	1.46
248	Lymphoma	Enrichment	TP53	1.46
249	Hemangioma	Enrichment	PTEN	1.46
250	Autosomal thrombocytopenia with normal platelets	Enrichment	CYCS	1.46
251	Herpes simplex virus encephalitis	Enrichment	TRAF3	1.46
252	Klippel-trenaunay-weber syndrome	Enrichment	PIK3CA	1.38
253	Li-fraumeni syndrome	Enrichment	TP53	1.38
254	Hemihyperplasia, isolated	Enrichment	PIK3CA	1.38
255	Epidermolysis bullosa, junctional 5b, with pyloric atresia	Enrichment	ITGA6	1.38
256	Anterior segment dysgenesis 5	Enrichment	COL4A1	1.38
257	Keratoconus	Enrichment	COL4A1	1.38
258	Adrenocortical carcinoma	Enrichment	TP53	1.38
259	Lung squamous cell carcinoma	Enrichment	PIK3CA	1.38
260	Thrombocytopenia	Enrichment	CYCS, ITGA2B	1.34
261	Esophageal cancer	Enrichment	TP53	1.31
262	Nevus, epidermal	Enrichment	PIK3CA	1.31
263	Thyroid cancer, nonmedullary, 2	Enrichment	PTEN	1.31
264	Glanzmann thrombasthenia 1	Enrichment	ITGA2B	1.31
265	Capillary malformation-arteriovenous malformation 1	Enrichment	PIK3CA	1.31
266	Essential thrombocythemia	Enrichment	TP53	1.31
267	Common variable immunodeficiency	Enrichment	NFKB1	1.31
268	Follicular thyroid carcinoma	Enrichment	PTEN	1.31
269	Overgrowth syndrome	Enrichment	PIK3R1	1.31
270	Hereditary clear cell renal cell carcinoma	Enrichment	FHIT	1.31
271	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	TP53	1.31
272	Glioma susceptibility 1	Enrichment	TP53	1.26
273	Lymphoma, non-hodgkin, familial	Enrichment	TP53	1.26
274	Congenital muscular dystrophy	Enrichment	LAMA2	1.26
275	Coronary heart disease 5	Enrichment	IKBKG	1.21
276	Arteriovenous malformation	Enrichment	PIK3CA	1.21
277	Primary hyperaldosteronism	Enrichment	TP53	1.21
278	Peters-plus syndrome	Enrichment	COL4A1	1.16
279	Amelogenesis imperfecta, type ie	Enrichment	LAMB3	1.16
280	Myopathy, x-linked, with excessive autophagy	Enrichment	PIK3CA	1.16
281	Ciliary dyskinesia, primary, 3	Enrichment	NFKB1	1.16
282	Polymicrogyria	Enrichment	AKT3	1.16
283	Melanoma	Enrichment	PTEN	1.16
284	Autosomal dominant macrothrombocytopenia	Enrichment	ITGA2B	1.16
285	Familial colorectal cancer	Enrichment	TP53	1.16
286	Xeroderma pigmentosum, variant type	Enrichment	DDB2	1.12
287	Meningioma, familial	Enrichment	PTEN	1.12
288	Myelodysplastic syndrome	Enrichment	TP53	1.12
289	Lung non-small cell carcinoma	Enrichment	PIK3CA	1.12
290	Uterine corpus cancer	Enrichment	PTEN	1.12
291	Presynaptic congenital myasthenic syndromes	Enrichment	LAMA5	1.12
292	Microphthalmia/coloboma 12	Enrichment	RARB	1.05
293	Neural tube defects	Enrichment	ITGB1	1.05
294	Amelogenesis imperfecta	Enrichment	LAMB3	1.05
295	Nk-cell enteropathy	Enrichment	PIK3CB	1.05
296	Pheochromocytoma	Enrichment	MAX	1.02
297	Walker-warburg syndrome	Enrichment	COL4A1	1.02
298	Isolated macular dystrophy	Enrichment	COL4A5	1.02
299	Coloboma of macula	Enrichment	RARB	1.00
300	Corpus callosum, agenesis of	Enrichment	COL4A1	1.00
301	Myopia	Enrichment	COL4A4	1.00
302	Anterior segment dysgenesis	Enrichment	COL4A1	1.00
303	Atypical hemolytic-uremic syndrome	Enrichment	COL4A5	1.00
304	Lynch syndrome	Enrichment	PIK3CA	1.00
305	Isolated corpus callosum agenesis	Enrichment	COL4A1	1.00
306	Intellectual disability-hypoplastic corpus callosum-preauricular tag syndrome	Enrichment	COL4A1	1.00
307	Creatine phosphokinase, elevated serum	Enrichment	LAMA2	0.97
308	Isolated elevated serum creatine phosphokinase levels	Enrichment	LAMA2	0.97
309	Beckwith-wiedemann syndrome	Enrichment	CDKN1C	0.92
310	Polycystic kidney disease	Enrichment	COL4A4	0.92
311	Williams-beuren syndrome	Enrichment	CDKN1C	0.88
312	Hepatoblastoma	Enrichment	TP53	0.86
313	Hereditary paraganglioma-pheochromocytoma syndromes	Enrichment	MAX	0.86
314	Microphthalmia	Enrichment	RARB	0.84
315	Multisystem inflammatory syndrome in children	Enrichment	TRAF3	0.84
316	Diamond-blackfan anemia 1	Enrichment	TP53	0.82
317	Precursor t-cell acute lymphoblastic leukemia	Enrichment	MYC	0.82
318	Pancreatic cancer	Enrichment	TP53	0.79
319	Severe covid-19	Enrichment	ITGAV	0.73
320	Primary autosomal recessive microcephaly	Enrichment	CDK6	0.69
321	Severe combined immunodeficiency	Enrichment	IKBKB	0.68
322	Cakut	Enrichment	COL4A1	0.67
323	Diamond-blackfan anemia	Enrichment	TP53	0.65
324	Leukemia, acute myeloid	Enrichment	TP53	0.61
325	Charcot-marie-tooth disease	Enrichment	LAMA2	0.60
326	Type 2 diabetes mellitus	Enrichment	AKT2	0.59
327	Hypertelorism	Enrichment	PIK3CA	0.51
328	Familial isolated dilated cardiomyopathy	Enrichment	LAMA4	0.50
329	Schizophrenia	Enrichment	FHIT	0.46
330	Autism	Enrichment	FHIT	0.40
331	Rare genetic deafness	Enrichment	COL4A5	0.37
332	Dilated cardiomyopathy	Enrichment	LAMA2	0.36
333	Congenital nervous system abnormality	Enrichment	PTEN	0.28
334	Nervous system disease	Enrichment	PTEN	0.28
335	Autism spectrum disorder	Enrichment	PTEN	0.27
336	Microcephaly	Enrichment	COL4A1	0.23
337	Hereditary retinal dystrophy	Enrichment	LAMA1	0.06
338	Fundus dystrophy	Enrichment	LAMA1	0.06

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Small cell lung cancer

Pathway Network for Small cell lung cancer

Member Pathways for Small cell lung cancer

Pathways in the Small cell lung cancer SuperPath

Associated Genes for Small cell lung cancer

Associated Disorders for Small cell lung cancer

Disorders associated with Small cell lung cancer SuperPath

STRING Interaction Network for Small cell lung cancer

Sources for Small cell lung cancer