SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome

No Pathway Network information available for SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome

Pathways in the SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome SuperPath

#	Name	Source	Genes
1	SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome	WikiPathways	ATM BRCA1 MDC1 MRE11 NBN PAXIP1 RAD18 RAD21 RAD50 SMC1A SMC3 (see all 11) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	SMC3	Structural Maintenance Of Chromosomes 3	Protein Coding	1
2	SMC1A	Structural Maintenance Of Chromosomes 1A	Protein Coding	1
3	BRCA1	BRCA1 DNA Repair Associated	Protein Coding	1
4	RAD21	RAD21 Cohesin Complex Component	Protein Coding	1
5	ATM	ATM Serine/Threonine Kinase	Protein Coding	1
6	NBN	Nibrin	Protein Coding	1
7	MRE11	MRE11 Double Strand Break Repair Nuclease	Protein Coding	1
8	RAD50	RAD50 Double Strand Break Repair Protein	Protein Coding	1
9	MDC1	Mediator Of DNA Damage Checkpoint 1	Protein Coding	1
10	RAD18	RAD18 E3 Ubiquitin Protein Ligase	Protein Coding	1
11	PAXIP1	PAX Interacting Protein 1	Protein Coding	1

Disorders associated with SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Hereditary breast ovarian cancer syndrome	Enrichment	ATM, BRCA1, MRE11, NBN, RAD50	9.38
2	Breast cancer	Enrichment	ATM, BRCA1, MRE11, NBN, RAD50	8.70
3	Ovarian cancer	Enrichment	ATM, BRCA1, MRE11, NBN, RAD50	8.04
4	Hereditary breast carcinoma	Enrichment	ATM, BRCA1, NBN, RAD50	7.51
5	Cornelia de lange syndrome 1	Enrichment	RAD21, SMC1A, SMC3	7.48
6	Cornelia de lange syndrome	Enrichment	RAD21, SMC1A, SMC3	7.48
7	Inherited cancer-predisposing syndrome	Enrichment	ATM, BRCA1, MRE11, NBN, RAD50	7.45
8	Breast-ovarian cancer, familial 1	Enrichment	ATM, BRCA1, NBN	6.95
9	Pancreatic cancer	Enrichment	ATM, BRCA1, NBN	6.04
10	Prostate cancer	Enrichment	ATM, BRCA1, NBN	5.84
11	Nijmegen breakage syndrome-like disorder	Enrichment	MRE11, RAD50	5.45
12	Gastric cancer	Enrichment	ATM, BRCA1, NBN	5.32
13	Wiedemann-steiner syndrome	Enrichment	SMC1A, SMC3	5.05
14	Colonic benign neoplasm	Enrichment	ATM, MRE11	4.67
15	Uterine corpus cancer	Enrichment	ATM, BRCA1	4.48
16	Endometrial cancer	Enrichment	ATM, BRCA1	3.90
17	Hepatocellular carcinoma	Enrichment	NBN, RAD50	3.86
18	Bladder cancer	Enrichment	ATM, BRCA1	3.62
19	Palmoplantar keratoderma, punctate type ii	Enrichment	BRCA1	3.09
20	Developmental and epileptic encephalopathy 85 with or without midline brain defects	Enrichment	SMC1A	3.09
21	Cornelia de lange syndrome 3 with or without midline brain defects	Enrichment	SMC3	3.09
22	Cornelia de lange syndrome 4 with or without midline brain defects	Enrichment	RAD21	3.09
23	Infant-type hemispheric glioma	Enrichment	BRCA1	3.09
24	Ataxia-telangiectasia-like disorder 1	Enrichment	MRE11	3.09
25	Mungan syndrome	Enrichment	RAD21	3.09
26	Endometrial serous adenocarcinoma	Enrichment	ATM	3.09
27	B-cell non-hodgkin lymphoma	Enrichment	ATM	3.09
28	Primary peritoneal carcinoma	Enrichment	BRCA1	3.09
29	Cornelia de lange syndrome 2	Enrichment	SMC1A	2.79
30	Fanconi anemia, complementation group s	Enrichment	BRCA1	2.79
31	Cardiac valvular dysplasia, x-linked	Enrichment	ATM	2.79
32	Pancreatic cancer 4	Enrichment	BRCA1	2.79
33	High grade glioma	Enrichment	ATM	2.79
34	T-cell prolymphocytic leukemia	Enrichment	ATM	2.79
35	Inflammatory breast carcinoma	Enrichment	BRCA1	2.79
36	Peritoneum cancer	Enrichment	BRCA1	2.79
37	Bilateral breast cancer	Enrichment	BRCA1	2.79
38	Colorectal cancer	Enrichment	ATM, BRCA1	2.67
39	Ataxia-telangiectasia	Enrichment	ATM	2.61
40	Nijmegen breakage syndrome	Enrichment	NBN	2.61
41	Polycythemia vera	Enrichment	ATM	2.61
42	Koolen-de vries syndrome	Enrichment	ATM	2.61
43	Adenocarcinoma	Enrichment	ATM	2.61
44	Trichorhinophalangeal syndrome, type ii	Enrichment	RAD21	2.49
45	Ataxia, early-onset, with oculomotor apraxia and hypoalbuminemia	Enrichment	MRE11	2.49
46	Polyposis syndrome, hereditary mixed, 1	Enrichment	BRCA1	2.49
47	Cholangiocarcinoma	Enrichment	BRCA1	2.49
48	Mantle cell lymphoma	Enrichment	ATM	2.49
49	Oculomotor apraxia	Enrichment	ATM	2.49
50	Breast-ovarian cancer, familial 2	Enrichment	BRCA1	2.39
51	Glioblastoma	Enrichment	ATM	2.39
52	Microcephaly	Enrichment	NBN, SMC1A	2.37
53	Clear cell renal cell carcinoma	Enrichment	ATM	2.31
54	Renal cell carcinoma, papillary, 1	Enrichment	ATM	2.25
55	Rett syndrome, congenital variant	Enrichment	SMC1A	2.19
56	Lynch syndrome 1	Enrichment	ATM	2.09
57	Leukemia, chronic lymphocytic	Enrichment	ATM	2.09
58	Aplastic anemia	Enrichment	NBN	2.09
59	Immune deficiency disease	Enrichment	ATM	2.05
60	Leukemia, acute lymphoblastic	Enrichment	NBN	2.05
61	Familial colorectal cancer type x	Enrichment	ATM	2.05
62	Premature menopause	Enrichment	NBN	1.98
63	Periventricular nodular heterotopia	Enrichment	BRCA1	1.95
64	Renal cell carcinoma, nonpapillary	Enrichment	ATM	1.92
65	Rhabdomyosarcoma	Enrichment	BRCA1	1.89
66	Gliosarcoma	Enrichment	ATM	1.89
67	Giant cell glioblastoma	Enrichment	ATM	1.86
68	Semilobar holoprosencephaly	Enrichment	SMC1A	1.84
69	Diffuse large b-cell lymphoma	Enrichment	NBN	1.82
70	Lissencephaly	Enrichment	NBN	1.77
71	Lung cancer	Enrichment	BRCA1	1.59
72	Fanconi anemia, complementation group a	Enrichment	BRCA1	1.55
73	Myeloma, multiple	Enrichment	ATM	1.35
74	Primary ovarian insufficiency	Enrichment	NBN	1.33
75	Congenital nervous system abnormality	Enrichment	SMC1A	1.08
76	Nervous system disease	Enrichment	SMC1A	1.08
77	Autism spectrum disorder	Enrichment	SMC3	1.07

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome

Pathway Network for SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome

Member Pathways for SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome

Pathways in the SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome SuperPath

Associated Genes for SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome

Associated Disorders for SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome

Disorders associated with SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome SuperPath

STRING Interaction Network for SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome

Sources for SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome