Smooth Muscle Contraction

No Pathway Network information available for Smooth Muscle Contraction

Pathways in the Smooth Muscle Contraction SuperPath

#	Name	Source	Genes
1	Smooth Muscle Contraction	Reactome	ACTA2 ACTG2 ALDH2 ANXA1 ANXA2 ANXA6 CACNA1G CACNA1H CACNA1I CALD1 CALM1 CALM2 CALM3 CAV3 DYSF GUCY1A1 GUCY1A2 GUCY1B1 ITGA1 ITGB5 LMOD1 MYH11 MYL10 MYL11 MYL12A MYL12B MYL5 MYL6 MYL6B MYL7 MYL9 MYLK PAK1 PAK2 PDE5A PXN SORBS1 SORBS3 TLN1 TPM1 TPM2 TPM3 TPM4 TRIM72 VCL (see all 45) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	SORBS3	Sorbin And SH3 Domain Containing 3	Protein Coding	1
2	MYL12B	Myosin Light Chain 12B	Protein Coding	1
3	MYL9	Myosin Light Chain 9	Protein Coding	1
4	SORBS1	Sorbin And SH3 Domain Containing 1	Protein Coding	1
5	MYL12A	Myosin Light Chain 12A	Protein Coding	1
6	MYL6B	Myosin Light Chain 6B	Protein Coding	1
7	ALDH2	Aldehyde Dehydrogenase 2 Family Member	Protein Coding	1
8	LMOD1	Leiomodin 1	Protein Coding	1
9	GUCY1A2	Guanylate Cyclase 1 Soluble Subunit Alpha 2	Protein Coding	1
10	GUCY1A1	Guanylate Cyclase 1 Soluble Subunit Alpha 1	Protein Coding	1
11	GUCY1B1	Guanylate Cyclase 1 Soluble Subunit Beta 1	Protein Coding	1
12	MYL11	Myosin Light Chain 11	Protein Coding	1
13	ANXA1	Annexin A1	Protein Coding	1
14	ANXA2	Annexin A2	Protein Coding	1
15	ANXA6	Annexin A6	Protein Coding	1
16	ITGA1	Integrin Subunit Alpha 1	Protein Coding	1
17	ITGB5	Integrin Subunit Beta 5	Protein Coding	1
18	MYH11	Myosin Heavy Chain 11	Protein Coding	1
19	MYL5	Myosin Light Chain 5	Protein Coding	1
20	MYL6	Myosin Light Chain 6	Protein Coding	1
21	MYLK	Myosin Light Chain Kinase	Protein Coding	1
22	TRIM72	Tripartite Motif Containing 72	Protein Coding	1
23	PAK1	P21 (RAC1) Activated Kinase 1	Protein Coding	1
24	PAK2	P21 (RAC1) Activated Kinase 2	Protein Coding	1
25	PXN	Paxillin	Protein Coding	1
26	MYL7	Myosin Light Chain 7	Protein Coding	1
27	ACTA2	Actin Alpha 2, Smooth Muscle	Protein Coding	1
28	TLN1	Talin 1	Protein Coding	1
29	TPM1	Tropomyosin 1	Protein Coding	1
30	TPM2	Tropomyosin 2	Protein Coding	1
31	TPM3	Tropomyosin 3	Protein Coding	1
32	TPM4	Tropomyosin 4	Protein Coding	1
33	ACTG2	Actin Gamma 2, Smooth Muscle	Protein Coding	1
34	VCL	Vinculin	Protein Coding	1
35	CALD1	Caldesmon 1	Protein Coding	1
36	CALM1	Calmodulin 1	Protein Coding	1
37	CALM2	Calmodulin 2	Protein Coding	1
38	CALM3	Calmodulin 3	Protein Coding	1
39	DYSF	Dysferlin	Protein Coding	1
40	CAV3	Caveolin 3	Protein Coding	1
41	PDE5A	Phosphodiesterase 5A	Protein Coding	1
42	CACNA1I	Calcium Voltage-Gated Channel Subunit Alpha1 I	Protein Coding	1
43	CACNA1H	Calcium Voltage-Gated Channel Subunit Alpha1 H	Protein Coding	1
44	CACNA1G	Calcium Voltage-Gated Channel Subunit Alpha1 G	Protein Coding	1
45	MYL10	Myosin Light Chain 10	Protein Coding	1

Disorders associated with Smooth Muscle Contraction SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Megacystis-microcolon-intestinal hypoperistalsis syndrome 1	Enrichment	ACTG2, LMOD1, MYH11, MYLK	9.91
2	Visceral myopathy 1	Enrichment	ACTG2, LMOD1, MYH11, MYLK	9.27
3	Catecholaminergic polymorphic ventricular tachycardia	Enrichment	CALM1, CALM2, CALM3	5.72
4	Long qt syndrome 1	Enrichment	CALM1, CALM2, CALM3, CAV3	5.57
5	Cap myopathy	Enrichment	TPM2, TPM3	4.49
6	Long qt syndrome	Enrichment	CALM1, CALM2, CAV3	3.84
7	Moyamoya disease 1	Enrichment	ACTA2, GUCY1A1	3.80
8	Inflammatory myofibroblastic tumor	Enrichment	TPM3, TPM4	3.80
9	Intestinal pseudo-obstruction	Enrichment	ACTG2, MYH11	3.80
10	Childhood-onset nemaline myopathy	Enrichment	TPM2, TPM3	3.65
11	Familial thoracic aortic aneurysm and dissection	Enrichment	MYH11, MYLK	3.42
12	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	ACTA2, MYH11, MYLK	3.39
13	Nemaline myopathy	Enrichment	TPM2, TPM3	3.32
14	Aortic aneurysm, familial thoracic 1	Enrichment	MYH11, MYLK	3.02
15	Congenital myopathy 4a, autosomal dominant	Enrichment	TPM2, TPM3	2.96
16	Sudden infant death syndrome	Enrichment	CALM2, CAV3	2.85
17	Cardiomyopathy, familial hypertrophic, 1	Enrichment	CAV3, TPM1	2.55
18	Cardiomyopathy, familial hypertrophic, 3	Enrichment	TPM1	2.48
19	Pulmonary atresia with intact ventricular septum	Enrichment	TPM1	2.48
20	Myopathy, distal, with anterior tibial onset	Enrichment	DYSF	2.48
21	Congenital myopathy 23	Enrichment	TPM2	2.48
22	Congenital myopathy 4b, autosomal recessive	Enrichment	TPM3	2.48
23	Megacystis-microcolon-intestinal hypoperistalsis syndrome 5	Enrichment	ACTG2	2.48
24	Bleeding disorder, platelet-type, 25	Enrichment	TPM4	2.48
25	Neurodevelopmental disorder with speech impairment and with or without seizures	Enrichment	CACNA1I	2.48
26	Knobloch syndrome 2	Enrichment	PAK2	2.48
27	Intellectual developmental disorder with macrocephaly, seizures, and speech delay	Enrichment	PAK1	2.48
28	Alcohol sensitivity, acute	Enrichment	ALDH2	2.48
29	Cardiomyopathy, dilated, 1w	Enrichment	VCL	2.48
30	Epilepsy, childhood absence 6	Enrichment	CACNA1H	2.48
31	Visceral neuropathy, familial, 3, autosomal dominant	Enrichment	ACTG2	2.48
32	Cardiomyopathy, familial hypertrophic, 15	Enrichment	VCL	2.48
33	Moyamoya disease 6 with or without achalasia	Enrichment	GUCY1A1	2.48
34	Long qt syndrome 16	Enrichment	CALM3	2.48
35	Autosomal dominant familial visceral neuropathy	Enrichment	ACTG2	2.48
36	Spinocerebellar ataxia 42	Enrichment	CACNA1G	2.48
37	Spinocerebellar ataxia 42, early-onset, severe, with neurodevelopmental deficits	Enrichment	CACNA1G	2.48
38	Hyperaldosteronism, familial, type iv	Enrichment	CACNA1H	2.48
39	Moyamoya disease with early-onset achalasia	Enrichment	GUCY1A1	2.48
40	Megacystis-microcolon-intestinal hypoperistalsis syndrome 3	Enrichment	LMOD1	2.48
41	Long qt syndrome 15	Enrichment	CALM2	2.48
42	Conn's syndrome	Enrichment	CACNA1H	2.48
43	Capillary leak syndrome	Enrichment	TLN1	2.48
44	Myopathic intestinal pseudoobstruction	Enrichment	ACTG2	2.48
45	Congenital generalized hypercontractile muscle stiffness syndrome	Enrichment	TPM3	2.48
46	Actg2 visceral myopathy	Enrichment	ACTG2	2.48
47	Congenital myopathy, paradas type	Enrichment	DYSF	2.48
48	Familial hypertrophic cardiomyopathy	Enrichment	CAV3, TPM1	2.27
49	Aortic aneurysm, familial thoracic 4	Enrichment	MYH11	2.18
50	Miyoshi muscular dystrophy 1	Enrichment	DYSF	2.18
51	Aortic aneurysm, familial thoracic 2	Enrichment	ACTA2	2.18
52	Ventricular tachycardia, catecholaminergic polymorphic, 4	Enrichment	CALM1	2.18
53	Smooth muscle dysfunction syndrome	Enrichment	ACTA2	2.18
54	Aortic aneurysm, familial thoracic 6	Enrichment	ACTA2	2.18
55	Moyamoya disease 5	Enrichment	ACTA2	2.18
56	Long qt syndrome 14	Enrichment	CALM1	2.18
57	Amed syndrome, digenic	Enrichment	ALDH2	2.18
58	Megacystis-microcolon-intestinal hypoperistalsis syndrome 2	Enrichment	MYH11	2.18
59	Visceral myopathy 2	Enrichment	MYH11	2.18
60	Arthrogryposis, distal, type 1c	Enrichment	MYL11	2.18
61	Megacystis-microcolon-intestinal hypoperistalsis syndrome 4	Enrichment	MYL9	2.18
62	Qualitative or quantitative defects of caveolin-3	Enrichment	CAV3	2.18
63	Intestinal obstruction	Enrichment	ACTG2	2.18
64	Distal arthrogryposis	Enrichment	MYL11, TPM2	2.07
65	Rippling muscle disease 2	Enrichment	CAV3	2.00
66	Long qt syndrome 9	Enrichment	CAV3	2.00
67	Aortic aneurysm, familial thoracic 7	Enrichment	MYLK	2.00
68	Myopathy, distal, tateyama type	Enrichment	CAV3	2.00
69	Tricuspid valve insufficiency	Enrichment	MYH11	2.00
70	Dysferlinopathy	Enrichment	DYSF	2.00
71	Autoimmune lymphoproliferative syndrome	Enrichment	ACTA2	1.88
72	Acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22)	Enrichment	MYH11	1.88
73	Knobloch syndrome	Enrichment	PAK2	1.88
74	Mitral valve insufficiency	Enrichment	MYH11	1.88
75	Intermediate nemaline myopathy	Enrichment	TPM3	1.88
76	Familial isolated dilated cardiomyopathy	Enrichment	TPM1, VCL	1.88
77	Arthrogryposis, distal, type 2b1	Enrichment	TPM2	1.78
78	Knobloch syndrome 1	Enrichment	PAK2	1.78
79	Autosomal recessive limb-girdle muscular dystrophy type 2b	Enrichment	DYSF	1.78
80	Atrial septal defect 1	Enrichment	TPM1	1.70
81	Alcohol dependence	Enrichment	ALDH2	1.70
82	Ventricular tachycardia, catecholaminergic polymorphic, 1, with or without atrial dysfunction and/or dilated cardiomyopathy	Enrichment	CALM1	1.70
83	Typical nemaline myopathy	Enrichment	TPM2	1.70
84	Childhood absence epilepsy	Enrichment	CACNA1H	1.70
85	Arthrogryposis, distal, type 1a	Enrichment	TPM2	1.58
86	Myopathy, tubular aggregate, 1	Enrichment	CAV3	1.58
87	Catecholaminergic polymorphic ventricular tachycardia 1	Enrichment	CALM1	1.58
88	Dilated cardiomyopathy	Enrichment	TPM1, VCL	1.54
89	Primary hyperaldosteronism	Enrichment	CACNA1H	1.53
90	Autosomal dominant macrothrombocytopenia	Enrichment	TPM4	1.49
91	Epilepsy, idiopathic generalized	Enrichment	CACNA1H	1.44
92	Muscular dystrophy, limb-girdle, autosomal recessive 2	Enrichment	DYSF	1.41
93	Lung cancer susceptibility 3	Enrichment	ACTA2	1.34
94	Myopia	Enrichment	MYH11	1.31
95	Creatine phosphokinase, elevated serum	Enrichment	CAV3	1.29
96	Isolated elevated serum creatine phosphokinase levels	Enrichment	CAV3	1.29
97	Cardiomyopathy, dilated, 1e	Enrichment	TPM1	1.26
98	Autosomal recessive limb-girdle muscular dystrophy	Enrichment	DYSF	1.21
99	Centronuclear myopathy	Enrichment	TPM3	1.17
100	Myocardial infarction	Enrichment	GUCY1A1	1.15
101	Muscular dystrophy	Enrichment	DYSF	1.12
102	Tetralogy of fallot	Enrichment	TPM1	1.08
103	Lung cancer	Enrichment	ACTA2	1.00
104	Connective tissue disease	Enrichment	ACTA2	1.00
105	Left ventricular noncompaction	Enrichment	TPM1	0.96
106	Myopathy	Enrichment	TPM3	0.90
107	Hypertrophic cardiomyopathy	Enrichment	TPM1	0.88
108	Autosomal dominant non-syndromic intellectual disability	Enrichment	CACNA1I	0.81
109	Spastic ataxia	Enrichment	CACNA1G	0.79

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Smooth Muscle Contraction

Pathway Network for Smooth Muscle Contraction

Member Pathways for Smooth Muscle Contraction

Pathways in the Smooth Muscle Contraction SuperPath

Associated Genes for Smooth Muscle Contraction

Associated Disorders for Smooth Muscle Contraction

Disorders associated with Smooth Muscle Contraction SuperPath

STRING Interaction Network for Smooth Muscle Contraction

Sources for Smooth Muscle Contraction