Somatroph axis (GH) and its relationship to dietary restriction and aging

No Pathway Network information available for Somatroph axis (GH) and its relationship to dietary restriction and aging

#	Name	Source	Genes
1	Somatroph axis (GH) and its relationship to dietary restriction and aging	WikiPathways	AKT1 FOXO1 IGF1R MTOR SIRT1

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	IGF1R	Insulin Like Growth Factor 1 Receptor	Protein Coding	1
2	MTOR	Mechanistic Target Of Rapamycin Kinase	Protein Coding	1
3	SIRT1	Sirtuin 1	Protein Coding	1
4	FOXO1	Forkhead Box O1	Protein Coding	1
5	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	1

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Proteus syndrome	Enrichment	AKT1	3.43
2	Cowden syndrome 6	Enrichment	AKT1	3.43
3	Cebalid syndrome	Enrichment	MTOR	3.13
4	Smith-kingsmore syndrome	Enrichment	MTOR	3.13
5	Growth delay due to insulin-like growth factor i resistance	Enrichment	IGF1R	2.96
6	Focal cortical dysplasia, type ii	Enrichment	MTOR	2.83
7	Isolated focal cortical dysplasia type ii	Enrichment	MTOR	2.83
8	Rhabdomyosarcoma 2	Enrichment	FOXO1	2.73
9	Insulin-like growth factor i	Enrichment	IGF1R	2.73
10	Hemimegalencephaly	Enrichment	MTOR	2.73
11	Breast adenocarcinoma	Enrichment	AKT1	2.66
12	Renal cell carcinoma, papillary, 1	Enrichment	MTOR	2.59
13	Overgrowth syndrome	Enrichment	MTOR	2.59
14	Cowden syndrome	Enrichment	AKT1	2.48
15	Meningioma	Enrichment	AKT1	2.35
16	Nk-cell enteropathy	Enrichment	IGF1R	2.32
17	Renal cell carcinoma, nonpapillary	Enrichment	MTOR	2.26
18	Rare genetic intellectual disability	Enrichment	MTOR	2.26
19	Diffuse large b-cell lymphoma	Enrichment	FOXO1	2.16
20	Hereditary breast carcinoma	Enrichment	AKT1	1.79
21	Breast cancer	Enrichment	AKT1	1.56
22	Colorectal cancer	Enrichment	AKT1	1.50
23	Ovarian cancer	Enrichment	AKT1	1.44
24	Microcephaly	Enrichment	IGF1R	1.35

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Pathway Network for Somatroph axis (GH) and its relationship to dietary restriction and aging