Sotorasib Pathway, Pharmacokinetics/Pharmacodynamics

No Pathway Network information available for Sotorasib Pathway, Pharmacokinetics/Pharmacodynamics

Pathways in the Sotorasib Pathway, Pharmacokinetics/Pharmacodynamics SuperPath

#	Name	Source	Genes
1	Sotorasib Pathway, Pharmacokinetics/Pharmacodynamics	PharmGKB	CYP2C8 CYP3A4 GGT1 GGT2P GGT5 GGT6 GGT7 KRAS (see all 8) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	KRAS	KRAS Proto-Oncogene, GTPase	Protein Coding	1
2	CYP2C8	Cytochrome P450 Family 2 Subfamily C Member 8	Protein Coding	1
3	CYP3A4	Cytochrome P450 Family 3 Subfamily A Member 4	Protein Coding	1
4	GGT7	Gamma-Glutamyltransferase 7	Protein Coding	1
5	GGT1	Gamma-Glutamyltransferase 1	Protein Coding	1
6	GGT6	Gamma-Glutamyltransferase 6	Protein Coding	1
7	GGT5	Gamma-Glutamyltransferase 5	Protein Coding	1
8	GGT2P	Gamma-Glutamyltransferase 2, Pseudogene	Pseudogene	1

Disorders associated with Sotorasib Pathway, Pharmacokinetics/Pharmacodynamics SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Oculoectodermal syndrome	Enrichment	KRAS	3.23
2	Glutathionuria	Enrichment	GGT1	3.23
3	Drug metabolism, altered, cyp2c8-related	Enrichment	CYP2C8	3.23
4	Cardiofaciocutaneous syndrome 2	Enrichment	KRAS	3.23
5	Vitamin d-dependent rickets, type 3	Enrichment	CYP3A4	3.23
6	Congenital pulmonary airway malformation	Enrichment	KRAS	3.23
7	Encephalocraniocutaneous lipomatosis	Enrichment	KRAS	2.93
8	Ras-associated autoimmune leukoproliferative disorder	Enrichment	KRAS	2.93
9	Cerebral dysgenesis, neuropathy, ichthyosis, and palmoplantar keratoderma syndrome	Enrichment	GGT2P	2.93
10	Schimmelpenning-feuerstein-mims syndrome	Enrichment	KRAS	2.63
11	Cardiofaciocutaneous syndrome 1	Enrichment	KRAS	2.63
12	Diffuse gastric and lobular breast cancer syndrome	Enrichment	KRAS	2.63
13	Cardiofaciocutaneous syndrome	Enrichment	KRAS	2.63
14	Lung sarcomatoid carcinoma	Enrichment	KRAS	2.63
15	Chronic myelogenous leukemia, bcr-abl1 positive	Enrichment	KRAS	2.63
16	Pilocytic astrocytoma	Enrichment	KRAS	2.63
17	Breast adenocarcinoma	Enrichment	KRAS	2.45
18	Lung squamous cell carcinoma	Enrichment	KRAS	2.45
19	Nevus, epidermal	Enrichment	KRAS	2.38
20	Capillary malformation-arteriovenous malformation 1	Enrichment	KRAS	2.38
21	Leukemia, chronic myeloid	Enrichment	KRAS	2.38
22	Noonan syndrome 3	Enrichment	KRAS	2.38
23	Gallbladder cancer	Enrichment	KRAS	2.38
24	Pilomyxoid astrocytoma	Enrichment	KRAS	2.38
25	Lung non-small cell carcinoma	Enrichment	KRAS	2.19
26	Juvenile myelomonocytic leukemia	Enrichment	KRAS	2.15
27	Lung cancer susceptibility 3	Enrichment	KRAS	2.08
28	Lynch syndrome	Enrichment	KRAS	2.05
29	Noonan syndrome and noonan-related syndrome	Enrichment	KRAS	2.05
30	Arteriovenous malformations of the brain	Enrichment	KRAS	1.95
31	Noonan syndrome 1	Enrichment	KRAS	1.87
32	Pancreatic cancer	Enrichment	KRAS	1.83
33	Rasopathy	Enrichment	KRAS	1.82
34	Bladder cancer	Enrichment	KRAS	1.77
35	Differentiated thyroid carcinoma	Enrichment	KRAS	1.77
36	Non-immune hydrops fetalis	Enrichment	KRAS	1.74
37	Lung cancer	Enrichment	KRAS	1.73
38	Leukemia, acute myeloid	Enrichment	KRAS	1.63
39	Gastric cancer	Enrichment	KRAS	1.60
40	Hereditary breast carcinoma	Enrichment	KRAS	1.59
41	Hereditary breast ovarian cancer syndrome	Enrichment	KRAS	1.50
42	Myeloma, multiple	Enrichment	KRAS	1.49
43	Breast cancer	Enrichment	KRAS	1.36
44	Ovarian cancer	Enrichment	KRAS	1.24

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Sotorasib Pathway, Pharmacokinetics/Pharmacodynamics

Pathway Network for Sotorasib Pathway, Pharmacokinetics/Pharmacodynamics

Member Pathways for Sotorasib Pathway, Pharmacokinetics/Pharmacodynamics

Pathways in the Sotorasib Pathway, Pharmacokinetics/Pharmacodynamics SuperPath

Associated Genes for Sotorasib Pathway, Pharmacokinetics/Pharmacodynamics

Associated Disorders for Sotorasib Pathway, Pharmacokinetics/Pharmacodynamics

Disorders associated with Sotorasib Pathway, Pharmacokinetics/Pharmacodynamics SuperPath

STRING Interaction Network for Sotorasib Pathway, Pharmacokinetics/Pharmacodynamics

Sources for Sotorasib Pathway, Pharmacokinetics/Pharmacodynamics