Sphingolipid metabolism

Pathway network for the Sphingolipid metabolism SuperPath

Sources:

Reactome
WikiPathways
PubChem

Pathways in the Sphingolipid metabolism SuperPath

#	Name	Source	Genes
1	Sphingolipid metabolism	Reactome	A4GALT ABCC1 ABCG2 ACER1 ACER2 ACER3 ALDH3A2 ALDH3B1 ALDH3B2 ARSA ARSB ARSD ARSF ARSG ARSH ARSI ARSJ ARSK ARSL ASAH1 ASAH2 B3GALNT1 B3GALT4 B3GNT5 B4GALNT1 B4GALT5 B4GALT6 CERK CERS1 CERS2 CERS3 CERS4 CERS5 CERS6 CERT1 CSNK1G2 CTSA CYB5B DEGS1 DEGS2 ENPP7 FA2H FUT1 FUT2 GAL3ST1 GALC GBA1 GBA2 GBA3 GLA GLB1 GLB1L GLB1L2 GLB1L3 GM2A HEXA HEXB KDSR M6PR MFSD2B NEU1 NEU2 NEU3 NEU4 ORMDL1 ORMDL2 ORMDL3 OSBP PLPP1 PLPP2 PLPP3 PPM1L PRKD1 PRKD2 PRKD3 PSAP SAMD8 SGMS1 SGMS2 SGPL1 SGPP1 SGPP2 SMPD1 SMPD2 SMPD3 SMPD4 SPHK1 SPHK2 SPNS2 SPTLC1 SPTLC2 SPTLC3 SPTSSA SPTSSB ST3GAL2 ST3GAL3 ST3GAL5 ST6GALNAC5 ST6GALNAC6 ST8SIA5 STS SUMF1 SUMF2 UGCG UGT8 VAPA VAPB (see all 107) (see less)
2	Glycosphingolipid metabolism	Reactome	A4GALT ARSA ARSB ARSD ARSF ARSG ARSH ARSI ARSJ ARSK ARSL ASAH1 ASAH2 B3GALNT1 B3GALT4 B3GNT5 B4GALNT1 B4GALT5 B4GALT6 CERK CTSA ENPP7 FUT1 FUT2 GAL3ST1 GALC GBA1 GBA2 GBA3 GLA GLB1 GLB1L GLB1L2 GLB1L3 GM2A HEXA HEXB M6PR NEU1 NEU2 NEU3 NEU4 PSAP SMPD1 SMPD2 SMPD3 SMPD4 ST3GAL2 ST3GAL3 ST3GAL5 ST6GALNAC5 ST6GALNAC6 ST8SIA5 STS SUMF1 SUMF2 UGCG UGT8 (see all 58) (see less)
3	Glycosphingolipid catabolism	Reactome	ARSA ARSB ARSD ARSF ARSG ARSH ARSI ARSJ ARSK ARSL ASAH1 ASAH2 CTSA ENPP7 GALC GBA1 GBA2 GBA3 GLA GLB1 GLB1L GLB1L2 GLB1L3 GM2A HEXA HEXB M6PR NEU1 NEU2 NEU3 NEU4 PSAP SMPD1 SMPD2 SMPD3 SMPD4 STS SUMF1 SUMF2 (see all 39) (see less)
4	Sphingolipid de novo biosynthesis	Reactome	ABCC1 ABCG2 CERS1 CERS2 CERS3 CERS4 CERS5 CERS6 CERT1 CSNK1G2 CYB5B DEGS1 DEGS2 FA2H KDSR MFSD2B ORMDL1 ORMDL2 ORMDL3 OSBP PPM1L PRKD1 PRKD2 PRKD3 SAMD8 SGMS1 SGMS2 SPHK1 SPHK2 SPNS2 SPTLC1 SPTLC2 SPTLC3 SPTSSA SPTSSB VAPA VAPB (see all 37) (see less)
5	Glycosphingolipid biosynthesis	Reactome	A4GALT B3GALNT1 B3GALT4 B3GNT5 B4GALNT1 B4GALT5 B4GALT6 CERK FUT1 FUT2 GAL3ST1 ST3GAL2 ST3GAL3 ST3GAL5 ST6GALNAC5 ST6GALNAC6 ST8SIA5 UGCG UGT8 (see all 19) (see less)
6	The activation of arylsulfatases	Reactome	ARSA ARSB ARSD ARSF ARSG ARSH ARSI ARSJ ARSK ARSL STS SUMF1 SUMF2 (see all 13) (see less)
7	Sphingolipid catabolism	Reactome	ACER1 ACER2 ACER3 ALDH3A2 ALDH3B1 ALDH3B2 PLPP1 PLPP2 PLPP3 SGPL1 SGPP1 SGPP2 (see all 12) (see less)
8	Biosynthesis and turnover of 1-deoxy-sphingoid bases	WikiPathways	ASAH1 KDSR SGPP1 SGPP2 SPHK1 SPHK2 SPTLC1 SPTLC2 (see all 8) (see less)
9	Sphingolipid metabolism overview	WikiPathways	KDSR SGMS2 SMPD1 UGCG
10	gala-series glycosphingolipids biosynthesis	PubChem	GAL3ST1 ST3GAL5 UGT8
11	Sphingolipid metabolism: integrated pathway	WikiPathways	PLPP2

Gene overlap in member pathways for Sphingolipid metabolism SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	ARSK	Arylsulfatase Family Member K	Protein Coding	4
2	ARSG	Arylsulfatase G	Protein Coding	4
3	KDSR	3-Ketodihydrosphingosine Reductase	Protein Coding	4
4	SUMF2	Sulfatase Modifying Factor 2	Protein Coding	4
5	SUMF1	Sulfatase Modifying Factor 1	Protein Coding	4
6	ARSI	Arylsulfatase Family Member I	Protein Coding	4
7	ARSH	Arylsulfatase Family Member H	Protein Coding	4
8	ARSA	Arylsulfatase A	Protein Coding	4
9	ARSB	Arylsulfatase B	Protein Coding	4
10	STS	Steroid Sulfatase	Protein Coding	4
11	ARSD	Arylsulfatase D	Protein Coding	4
12	ARSL	Arylsulfatase L	Protein Coding	4
13	ARSF	Arylsulfatase F	Protein Coding	4
14	ASAH1	N-Acylsphingosine Amidohydrolase 1	Protein Coding	4
15	SMPD1	Sphingomyelin Phosphodiesterase 1	Protein Coding	4
16	UGCG	UDP-Glucose Ceramide Glucosyltransferase	Protein Coding	4
17	UGT8	UDP Glycosyltransferase 8	Protein Coding	4
18	ARSJ	Arylsulfatase Family Member J	Protein Coding	4
19	ST3GAL5	ST3 Beta-Galactoside Alpha-2,3-Sialyltransferase 5	Protein Coding	4
20	GAL3ST1	Galactose-3-O-Sulfotransferase 1	Protein Coding	4
21	SPTLC1	Serine Palmitoyltransferase Long Chain Base Subunit 1	Protein Coding	3
22	NEU3	Neuraminidase 3	Protein Coding	3
23	GLB1L3	Galactosidase Beta 1 Like 3	Protein Coding	3
24	NEU4	Neuraminidase 4	Protein Coding	3
25	SGPP2	Sphingosine-1-Phosphate Phosphatase 2	Protein Coding	3
26	SGMS2	Sphingomyelin Synthase 2	Protein Coding	3
27	FUT1	Fucosyltransferase 1 (H Blood Group)	Protein Coding	3
28	FUT2	Fucosyltransferase 2 (H Blood Group)	Protein Coding	3
29	GALC	Galactosylceramidase	Protein Coding	3
30	B4GALNT1	Beta-1,4-N-Acetyl-Galactosaminyltransferase 1	Protein Coding	3
31	GBA1	Glucosylceramidase Beta 1	Protein Coding	3
32	GLA	Galactosidase Alpha	Protein Coding	3
33	GLB1	Galactosidase Beta 1	Protein Coding	3
34	GM2A	Ganglioside GM2 Activator	Protein Coding	3
35	ST8SIA5	ST8 Alpha-N-Acetyl-Neuraminide Alpha-2,8-Sialyltransferase 5	Protein Coding	3
36	HEXA	Hexosaminidase Subunit Alpha	Protein Coding	3
37	HEXB	Hexosaminidase Subunit Beta	Protein Coding	3
38	ST6GALNAC6	ST6 N-Acetylgalactosaminide Alpha-2,6-Sialyltransferase 6	Protein Coding	3
39	ENPP7	Ectonucleotide Pyrophosphatase/Phosphodiesterase 7	Protein Coding	3
40	M6PR	Mannose-6-Phosphate Receptor, Cation Dependent	Protein Coding	3
41	NEU1	Neuraminidase 1	Protein Coding	3
42	NEU2	Neuraminidase 2	Protein Coding	3
43	A4GALT	Alpha 1,4-Galactosyltransferase (P1PK Blood Group)	Protein Coding	3
44	CTSA	Cathepsin A	Protein Coding	3
45	SMPD3	Sphingomyelin Phosphodiesterase 3	Protein Coding	3
46	SMPD4	Sphingomyelin Phosphodiesterase 4	Protein Coding	3
47	PSAP	Prosaposin	Protein Coding	3
48	ASAH2	N-Acylsphingosine Amidohydrolase 2	Protein Coding	3
49	SPHK2	Sphingosine Kinase 2	Protein Coding	3
50	GBA2	Glucosylceramidase Beta 2	Protein Coding	3
51	GBA3	Glucosylceramidase Beta 3 (Gene/Pseudogene)	Protein Coding	3
52	CERK	Ceramide Kinase	Protein Coding	3
53	ST3GAL2	ST3 Beta-Galactoside Alpha-2,3-Sialyltransferase 2	Protein Coding	3
54	ST3GAL3	ST3 Beta-Galactoside Alpha-2,3-Sialyltransferase 3	Protein Coding	3
55	SMPD2	Sphingomyelin Phosphodiesterase 2	Protein Coding	3
56	GLB1L	Galactosidase Beta 1 Like	Protein Coding	3
57	SGPP1	Sphingosine-1-Phosphate Phosphatase 1	Protein Coding	3
58	ST6GALNAC5	ST6 N-Acetylgalactosaminide Alpha-2,6-Sialyltransferase 5	Protein Coding	3
59	B3GNT5	UDP-GlcNAc:BetaGal Beta-1,3-N-Acetylglucosaminyltransferase 5	Protein Coding	3
60	PLPP2	Phospholipid Phosphatase 2	Protein Coding	3
61	B3GALT4	Beta-1,3-Galactosyltransferase 4	Protein Coding	3
62	B3GALNT1	Beta-1,3-N-Acetylgalactosaminyltransferase 1 (Globoside Blood Group)	Protein Coding	3
63	SPHK1	Sphingosine Kinase 1	Protein Coding	3
64	GLB1L2	Galactosidase Beta 1 Like 2	Protein Coding	3
65	B4GALT6	Beta-1,4-Galactosyltransferase 6	Protein Coding	3
66	B4GALT5	Beta-1,4-Galactosyltransferase 5	Protein Coding	3
67	SPTLC2	Serine Palmitoyltransferase Long Chain Base Subunit 2	Protein Coding	3
68	CERT1	Ceramide Transporter 1	Protein Coding	2
69	CERS1	Ceramide Synthase 1	Protein Coding	2
70	DEGS2	Delta 4-Desaturase, Sphingolipid 2	Protein Coding	2
71	SPNS2	SPNS Lysolipid Transporter 2, Sphingosine-1-Phosphate	Protein Coding	2
72	ACER1	Alkaline Ceramidase 1	Protein Coding	2
73	SAMD8	Sterile Alpha Motif Domain Containing 8	Protein Coding	2
74	CSNK1G2	Casein Kinase 1 Gamma 2	Protein Coding	2
75	PPM1L	Protein Phosphatase, Mg2+/Mn2+ Dependent 1L	Protein Coding	2
76	SPTSSB	Serine Palmitoyltransferase Small Subunit B	Protein Coding	2
77	SPTSSA	Serine Palmitoyltransferase Small Subunit A	Protein Coding	2
78	CERS3	Ceramide Synthase 3	Protein Coding	2
79	ALDH3B1	Aldehyde Dehydrogenase 3 Family Member B1	Protein Coding	2
80	ALDH3B2	Aldehyde Dehydrogenase 3 Family Member B2	Protein Coding	2
81	ALDH3A2	Aldehyde Dehydrogenase 3 Family Member A2	Protein Coding	2
82	PRKD3	Protein Kinase D3	Protein Coding	2
83	CERS6	Ceramide Synthase 6	Protein Coding	2
84	PRKD2	Protein Kinase D2	Protein Coding	2
85	SGMS1	Sphingomyelin Synthase 1	Protein Coding	2
86	ORMDL2	ORMDL Sphingolipid Biosynthesis Regulator 2	Protein Coding	2
87	CERS2	Ceramide Synthase 2	Protein Coding	2
88	ACER2	Alkaline Ceramidase 2	Protein Coding	2
89	MFSD2B	MFSD2 Lysolipid Transporter B, Sphingolipid	Protein Coding	2
90	ABCC1	ATP Binding Cassette Subfamily C Member 1 (ABCC1 Blood Group)	Protein Coding	2
91	OSBP	Oxysterol Binding Protein~Name Same As:- HGNC:17242	Protein Coding	2
92	SPTLC3	Serine Palmitoyltransferase Long Chain Base Subunit 3	Protein Coding	2
93	ACER3	Alkaline Ceramidase 3	Protein Coding	2
94	PRKD1	Protein Kinase D1	Protein Coding	2
95	FA2H	Fatty Acid 2-Hydroxylase	Protein Coding	2
96	CERS4	Ceramide Synthase 4	Protein Coding	2
97	CYB5B	Cytochrome B5 Type B	Protein Coding	2
98	DEGS1	Delta 4-Desaturase, Sphingolipid 1	Protein Coding	2
99	PLPP1	Phospholipid Phosphatase 1	Protein Coding	2
100	PLPP3	Phospholipid Phosphatase 3	Protein Coding	2
101	SGPL1	Sphingosine-1-Phosphate Lyase 1	Protein Coding	2
102	CERS5	Ceramide Synthase 5	Protein Coding	2
103	VAPB	VAMP Associated Protein B And C	Protein Coding	2
104	VAPA	VAMP Associated Protein A	Protein Coding	2
105	ORMDL1	ORMDL Sphingolipid Biosynthesis Regulator 1	Protein Coding	2
106	ORMDL3	ORMDL Sphingolipid Biosynthesis Regulator 3	Protein Coding	2
107	ABCG2	ATP Binding Cassette Subfamily G Member 2 (JR Blood Group)	Protein Coding	2

Disorders associated with Sphingolipid metabolism SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Metachromatic leukodystrophy	Enrichment	ARSA, ARSB, PSAP	6.36
2	Blood group, p1pk system	Enrichment	A4GALT, B3GALNT1	5.73
3	Bombay phenotype	Enrichment	FUT1, FUT2	5.73
4	Multiple sulfatase deficiency	Enrichment	SUMF1, SUMF2	5.59
5	Hereditary sensory and autonomic neuropathy type 1	Enrichment	SPTLC1, SPTLC2	5.20
6	Gm2-gangliosidosis, ab variant	Enrichment	GM2A, HEXA	5.09
7	Leukodystrophy	Enrichment	ARSA, DEGS1, GALC, HEXA	4.79
8	Tay-sachs disease	Enrichment	GM2A, HEXA	4.62
9	Krabbe disease	Enrichment	GALC, PSAP	4.32
10	Fabry disease	Enrichment	GALC, GLA	4.10
11	Acid sphingomyelinase deficiency	Enrichment	SMPD1	3.53
12	Erythrokeratodermia variabilis et progressiva 4	Enrichment	KDSR	3.53
13	Salt and pepper developmental regression syndrome	Enrichment	ST3GAL5	3.35
14	Salt and pepper syndrome	Enrichment	ST3GAL5	3.35
15	Spastic ataxia	Enrichment	ARSA, GALC, GLB1	3.33
16	Calvarial doughnut lesions with bone fragility	Enrichment	SGMS2	3.23
17	Neuropathy, hereditary sensory and autonomic, type ia	Enrichment	SPTLC1	3.23
18	Keloid formation	Enrichment	ASAH1	3.23
19	Amyotrophic lateral sclerosis 27, juvenile	Enrichment	SPTLC1	3.23
20	Neuropathy, hereditary sensory and autonomic, type ic	Enrichment	SPTLC2	3.23
21	Asah1-related disorders	Enrichment	ASAH1	3.23
22	Niemann-pick disease, type a	Enrichment	SMPD1	3.05
23	Niemann-pick disease, type b	Enrichment	SMPD1	3.05
24	Ceroid lipofuscinosis, neuronal, 6a	Enrichment	SMPD1	3.05
25	Leukodystrophy, progressive, early childhood-onset	Enrichment	ACER3	3.05
26	Reni syndrome	Enrichment	SGPL1	3.05
27	Alkaline ceramidase 3 deficiency	Enrichment	ACER3	3.05
28	Chondrodysplasia punctata, brachytelephalangic, autosomal	Enrichment	ARSL	3.02
29	Chondrodysplasia punctata 1, x-linked recessive	Enrichment	ARSL	3.02
30	Mucopolysaccharidosis, type x	Enrichment	ARSK	3.02
31	X-linked chondrodysplasia punctata 1	Enrichment	ARSL	3.02
32	Syndromic recessive x-linked ichthyosis	Enrichment	STS	3.02
33	Autosomal recessive spastic paraplegia type 66	Enrichment	ARSI	3.02
34	Spinal muscular atrophy with progressive myoclonic epilepsy	Enrichment	ASAH1	2.93
35	Farber lipogranulomatosis	Enrichment	ASAH1	2.93
36	Parkinson's disease	Enrichment	GBA1, PSAP	2.87
37	Spastic paraplegia 26, autosomal recessive	Enrichment	B4GALNT1	2.85
38	Intellectual developmental disorder, autosomal recessive 12	Enrichment	ST3GAL3	2.85
39	Blood group, globoside system	Enrichment	B3GALNT1	2.85
40	St3gal3-cdg	Enrichment	ST3GAL3	2.85
41	Niemann-pick disease, type c1	Enrichment	SMPD1	2.83
42	Niemann-pick disease	Enrichment	SMPD1	2.83
43	Sjogren-larsson syndrome	Enrichment	ALDH3A2	2.75
44	Usher syndrome, type iv	Enrichment	ARSG	2.72
45	Ichthyosis, x-linked	Enrichment	STS	2.72
46	Parkinson disease, late-onset	Enrichment	GBA1, PSAP	2.67
47	Erythrokeratodermia variabilis et progressiva 1	Enrichment	KDSR	2.63
48	Hydrops fetalis, nonimmune	Enrichment	CTSA, NEU1	2.60
49	Uric acid concentration, serum, quantitative trait locus 1	Enrichment	ABCG2	2.56
50	Ichthyosis, congenital, autosomal recessive 9	Enrichment	CERS3	2.56
51	Spinal muscular atrophy, late-onset, finkel type	Enrichment	VAPB	2.56
52	Leukodystrophy, hypomyelinating, 18	Enrichment	DEGS1	2.56
53	Deafness, autosomal dominant 77	Enrichment	ABCC1	2.56
54	Amyotrophic lateral sclerosis 8	Enrichment	VAPB	2.56
55	Spastic paraplegia 90a, autosomal dominant	Enrichment	SPTSSA	2.56
56	Congenital heart defects and ectodermal dysplasia	Enrichment	PRKD1	2.56
57	Blood group, junior system	Enrichment	ABCG2	2.56
58	Deafness, autosomal recessive 115	Enrichment	SPNS2	2.56
59	Autosomal dominant adult-onset proximal spinal muscular atrophy	Enrichment	VAPB	2.56
60	Spastic paraplegia 90b, autosomal recessive	Enrichment	SPTSSA	2.56
61	Malignant epithelial tumor of salivary glands	Enrichment	PRKD1	2.56
62	Vitamin b12 plasma level quantitative trait locus 1	Enrichment	FUT2	2.55
63	Developmental and epileptic encephalopathy 15	Enrichment	ST3GAL3	2.55
64	Mucopolysaccharidosis, type vi	Enrichment	ARSB	2.54
65	Neurologic, endocrine, and pancreatic disease, multisystem, infantile-onset 2	Enrichment	ARSA	2.54
66	Metachromatic leukodystrophy due to saposin b deficiency	Enrichment	PSAP	2.54
67	Neuraminidase deficiency	Enrichment	NEU1	2.54
68	Neurodevelopmental disorder with microcephaly, arthrogryposis, and structural brain anomalies	Enrichment	SMPD4	2.54
69	Sandhoff disease	Enrichment	HEXB	2.54
70	Parkinson disease 24, autosomal dominant	Enrichment	PSAP	2.54
71	Gaucher disease, atypical, due to saposin c deficiency	Enrichment	PSAP	2.54
72	Krabbe disease, atypical, due to saposin a deficiency	Enrichment	PSAP	2.54
73	Autosomal recessive cerebellar ataxia with late-onset spasticity	Enrichment	GBA2	2.54
74	Glb1-related disorders	Enrichment	GLB1	2.54
75	Cathepsin a-related arteriopathy-strokes-leukoencephalopathy	Enrichment	CTSA	2.54
76	Congenital nervous system abnormality	Enrichment	ARSA, ASAH1, GALC	2.46
77	Nervous system disease	Enrichment	ARSA, ASAH1, GALC	2.46
78	Non-immune hydrops fetalis	Enrichment	CTSA, NEU1	2.45
79	Spinocerebellar ataxia 15	Enrichment	SUMF1	2.42
80	Caffey disease	Enrichment	A4GALT	2.38
81	Juvenile amyotrophic lateral sclerosis	Enrichment	SPTLC1	2.28
82	Spastic paraplegia 35, autosomal recessive, with or without neurodegeneration	Enrichment	FA2H	2.26
83	Neurodevelopmental disorder with hypotonia, speech delay, and dysmorphic facies	Enrichment	CERT1	2.26
84	Hereditary spastic paraplegia 35	Enrichment	FA2H	2.26
85	Epilepsy, progressive myoclonic, 8	Enrichment	CERS1	2.26
86	Spinocerebellar ataxia, autosomal recessive 16	Enrichment	SUMF1	2.24
87	Gaucher disease, type iiic	Enrichment	GBA1	2.24
88	Gaucher disease, perinatal lethal	Enrichment	GBA1	2.24
89	Gaucher disease, type iii	Enrichment	GBA1	2.24
90	Galactosialidosis	Enrichment	CTSA	2.24
91	Combined saposin deficiency	Enrichment	PSAP	2.24
92	Spastic paraplegia 46, autosomal recessive	Enrichment	GBA2	2.24
93	Combined psap deficiency	Enrichment	PSAP	2.24
94	Status epilepticus	Enrichment	GALC	2.24
95	Glycoproteinosis	Enrichment	NEU1	2.24
96	Combined deficiency of sialidase and beta galactosidase	Enrichment	CTSA	2.24
97	Usher syndrome, type iiia	Enrichment	ARSG	2.17
98	Rett syndrome, congenital variant	Enrichment	ARSJ	2.12
99	Right atrial isomerism	Enrichment	CERS1	2.09
100	Congenital heart defects, multiple types, 6	Enrichment	CERS1	2.09
101	Weill-marchesani syndrome 4	Enrichment	CERS3	2.09
102	Gm1-gangliosidosis, type i	Enrichment	GLB1	2.07
103	Mucopolysaccharidosis, type ivb	Enrichment	GLB1	2.07
104	Gaucher disease, type ii	Enrichment	GBA1	2.07
105	Gm1-gangliosidosis, type ii	Enrichment	GLB1	2.07
106	Gm1-gangliosidosis, type iii	Enrichment	GLB1	2.07
107	Gm1 gangliosidosis	Enrichment	GLB1	2.07
108	Gaucher's disease	Enrichment	GBA1	2.07
109	Beckwith-wiedemann syndrome	Enrichment	GALC, SPTLC1	2.06
110	Transposition of the great arteries	Enrichment	CERS1	1.96
111	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	SPTLC1, VAPB	1.96
112	Gaucher disease, type i	Enrichment	GBA1	1.94
113	Sensory peripheral neuropathy	Enrichment	SPTLC3	1.87
114	Coffin-siris syndrome 1	Enrichment	ARSL	1.85
115	Dementia, lewy body	Enrichment	GBA1	1.84
116	Amblyopia	Enrichment	GALC	1.84
117	Dementia	Enrichment	GBA1	1.84
118	Double outlet right ventricle	Enrichment	CERS1	1.79
119	Spondyloepiphyseal dysplasia with congenital joint dislocations	Enrichment	GLB1	1.77
120	Progressive familial intrahepatic cholestasis	Enrichment	GLB1	1.70
121	Parkinsonism	Enrichment	GBA1	1.70
122	Fetal akinesia deformation sequence 1	Enrichment	ASAH1	1.67
123	Charcot-marie-tooth disease	Enrichment	SPTLC1	1.62
124	Benign epilepsy with centrotemporal spikes	Enrichment	ASAH1	1.62
125	Distal arthrogryposis	Enrichment	ASAH1	1.61
126	Centralopathic epilepsy	Enrichment	ASAH1	1.60
127	Neurodegeneration with brain iron accumulation	Enrichment	FA2H	1.57
128	Congenital nonbullous ichthyosiform erythroderma	Enrichment	CERS3	1.57
129	Ichthyosis	Enrichment	CERS3	1.53
130	Usher syndrome	Enrichment	ARSG	1.51
131	Movement disease	Enrichment	GBA1	1.51
132	Cerebral palsy	Enrichment	ALDH3A2	1.47
133	Nephrotic syndrome	Enrichment	SGPL1	1.43
134	Autosomal recessive congenital ichthyosis	Enrichment	CERS3	1.40
135	Hereditary spastic paraplegia	Enrichment	FA2H, GBA2	1.36
136	Hypertension	Enrichment	GBA1	1.35
137	Heart, malformation of	Enrichment	CERS1	1.32
138	Developmental and epileptic encephalopathy	Enrichment	ST3GAL3	1.31
139	Visceral heterotaxy	Enrichment	CERS1	1.23
140	Skin disease	Enrichment	CERS3	1.23
141	Hepatoblastoma	Enrichment	GBA1	1.23
142	Tetralogy of fallot	Enrichment	CERS1	1.16
143	Strabismus	Enrichment	GALC	1.13
144	Visceral heterotaxy 5	Enrichment	CERS1	1.09
145	Peripheral nervous system disease	Enrichment	SPTLC3	1.08
146	Neuropathy	Enrichment	SPTLC3	1.08
147	Familial hypertrophic cardiomyopathy	Enrichment	GLA	1.04
148	Hypertrophic cardiomyopathy	Enrichment	GLA	0.93
149	Sensorineural hearing loss	Enrichment	SPNS2	0.91
150	Thrombocytopenia	Enrichment	GBA1	0.89
151	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	ABCC1	0.88
152	Complex neurodevelopmental disorder	Enrichment	CERT1	0.54

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Sphingolipid metabolism

Pathway Network for Sphingolipid metabolism

Pathway network for the Sphingolipid metabolism SuperPath

Member Pathways for Sphingolipid metabolism

Pathways in the Sphingolipid metabolism SuperPath

Gene overlap in member pathways for Sphingolipid metabolism SuperPath

Associated Genes for Sphingolipid metabolism

Associated Disorders for Sphingolipid metabolism

Disorders associated with Sphingolipid metabolism SuperPath

STRING Interaction Network for Sphingolipid metabolism

Sources for Sphingolipid metabolism