Sphingolipid metabolism in senescence

No Pathway Network information available for Sphingolipid metabolism in senescence

Pathways in the Sphingolipid metabolism in senescence SuperPath

#	Name	Source	Genes
1	Sphingolipid metabolism in senescence	WikiPathways	ASAH1 CDK2 CDK4 CERS2 CERS4 DEGS1 E2F1 GLB1 KDSR MAPK1 MTOR PRKCA PRKCB RB1 RPP38 S1PR1 S1PR2 S1PR5 SGMS2 SGPP1 SMPD3 SPHK1 SPTLC1 TERT UGCG (see all 25) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	UGCG	UDP-Glucose Ceramide Glucosyltransferase	Protein Coding	1
2	TERT	Telomerase Reverse Transcriptase	Protein Coding	1
3	KDSR	3-Ketodihydrosphingosine Reductase	Protein Coding	1
4	SPTLC1	Serine Palmitoyltransferase Long Chain Base Subunit 1	Protein Coding	1
5	PRKCA	Protein Kinase C Alpha	Protein Coding	1
6	PRKCB	Protein Kinase C Beta	Protein Coding	1
7	SGPP1	Sphingosine-1-Phosphate Phosphatase 1	Protein Coding	1
8	CERS4	Ceramide Synthase 4	Protein Coding	1
9	CERS2	Ceramide Synthase 2	Protein Coding	1
10	SGMS2	Sphingomyelin Synthase 2	Protein Coding	1
11	S1PR2	Sphingosine-1-Phosphate Receptor 2	Protein Coding	1
12	SPHK1	Sphingosine Kinase 1	Protein Coding	1
13	DEGS1	Delta 4-Desaturase, Sphingolipid 1	Protein Coding	1
14	RB1	RB Transcriptional Corepressor 1	Protein Coding	1
15	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	1
16	SMPD3	Sphingomyelin Phosphodiesterase 3	Protein Coding	1
17	S1PR5	Sphingosine-1-Phosphate Receptor 5	Protein Coding	1
18	ASAH1	N-Acylsphingosine Amidohydrolase 1	Protein Coding	1
19	GLB1	Galactosidase Beta 1	Protein Coding	1
20	MTOR	Mechanistic Target Of Rapamycin Kinase	Protein Coding	1
21	S1PR1	Sphingosine-1-Phosphate Receptor 1	Protein Coding	1
22	E2F1	E2F Transcription Factor 1	Protein Coding	1
23	RPP38	Ribonuclease P/MRP Subunit P38	Protein Coding	1
24	CDK4	Cyclin Dependent Kinase 4	Protein Coding	1
25	CDK2	Cyclin Dependent Kinase 2	Protein Coding	1

Disorders associated with Sphingolipid metabolism in senescence SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Melanoma, cutaneous malignant 1	Enrichment	CDK4, TERT	3.36
2	Bladder cancer	Enrichment	RB1, TERT	2.89
3	Neuropathy, hereditary sensory and autonomic, type ia	Enrichment	SPTLC1	2.73
4	Melanoma, cutaneous malignant 3	Enrichment	CDK4	2.73
5	Keloid formation	Enrichment	ASAH1	2.73
6	Noonan syndrome 13	Enrichment	MAPK1	2.73
7	Leukodystrophy, hypomyelinating, 18	Enrichment	DEGS1	2.73
8	Amyotrophic lateral sclerosis 27, juvenile	Enrichment	SPTLC1	2.73
9	Deafness, autosomal recessive 68	Enrichment	S1PR2	2.73
10	Erythrokeratodermia variabilis et progressiva 4	Enrichment	KDSR	2.73
11	Autosomal recessive dyskeratosis congenita 4	Enrichment	TERT	2.73
12	Trilateral retinoblastoma	Enrichment	RB1	2.73
13	Asah1-related disorders	Enrichment	ASAH1	2.73
14	Glb1-related disorders	Enrichment	GLB1	2.73
15	Lung oat cell carcinoma	Enrichment	RB1	2.73
16	Calvarial doughnut lesions with bone fragility	Enrichment	SGMS2	2.43
17	Spinal muscular atrophy with progressive myoclonic epilepsy	Enrichment	ASAH1	2.43
18	Farber lipogranulomatosis	Enrichment	ASAH1	2.43
19	Pulmonary fibrosis and/or bone marrow failure syndrome, telomere-related, 1	Enrichment	TERT	2.43
20	Chromosome 13q14 deletion syndrome	Enrichment	RB1	2.43
21	Cebalid syndrome	Enrichment	MTOR	2.43
22	Melanoma, cutaneous malignant 9	Enrichment	TERT	2.43
23	Smith-kingsmore syndrome	Enrichment	MTOR	2.43
24	Idiopathic interstitial pneumonia	Enrichment	TERT	2.43
25	Familial retinoblastoma	Enrichment	RB1	2.43
26	Retinoblastoma	Enrichment	RB1	2.26
27	Gm1-gangliosidosis, type i	Enrichment	GLB1	2.26
28	Mucopolysaccharidosis, type ivb	Enrichment	GLB1	2.26
29	Gm1-gangliosidosis, type ii	Enrichment	GLB1	2.26
30	Osteogenic sarcoma	Enrichment	RB1	2.26
31	Gm1-gangliosidosis, type iii	Enrichment	GLB1	2.26
32	Woolly hair, autosomal recessive 3	Enrichment	RB1	2.26
33	Hypotrichosis 8	Enrichment	RB1	2.26
34	Dedifferentiated liposarcoma	Enrichment	CDK4	2.26
35	Interstitial lung disease	Enrichment	TERT	2.26
36	Gm1 gangliosidosis	Enrichment	GLB1	2.26
37	Squamous cell carcinoma	Enrichment	RB1	2.26
38	Macrocytic anemia	Enrichment	TERT	2.26
39	Bone osteosarcoma	Enrichment	RB1	2.26
40	Well-differentiated liposarcoma	Enrichment	CDK4	2.26
41	Small cell cancer of the lung	Enrichment	RB1	2.13
42	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	2.13
43	Focal cortical dysplasia, type ii	Enrichment	MTOR	2.13
44	Lynch syndrome 4	Enrichment	RB1	2.13
45	Lung sarcomatoid carcinoma	Enrichment	TERT	2.13
46	Isolated focal cortical dysplasia type ii	Enrichment	MTOR	2.13
47	Hemimegalencephaly	Enrichment	MTOR	2.04
48	Idiopathic aplastic anemia	Enrichment	TERT	2.04
49	Dyskeratosis congenita, autosomal dominant 1	Enrichment	TERT	1.96
50	Spondyloepiphyseal dysplasia with congenital joint dislocations	Enrichment	GLB1	1.96
51	Pulmonary fibrosis	Enrichment	TERT	1.96
52	Adrenocortical carcinoma	Enrichment	TERT	1.96
53	Hoyeraal-hreidarsson syndrome	Enrichment	TERT	1.96
54	Kidney clear cell sarcoma	Enrichment	TERT	1.96
55	Renal cell carcinoma, papillary, 1	Enrichment	MTOR	1.89
56	Dyskeratosis congenita, autosomal dominant 2	Enrichment	TERT	1.89
57	Progressive familial intrahepatic cholestasis	Enrichment	GLB1	1.89
58	Hereditary sensory and autonomic neuropathy type 1	Enrichment	SPTLC1	1.89
59	Overgrowth syndrome	Enrichment	MTOR	1.89
60	Erythrokeratodermia variabilis et progressiva 1	Enrichment	KDSR	1.83
61	Juvenile amyotrophic lateral sclerosis	Enrichment	SPTLC1	1.78
62	Aplastic anemia	Enrichment	TERT	1.74
63	Specific learning disability	Enrichment	MAPK1	1.70
64	Meningioma	Enrichment	TERT	1.66
65	Lip and oral cavity carcinoma	Enrichment	RB1	1.66
66	Inherited cancer-predisposing syndrome	Enrichment	CDK4, RB1	1.61
67	Lung cancer susceptibility 3	Enrichment	RB1	1.59
68	Renal cell carcinoma, nonpapillary	Enrichment	MTOR	1.56
69	Rare genetic intellectual disability	Enrichment	MTOR	1.56
70	Interstitial lung disease 2	Enrichment	TERT	1.51
71	Beckwith-wiedemann syndrome	Enrichment	SPTLC1	1.49
72	Heart, malformation of	Enrichment	MAPK1	1.49
73	Dyskeratosis congenita	Enrichment	TERT	1.46
74	Leukodystrophy	Enrichment	DEGS1	1.44
75	Hepatoblastoma	Enrichment	TERT	1.42
76	Hepatocellular carcinoma	Enrichment	TERT	1.40
77	Differentiated thyroid carcinoma	Enrichment	TERT	1.28
78	Fetal akinesia deformation sequence 1	Enrichment	ASAH1	1.18
79	Leukemia, acute myeloid	Enrichment	TERT	1.15
80	Charcot-marie-tooth disease	Enrichment	SPTLC1	1.14
81	Benign epilepsy with centrotemporal spikes	Enrichment	ASAH1	1.14
82	Distal arthrogryposis	Enrichment	ASAH1	1.13
83	Centralopathic epilepsy	Enrichment	ASAH1	1.12
84	Gastric cancer	Enrichment	CDK4	1.12
85	Spastic ataxia	Enrichment	GLB1	1.03
86	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	SPTLC1	0.99
87	Rare autosomal recessive non-syndromic sensorineural deafness type dfnb	Enrichment	S1PR2	0.82
88	Ovarian cancer	Enrichment	RB1	0.77
89	Congenital nervous system abnormality	Enrichment	ASAH1	0.75
90	Nervous system disease	Enrichment	ASAH1	0.75
91	Microcephaly	Enrichment	MAPK1	0.69

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Sphingolipid metabolism in senescence

Pathway Network for Sphingolipid metabolism in senescence

Member Pathways for Sphingolipid metabolism in senescence

Pathways in the Sphingolipid metabolism in senescence SuperPath

Associated Genes for Sphingolipid metabolism in senescence

Associated Disorders for Sphingolipid metabolism in senescence

Disorders associated with Sphingolipid metabolism in senescence SuperPath

STRING Interaction Network for Sphingolipid metabolism in senescence

Sources for Sphingolipid metabolism in senescence