Sphingolipid pathway

No Pathway Network information available for Sphingolipid pathway

Pathways in the Sphingolipid pathway SuperPath

#	Name	Source	Genes
1	Sphingolipid pathway	WikiPathways	ACER1 ASAH1 ASAH2 B4GALT6 CERK CERS2 CERS3 CERS4 CERS5 CERS6 CERT1 GAL3ST1 KDSR PLPP1 SERINC1 SGMS1 SGMS2 SGPL1 SGPP2 SPHK1 SPHK2 SPTLC1 SPTLC2 SPTLC3 UGCG (see all 25) (see less)
2	Synthesis of ceramides and 1-deoxyceramides	WikiPathways	A3GALT2 A4GALT ASAH1 B3GNT5 B4GALNT1 B4GALT1 CERK CERS1 CERS2 CERS3 CERS4 CERS5 CERS6 DES DGAT1 KDSR SGMS1 SGMS2 SPHK1 SPTLC1 UGCG UGT8 (see all 22) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	UGCG	UDP-Glucose Ceramide Glucosyltransferase	Protein Coding	2
2	SGMS2	Sphingomyelin Synthase 2	Protein Coding	2
3	CERS5	Ceramide Synthase 5	Protein Coding	2
4	CERS4	Ceramide Synthase 4	Protein Coding	2
5	CERS2	Ceramide Synthase 2	Protein Coding	2
6	SGMS1	Sphingomyelin Synthase 1	Protein Coding	2
7	SPHK1	Sphingosine Kinase 1	Protein Coding	2
8	CERK	Ceramide Kinase	Protein Coding	2
9	ASAH1	N-Acylsphingosine Amidohydrolase 1	Protein Coding	2
10	CERS6	Ceramide Synthase 6	Protein Coding	2
11	KDSR	3-Ketodihydrosphingosine Reductase	Protein Coding	2
12	CERS3	Ceramide Synthase 3	Protein Coding	2
13	SPTLC1	Serine Palmitoyltransferase Long Chain Base Subunit 1	Protein Coding	2
14	B4GALT6	Beta-1,4-Galactosyltransferase 6	Protein Coding	1
15	SGPL1	Sphingosine-1-Phosphate Lyase 1	Protein Coding	1
16	SPTLC3	Serine Palmitoyltransferase Long Chain Base Subunit 3	Protein Coding	1
17	SGPP2	Sphingosine-1-Phosphate Phosphatase 2	Protein Coding	1
18	ACER1	Alkaline Ceramidase 1	Protein Coding	1
19	SPTLC2	Serine Palmitoyltransferase Long Chain Base Subunit 2	Protein Coding	1
20	GAL3ST1	Galactose-3-O-Sulfotransferase 1	Protein Coding	1
21	PLPP1	Phospholipid Phosphatase 1	Protein Coding	1
22	SPHK2	Sphingosine Kinase 2	Protein Coding	1
23	ASAH2	N-Acylsphingosine Amidohydrolase 2	Protein Coding	1
24	CERT1	Ceramide Transporter 1	Protein Coding	1
25	SERINC1	Serine Incorporator 1	Protein Coding	1
26	B3GNT5	UDP-GlcNAc:BetaGal Beta-1,3-N-Acetylglucosaminyltransferase 5	Protein Coding	1
27	UGT8	UDP Glycosyltransferase 8	Protein Coding	1
28	A3GALT2	Alpha 1,3-Galactosyltransferase 2	Protein Coding	1
29	DGAT1	Diacylglycerol O-Acyltransferase 1	Protein Coding	1
30	A4GALT	Alpha 1,4-Galactosyltransferase (P1PK Blood Group)	Protein Coding	1
31	B4GALT1	Beta-1,4-Galactosyltransferase 1	Protein Coding	1
32	B4GALNT1	Beta-1,4-N-Acetyl-Galactosaminyltransferase 1	Protein Coding	1
33	DES	Desmin	Protein Coding	1
34	CERS1	Ceramide Synthase 1	Protein Coding	1

Disorders associated with Sphingolipid pathway SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Hereditary sensory and autonomic neuropathy type 1	Enrichment	SPTLC1, SPTLC2	4.17
2	Neuropathy, hereditary sensory and autonomic, type ia	Enrichment	SPTLC1	2.79
3	Spastic paraplegia 26, autosomal recessive	Enrichment	B4GALNT1	2.79
4	Congenital disorder of glycosylation, type iid	Enrichment	B4GALT1	2.79
5	Keloid formation	Enrichment	ASAH1	2.79
6	Ichthyosis, congenital, autosomal recessive 9	Enrichment	CERS3	2.79
7	Scapuloperoneal syndrome, neurogenic, kaeser type	Enrichment	DES	2.79
8	Amyotrophic lateral sclerosis 27, juvenile	Enrichment	SPTLC1	2.79
9	Combined low ldl and fibrinogen	Enrichment	B4GALT1	2.79
10	Erythrokeratodermia variabilis et progressiva 4	Enrichment	KDSR	2.79
11	Asah1-related disorders	Enrichment	ASAH1	2.79
12	Neuropathy, hereditary sensory and autonomic, type ic	Enrichment	SPTLC2	2.73
13	Reni syndrome	Enrichment	SGPL1	2.73
14	Calvarial doughnut lesions with bone fragility	Enrichment	SGMS2	2.49
15	Blood group, p1pk system	Enrichment	A4GALT	2.49
16	Spinal muscular atrophy with progressive myoclonic epilepsy	Enrichment	ASAH1	2.49
17	Farber lipogranulomatosis	Enrichment	ASAH1	2.49
18	Cardiomyopathy, dilated, 1i	Enrichment	DES	2.49
19	Progressive familial heart block	Enrichment	DES	2.49
20	Epilepsy, progressive myoclonic, 8	Enrichment	CERS1	2.49
21	Neurodevelopmental disorder with hypotonia, speech delay, and dysmorphic facies	Enrichment	CERT1	2.43
22	Right atrial isomerism	Enrichment	CERS1	2.31
23	Myopathy, myofibrillar, 1	Enrichment	DES	2.31
24	Caffey disease	Enrichment	A4GALT	2.31
25	Congenital heart defects, multiple types, 6	Enrichment	CERS1	2.31
26	Weill-marchesani syndrome 4	Enrichment	CERS3	2.31
27	Diarrhea 7, protein-losing enteropathy type	Enrichment	DGAT1	2.19
28	Transposition of the great arteries	Enrichment	CERS1	2.19
29	Congenital diarrhea 7 with exudative enteropathy	Enrichment	DGAT1	2.09
30	Sensory peripheral neuropathy	Enrichment	SPTLC3	2.04
31	Diarrhea	Enrichment	DGAT1	2.01
32	Double outlet right ventricle	Enrichment	CERS1	2.01
33	Myofibrillar myopathy	Enrichment	DES	1.95
34	Erythrokeratodermia variabilis et progressiva 1	Enrichment	KDSR	1.89
35	Juvenile amyotrophic lateral sclerosis	Enrichment	SPTLC1	1.84
36	Congenital nonbullous ichthyosiform erythroderma	Enrichment	CERS3	1.79
37	Ichthyosis	Enrichment	CERS3	1.75
38	Autosomal recessive congenital ichthyosis	Enrichment	CERS3	1.62
39	Arrhythmogenic right ventricular cardiomyopathy	Enrichment	DES	1.59
40	Cardiomyopathy, dilated, 1e	Enrichment	DES	1.56
41	Beckwith-wiedemann syndrome	Enrichment	SPTLC1	1.54
42	Heart, malformation of	Enrichment	CERS1	1.54
43	Neuromuscular disease	Enrichment	DES	1.54
44	Visceral heterotaxy	Enrichment	CERS1	1.45
45	Skin disease	Enrichment	CERS3	1.45
46	Tetralogy of fallot	Enrichment	CERS1	1.38
47	Visceral heterotaxy 5	Enrichment	CERS1	1.31
48	Familial hypertrophic cardiomyopathy	Enrichment	DES	1.28
49	Peripheral nervous system disease	Enrichment	SPTLC3	1.24
50	Neuropathy	Enrichment	SPTLC3	1.24
51	Fetal akinesia deformation sequence 1	Enrichment	ASAH1	1.23
52	Charcot-marie-tooth disease	Enrichment	SPTLC1	1.19
53	Benign epilepsy with centrotemporal spikes	Enrichment	ASAH1	1.19
54	Distal arthrogryposis	Enrichment	ASAH1	1.18
55	Centralopathic epilepsy	Enrichment	ASAH1	1.17
56	Nephrotic syndrome	Enrichment	SGPL1	1.12
57	Familial isolated dilated cardiomyopathy	Enrichment	DES	1.08
58	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	SPTLC1	1.05
59	Dilated cardiomyopathy	Enrichment	DES	0.91
60	Congenital nervous system abnormality	Enrichment	ASAH1	0.80
61	Nervous system disease	Enrichment	ASAH1	0.80
62	Complex neurodevelopmental disorder	Enrichment	CERT1	0.69

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Sphingolipid pathway

Pathway Network for Sphingolipid pathway

Member Pathways for Sphingolipid pathway

Pathways in the Sphingolipid pathway SuperPath

Associated Genes for Sphingolipid pathway

Associated Disorders for Sphingolipid pathway

Disorders associated with Sphingolipid pathway SuperPath

STRING Interaction Network for Sphingolipid pathway

Sources for Sphingolipid pathway