Sphingosine 1-phosphate (S1P) pathway
Pathways in the Sphingosine 1-phosphate (S1P) pathway SuperPath
| # | Name | Source | Genes |
|---|---|---|---|
| 1 | Sphingosine 1-phosphate (S1P) pathway | PubChem |
Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways
| # | Symbol | Description | Category | # Related Pathways |
|---|---|---|---|---|
| 1 | S1PR5 | Sphingosine-1-Phosphate Receptor 5 | Protein Coding | 1 |
| 2 | S1PR4 | Sphingosine-1-Phosphate Receptor 4 | Protein Coding | 1 |
| 3 | S1PR2 | Sphingosine-1-Phosphate Receptor 2 | Protein Coding | 1 |
| 4 | SGPP1 | Sphingosine-1-Phosphate Phosphatase 1 | Protein Coding | 1 |
| 5 | SGPL1 | Sphingosine-1-Phosphate Lyase 1 | Protein Coding | 1 |
| 6 | S1PR3 | Sphingosine-1-Phosphate Receptor 3 | Protein Coding | 1 |
| 7 | S1PR1 | Sphingosine-1-Phosphate Receptor 1 | Protein Coding | 1 |
| 8 | ABCC1 | ATP Binding Cassette Subfamily C Member 1 (ABCC1 Blood Group) | Protein Coding | 1 |
| 9 | GNA12 | G Protein Subunit Alpha 12 | Protein Coding | 1 |
| 10 | GNA13 | G Protein Subunit Alpha 13 | Protein Coding | 1 |
Disorders associated with Sphingosine 1-phosphate (S1P) pathway SuperPath
according to GeneCards Suite gene sharing
| # | Disorder | Type | Genes | Score |
|---|---|---|---|---|
| 1 | Deafness, autosomal dominant 77 | Enrichment | ABCC1 | 3.13 |
| 2 | Deafness, autosomal recessive 68 | Enrichment | S1PR2 | 3.13 |
| 3 | Reni syndrome | Enrichment | SGPL1 | 3.13 |
| 4 | Nephrotic syndrome | Enrichment | SGPL1 | 1.50 |
| 5 | Rare autosomal dominant non-syndromic sensorineural deafness type dfna | Enrichment | ABCC1 | 1.42 |
| 6 | Rare autosomal recessive non-syndromic sensorineural deafness type dfnb | Enrichment | S1PR2 | 1.20 |
