SREBF and miR33 in cholesterol and lipid homeostasis

No Pathway Network information available for SREBF and miR33 in cholesterol and lipid homeostasis

Pathways in the SREBF and miR33 in cholesterol and lipid homeostasis SuperPath

#	Name	Source	Genes
1	SREBF and miR33 in cholesterol and lipid homeostasis	WikiPathways	ABCA1 FASN HMGCR HMGCS1 LDLR MED15 MTOR NR1H3 PPARA PPARGC1A PRKAA1 SCD SIRT1 SIRT6 SREBF1 SREBF2 (see all 16) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	HMGCS1	3-Hydroxy-3-Methylglutaryl-CoA Synthase 1	Protein Coding	1
2	SREBF2	Sterol Regulatory Element Binding Transcription Factor 2	Protein Coding	1
3	SREBF1	Sterol Regulatory Element Binding Transcription Factor 1	Protein Coding	1
4	SCD	Stearoyl-CoA Desaturase	Protein Coding	1
5	PRKAA1	Protein Kinase AMP-Activated Catalytic Subunit Alpha 1	Protein Coding	1
6	PPARA	Peroxisome Proliferator Activated Receptor Alpha	Protein Coding	1
7	SIRT6	Sirtuin 6	Protein Coding	1
8	LDLR	Low Density Lipoprotein Receptor	Protein Coding	1
9	HMGCR	3-Hydroxy-3-Methylglutaryl-CoA Reductase	Protein Coding	1
10	MTOR	Mechanistic Target Of Rapamycin Kinase	Protein Coding	1
11	SIRT1	Sirtuin 1	Protein Coding	1
12	FASN	Fatty Acid Synthase	Protein Coding	1
13	ABCA1	ATP Binding Cassette Subfamily A Member 1	Protein Coding	1
14	PPARGC1A	PPARG Coactivator 1 Alpha	Protein Coding	1
15	NR1H3	Nuclear Receptor Subfamily 1 Group H Member 3	Protein Coding	1
16	MED15	Mediator Complex Subunit 15	Protein Coding	1

Disorders associated with SREBF and miR33 in cholesterol and lipid homeostasis SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Coronary heart disease 5	Enrichment	ABCA1, LDLR	4.33
2	Mucoepithelial dysplasia, hereditary	Enrichment	SREBF1	2.93
3	Ifap syndrome 2	Enrichment	SREBF1	2.93
4	Low density lipoprotein cholesterol level quantitative trait locus 3	Enrichment	HMGCR	2.93
5	Muscular dystrophy, limb-girdle, autosomal recessive 28	Enrichment	HMGCR	2.93
6	Lethal brain and heart developmental defects	Enrichment	SIRT6	2.93
7	Hypoalphalipoproteinemia	Enrichment	ABCA1	2.93
8	Tangier disease	Enrichment	ABCA1	2.63
9	Cebalid syndrome	Enrichment	MTOR	2.63
10	Hyperlipoproteinemia, type iii	Enrichment	LDLR	2.63
11	Smith-kingsmore syndrome	Enrichment	MTOR	2.63
12	Hypercholesterolemia, familial, 2	Enrichment	LDLR	2.45
13	Ifap syndrome 1, with or without bresheck syndrome	Enrichment	SREBF1	2.45
14	Intellectual developmental disorder with microcephaly and pontine and cerebellar hypoplasia	Enrichment	LDLR	2.45
15	Hypercholesterolemia, familial, 4	Enrichment	LDLR	2.45
16	Hypoalphalipoproteinemia, primary, 2	Enrichment	ABCA1	2.45
17	Syndromic x-linked intellectual disability najm type	Enrichment	LDLR	2.45
18	Hypoalphalipoproteinemia, primary, 1	Enrichment	ABCA1	2.33
19	Focal cortical dysplasia, type ii	Enrichment	MTOR	2.33
20	Isolated focal cortical dysplasia type ii	Enrichment	MTOR	2.33
21	Hyperlipidemia, familial combined, 3	Enrichment	LDLR	2.23
22	Congenital myopathy 3 with rigid spine	Enrichment	HMGCS1	2.23
23	Hemimegalencephaly	Enrichment	MTOR	2.23
24	Cowden syndrome 1	Enrichment	LDLR	2.15
25	Lipid metabolism disorder	Enrichment	LDLR	2.15
26	Renal cell carcinoma, papillary, 1	Enrichment	MTOR	2.08
27	Overgrowth syndrome	Enrichment	MTOR	2.08
28	Homozygous familial hypercholesterolemia	Enrichment	LDLR	2.03
29	Limb-girdle muscular dystrophy	Enrichment	HMGCR	1.98
30	Hypercholesterolemia, familial, 1	Enrichment	LDLR	1.82
31	Multiple sclerosis	Enrichment	NR1H3	1.79
32	Renal cell carcinoma, nonpapillary	Enrichment	MTOR	1.76
33	Familial hypercholesterolemia	Enrichment	LDLR	1.76
34	Rare genetic intellectual disability	Enrichment	MTOR	1.76
35	Hirschsprung disease 1	Enrichment	SREBF1	1.47
36	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	PPARGC1A	1.18
37	Primary ovarian insufficiency	Enrichment	SIRT6	1.17
38	Breast cancer	Enrichment	ABCA1	1.07

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

SREBF and miR33 in cholesterol and lipid homeostasis

Pathway Network for SREBF and miR33 in cholesterol and lipid homeostasis

Member Pathways for SREBF and miR33 in cholesterol and lipid homeostasis

Pathways in the SREBF and miR33 in cholesterol and lipid homeostasis SuperPath

Associated Genes for SREBF and miR33 in cholesterol and lipid homeostasis

Associated Disorders for SREBF and miR33 in cholesterol and lipid homeostasis

Disorders associated with SREBF and miR33 in cholesterol and lipid homeostasis SuperPath

STRING Interaction Network for SREBF and miR33 in cholesterol and lipid homeostasis

Sources for SREBF and miR33 in cholesterol and lipid homeostasis