Stabilization and expansion of the E-cadherin adherens junction

No Pathway Network information available for Stabilization and expansion of the E-cadherin adherens junction

Pathways in the Stabilization and expansion of the E-cadherin adherens junction SuperPath

#	Name	Source	Genes
1	Stabilization and expansion of the E-cadherin adherens junction	PubChem	ABI1 ACTN1 AFDN AQP3 AQP5 ARF6 CAMSAP3 CDH1 CTNNA1 CTNNB1 CTNND1 CYFIP2 DIAPH1 EFNA1 EGF EGFR ENAH EPHA2 EXOC1 EXOC3 EXOC4 GIT1 HGF IGF1R KIFC3 LIMA1 LPP MET MGAT3 MYL2 MYO6 NCK1 NCKAP1 NECTIN2 PIP5K1C PLEKHA7 RHOA ROCK1 STX4 VASP VCL ZYX (see all 42) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	LPP	LIM Domain Containing Preferred Translocation Partner In Lipoma	Protein Coding	1
2	LIMA1	LIM Domain And Actin Binding 1	Protein Coding	1
3	CAMSAP3	Calmodulin Regulated Spectrin Associated Protein Family Member 3	Protein Coding	1
4	PLEKHA7	Pleckstrin Homology Domain Containing A7	Protein Coding	1
5	KIFC3	Kinesin Family Member C3	Protein Coding	1
6	ENAH	ENAH Actin Regulator	Protein Coding	1
7	AFDN	Afadin, Adherens Junction Formation Factor	Protein Coding	1
8	EPHA2	EPH Receptor A2	Protein Coding	1
9	EFNA1	Ephrin A1	Protein Coding	1
10	ABI1	Abl Interactor 1	Protein Coding	1
11	CYFIP2	Cytoplasmic FMR1 Interacting Protein 2	Protein Coding	1
12	ZYX	Zyxin	Protein Coding	1
13	MYL2	Myosin Light Chain 2	Protein Coding	1
14	MGAT3	Beta-1,4-Mannosyl-Glycoprotein 4-Beta-N-Acetylglucosaminyltransferase	Protein Coding	1
15	HGF	Hepatocyte Growth Factor	Protein Coding	1
16	IGF1R	Insulin Like Growth Factor 1 Receptor	Protein Coding	1
17	DIAPH1	Diaphanous Related Formin 1	Protein Coding	1
18	NCKAP1	NCK Associated Protein 1	Protein Coding	1
19	EGF	Epidermal Growth Factor	Protein Coding	1
20	ROCK1	Rho Associated Coiled-Coil Containing Protein Kinase 1	Protein Coding	1
21	ACTN1	Actinin Alpha 1	Protein Coding	1
22	VASP	Vasodilator Stimulated Phosphoprotein	Protein Coding	1
23	NECTIN2	Nectin Cell Adhesion Molecule 2	Protein Coding	1
24	CTNND1	Catenin Delta 1	Protein Coding	1
25	CTNNB1	Catenin Beta 1	Protein Coding	1
26	CTNNA1	Catenin Alpha 1	Protein Coding	1
27	VCL	Vinculin	Protein Coding	1
28	CDH1	Cadherin 1	Protein Coding	1
29	GIT1	GIT ArfGAP 1	Protein Coding	1
30	NCK1	NCK Adaptor Protein 1	Protein Coding	1
31	RHOA	Ras Homolog Family Member A	Protein Coding	1
32	MET	MET Proto-Oncogene, Receptor Tyrosine Kinase	Protein Coding	1
33	EXOC4	Exocyst Complex Component 4	Protein Coding	1
34	EXOC1	Exocyst Complex Component 1	Protein Coding	1
35	EXOC3	Exocyst Complex Component 3	Protein Coding	1
36	ARF6	ARF GTPase 6	Protein Coding	1
37	PIP5K1C	Phosphatidylinositol-4-Phosphate 5-Kinase Type 1 Gamma	Protein Coding	1
38	MYO6	Myosin VI	Protein Coding	1
39	STX4	Syntaxin 4	Protein Coding	1
40	AQP3	Aquaporin 3 (Gill Blood Group)	Protein Coding	1
41	AQP5	Aquaporin 5	Protein Coding	1
42	EGFR	Epidermal Growth Factor Receptor	Protein Coding	1

Disorders associated with Stabilization and expansion of the E-cadherin adherens junction SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Cleft lip with or without cleft palate	Enrichment	CDH1, CTNND1, PLEKHA7	6.26
2	Blepharocheilodontic syndrome 1	Enrichment	CDH1, CTNND1	5.03
3	Childhood hepatocellular carcinoma	Enrichment	CTNNB1, MET	5.03
4	Diffuse gastric and lobular breast cancer syndrome	Enrichment	CDH1, CTNNA1	4.25
5	Colorectal cancer	Enrichment	CDH1, CTNNA1, CTNNB1, MET	3.83
6	Ovarian cancer	Enrichment	CDH1, CTNNB1, EGFR, MET	3.58
7	Adult hepatocellular carcinoma	Enrichment	CTNNB1, EGF	3.48
8	Inherited cancer-predisposing syndrome	Enrichment	CDH1, CTNNA1, EGFR, MET	3.14
9	Hepatocellular carcinoma	Enrichment	CTNNB1, MET	2.68
10	Rare autosomal recessive non-syndromic sensorineural deafness type dfnb	Enrichment	HGF, MET, MYO6	2.58
11	Hypomagnesemia 4, renal	Enrichment	EGF	2.51
12	Macular dystrophy, patterned, 2	Enrichment	CTNNA1	2.51
13	Deafness, autosomal recessive 39	Enrichment	HGF	2.51
14	Deafness, autosomal dominant 22	Enrichment	MYO6	2.51
15	Deafness, autosomal dominant 1, with or without thrombocytopenia	Enrichment	DIAPH1	2.51
16	Osteofibrous dysplasia	Enrichment	MET	2.51
17	Deafness, autosomal recessive 37	Enrichment	MYO6	2.51
18	Deafness, autosomal recessive 97	Enrichment	MET	2.51
19	Cardiomyopathy, dilated, 1w	Enrichment	VCL	2.51
20	Autism 9	Enrichment	MET	2.51
21	Cardiomyopathy, familial hypertrophic, 15	Enrichment	VCL	2.51
22	Deafness, autosomal recessive 123	Enrichment	STX4	2.51
23	Bleeding disorder, platelet-type, 15	Enrichment	ACTN1	2.51
24	Seizures, cortical blindness, and microcephaly syndrome	Enrichment	DIAPH1	2.51
25	Ectodermal dysplasia with facial dysmorphism and acral, ocular, and brain anomalies	Enrichment	RHOA	2.51
26	Diaph1-related sensorineural hearing loss-thrombocytopenia syndrome	Enrichment	DIAPH1	2.51
27	Low density lipoprotein cholesterol level quantitative trait locus 8	Enrichment	LIMA1	2.51
28	Linear hypopigmentation and craniofacial asymmetry with acral, ocular and brain anomalies	Enrichment	RHOA	2.51
29	Adenoid ameloblastoma	Enrichment	CTNNB1	2.51
30	Arthrogryposis, distal, type 11	Enrichment	MET	2.51
31	Breast lobular carcinoma	Enrichment	CDH1	2.51
32	Progressive sensorineural hearing loss-hypertrophic cardiomyopathy syndrome	Enrichment	MYO6	2.51
33	Autosomal dominant nonsyndromic hearing loss 22	Enrichment	MYO6	2.51
34	Egf-related primary hypomagnesemia with intellectual disability	Enrichment	EGF	2.51
35	Microcystic stromal tumor	Enrichment	CTNNB1	2.51
36	Bladder cancer	Enrichment	CTNNB1, EGFR	2.44
37	Lung cancer	Enrichment	EGFR, MET	2.36
38	Osteopathia striata with cranial sclerosis	Enrichment	CTNNB1	2.21
39	Palmoplantar keratoderma, bothnian type	Enrichment	AQP5	2.21
40	Lethal congenital contracture syndrome 3	Enrichment	PIP5K1C	2.21
41	Immunodeficiency 72 with autoinflammation and lymphoproliferation	Enrichment	NCKAP1	2.21
42	Blepharocheilodontic syndrome 2	Enrichment	CTNND1	2.21
43	Cardiomyopathy, familial hypertrophic, 10	Enrichment	MYL2	2.21
44	Papillary renal cell carcinoma	Enrichment	MET	2.21
45	Myopathy, myofibrillar, 12, infantile-onset, with cardiomyopathy	Enrichment	MYL2	2.21
46	Juvenile nasopharyngeal angiofibroma	Enrichment	CTNNB1	2.21
47	Teratoma	Enrichment	CTNNB1	2.21
48	Immunodeficiency 72	Enrichment	NCKAP1	2.21
49	Microcephaly	Enrichment	CTNNB1, DIAPH1, IGF1R	2.19
50	Desmoid disease, hereditary	Enrichment	CTNNB1	2.03
51	Neurodevelopmental disorder with spastic diplegia and visual defects	Enrichment	CTNNB1	2.03
52	Neonatal nephrocutaneous inflammatory syndrome	Enrichment	EGFR	2.03
53	Anus, imperforate	Enrichment	CTNNB1	2.03
54	Exudative vitreoretinopathy 7	Enrichment	CTNNB1	2.03
55	Developmental and epileptic encephalopathy 65	Enrichment	CYFIP2	2.03
56	Desmoid tumor	Enrichment	CTNNB1	2.03
57	Butterfly-shaped pigment dystrophy	Enrichment	CTNNA1	2.03
58	Growth delay due to insulin-like growth factor i resistance	Enrichment	IGF1R	2.03
59	Neonatal inflammatory skin and bowel disease	Enrichment	EGFR	2.03
60	Renal cell carcinoma	Enrichment	MET	2.03
61	Sensorineural hearing loss	Enrichment	HGF, STX4	2.02
62	Polyposis syndrome, hereditary mixed, 1	Enrichment	CTNNA1	1.91
63	Pilomatrixoma	Enrichment	CTNNB1	1.91
64	Alazami syndrome	Enrichment	CTNNB1	1.91
65	Craniopharyngioma	Enrichment	CTNNB1	1.91
66	Cataract 6, multiple types	Enrichment	EPHA2	1.81
67	Exudative vitreoretinopathy 1	Enrichment	CTNNB1	1.81
68	Insulin-like growth factor i	Enrichment	IGF1R	1.81
69	Aniridia	Enrichment	EPHA2	1.81
70	Cowden syndrome 1	Enrichment	EGFR	1.73
71	Weyers acrofacial dysostosis	Enrichment	CTNNB1	1.73
72	Hemihyperplasia, isolated	Enrichment	RHOA	1.73
73	Moyamoya disease 1	Enrichment	DIAPH1	1.73
74	Epidermolysis bullosa, junctional 5b, with pyloric atresia	Enrichment	MYO6	1.73
75	Pendred syndrome	Enrichment	DIAPH1	1.73
76	Adrenocortical carcinoma	Enrichment	CTNNB1	1.73
77	Lung squamous cell carcinoma	Enrichment	EGFR	1.73
78	Squamous cell carcinoma, head and neck	Enrichment	EGFR	1.67
79	Renal cell carcinoma, papillary, 1	Enrichment	MET	1.67
80	Gallbladder cancer	Enrichment	CTNNB1	1.67
81	Familial isolated restrictive cardiomyopathy	Enrichment	MYL2	1.67
82	Arthrogryposis, distal, type 1a	Enrichment	MET	1.61
83	Exudative vitreoretinopathy	Enrichment	CTNNB1	1.61
84	Early-onset posterior polar cataract	Enrichment	EPHA2	1.61
85	Rare genetic deafness	Enrichment	DIAPH1, MYO6	1.61
86	Dilated cardiomyopathy	Enrichment	MYL2, VCL	1.60
87	Autosomal dominant macrothrombocytopenia	Enrichment	ACTN1	1.52
88	Lung non-small cell carcinoma	Enrichment	EGFR	1.47
89	Lip and oral cavity carcinoma	Enrichment	EGFR	1.44
90	Nk-cell enteropathy	Enrichment	IGF1R	1.40
91	Medulloblastoma	Enrichment	CTNNB1	1.37
92	Lung cancer susceptibility 3	Enrichment	EGFR	1.37
93	Heart disease	Enrichment	MYL2	1.37
94	Cataract	Enrichment	EPHA2	1.37
95	Cleft lip/palate	Enrichment	CDH1	1.37
96	Renal cell carcinoma, nonpapillary	Enrichment	MET	1.34
97	Congenital myopathy 4a, autosomal dominant	Enrichment	MYL2	1.34
98	Gliosarcoma	Enrichment	EGFR	1.31
99	Cardiomyopathy, dilated, 1e	Enrichment	MYL2	1.29
100	Cataract 44	Enrichment	EPHA2	1.29
101	Polycystic liver disease	Enrichment	CTNNB1	1.29
102	Giant cell glioblastoma	Enrichment	EGFR	1.29
103	Autosomal dominant polycystic liver disease	Enrichment	CTNNB1	1.29
104	Early-onset nuclear cataract	Enrichment	EPHA2	1.27
105	Arteriovenous malformations of the brain	Enrichment	EGFR	1.24
106	Craniosynostosis	Enrichment	CTNNA1	1.22
107	Endometrial cancer	Enrichment	CDH1	1.20
108	Hepatoblastoma	Enrichment	CTNNB1	1.20
109	Ear malformation	Enrichment	MYO6	1.14
110	Auditory neuropathy	Enrichment	DIAPH1	1.11
111	Prostate cancer	Enrichment	CDH1	1.07
112	Meckel syndrome, type 1	Enrichment	EXOC4	1.07
113	Familial hypertrophic cardiomyopathy	Enrichment	MYL2	1.01
114	Non-syndromic genetic deafness	Enrichment	MYO6	0.98
115	Leukemia, acute myeloid	Enrichment	LPP	0.93
116	Epilepsy	Enrichment	DIAPH1	0.93
117	Nonsyndromic hearing loss	Enrichment	MYO6	0.91
118	Gastric cancer	Enrichment	CDH1	0.90
119	Hypertrophic cardiomyopathy	Enrichment	MYL2	0.90
120	Hereditary breast carcinoma	Enrichment	CDH1	0.89
121	Thrombocytopenia	Enrichment	ACTN1	0.86
122	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	MYO6	0.83
123	Familial isolated dilated cardiomyopathy	Enrichment	VCL	0.82
124	Hereditary breast ovarian cancer syndrome	Enrichment	CTNNA1	0.80
125	Undetermined early-onset epileptic encephalopathy	Enrichment	CYFIP2	0.80
126	Schizophrenia	Enrichment	LPP	0.78
127	Breast cancer	Enrichment	CDH1	0.68
128	Congenital nervous system abnormality	Enrichment	CTNNB1	0.55
129	Nervous system disease	Enrichment	CTNNB1	0.55
130	Hereditary retinal dystrophy	Enrichment	CTNNA1	0.22
131	Fundus dystrophy	Enrichment	CTNNA1	0.22

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Stabilization and expansion of the E-cadherin adherens junction

Pathway Network for Stabilization and expansion of the E-cadherin adherens junction

Member Pathways for Stabilization and expansion of the E-cadherin adherens junction

Pathways in the Stabilization and expansion of the E-cadherin adherens junction SuperPath

Associated Genes for Stabilization and expansion of the E-cadherin adherens junction

Associated Disorders for Stabilization and expansion of the E-cadherin adherens junction

Disorders associated with Stabilization and expansion of the E-cadherin adherens junction SuperPath

STRING Interaction Network for Stabilization and expansion of the E-cadherin adherens junction

Sources for Stabilization and expansion of the E-cadherin adherens junction