Statin inhibition of cholesterol production

Pathway network for the Statin inhibition of cholesterol production SuperPath

Sources:

WikiPathways
PharmGKB

Pathways in the Statin inhibition of cholesterol production SuperPath

#	Name	Source	Genes
1	Statin inhibition of cholesterol production	WikiPathways	ABCA1 ABCG5 ABCG8 APOA1 APOA2 APOA4 APOA5 APOB APOC1 APOC2 APOC3 APOE CETP CYP7A1 DGAT1 FDFT1 HMGCR LCAT LDLR LIPC LPL LRP1 MIR33A MIR33B PLTP SCARB1 SOAT1 SQLE (see all 28) (see less)
2	Statin Pathway, Pharmacodynamics	PharmGKB	ABCB1 ABCG5 ABCG8 APOA1 APOA4 APOA5 APOB APOC1 APOC2 APOC3 APOE CYP7A1 DGAT1 FDFT1 HMGCR LCAT LDLR LIPC LPL LRP1 MTTP PLTP SCARB1 SOAT1 SQLE (see all 25) (see less)
3	Familial hyperlipidemia type 3	WikiPathways	APOA1 APOA2 APOA4 APOE CETP LCAT LDLR LIPC LPL LRP1 PLTP SCARB1 VLDLR (see all 13) (see less)
4	Lipid particles composition	WikiPathways	APOA1 APOA2 APOB APOC2 APOC3 APOE CETP LCAT LDLR LPL (see all 10) (see less)

Gene overlap in member pathways for Statin inhibition of cholesterol production SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	LPL	Lipoprotein Lipase	Protein Coding	4
2	LDLR	Low Density Lipoprotein Receptor	Protein Coding	4
3	LCAT	Lecithin-Cholesterol Acyltransferase	Protein Coding	4
4	APOE	Apolipoprotein E	Protein Coding	4
5	APOA1	Apolipoprotein A1	Protein Coding	4
6	SCARB1	Scavenger Receptor Class B Member 1	Protein Coding	3
7	PLTP	Phospholipid Transfer Protein	Protein Coding	3
8	LRP1	LDL Receptor Related Protein 1	Protein Coding	3
9	LIPC	Lipase C, Hepatic Type	Protein Coding	3
10	APOC3	Apolipoprotein C3	Protein Coding	3
11	APOC2	Apolipoprotein C2	Protein Coding	3
12	APOB	Apolipoprotein B	Protein Coding	3
13	APOA4	Apolipoprotein A4	Protein Coding	3
14	APOA2	Apolipoprotein A2	Protein Coding	3
15	CETP	Cholesteryl Ester Transfer Protein	Protein Coding	3
16	DGAT1	Diacylglycerol O-Acyltransferase 1	Protein Coding	2
17	SQLE	Squalene Epoxidase	Protein Coding	2
18	SOAT1	Sterol O-Acyltransferase 1	Protein Coding	2
19	ABCG8	ATP Binding Cassette Subfamily G Member 8	Protein Coding	2
20	ABCG5	ATP Binding Cassette Subfamily G Member 5	Protein Coding	2
21	APOC1	Apolipoprotein C1	Protein Coding	2
22	HMGCR	3-Hydroxy-3-Methylglutaryl-CoA Reductase	Protein Coding	2
23	FDFT1	Farnesyl-Diphosphate Farnesyltransferase 1	Protein Coding	2
24	CYP7A1	Cytochrome P450 Family 7 Subfamily A Member 1	Protein Coding	2
25	APOA5	Apolipoprotein A5	Protein Coding	2
26	MIR33B	MicroRNA 33b	RNA Gene	1
27	ABCA1	ATP Binding Cassette Subfamily A Member 1	Protein Coding	1
28	MIR33A	MicroRNA 33a	RNA Gene	1
29	ABCB1	ATP Binding Cassette Subfamily B Member 1	Protein Coding	1
30	MTTP	Microsomal Triglyceride Transfer Protein	Protein Coding	1
31	VLDLR	Very Low Density Lipoprotein Receptor	Protein Coding	1

Disorders associated with Statin inhibition of cholesterol production SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Lipid metabolism disorder	Enrichment	ABCG5, ABCG8, APOE, LDLR, LIPC	10.71
2	Coronary heart disease 5	Enrichment	ABCA1, ABCG5, ABCG8, APOB, LDLR	10.66
3	Familial hypercholesterolemia	Enrichment	APOA2, APOB, APOE, LDLR	9.67
4	Homozygous familial hypercholesterolemia	Enrichment	ABCG5, ABCG8, APOB, LDLR	9.19
5	Hyperlipidemia, familial combined, 3	Enrichment	APOB, LDLR, LPL	8.54
6	Hyperalphalipoproteinemia 1	Enrichment	APOC3, CETP, SCARB1	8.10
7	Hypercholesterolemia, familial, 1	Enrichment	APOA2, APOB, LDLR	7.09
8	Hyperlipoproteinemia, type iii	Enrichment	APOE, LDLR	6.31
9	Hypercholesterolemia, familial, 2	Enrichment	APOB, LDLR	5.83
10	Coronary artery anomaly	Enrichment	APOC3, LPL	5.53
11	Gallbladder disease 4	Enrichment	ABCG5, ABCG8	5.49
12	Sitosterolemia 1	Enrichment	ABCG5, ABCG8	5.01
13	Sitosterolemia	Enrichment	ABCG5, ABCG8	5.01
14	Hypoalphalipoproteinemia, primary, 2	Enrichment	ABCA1, APOA1	4.91
15	Hypoalphalipoproteinemia, primary, 1	Enrichment	ABCA1, APOA1	4.61
16	Sea-blue histiocyte disease	Enrichment	APOE	3.13
17	Lipoprotein glomerulopathy	Enrichment	APOE	3.13
18	Apolipoprotein c-iii deficiency	Enrichment	APOC3	3.13
19	Aapoaii amyloidosis	Enrichment	APOA2	3.13
20	Atrophoderma vermiculata	Enrichment	LRP1	3.02
21	High density lipoprotein cholesterol level quantitative trait locus 6	Enrichment	SCARB1	3.02
22	Keratosis pilaris atrophicans	Enrichment	LRP1	3.02
23	Hepatic lipase deficiency	Enrichment	LIPC	3.02
24	High density lipoprotein cholesterol level quantitative trait locus 12	Enrichment	LIPC	3.02
25	Tubulointerstitial kidney disease, autosomal dominant 6	Enrichment	APOA4	3.02
26	Cerebellar hypoplasia	Enrichment	VLDLR	3.02
27	Hyperlipidemia due to hepatic triglyceride lipase deficiency	Enrichment	LIPC	3.02
28	Fish-eye disease	Enrichment	LCAT	2.83
29	Apolipoprotein c-ii deficiency	Enrichment	APOC2	2.83
30	Hyperlipoproteinemia, type i	Enrichment	LPL	2.83
31	Lecithin:cholesterol acyltransferase deficiency	Enrichment	LCAT	2.83
32	Alzheimer disease 3	Enrichment	APOE	2.83
33	Lipase deficiency, combined	Enrichment	LPL	2.83
34	Hypobetalipoproteinemia, familial, 1	Enrichment	APOB	2.83
35	Familial apolipoprotein c-ii deficiency	Enrichment	APOC2	2.83
36	Hypobetalipoproteinemia	Enrichment	APOB	2.83
37	Familial lipoprotein lipase deficiency	Enrichment	LPL	2.83
38	Hypoalphalipoproteinemia, primary, 2, intermediate	Enrichment	APOA1	2.83
39	Amyloidosis, hereditary systemic 3	Enrichment	APOA1	2.83
40	Abetalipoproteinemia	Enrichment	MTTP	2.73
41	Colchicine resistance	Enrichment	ABCB1	2.73
42	Encephalopathy, acute transient	Enrichment	ABCB1	2.73
43	Familial apolipoprotein a5 deficiency	Enrichment	APOA5	2.73
44	Inflammatory bowel disease 13	Enrichment	ABCB1	2.73
45	Hypercholesterolemia due to cholesterol 7alpha-hydroxylase deficiency	Enrichment	CYP7A1	2.73
46	Low density lipoprotein cholesterol level quantitative trait locus 3	Enrichment	HMGCR	2.73
47	Muscular dystrophy, limb-girdle, autosomal recessive 28	Enrichment	HMGCR	2.73
48	Developmental dysplasia of the hip 3	Enrichment	LRP1	2.72
49	Cerebellar ataxia, impaired intellectual development, and dysequilibrium syndrome	Enrichment	VLDLR	2.72
50	Hypoalphalipoproteinemia	Enrichment	ABCA1	2.69
51	Intellectual developmental disorder with microcephaly and pontine and cerebellar hypoplasia	Enrichment	LDLR	2.66
52	Alzheimer disease 4	Enrichment	APOE	2.66
53	Hypercholesterolemia, familial, 4	Enrichment	LDLR	2.66
54	Syndromic x-linked intellectual disability najm type	Enrichment	LDLR	2.66
55	Spastic paraplegia 50, autosomal recessive	Enrichment	APOA1	2.66
56	Keratosis follicularis spinulosa decalvans	Enrichment	LRP1	2.54
57	Macular degeneration, age-related, 1	Enrichment	APOE	2.53
58	Alzheimer disease 2	Enrichment	APOE	2.43
59	Amyloidosis, hereditary systemic 2	Enrichment	APOA1	2.43
60	Hyperlipoproteinemia, type v	Enrichment	APOA5	2.43
61	Abdominal obesity-metabolic syndrome 1	Enrichment	MTTP	2.43
62	Sitosterolemia 2	Enrichment	ABCG5	2.43
63	Squalene synthase deficiency	Enrichment	FDFT1	2.43
64	Short-rib thoracic dysplasia 15 with polydactyly	Enrichment	ABCG5	2.43
65	Tangier disease	Enrichment	ABCA1	2.38
66	Cowden syndrome 1	Enrichment	LDLR	2.35
67	Cerebellar ataxia, impaired intellectual development, and dysequilibrium syndrome 1	Enrichment	VLDLR	2.24
68	Hypertriglyceridemia 1	Enrichment	APOA5	2.13
69	Diarrhea 7, protein-losing enteropathy type	Enrichment	DGAT1	2.13
70	Congenital diarrhea 7 with exudative enteropathy	Enrichment	DGAT1	2.04
71	Alzheimer's disease	Enrichment	APOE	2.02
72	Diarrhea	Enrichment	DGAT1	1.96
73	Alzheimer disease, familial, 1	Enrichment	APOE	1.90
74	Cardiomyopathy, dilated, 1a	Enrichment	LPL	1.81
75	Limb-girdle muscular dystrophy	Enrichment	HMGCR	1.78
76	Epilepsy, idiopathic generalized	Enrichment	ABCB1	1.70
77	Type 2 diabetes mellitus	Enrichment	LIPC	1.40
78	Short-rib thoracic dysplasia 1 with or without polydactyly	Enrichment	ABCG5	1.23
79	Congenital nervous system abnormality	Enrichment	VLDLR	1.01
80	Nervous system disease	Enrichment	VLDLR	1.01
81	Breast cancer	Enrichment	ABCA1	0.84

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Statin inhibition of cholesterol production

Pathway Network for Statin inhibition of cholesterol production

Pathway network for the Statin inhibition of cholesterol production SuperPath

Member Pathways for Statin inhibition of cholesterol production

Pathways in the Statin inhibition of cholesterol production SuperPath

Gene overlap in member pathways for Statin inhibition of cholesterol production SuperPath

Associated Genes for Statin inhibition of cholesterol production

Associated Disorders for Statin inhibition of cholesterol production

Disorders associated with Statin inhibition of cholesterol production SuperPath

STRING Interaction Network for Statin inhibition of cholesterol production

Sources for Statin inhibition of cholesterol production