Statin Pathway - Generalized, Pharmacokinetics

Pathway network for the Statin Pathway - Generalized, Pharmacokinetics SuperPath

Sources:

PharmGKB
WikiPathways
Reactome

Pathways in the Statin Pathway - Generalized, Pharmacokinetics SuperPath

#	Name	Source	Genes
1	Statin Pathway - Generalized, Pharmacokinetics	PharmGKB	ABCB1 ABCB11 ABCC2 ABCG2 CYP2C19 CYP2C8 CYP2C9 CYP2D6 CYP3A4 CYP3A5 SLC15A1 SLC22A6 SLC22A8 SLCO1A2 SLCO1B1 SLCO1B3 SLCO2B1 UGT1A1 UGT1A3 UGT2B7 (see all 20) (see less)
2	Diclofenac Pathway, Pharmacokinetics	PharmGKB	ABCC2 ABCC3 ABCG2 CYP2B6 CYP2C18 CYP2C19 CYP2C8 CYP2C9 CYP3A4 GSTA1 GSTM1 GSTP1 SLC22A11 SLC22A6 SLC22A7 SLC22A8 SLCO1B1 SLCO2B1 UGT2B7 (see all 19) (see less)
3	Ibuprofen Pathway, Pharmacokinetics	PharmGKB	ABCC2 ABCC4 AMACR CYP2C19 CYP2C8 CYP2C9 CYP3A4 SLC22A6 SLC22A8 SLC22A9 SLCO1B1 SLCO1B3 UGT1A3 UGT1A9 UGT2B17 UGT2B4 UGT2B7 (see all 17) (see less)
4	Cabozantinib Pathway, Pharmacokinetics/Pharmacodynamics	PharmGKB	ABCB1 ABCB11 ABCC2 ABCG2 AXL CYP2C8 CYP2C9 CYP3A4 KDR MET RET SLC22A6 SLC22A8 SLC47A1 SLC47A2 SLCO1B1 SLCO1B3 (see all 17) (see less)
5	Rosuvastatin Pathway, Pharmacokinetics	PharmGKB	ABCB11 ABCC2 ABCG2 CYP2C19 CYP2C9 SLC10A1 SLCO1B1 SLCO1B3 SLCO2B1 UGT1A1 UGT1A3 (see all 11) (see less)
6	Pravastatin Pathway, Pharmacokinetics	PharmGKB	ABCB1 ABCB11 ABCC2 ABCC3 ABCG2 SLC22A6 SLC22A8 SLCO1B1 SLCO1B3 SLCO2B1 (see all 10) (see less)
7	Fluvastatin Pathway, Pharmacokinetics	PharmGKB	ABCC2 ABCG2 CYP1A1 CYP2C8 CYP2C9 CYP2D6 CYP3A4 SLCO1B1 SLCO2B1 (see all 9) (see less)
8	Clobazam Pathway, Pharmacokinetics	PharmGKB	CYP2B6 CYP2C18 CYP2C19 CYP2C9 CYP3A4
9	Abrocitinib Pathway, Pharmacokinetics	PharmGKB	CYP2B6 CYP2C19 CYP2C9 CYP3A4 SLC22A8
10	Elexacaftor Pathway, Pharmacokinetics	PharmGKB	CYP3A4 CYP3A5 SLCO1B1 SLCO1B3
11	Labetalol Pathway, Pharmacokinetics	PharmGKB	ABCB1 CYP2C19 UGT1A1 UGT2B7
12	Diclofenac metabolic pathway	WikiPathways	CYP2B6 CYP2C18 CYP2C19 CYP2C8
13	Rosiglitazone Pathway, Pharmacokinetics	PharmGKB	CYP2C8 CYP2C9 SLCO1B1
14	Anti-diabetic Drug Repaglinide Pathway, Pharmacokinetics	PharmGKB	CYP2C8 CYP3A4 SLCO1B1
15	Anti-diabetic Drug Nateglinide Pathway, Pharmacokinetics	PharmGKB	CYP2C9 CYP3A4 SLCO1B1
16	Defective SLCO1B1 causes hyperbilirubinemia, Rotor type (HBLRR)	Reactome	SLCO1B1
17	Defective ABCB11 causes PFIC2 and BRIC2	Reactome	ABCB11
18	Defective SLCO1B3 causes hyperbilirubinemia, Rotor type (HBLRR)	Reactome	SLCO1B3

Gene overlap in member pathways for Statin Pathway - Generalized, Pharmacokinetics SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	SLCO1B1	Solute Carrier Organic Anion Transporter Family Member 1B1	Protein Coding	12
2	CYP2C9	Cytochrome P450 Family 2 Subfamily C Member 9	Protein Coding	10
3	CYP3A4	Cytochrome P450 Family 3 Subfamily A Member 4	Protein Coding	10
4	CYP2C19	Cytochrome P450 Family 2 Subfamily C Member 19	Protein Coding	8
5	CYP2C8	Cytochrome P450 Family 2 Subfamily C Member 8	Protein Coding	8
6	SLCO1B3	Solute Carrier Organic Anion Transporter Family Member 1B3	Protein Coding	7
7	ABCC2	ATP Binding Cassette Subfamily C Member 2	Protein Coding	7
8	SLC22A8	Solute Carrier Family 22 Member 8	Protein Coding	6
9	ABCG2	ATP Binding Cassette Subfamily G Member 2 (JR Blood Group)	Protein Coding	6
10	ABCB11	ATP Binding Cassette Subfamily B Member 11	Protein Coding	5
11	SLC22A6	Solute Carrier Family 22 Member 6	Protein Coding	5
12	SLCO2B1	Solute Carrier Organic Anion Transporter Family Member 2B1	Protein Coding	5
13	UGT2B7	UDP Glucuronosyltransferase Family 2 Member B7	Protein Coding	4
14	ABCB1	ATP Binding Cassette Subfamily B Member 1	Protein Coding	4
15	CYP2B6	Cytochrome P450 Family 2 Subfamily B Member 6	Protein Coding	4
16	UGT1A1	UDP Glucuronosyltransferase Family 1 Member A1	Protein Coding	3
17	UGT1A3	UDP Glucuronosyltransferase Family 1 Member A3	Protein Coding	3
18	CYP2C18	Cytochrome P450 Family 2 Subfamily C Member 18	Protein Coding	3
19	CYP2D6	Cytochrome P450 Family 2 Subfamily D Member 6 (Gene/Pseudogene)	Protein Coding	2
20	CYP3A5	Cytochrome P450 Family 3 Subfamily A Member 5	Protein Coding	2
21	ABCC3	ATP Binding Cassette Subfamily C Member 3	Protein Coding	2
22	SLC15A1	Solute Carrier Family 15 Member 1	Protein Coding	1
23	SLCO1A2	Solute Carrier Organic Anion Transporter Family Member 1A2	Protein Coding	1
24	GSTA1	Glutathione S-Transferase Alpha 1	Protein Coding	1
25	GSTM1	Glutathione S-Transferase Mu 1	Protein Coding	1
26	GSTP1	Glutathione S-Transferase Pi 1	Protein Coding	1
27	SLC22A11	Solute Carrier Family 22 Member 11	Protein Coding	1
28	SLC22A7	Solute Carrier Family 22 Member 7	Protein Coding	1
29	UGT2B4	UDP Glucuronosyltransferase Family 2 Member B4	Protein Coding	1
30	UGT2B17	UDP Glucuronosyltransferase Family 2 Member B17	Protein Coding	1
31	UGT1A9	UDP Glucuronosyltransferase Family 1 Member A9	Protein Coding	1
32	ABCC4	ATP Binding Cassette Subfamily C Member 4 (PEL Blood Group)	Protein Coding	1
33	AMACR	Alpha-Methylacyl-CoA Racemase	Protein Coding	1
34	SLC22A9	Solute Carrier Family 22 Member 9	Protein Coding	1
35	RET	Ret Proto-Oncogene	Protein Coding	1
36	MET	MET Proto-Oncogene, Receptor Tyrosine Kinase	Protein Coding	1
37	KDR	Kinase Insert Domain Receptor	Protein Coding	1
38	AXL	AXL Receptor Tyrosine Kinase	Protein Coding	1
39	SLC47A1	Solute Carrier Family 47 Member 1	Protein Coding	1
40	SLC47A2	Solute Carrier Family 47 Member 2	Protein Coding	1
41	SLC10A1	Solute Carrier Family 10 Member 1	Protein Coding	1
42	CYP1A1	Cytochrome P450 Family 1 Subfamily A Member 1	Protein Coding	1

Disorders associated with Statin Pathway - Generalized, Pharmacokinetics SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Bilirubin metabolic disorder	Direct
2	Intrahepatic cholestasis	Direct
3	Gilbert syndrome	Enrichment	SLCO1B1, UGT1A1, UGT1A3	7.19
4	Hyperbilirubinemia, rotor type	Enrichment	SLCO1B1, SLCO1B3	6.71
5	Crigler-najjar syndrome, type i	Enrichment	UGT1A1, UGT1A3	4.57
6	Hyperbilirubinemia, transient familial neonatal	Enrichment	UGT1A1, UGT1A3	4.57
7	Bilirubin, serum level of, quantitative trait locus 1	Enrichment	UGT1A1, UGT1A3	4.57
8	Crigler-najjar syndrome, type ii	Enrichment	UGT1A1, UGT1A3	4.57
9	Drug metabolism, altered, cyp2c8-related	Enrichment	CYP2C8	3.66
10	Vitamin d-dependent rickets, type 3	Enrichment	CYP3A4	3.66
11	Drug metabolism, poor, cyp2c19-related	Enrichment	CYP2C19	3.53
12	Colchicine resistance	Enrichment	ABCB1	3.53
13	Encephalopathy, acute transient	Enrichment	ABCB1	3.53
14	Inflammatory bowel disease 13	Enrichment	ABCB1	3.53
15	Efavirenz, poor metabolism of	Enrichment	CYP2B6	3.53
16	Hepatocellular carcinoma	Enrichment	MET, RET	3.47
17	Tetralogy of fallot	Enrichment	KDR, RET	3.33
18	Coumarin resistance	Enrichment	CYP2C9	3.18
19	Uric acid concentration, serum, quantitative trait locus 1	Enrichment	ABCG2	3.18
20	Drug metabolism, poor, cyp2d6-related	Enrichment	CYP2D6	3.18
21	Blood group, junior system	Enrichment	ABCG2	3.18
22	Hypercholanemia, familial, 2	Enrichment	SLC10A1	3.09
23	Bone mineral density quantitative trait locus 12	Enrichment	UGT2B17	2.90
24	Multiple endocrine neoplasia, type iib	Enrichment	RET	2.90
25	Osteofibrous dysplasia	Enrichment	MET	2.90
26	Deafness, autosomal recessive 97	Enrichment	MET	2.90
27	Autism 9	Enrichment	MET	2.90
28	Tufted angioma of skin	Enrichment	KDR	2.90
29	Arthrogryposis, distal, type 11	Enrichment	MET	2.90
30	Thyroid cancer	Enrichment	RET	2.90
31	Gastrointestinal system disease	Enrichment	RET	2.90
32	Multiple endocrine neoplasia	Enrichment	RET	2.90
33	Cholestasis, progressive familial intrahepatic, 3	Enrichment	ABCB11	2.83
34	Cholestasis, benign recurrent intrahepatic, 2	Enrichment	ABCB11	2.83
35	Cholestasis, progressive familial intrahepatic, 4	Enrichment	ABCB11	2.83
36	Cholestasis, intrahepatic, of pregnancy 3	Enrichment	ABCB11	2.83
37	Cholestasis, progressive familial intrahepatic, 2	Enrichment	ABCB11	2.83
38	Dubin-johnson syndrome	Enrichment	ABCC2	2.70
39	Bile acid synthesis defect, congenital, 4	Enrichment	AMACR	2.60
40	Alpha-methylacyl-coa racemase deficiency	Enrichment	AMACR	2.60
41	Angioma, tufted	Enrichment	KDR	2.60
42	Childhood hepatocellular carcinoma	Enrichment	MET	2.60
43	Papillary renal cell carcinoma	Enrichment	MET	2.60
44	Medullary thyroid carcinoma	Enrichment	RET	2.60
45	Kala-azar 2	Enrichment	GSTP1	2.55
46	Intrahepatic cholestasis of pregnancy	Enrichment	ABCB11	2.53
47	Epilepsy, idiopathic generalized	Enrichment	ABCB1	2.49
48	Thyroid carcinoma, familial medullary	Enrichment	RET	2.43
49	Gingival overgrowth	Enrichment	RET	2.43
50	Renal cell carcinoma	Enrichment	MET	2.43
51	Pseudoxanthoma elasticum	Enrichment	ABCC2	2.40
52	Familial hypercholanemia	Enrichment	SLC10A1	2.31
53	Central hypoventilation syndrome, congenital, 1	Enrichment	RET	2.30
54	Haddad syndrome	Enrichment	RET	2.30
55	Hypertension, essential	Enrichment	CYP3A5	2.30
56	Progressive familial intrahepatic cholestasis	Enrichment	ABCB11	2.29
57	Colorectal cancer	Enrichment	MET, RET	2.28
58	Multiple endocrine neoplasia, type iia	Enrichment	RET	2.20
59	Ovarian cancer	Enrichment	MET, RET	2.16
60	Hemangioma, capillary infantile	Enrichment	KDR	2.13
61	Sporadic pheochromocytoma/secreting paraganglioma	Enrichment	RET	2.13
62	Renal cell carcinoma, papillary, 1	Enrichment	MET	2.06
63	Arthrogryposis, distal, type 1a	Enrichment	MET	2.00
64	Renal hypodysplasia/aplasia 1	Enrichment	RET	2.00
65	Hypothyroidism	Enrichment	RET	2.00
66	Congenital central hypoventilation syndrome	Enrichment	RET	1.95
67	Renal agenesis, bilateral	Enrichment	RET	1.95
68	Inherited cancer-predisposing syndrome	Enrichment	MET, RET	1.93
69	Renal hypodysplasia/aplasia 3	Enrichment	RET	1.83
70	Nk-cell enteropathy	Enrichment	AXL	1.79
71	Pheochromocytoma	Enrichment	RET	1.76
72	Renal cell carcinoma, nonpapillary	Enrichment	MET	1.73
73	Hereditary paraganglioma-pheochromocytoma syndromes	Enrichment	RET	1.58
74	Hirschsprung disease 1	Enrichment	RET	1.45
75	Differentiated thyroid carcinoma	Enrichment	RET	1.45
76	Lung cancer	Enrichment	MET	1.40
77	Hereditary breast carcinoma	Enrichment	RET	1.27
78	Sensorineural hearing loss	Enrichment	RET	1.23
79	Hypertelorism	Enrichment	RET	1.20
80	Primary ovarian insufficiency	Enrichment	KDR	1.15
81	Breast cancer	Enrichment	RET	1.05
82	Rare autosomal recessive non-syndromic sensorineural deafness type dfnb	Enrichment	MET	0.97

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Statin Pathway - Generalized, Pharmacokinetics

Pathway Network for Statin Pathway - Generalized, Pharmacokinetics

Pathway network for the Statin Pathway - Generalized, Pharmacokinetics SuperPath

Member Pathways for Statin Pathway - Generalized, Pharmacokinetics

Pathways in the Statin Pathway - Generalized, Pharmacokinetics SuperPath

Gene overlap in member pathways for Statin Pathway - Generalized, Pharmacokinetics SuperPath

Associated Genes for Statin Pathway - Generalized, Pharmacokinetics

Associated Disorders for Statin Pathway - Generalized, Pharmacokinetics

Disorders associated with Statin Pathway - Generalized, Pharmacokinetics SuperPath

STRING Interaction Network for Statin Pathway - Generalized, Pharmacokinetics

Sources for Statin Pathway - Generalized, Pharmacokinetics