Striated muscle contraction pathway

No Pathway Network information available for Striated muscle contraction pathway

Pathways in the Striated muscle contraction pathway SuperPath

#	Name	Source	Genes
1	Striated muscle contraction pathway	WikiPathways	ACTA1 ACTA2 ACTC1 ACTG1 ACTN2 ACTN3 ACTN4 DES DMD MYBPC1 MYBPC2 MYBPC3 MYH3 MYH6 MYH8 MYL1 MYL2 MYL3 MYL4 MYL9 MYOM1 NEB TCAP TMOD1 TNNC1 TNNC2 TNNI1 TNNI2 TNNI3 TNNT1 TNNT2 TNNT3 TPM1 TPM2 TPM3 TPM4 TTN VIM (see all 38) (see less)
2	Striated Muscle Contraction	Reactome	ACTA1 ACTC1 ACTN2 ACTN3 DES DMD MYBPC1 MYBPC2 MYBPC3 MYH3 MYH6 MYH8 MYL1 MYL2 MYL3 MYL4 NEB TCAP TMOD1 TMOD2 TMOD3 TMOD4 TNNC1 TNNC2 TNNI1 TNNI2 TNNI3 TNNT1 TNNT2 TNNT3 TPM1 TPM2 TPM3 TPM4 TTN VIM (see all 36) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	TNNT3	Troponin T3, Fast Skeletal Type	Protein Coding	2
2	ACTN2	Actinin Alpha 2	Protein Coding	2
3	TCAP	Titin-Cap	Protein Coding	2
4	VIM	Vimentin	Protein Coding	2
5	TTN	Titin	Protein Coding	2
6	TPM4	Tropomyosin 4	Protein Coding	2
7	TPM3	Tropomyosin 3	Protein Coding	2
8	TPM2	Tropomyosin 2	Protein Coding	2
9	TPM1	Tropomyosin 1	Protein Coding	2
10	TNNT2	Troponin T2, Cardiac Type	Protein Coding	2
11	TNNT1	Troponin T1, Slow Skeletal Type	Protein Coding	2
12	TNNI3	Troponin I3, Cardiac Type	Protein Coding	2
13	TNNI2	Troponin I2, Fast Skeletal Type	Protein Coding	2
14	TNNC1	Troponin C1, Slow Skeletal And Cardiac Type	Protein Coding	2
15	TMOD1	Tropomodulin 1	Protein Coding	2
16	ACTC1	Actin Alpha Cardiac Muscle 1	Protein Coding	2
17	ACTA1	Actin Alpha 1, Skeletal Muscle	Protein Coding	2
18	NEB	Nebulin	Protein Coding	2
19	MYL4	Myosin Light Chain 4	Protein Coding	2
20	MYL3	Myosin Light Chain 3	Protein Coding	2
21	MYL2	Myosin Light Chain 2	Protein Coding	2
22	MYL1	Myosin Light Chain 1	Protein Coding	2
23	MYH8	Myosin Heavy Chain 8	Protein Coding	2
24	MYH6	Myosin Heavy Chain 6	Protein Coding	2
25	MYH3	Myosin Heavy Chain 3	Protein Coding	2
26	MYBPC3	Myosin Binding Protein C3	Protein Coding	2
27	MYBPC1	Myosin Binding Protein C1	Protein Coding	2
28	DMD	Dystrophin	Protein Coding	2
29	DES	Desmin	Protein Coding	2
30	ACTN3	Actinin Alpha 3	Protein Coding	2
31	TNNI1	Troponin I1, Slow Skeletal Type	Protein Coding	2
32	TNNC2	Troponin C2, Fast Skeletal Type	Protein Coding	2
33	MYBPC2	Myosin Binding Protein C2	Protein Coding	2
34	ACTN4	Actinin Alpha 4	Protein Coding	1
35	ACTG1	Actin Gamma 1	Protein Coding	1
36	ACTA2	Actin Alpha 2, Smooth Muscle	Protein Coding	1
37	MYL9	Myosin Light Chain 9	Protein Coding	1
38	MYOM1	Myomesin 1	Protein Coding	1
39	TMOD4	Tropomodulin 4	Protein Coding	1
40	TMOD3	Tropomodulin 3	Protein Coding	1
41	TMOD2	Tropomodulin 2	Protein Coding	1

Disorders associated with Striated muscle contraction pathway SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Hypertrophic cardiomyopathy	Enrichment	ACTC1, ACTN2, MYBPC3, MYL2, MYL3, TCAP, TNNC1, TNNI3, TNNT2, TPM1, TTN	11.45
2	Familial isolated dilated cardiomyopathy	Enrichment	ACTC1, ACTN2, DES, DMD, MYBPC3, MYH6, TCAP, TNNC1, TNNI3, TNNT2, TPM1, TTN	11.14
3	Familial hypertrophic cardiomyopathy	Enrichment	ACTC1, ACTN2, DES, DMD, MYBPC3, MYL2, MYL3, TCAP, TNNI3, TNNT2, TPM1	10.98
4	Left ventricular noncompaction	Enrichment	ACTC1, ACTN2, MYBPC3, TNNI3, TNNT2, TPM1, TTN	10.96
5	Dilated cardiomyopathy	Enrichment	ACTA1, ACTC1, ACTN2, DES, DMD, MYBPC3, MYH6, MYL2, TCAP, TNNI3, TNNT2, TPM1, TTN	10.86
6	Arthrogryposis, distal, type 1a	Enrichment	MYBPC1, MYH3, TNNI2, TNNT3, TPM2	10.39
7	Arthrogryposis, distal, type 2b1	Enrichment	MYH3, TNNI2, TNNT3, TPM2	9.63
8	Cardiomyopathy, dilated, 1e	Enrichment	DES, MYL2, TNNC1, TPM1, TTN	9.24
9	Distal arthrogryposis	Enrichment	ACTA1, ACTC1, MYBPC1, MYH3, TNNI2, TPM2	8.96
10	Childhood-onset nemaline myopathy	Enrichment	ACTA1, NEB, TPM2, TPM3	8.83
11	Cardiomyopathy, familial hypertrophic, 1	Enrichment	MYBPC3, MYH6, TNNI3, TNNT2, TPM1	8.39
12	Nemaline myopathy	Enrichment	ACTA1, NEB, TPM2, TPM3	8.06
13	Congenital myopathy 4a, autosomal dominant	Enrichment	ACTA1, MYL2, TPM2, TPM3	7.25
14	Intermediate nemaline myopathy	Enrichment	ACTA1, NEB, TPM3	7.16
15	Typical nemaline myopathy	Enrichment	ACTA1, NEB, TPM2	6.47
16	Familial isolated restrictive cardiomyopathy	Enrichment	MYL2, TNNI3, TNNT2	6.22
17	Myocarditis	Enrichment	TNNI3, TNNT2, TTN	6.02
18	Cardiomyopathy, familial hypertrophic, 4	Enrichment	MYBPC3, TNNI3, TNNT2	5.85
19	Myopathy	Enrichment	ACTA1, DMD, TPM3, TTN	5.45
20	Restrictive cardiomyopathy	Enrichment	TNNI3, TNNT2, TTN	5.43
21	Cardiomyopathy, dilated, 1i	Enrichment	DES, MYBPC3	5.16
22	Cardiomyopathy, familial hypertrophic, 25	Enrichment	TCAP, TNNI3	5.16
23	Arrhythmogenic right ventricular cardiomyopathy	Enrichment	ACTN2, DES, MYBPC3	5.03
24	Sudden infant death syndrome	Enrichment	MYBPC3, TNNI3, TTN	4.94
25	Neuromuscular disease	Enrichment	ACTA1, DES, TTN	4.87
26	Myopathy, myofibrillar, 1	Enrichment	DES, TTN	4.69
27	Cap myopathy	Enrichment	TPM2, TPM3	4.69
28	Cardiomyopathy, dilated, 1a	Enrichment	MYBPC3, TNNI3, TTN	4.66
29	Centronuclear myopathy	Enrichment	ACTA1, TPM3, TTN	4.66
30	Muscular dystrophy	Enrichment	DMD, NEB, TTN	4.48
31	Nemaline myopathy 2	Enrichment	ACTA1, NEB	4.39
32	Congenital myopathy 3 with rigid spine	Enrichment	ACTA1, TTN	4.17
33	Severe congenital nemaline myopathy	Enrichment	ACTA1, NEB	4.17
34	Inflammatory myofibroblastic tumor	Enrichment	TPM3, TPM4	3.99
35	Creatine phosphokinase, elevated serum	Enrichment	DMD, TCAP	3.10
36	Wolff-parkinson-white syndrome	Enrichment	TNNT2, TTN	3.10
37	Isolated elevated serum creatine phosphokinase levels	Enrichment	DMD, TCAP	3.10
38	Patent foramen ovale	Enrichment	ACTC1, MYH6	2.99
39	Congenital myopathy	Enrichment	ACTA1, TTN	2.94
40	Familial atrial fibrillation	Enrichment	MYL4, TTN	2.74
41	Cardiomyopathy, familial hypertrophic, 2	Enrichment	TNNT2	2.58
42	Cardiomyopathy, familial hypertrophic, 3	Enrichment	TPM1	2.58
43	Contractures, pterygia, and spondylocarpotarsal fusion syndrome 1a	Enrichment	MYH3	2.58
44	Pulmonary atresia with intact ventricular septum	Enrichment	TPM1	2.58
45	Muscular dystrophy, becker type	Enrichment	DMD	2.58
46	Cardiomyopathy, dilated, 2a	Enrichment	TNNI3	2.58
47	Cardiomyopathy, familial hypertrophic, 8	Enrichment	MYL3	2.58
48	Cardiomyopathy, dilated, 1aa, with or without left ventricular noncompaction	Enrichment	ACTN2	2.58
49	Cardiomyopathy, familial restrictive, 3	Enrichment	TNNT2	2.58
50	Congenital myopathy 23	Enrichment	TPM2	2.58
51	Congenital myopathy 2a, typical, autosomal dominant	Enrichment	ACTA1	2.58
52	Cardiomyopathy, familial hypertrophic, 7	Enrichment	TNNI3	2.58
53	Left ventricular noncompaction 10	Enrichment	MYBPC3	2.58
54	Congenital myopathy 4b, autosomal recessive	Enrichment	TPM3	2.58
55	Nemaline myopathy 5a, autosomal recessive, severe infantile	Enrichment	TNNT1	2.58
56	Lethal congenital contracture syndrome 4	Enrichment	MYBPC1	2.58
57	Myopathy, scapulohumeroperoneal	Enrichment	ACTA1	2.58
58	Cardiomyopathy, dilated, 1ee	Enrichment	MYH6	2.58
59	Sick sinus syndrome 3	Enrichment	MYH6	2.58
60	Scapuloperoneal syndrome, neurogenic, kaeser type	Enrichment	DES	2.58
61	Congenital myopathy 16	Enrichment	MYBPC1	2.58
62	Muscular dystrophy, limb-girdle, autosomal recessive 7	Enrichment	TCAP	2.58
63	Bleeding disorder, platelet-type, 25	Enrichment	TPM4	2.58
64	Congenital myopathy 8	Enrichment	ACTN2	2.58
65	Cardiomyopathy, dilated, 3b	Enrichment	DMD	2.58
66	Atrial fibrillation, familial, 18	Enrichment	MYL4	2.58
67	Actn3 deficiency	Enrichment	ACTN3	2.58
68	Cardiomyopathy, familial hypertrophic, 14	Enrichment	MYH6	2.58
69	Autosomal recessive limb-girdle muscular dystrophy type 2g	Enrichment	TCAP	2.58
70	Congenital myopathy 2b, severe infantile, autosomal recessive	Enrichment	ACTA1	2.58
71	Cardiomyopathy, dilated, 1z	Enrichment	TNNC1	2.58
72	Cardiomyopathy, familial hypertrophic, 13	Enrichment	TNNC1	2.58
73	Arthrogryposis, distal, type 1b	Enrichment	MYBPC1	2.58
74	Congenital myopathy 15	Enrichment	TNNC2	2.58
75	Congenital myopathy 2c, severe infantile, autosomal dominant	Enrichment	ACTA1	2.58
76	Myopathy, distal, 6, adult-onset, autosomal dominant	Enrichment	ACTN2	2.58
77	Congenital myopathy 14	Enrichment	MYL1	2.58
78	Nemaline myopathy 5b, autosomal recessive, childhood-onset	Enrichment	TNNT1	2.58
79	Arthrogryposis, distal, type 2b2	Enrichment	TNNT3	2.58
80	Nemaline myopathy 5a	Enrichment	TNNT1	2.58
81	Mybpc1-related autosomal recessive non-lethal arthrogryposis multiplex congenita syndrome	Enrichment	MYBPC1	2.58
82	Symptomatic form of muscular dystrophy of duchenne and becker in female carriers	Enrichment	DMD	2.58
83	Childhood-onset progressive contractures-limb-girdle weakness-muscle dystrophy syndrome	Enrichment	TTN	2.58
84	Zebra body myopathy	Enrichment	ACTA1	2.58
85	Duchenne and becker muscular dystrophy	Enrichment	DMD	2.58
86	Actin-accumulation myopathy	Enrichment	ACTA1	2.58
87	Premature aging	Enrichment	VIM	2.58
88	Congenital generalized hypercontractile muscle stiffness syndrome	Enrichment	TPM3	2.58
89	Distal nebulin myopathy	Enrichment	NEB	2.58
90	Qualitative or quantitative defects of dystrophin	Enrichment	DMD	2.58
91	Focal segmental glomerulosclerosis 1	Enrichment	ACTN4	2.55
92	Liver disease	Enrichment	MYOM1	2.55
93	Long qt syndrome	Enrichment	MYBPC3, MYH6	2.52
94	Cardiomyopathy, familial restrictive, 1	Enrichment	TNNI3	2.28
95	Arthrogryposis, distal, type 2a	Enrichment	MYH3	2.28
96	Lethal congenital contracture syndrome 3	Enrichment	MYBPC1	2.28
97	Cardiomyopathy, dilated, 1r	Enrichment	ACTC1	2.28
98	Arthrogryposis, distal, type 7	Enrichment	MYH8	2.28
99	Cardiomyopathy, familial hypertrophic, 11	Enrichment	ACTC1	2.28
100	Cardiomyopathy, dilated, 1dd	Enrichment	TNNT2	2.28
101	Cardiomyopathy, dilated, 1ff	Enrichment	TNNI3	2.28
102	Atrial septal defect 5	Enrichment	ACTC1	2.28
103	Arthrogryposis, distal, type 2b3	Enrichment	MYH3	2.28
104	Cardiomyopathy, dilated, 1d	Enrichment	TNNT2	2.28
105	Nemaline myopathy 5c, autosomal dominant	Enrichment	TNNT1	2.28
106	Atrial septal defect 3	Enrichment	MYH6	2.28
107	Progressive familial heart block	Enrichment	DES	2.28
108	Cataract 30	Enrichment	VIM	2.28
109	Cardiomyopathy, familial hypertrophic, 10	Enrichment	MYL2	2.28
110	Myopathy, myofibrillar, 12, infantile-onset, with cardiomyopathy	Enrichment	MYL2	2.28
111	Inclusion myopathy	Enrichment	TTN	2.28
112	Carney complex - trismus - pseudocamptodactyly syndrome	Enrichment	MYH8	2.28
113	Aortic aneurysm, familial thoracic 2	Enrichment	ACTA2	2.25
114	Deafness, autosomal dominant 20	Enrichment	ACTG1	2.25
115	Smooth muscle dysfunction syndrome	Enrichment	ACTA2	2.25
116	Aortic aneurysm, familial thoracic 6	Enrichment	ACTA2	2.25
117	Baraitser-winter syndrome 2	Enrichment	ACTG1	2.25
118	Moyamoya disease 5	Enrichment	ACTA2	2.25
119	Baraitser-winter cerebrofrontofacial syndrome	Enrichment	ACTG1	2.25
120	Megacystis-microcolon-intestinal hypoperistalsis syndrome 4	Enrichment	MYL9	2.25
121	Muscular dystrophy, duchenne type	Enrichment	DMD	2.10
122	Spondylocarpotarsal synostosis syndrome	Enrichment	MYH3	2.10
123	Nonaka myopathy	Enrichment	TTN	2.10
124	Arthrogryposis multiplex congenita 6	Enrichment	NEB	2.10
125	Intrinsic cardiomyopathy	Enrichment	ACTN2	2.10
126	Myopathy, centronuclear, 2	Enrichment	TTN	1.98
127	Carney complex variant	Enrichment	MYH8	1.98
128	Left ventricular noncompaction 2	Enrichment	TTN	1.98
129	Contractures, pterygia, and spondylocarpotarsal fusion syndrome 1b	Enrichment	MYH3	1.98
130	Familial sick sinus syndrome	Enrichment	MYH6	1.98
131	Autoimmune lymphoproliferative syndrome	Enrichment	ACTA2	1.95
132	Feingold syndrome 1	Enrichment	TTN	1.88
133	Arrhythmogenic right ventricular dysplasia, familial, 1	Enrichment	TTN	1.88
134	Congenital myopathy 1b, autosomal recessive	Enrichment	TTN	1.88
135	Arrhythmogenic right ventricular dysplasia 1	Enrichment	TTN	1.88
136	Histiocytoid hemangioma	Enrichment	VIM	1.88
137	Hypoglycemia	Enrichment	MYOM1	1.86
138	Coloboma of choroid and retina	Enrichment	ACTG1	1.86
139	Atrial septal defect 1	Enrichment	TPM1	1.80
140	Moyamoya disease 1	Enrichment	ACTA2	1.78
141	Brugada syndrome 1	Enrichment	MYBPC3	1.73
142	Third-degree atrioventricular block	Enrichment	TTN	1.73
143	Myofibrillar myopathy	Enrichment	DES	1.73
144	Multiple pterygium syndrome, lethal type	Enrichment	NEB	1.68
145	Orthostatic intolerance	Enrichment	TTN	1.68
146	Congenital muscular dystrophy	Enrichment	TTN	1.68
147	Hypoplastic left heart syndrome	Enrichment	MYH6	1.68
148	Orofacial cleft 1	Enrichment	TTN	1.63
149	Arrhythmogenic right ventricular dysplasia, familial, 9	Enrichment	TTN	1.63
150	Limb-girdle muscular dystrophy	Enrichment	TTN	1.63
151	Cataract 30, multiple types	Enrichment	VIM	1.58
152	Tibial muscular dystrophy, tardive	Enrichment	TTN	1.58
153	Myopathy, myofibrillar, 9, with early respiratory failure	Enrichment	TTN	1.58
154	Tibial muscular dystrophy	Enrichment	TTN	1.58
155	Autosomal dominant macrothrombocytopenia	Enrichment	TPM4	1.58
156	Cat eye syndrome	Enrichment	ACTG1	1.56
157	Pectus excavatum	Enrichment	DMD	1.54
158	Cardiomyopathy, familial hypertrophic, 9	Enrichment	TTN	1.54
159	Atrial heart septal defect	Enrichment	DMD	1.54
160	Interatrial communication	Enrichment	DMD	1.54
161	Inherited isolated arrhythmogenic ventricular dysplasia, biventricular variant	Enrichment	TTN	1.50
162	Inherited isolated arrhythmogenic cardiomyopathy, dominant-left variant	Enrichment	TTN	1.50
163	Congenital myopathy 5 with cardiomyopathy	Enrichment	TTN	1.47
164	Heart disease	Enrichment	MYL2	1.44
165	Inherited isolated arrhythmogenic cardiomyopathy, dominant-right variant	Enrichment	TTN	1.44
166	Lung cancer susceptibility 3	Enrichment	ACTA2	1.41
167	Beckwith-wiedemann syndrome	Enrichment	DMD	1.33
168	Heart, malformation of	Enrichment	MYH6	1.33
169	Muscular dystrophy, limb-girdle, autosomal recessive 10	Enrichment	TTN	1.31
170	Autosomal recessive limb-girdle muscular dystrophy type 2j	Enrichment	TTN	1.27
171	Cardiomyopathy, dilated, 1g	Enrichment	TTN	1.25
172	Lissencephaly	Enrichment	ACTG1	1.24
173	Tetralogy of fallot	Enrichment	TPM1	1.18
174	Hydrops fetalis, nonimmune	Enrichment	ACTA1	1.18
175	Brugada syndrome	Enrichment	MYBPC3	1.18
176	Non-immune hydrops fetalis	Enrichment	ACTA1	1.10
177	Lung cancer	Enrichment	ACTA2	1.07
178	Connective tissue disease	Enrichment	ACTA2	1.07
179	Fanconi anemia, complementation group a	Enrichment	DMD	1.05
180	Cakut	Enrichment	ACTG1	1.04
181	Genetic steroid-resistant nephrotic syndrome	Enrichment	ACTN4	1.04
182	Non-syndromic x-linked intellectual disability	Enrichment	DMD	1.04
183	Fetal akinesia deformation sequence 1	Enrichment	ACTA1	1.03
184	Non-syndromic genetic deafness	Enrichment	ACTG1	1.02
185	Cerebral palsy	Enrichment	TTN	1.01
186	Nonsyndromic hearing loss	Enrichment	ACTG1	0.95
187	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	ACTA2	0.93
188	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	ACTG1	0.87
189	Schizophrenia	Enrichment	DMD	0.84
190	Autism	Enrichment	DMD	0.76
191	Rare genetic deafness	Enrichment	ACTG1	0.70
192	Colorectal cancer	Enrichment	DMD	0.68
193	Microcephaly	Enrichment	ACTG1	0.53

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Striated muscle contraction pathway

Pathway Network for Striated muscle contraction pathway

Member Pathways for Striated muscle contraction pathway

Pathways in the Striated muscle contraction pathway SuperPath

Associated Genes for Striated muscle contraction pathway

Associated Disorders for Striated muscle contraction pathway

Disorders associated with Striated muscle contraction pathway SuperPath

STRING Interaction Network for Striated muscle contraction pathway

Sources for Striated muscle contraction pathway