Succinylcholine Pathway, Pharmacokinetics/Pharmacodynamics

No Pathway Network information available for Succinylcholine Pathway, Pharmacokinetics/Pharmacodynamics

Pathways in the Succinylcholine Pathway, Pharmacokinetics/Pharmacodynamics SuperPath

#	Name	Source	Genes
1	Succinylcholine Pathway, Pharmacokinetics/Pharmacodynamics	PharmGKB	ATP2A1 ATP2A2 BCHE CACNA1S CACNA2D1 CACNB1 CACNG1 CHRNA1 CHRNB1 CHRND CHRNE RYR1 (see all 12) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	RYR1	Ryanodine Receptor 1	Protein Coding	1
2	BCHE	Butyrylcholinesterase	Protein Coding	1
3	CACNA1S	Calcium Voltage-Gated Channel Subunit Alpha1 S	Protein Coding	1
4	CACNA2D1	Calcium Voltage-Gated Channel Auxiliary Subunit Alpha2delta 1	Protein Coding	1
5	CACNB1	Calcium Voltage-Gated Channel Auxiliary Subunit Beta 1	Protein Coding	1
6	CACNG1	Calcium Voltage-Gated Channel Auxiliary Subunit Gamma 1	Protein Coding	1
7	ATP2A1	ATPase Sarcoplasmic/Endoplasmic Reticulum Ca2+ Transporting 1	Protein Coding	1
8	ATP2A2	ATPase Sarcoplasmic/Endoplasmic Reticulum Ca2+ Transporting 2	Protein Coding	1
9	CHRNA1	Cholinergic Receptor Nicotinic Alpha 1 Subunit	Protein Coding	1
10	CHRNB1	Cholinergic Receptor Nicotinic Beta 1 Subunit	Protein Coding	1
11	CHRND	Cholinergic Receptor Nicotinic Delta Subunit	Protein Coding	1
12	CHRNE	Cholinergic Receptor Nicotinic Epsilon Subunit	Protein Coding	1

Disorders associated with Succinylcholine Pathway, Pharmacokinetics/Pharmacodynamics SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Myasthenic syndrome, congenital, 1a, slow-channel	Enrichment	CHRNA1, CHRNB1, CHRND, CHRNE	10.51
2	Postsynaptic congenital myasthenic syndromes	Enrichment	CHRNA1, CHRNB1, CHRND, CHRNE	9.76
3	Centronuclear myopathy	Enrichment	CACNA1S, CHRNA1, CHRND, RYR1	8.68
4	Myasthenic syndrome, congenital, 1b, fast-channel	Enrichment	CHRNA1, CHRND, CHRNE	8.67
5	Multiple pterygium syndrome, lethal type	Enrichment	CHRNA1, CHRND, RYR1	7.53
6	Congenital myopathy	Enrichment	CACNA1S, CHRNA1, RYR1	6.29
7	Malignant hyperthermia	Enrichment	CACNA1S, RYR1	5.37
8	Congenital myasthenic syndrome	Enrichment	CHRNA1, CHRNE	4.19
9	Fetal akinesia deformation sequence 1	Enrichment	CHRND, RYR1	3.33
10	Distal arthrogryposis	Enrichment	CHRND, RYR1	3.22
11	Thyrotoxic periodic paralysis 1	Enrichment	CACNA1S	3.05
12	Myasthenic syndrome, congenital, 2a, slow-channel	Enrichment	CHRNB1	3.05
13	Myasthenic syndrome, congenital, 2c, associated with acetylcholine receptor deficiency	Enrichment	CHRNB1	3.05
14	Myasthenic syndrome, congenital, 3a, slow-channel	Enrichment	CHRND	3.05
15	Congenital myopathy 18	Enrichment	CACNA1S	3.05
16	Myasthenic syndrome, congenital, 3c, associated with acetylcholine receptor deficiency	Enrichment	CHRND	3.05
17	Myasthenic syndrome, congenital, 3b, fast-channel	Enrichment	CHRND	3.05
18	Malignant hyperthermia 5	Enrichment	CACNA1S	3.05
19	Developmental and epileptic encephalopathy 110	Enrichment	CACNA2D1	3.05
20	Butyrylcholinesterase deficiency	Enrichment	BCHE	3.05
21	Congenital myopathy with myasthenic-like onset	Enrichment	RYR1	3.05
22	Rhabdomyolysis 2	Enrichment	ATP2A2	3.05
23	Periodic paralysis with transient compartment-like syndrome	Enrichment	CACNA1S	3.05
24	Calf-predominant weakness-gastrocnemius medialis atrophy-distal myopathy	Enrichment	RYR1	3.05
25	Benign samaritan congenital myopathy	Enrichment	RYR1	3.05
26	Malignant hyperthermia 1	Enrichment	RYR1	2.75
27	Acrokeratosis verruciformis	Enrichment	ATP2A2	2.75
28	Brody disease	Enrichment	ATP2A1	2.75
29	King-denborough syndrome	Enrichment	RYR1	2.75
30	Exercise-induced malignant hyperthermia	Enrichment	RYR1	2.75
31	Darier-white disease	Enrichment	ATP2A2	2.58
32	Lynch syndrome 5	Enrichment	RYR1	2.58
33	Bronchopulmonary dysplasia	Enrichment	RYR1	2.58
34	Thyrotoxic periodic paralysis	Enrichment	CACNA1S	2.58
35	Congenital myopathy 1a, autosomal dominant, with malignant hyperthermia	Enrichment	RYR1	2.45
36	Myopathy, centronuclear, 2	Enrichment	RYR1	2.45
37	Sacral defect with anterior meningocele	Enrichment	RYR1	2.45
38	Intellectual developmental disorder, autosomal dominant 26	Enrichment	RYR1	2.45
39	Congenital myopathy 1a	Enrichment	RYR1	2.45
40	Congenital myopathy 1b, autosomal recessive	Enrichment	RYR1	2.35
41	Myasthenic syndrome, congenital, 4a, slow-channel	Enrichment	CHRNE	2.35
42	Cardiac arrest	Enrichment	CACNA2D1	2.35
43	Myasthenic syndrome, congenital, 4b, fast-channel	Enrichment	CHRNE	2.35
44	Congenital short qt syndrome	Enrichment	CACNA2D1	2.35
45	Hypokalemic periodic paralysis, type 1	Enrichment	CACNA1S	2.28
46	Myopathy, centronuclear, 1	Enrichment	RYR1	2.28
47	Brugada syndrome 1	Enrichment	CACNA2D1	2.21
48	Congenital muscular dystrophy	Enrichment	RYR1	2.15
49	Hydrops fetalis	Enrichment	RYR1	2.10
50	Myasthenic syndrome, congenital, 4c, associated with acetylcholine receptor deficiency	Enrichment	CHRNE	2.05
51	Clubfoot, congenital, with or without deficiency of long bones and/or mirror-image polydactyly	Enrichment	RYR1	1.94
52	Clubfoot	Enrichment	RYR1	1.94
53	Congenital myopathy 4a, autosomal dominant	Enrichment	RYR1	1.88
54	Arrhythmogenic right ventricular cardiomyopathy	Enrichment	RYR1	1.85
55	Beckwith-wiedemann syndrome	Enrichment	RYR1	1.80
56	Neuromuscular disease	Enrichment	RYR1	1.80
57	Scoliosis	Enrichment	RYR1	1.68
58	Hydrops fetalis, nonimmune	Enrichment	CHRNA1	1.64
59	Brugada syndrome	Enrichment	CACNA2D1	1.64
60	Long qt syndrome	Enrichment	CACNA1S	1.57
61	Non-immune hydrops fetalis	Enrichment	CHRNA1	1.57
62	Myopathy	Enrichment	RYR1	1.46
63	Undetermined early-onset epileptic encephalopathy	Enrichment	CACNA2D1	1.31
64	Autism	Enrichment	CHRNA1	1.21
65	Breast cancer	Enrichment	CACNA2D1	1.19

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Succinylcholine Pathway, Pharmacokinetics/Pharmacodynamics

Pathway Network for Succinylcholine Pathway, Pharmacokinetics/Pharmacodynamics

Member Pathways for Succinylcholine Pathway, Pharmacokinetics/Pharmacodynamics

Pathways in the Succinylcholine Pathway, Pharmacokinetics/Pharmacodynamics SuperPath

Associated Genes for Succinylcholine Pathway, Pharmacokinetics/Pharmacodynamics

Associated Disorders for Succinylcholine Pathway, Pharmacokinetics/Pharmacodynamics

Disorders associated with Succinylcholine Pathway, Pharmacokinetics/Pharmacodynamics SuperPath

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