Sulfatase and aromatase pathway
Pathways in the Sulfatase and aromatase pathway SuperPath
| # | Name | Source | Genes |
|---|---|---|---|
| 1 | Sulfatase and aromatase pathway | WikiPathways | |
| 2 | Aromatase Inhibitor Pathway (Breast Cell), Pharmacodynamics | PharmGKB |
Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways
| # | Symbol | Description | Category | # Related Pathways |
|---|---|---|---|---|
| 1 | ESR2 | Estrogen Receptor 2 | Protein Coding | 2 |
| 2 | CYP19A1 | Cytochrome P450 Family 19 Subfamily A Member 1 | Protein Coding | 2 |
| 3 | ESR1 | Estrogen Receptor 1 | Protein Coding | 2 |
| 4 | HSD17B1 | Hydroxysteroid 17-Beta Dehydrogenase 1 | Protein Coding | 2 |
| 5 | SLCO4A1 | Solute Carrier Organic Anion Transporter Family Member 4A1 | Protein Coding | 1 |
| 6 | HSD3B1 | Hydroxy-Delta-5-Steroid Dehydrogenase, 3 Beta- And Steroid Delta-Isomerase 1 | Protein Coding | 1 |
| 7 | HSD17B2 | Hydroxysteroid 17-Beta Dehydrogenase 2 | Protein Coding | 1 |
| 8 | SLCO1B1 | Solute Carrier Organic Anion Transporter Family Member 1B1 | Protein Coding | 1 |
| 9 | SLCO4C1 | Solute Carrier Organic Anion Transporter Family Member 4C1 | Protein Coding | 1 |
| 10 | SLCO2B1 | Solute Carrier Organic Anion Transporter Family Member 2B1 | Protein Coding | 1 |
| 11 | HSD17B3 | Hydroxysteroid 17-Beta Dehydrogenase 3 | Protein Coding | 1 |
| 12 | SULT1E1 | Sulfotransferase Family 1E Member 1 | Protein Coding | 1 |
| 13 | SLCO1A2 | Solute Carrier Organic Anion Transporter Family Member 1A2 | Protein Coding | 1 |
| 14 | SLCO1B3 | Solute Carrier Organic Anion Transporter Family Member 1B3 | Protein Coding | 1 |
Disorders associated with Sulfatase and aromatase pathway SuperPath
according to GeneCards Suite gene sharing
| # | Disorder | Type | Genes | Score |
|---|---|---|---|---|
| 1 | Hyperbilirubinemia, rotor type | Enrichment | SLCO1B1, SLCO1B3 | 5.53 |
| 2 | Ovarian dysgenesis 8 | Enrichment | ESR2 | 3.53 |
| 3 | Thyroid carcinoma, familial medullary | Enrichment | ESR2 | 3.05 |
| 4 | Aromatase excess syndrome | Enrichment | CYP19A1 | 3.05 |
| 5 | Estrogen resistance | Enrichment | ESR1 | 3.05 |
| 6 | Migraine without aura | Enrichment | ESR1 | 3.05 |
| 7 | Aromatase deficiency | Enrichment | CYP19A1 | 3.05 |
| 8 | Arthrogryposis multiplex congenita 3, myogenic type | Enrichment | ESR1 | 2.93 |
| 9 | 17-beta hydroxysteroid dehydrogenase iii deficiency | Enrichment | HSD17B3 | 2.69 |
| 10 | Migraine with or without aura 1 | Enrichment | ESR1 | 2.49 |
| 11 | Pseudohermaphroditism | Enrichment | HSD17B3 | 2.29 |
| 12 | Myocardial infarction | Enrichment | ESR1 | 2.19 |
| 13 | Difference of sex development | Enrichment | HSD17B3 | 2.08 |
| 14 | Gilbert syndrome | Enrichment | SLCO1B1 | 1.95 |
| 15 | Epilepsy, myoclonic juvenile | Enrichment | HSD17B3 | 1.95 |
| 16 | Hereditary breast carcinoma | Enrichment | ESR1 | 1.89 |
| 17 | Primary ovarian insufficiency | Enrichment | CYP19A1 | 1.76 |
| 18 | Breast cancer | Enrichment | ESR1 | 1.66 |
