Sulfur amino acid metabolism

Pathway network for the Sulfur amino acid metabolism SuperPath

Sources:

Reactome
WikiPathways
PubChem

Pathways in the Sulfur amino acid metabolism SuperPath

#	Name	Source	Genes
1	Sulfur amino acid metabolism	Reactome	ADI1 ADO AHCY BHMT BHMT2 CBS CDO1 CSAD CTH ENOPH1 ETHE1 FMO1 GADL1 GOT1 GOT2 LOC102724560 MAT1A MPST MRI1 MTAP MTR MTRR SLC25A10 SQOR SUOX TST TSTD1 TXN2 (see all 28) (see less)
2	Degradation of cysteine and homocysteine	Reactome	ADO CDO1 CSAD CTH ETHE1 FMO1 GADL1 GOT2 MPST SLC25A10 SQOR SUOX TST TSTD1 TXN2 (see all 15) (see less)
3	Cysteine and methionine catabolism	WikiPathways	AHCY BHMT CBS CDO1 CSAD CTH ETHE1 GOT1 GSS LOC102724560 MPST MTR SQOR (see all 13) (see less)
4	Sulfide oxidation to sulfate	Reactome	ETHE1 SLC25A10 SQOR SUOX TST TSTD1 (see all 6) (see less)
5	Methionine salvage pathway	Reactome	ADI1 ENOPH1 GOT1 MRI1 MTAP
6	sulfide oxidation IV (metazoa)	PubChem	SQOR SUOX TST
7	Ethylmalonic encephalopathy	WikiPathways	ETHE1 SUOX TST
8	thiosulfate disproportionation III (rhodanese)	PubChem	TST

Gene overlap in member pathways for Sulfur amino acid metabolism SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	TST	Thiosulfate Sulfurtransferase	Protein Coding	6
2	ETHE1	ETHE1 Persulfide Dioxygenase	Protein Coding	5
3	SQOR	Sulfide Quinone Oxidoreductase	Protein Coding	5
4	SUOX	Sulfite Oxidase	Protein Coding	5
5	TSTD1	Thiosulfate Sulfurtransferase Like Domain Containing 1	Protein Coding	3
6	CDO1	Cysteine Dioxygenase Type 1	Protein Coding	3
7	SLC25A10	Solute Carrier Family 25 Member 10	Protein Coding	3
8	CTH	Cystathionine Gamma-Lyase	Protein Coding	3
9	GOT1	Glutamic-Oxaloacetic Transaminase 1	Protein Coding	3
10	MPST	Mercaptopyruvate Sulfurtransferase	Protein Coding	3
11	CSAD	Cysteine Sulfinic Acid Decarboxylase	Protein Coding	3
12	LOC102724560	Cystathionine Beta-Synthase Like	Protein Coding	2
13	AHCY	Adenosylhomocysteinase	Protein Coding	2
14	FMO1	Flavin Containing Dimethylaniline Monoxygenase 1	Protein Coding	2
15	TXN2	Thioredoxin 2	Protein Coding	2
16	GOT2	Glutamic-Oxaloacetic Transaminase 2	Protein Coding	2
17	GADL1	Glutamate Decarboxylase Like 1	Protein Coding	2
18	MTAP	Methylthioadenosine Phosphorylase	Protein Coding	2
19	MTR	5-Methyltetrahydrofolate-Homocysteine Methyltransferase	Protein Coding	2
20	ADI1	Acireductone Dioxygenase 1	Protein Coding	2
21	ENOPH1	Enolase-Phosphatase 1	Protein Coding	2
22	BHMT	Betaine--Homocysteine S-Methyltransferase	Protein Coding	2
23	MRI1	Methylthioribose-1-Phosphate Isomerase 1	Protein Coding	2
24	ADO	2-Aminoethanethiol Dioxygenase	Protein Coding	2
25	CBS	Cystathionine Beta-Synthase	Protein Coding	2
26	BHMT2	Betaine--Homocysteine S-Methyltransferase 2	Protein Coding	1
27	MAT1A	Methionine Adenosyltransferase 1A	Protein Coding	1
28	MTRR	5-Methyltetrahydrofolate-Homocysteine Methyltransferase Reductase	Protein Coding	1
29	GSS	Glutathione Synthetase	Protein Coding	1

Disorders associated with Sulfur amino acid metabolism SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Homocystinuria	Enrichment	CBS, MTR	5.59
2	Homocystinuria-megaloblastic anemia, cblg type	Enrichment	MTR, MTRR	4.91
3	Neural tube defects, folate-sensitive	Enrichment	MTR, MTRR	4.61
4	Sulfite oxidase deficiency, isolated	Enrichment	SUOX	3.66
5	Sulfide:quinone oxidoreductase deficiency	Enrichment	SQOR	3.66
6	Aspartate aminotransferase, serum level of, quantitative trait locus 1	Enrichment	GOT1	3.43
7	Encephalopathy, ethylmalonic	Enrichment	ETHE1	3.35
8	Mitochondrial dna depletion syndrome 19	Enrichment	SLC25A10	3.35
9	Diaphyseal medullary stenosis with malignant fibrous histiocytoma	Enrichment	MTAP	3.13
10	Diaphyseal medullary stenosis-bone malignancy syndrome	Enrichment	MTAP	3.13
11	Cystathioninuria	Enrichment	CTH	3.02
12	Glutathione synthetase deficiency	Enrichment	GSS	3.02
13	Anemia, congenital, nonspherocytic hemolytic, 6	Enrichment	GSS	3.02
14	Hypermethioninemia with s-adenosylhomocysteine hydrolase deficiency	Enrichment	AHCY	3.02
15	Hyperhomocysteinemia	Enrichment	CBS	3.02
16	Combined oxidative phosphorylation deficiency 29	Enrichment	TXN2	2.96
17	Disorders of intracellular cobalamin metabolism	Enrichment	MTR	2.72
18	Homocystinuria without methylmalonic aciduria	Enrichment	MTRR	2.69
19	Bainbridge-ropers syndrome	Enrichment	GADL1	2.66
20	Developmental and epileptic encephalopathy 82	Enrichment	GOT2	2.66
21	Homocystinuria due to cystathionine beta-synthase deficiency	Enrichment	CBS	2.54
22	Homocystinuria-megaloblastic anemia, cble type	Enrichment	MTRR	2.38
23	Methionine adenosyltransferase i/iii deficiency	Enrichment	MAT1A	2.38
24	Methionine adenosyltransferase deficiency	Enrichment	MAT1A	2.38
25	Down syndrome	Enrichment	MTRR	2.08
26	Mitochondrial complex i deficiency, nuclear type 1	Enrichment	SLC25A10	1.78
27	Congenital nervous system abnormality	Enrichment	ETHE1	1.63
28	Nervous system disease	Enrichment	ETHE1	1.63
29	Connective tissue disease	Enrichment	CBS	1.52
30	Epilepsy	Enrichment	MTR	1.42
31	Developmental and epileptic encephalopathy	Enrichment	GOT2	1.41
32	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	CBS	1.38

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Sulfur amino acid metabolism

Pathway Network for Sulfur amino acid metabolism

Pathway network for the Sulfur amino acid metabolism SuperPath

Member Pathways for Sulfur amino acid metabolism

Pathways in the Sulfur amino acid metabolism SuperPath

Gene overlap in member pathways for Sulfur amino acid metabolism SuperPath

Associated Genes for Sulfur amino acid metabolism

Associated Disorders for Sulfur amino acid metabolism

Disorders associated with Sulfur amino acid metabolism SuperPath

STRING Interaction Network for Sulfur amino acid metabolism

Sources for Sulfur amino acid metabolism