SUMOylation of transcription cofactors

No Pathway Network information available for SUMOylation of transcription cofactors

Pathways in the SUMOylation of transcription cofactors SuperPath

#	Name	Source	Genes
1	SUMOylation of transcription cofactors	Reactome	BMI1 CASP8AP2 CBX2 CBX4 CBX8 COMMD3-BMI1 CREBBP CTBP1 DAXX DDX17 DDX5 EP300 HIPK2 ING2 MBD1 MRTFA NCOA1 NCOA2 NCOR2 NPM1 NRIP1 PARK7 PCGF2 PHC1 PHC2 PHC3 PIAS1 PIAS2 PIAS3 PIAS4 PPARGC1A RING1 RNF2 SAFB SCMH1 SIN3A SUMO1 SUMO2 SUMO3 TOPORS TRIM28 UBE2I UHRF2 ZNF131 ZNF350 (see all 45) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	COMMD3-BMI1	COMMD3-BMI1 Readthrough	Protein Coding	1
2	TRIM28	Tripartite Motif Containing 28	Protein Coding	1
3	TOPORS	TOP1 Binding Arginine/Serine Rich Protein, E3 Ubiquitin Ligase	Protein Coding	1
4	PIAS3	Protein Inhibitor Of Activated STAT 3	Protein Coding	1
5	NCOA2	Nuclear Receptor Coactivator 2	Protein Coding	1
6	DDX17	DEAD-Box Helicase 17	Protein Coding	1
7	PPARGC1A	PPARG Coactivator 1 Alpha	Protein Coding	1
8	PARK7	Parkinsonism Associated Deglycase	Protein Coding	1
9	UHRF2	Ubiquitin Like With PHD And Ring Finger Domains 2	Protein Coding	1
10	CREBBP	CREB Binding Lysine Acetyltransferase	Protein Coding	1
11	CTBP1	C-Terminal Binding Protein 1	Protein Coding	1
12	DAXX	Death Domain Associated Protein	Protein Coding	1
13	DDX5	DEAD-Box Helicase 5	Protein Coding	1
14	PHC1	Polyhomeotic Homolog 1	Protein Coding	1
15	PHC2	Polyhomeotic Homolog 2	Protein Coding	1
16	EP300	EP300 Lysine Acetyltransferase	Protein Coding	1
17	SCMH1	Scm Polycomb Group Protein Homolog 1	Protein Coding	1
18	SIN3A	SIN3 Transcription Regulator Family Member A	Protein Coding	1
19	HIPK2	Homeodomain Interacting Protein Kinase 2	Protein Coding	1
20	ING2	Inhibitor Of Growth Family Member 2	Protein Coding	1
21	MBD1	Methyl-CpG Binding Domain Protein 1	Protein Coding	1
22	NPM1	Nucleophosmin 1	Protein Coding	1
23	PIAS4	Protein Inhibitor Of Activated STAT 4	Protein Coding	1
24	CBX8	Chromobox 8	Protein Coding	1
25	MRTFA	Myocardin Related Transcription Factor A	Protein Coding	1
26	ZNF350	Zinc Finger Protein 350	Protein Coding	1
27	RING1	Ring Finger Protein 1	Protein Coding	1
28	RNF2	Ring Finger Protein 2	Protein Coding	1
29	SAFB	Scaffold Attachment Factor B	Protein Coding	1
30	BMI1	BMI1 Proto-Oncogene, Polycomb Ring Finger	Protein Coding	1
31	SUMO3	Small Ubiquitin Like Modifier 3	Protein Coding	1
32	SUMO2	Small Ubiquitin Like Modifier 2	Protein Coding	1
33	UBE2I	Ubiquitin Conjugating Enzyme E2 I	Protein Coding	1
34	SUMO1	Small Ubiquitin Like Modifier 1	Protein Coding	1
35	ZNF131	Zinc Finger Protein 131	Protein Coding	1
36	PCGF2	Polycomb Group Ring Finger 2	Protein Coding	1
37	PHC3	Polyhomeotic Homolog 3	Protein Coding	1
38	NRIP1	Nuclear Receptor Interacting Protein 1	Protein Coding	1
39	CBX2	Chromobox 2	Protein Coding	1
40	CBX4	Chromobox 4	Protein Coding	1
41	PIAS1	Protein Inhibitor Of Activated STAT 1	Protein Coding	1
42	NCOA1	Nuclear Receptor Coactivator 1	Protein Coding	1
43	PIAS2	Protein Inhibitor Of Activated STAT 2	Protein Coding	1
44	NCOR2	Nuclear Receptor Corepressor 2	Protein Coding	1
45	CASP8AP2	Caspase 8 Associated Protein 2	Protein Coding	1

Disorders associated with SUMOylation of transcription cofactors SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Rubinstein-taybi syndrome 1	Enrichment	CREBBP, EP300	3.80
2	Chromosome 16p13.3 deletion syndrome, proximal	Enrichment	CREBBP, EP300	3.80
3	Rare genetic intellectual disability	Enrichment	CREBBP, EP300	2.96
4	46,xy sex reversal 5	Enrichment	CBX2	2.48
5	Microcephaly 11, primary, autosomal recessive	Enrichment	PHC1	2.48
6	Luo-schoch-yamamoto syndrome	Enrichment	RNF2	2.48
7	Orofacial cleft 10	Enrichment	SUMO1	2.48
8	Parkinson disease 7, autosomal recessive early-onset	Enrichment	PARK7	2.48
9	Retinitis pigmentosa 31	Enrichment	TOPORS	2.48
10	Congenital anomalies of kidney and urinary tract 3	Enrichment	NRIP1	2.48
11	Menke-hennekam syndrome 1	Enrichment	CREBBP	2.48
12	Turnpenny-fry syndrome	Enrichment	PCGF2	2.48
13	Rubinstein-taybi syndrome due to 16p13.3 microdeletion	Enrichment	CREBBP	2.48
14	Chromosome 15q24 deletion syndrome	Enrichment	SIN3A	2.48
15	Acute myeloid leukemia with multilineage dysplasia	Enrichment	NPM1	2.48
16	Acute myeloid leukemia with npm1 somatic mutations	Enrichment	NPM1	2.48
17	Wilms tumor 7	Enrichment	TRIM28	2.48
18	Menke-hennekam syndrome	Enrichment	CREBBP	2.48
19	Amyotrophic lateral sclerosis-parkinsonism/dementia complex 1	Enrichment	PARK7	2.18
20	Thumb deformity	Enrichment	CREBBP	2.18
21	Hypotonia, ataxia, developmental delay, and tooth enamel defect syndrome	Enrichment	CTBP1	2.18
22	Immunodeficiency 66	Enrichment	MRTFA	2.18
23	Menke-hennekam syndrome 2	Enrichment	EP300	2.18
24	Acute myeloid leukemia with kat6a-crebbp fusion	Enrichment	CREBBP	2.18
25	Witteveen-kolk syndrome	Enrichment	SIN3A	2.18
26	Acute myeloid leukemia without maturation	Enrichment	NPM1	2.18
27	Lymphomatoid papulosis	Enrichment	NPM1	2.18
28	Primary cutaneous anaplastic large cell lymphoma	Enrichment	NPM1	2.18
29	Megakaryoblastic acute myeloid leukemia with t(1;22)(p13;q13)	Enrichment	MRTFA	2.18
30	Tethered spinal cord syndrome	Enrichment	CREBBP	2.00
31	Intraocular pressure quantitative trait locus	Enrichment	CREBBP	2.00
32	Myeloma, multiple	Enrichment	CREBBP, NCOR2	1.83
33	Rubinstein-taybi syndrome 2	Enrichment	EP300	1.78
34	Acute myeloid leukemia with maturation	Enrichment	NPM1	1.78
35	Wolf-hirschhorn syndrome	Enrichment	CTBP1	1.70
36	Wilms tumor 5	Enrichment	TRIM28	1.70
37	Parkinson disease 6, autosomal recessive early-onset	Enrichment	PARK7	1.70
38	Hypertrichosis	Enrichment	CREBBP	1.70
39	Charge syndrome	Enrichment	EP300	1.53
40	Orofaciodigital syndrome vi	Enrichment	TOPORS	1.44
41	46,xy complete gonadal dysgenesis	Enrichment	CBX2	1.44
42	Early-onset parkinson's disease	Enrichment	PARK7	1.41
43	Acute promyelocytic leukemia	Enrichment	NPM1	1.37
44	Heart disease	Enrichment	CREBBP	1.34
45	Polydactyly, postaxial, type a1	Enrichment	EP300	1.31
46	Wilms tumor 1	Enrichment	TRIM28	1.31
47	Corpus callosum, agenesis of	Enrichment	CREBBP	1.31
48	Isolated corpus callosum agenesis	Enrichment	CREBBP	1.31
49	Intellectual disability-hypoplastic corpus callosum-preauricular tag syndrome	Enrichment	CREBBP	1.31
50	Isolated congenital microcephaly	Enrichment	PHC1	1.29
51	Diffuse large b-cell lymphoma	Enrichment	CREBBP	1.21
52	Dyskeratosis congenita	Enrichment	NPM1	1.21
53	Tooth agenesis	Enrichment	SUMO1	1.15
54	Scoliosis	Enrichment	CREBBP	1.12
55	Primary autosomal recessive microcephaly	Enrichment	PHC1	1.00
56	Nephronophthisis	Enrichment	PIAS1	0.98
57	Cakut	Enrichment	NRIP1	0.97
58	Leukemia, acute myeloid	Enrichment	NPM1	0.90
59	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	PPARGC1A	0.76
60	Autism	Enrichment	CREBBP	0.67
61	Colorectal cancer	Enrichment	EP300	0.60
62	Congenital nervous system abnormality	Enrichment	CREBBP	0.53
63	Nervous system disease	Enrichment	CREBBP	0.53
64	Microcephaly	Enrichment	EP300	0.47
65	Complex neurodevelopmental disorder	Enrichment	RNF2	0.47
66	Retinitis pigmentosa	Enrichment	TOPORS	0.29
67	Hereditary retinal dystrophy	Enrichment	TOPORS	0.21
68	Fundus dystrophy	Enrichment	TOPORS	0.21

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

SUMOylation of transcription cofactors

Pathway Network for SUMOylation of transcription cofactors

Member Pathways for SUMOylation of transcription cofactors

Pathways in the SUMOylation of transcription cofactors SuperPath

Associated Genes for SUMOylation of transcription cofactors

Associated Disorders for SUMOylation of transcription cofactors

Disorders associated with SUMOylation of transcription cofactors SuperPath

STRING Interaction Network for SUMOylation of transcription cofactors

Sources for SUMOylation of transcription cofactors