Sunitinib Pathway, Pharmacokinetics/Pharmacodynamics

Pathway network for the Sunitinib Pathway, Pharmacokinetics/Pharmacodynamics SuperPath

Sources:

PharmGKB

Pathways in the Sunitinib Pathway, Pharmacokinetics/Pharmacodynamics SuperPath

#	Name	Source	Genes
1	Sunitinib Pathway, Pharmacokinetics/Pharmacodynamics	PharmGKB	ABCB1 ABCG2 CYP1A1 CYP1A2 CYP3A4 CYP3A5 FLT1 FLT3 FLT4 KDR KIT NR1I2 NR1I3 PDGFRA PDGFRB (see all 15) (see less)
2	Pazopanib Pathway, Pharmacokinetics	PharmGKB	ABCB1 ABCG2 CYP1A2 CYP2C19 CYP2C9 CYP2D6 CYP3A4 FLT1 FLT4 KDR KIT PDGFRA PDGFRB SLC22A2 SLC47A1 SLC47A2 SLCO1B1 SLCO1B3 UGT1A1 (see all 19) (see less)
3	Quizartinib Pathway, Pharmacokinetics/Pharmacodynamics	PharmGKB	CYP3A4 CYP3A5 FLT3

Gene overlap in member pathways for Sunitinib Pathway, Pharmacokinetics/Pharmacodynamics SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	CYP3A4	Cytochrome P450 Family 3 Subfamily A Member 4	Protein Coding	3
2	KDR	Kinase Insert Domain Receptor	Protein Coding	2
3	KIT	KIT Proto-Oncogene, Receptor Tyrosine Kinase	Protein Coding	2
4	PDGFRA	Platelet Derived Growth Factor Receptor Alpha	Protein Coding	2
5	PDGFRB	Platelet Derived Growth Factor Receptor Beta	Protein Coding	2
6	FLT1	Fms Related Receptor Tyrosine Kinase 1	Protein Coding	2
7	FLT3	Fms Related Receptor Tyrosine Kinase 3	Protein Coding	2
8	FLT4	Fms Related Receptor Tyrosine Kinase 4	Protein Coding	2
9	ABCB1	ATP Binding Cassette Subfamily B Member 1	Protein Coding	2
10	CYP1A2	Cytochrome P450 Family 1 Subfamily A Member 2	Protein Coding	2
11	CYP3A5	Cytochrome P450 Family 3 Subfamily A Member 5	Protein Coding	2
12	ABCG2	ATP Binding Cassette Subfamily G Member 2 (JR Blood Group)	Protein Coding	2
13	NR1I2	Nuclear Receptor Subfamily 1 Group I Member 2	Protein Coding	1
14	CYP1A1	Cytochrome P450 Family 1 Subfamily A Member 1	Protein Coding	1
15	NR1I3	Nuclear Receptor Subfamily 1 Group I Member 3	Protein Coding	1
16	SLC22A2	Solute Carrier Family 22 Member 2	Protein Coding	1
17	UGT1A1	UDP Glucuronosyltransferase Family 1 Member A1	Protein Coding	1
18	SLCO1B3	Solute Carrier Organic Anion Transporter Family Member 1B3	Protein Coding	1
19	CYP2C19	Cytochrome P450 Family 2 Subfamily C Member 19	Protein Coding	1
20	CYP2C9	Cytochrome P450 Family 2 Subfamily C Member 9	Protein Coding	1
21	CYP2D6	Cytochrome P450 Family 2 Subfamily D Member 6 (Gene/Pseudogene)	Protein Coding	1
22	SLCO1B1	Solute Carrier Organic Anion Transporter Family Member 1B1	Protein Coding	1
23	SLC47A1	Solute Carrier Family 47 Member 1	Protein Coding	1
24	SLC47A2	Solute Carrier Family 47 Member 2	Protein Coding	1

Disorders associated with Sunitinib Pathway, Pharmacokinetics/Pharmacodynamics SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Hyperbilirubinemia, rotor type	Enrichment	SLCO1B1, SLCO1B3	5.25
2	Acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22)	Enrichment	FLT3, KIT	5.16
3	Acute myeloid leukemia with maturation	Enrichment	FLT3, KIT	4.94
4	Acute myeloid leukemia with t(8;21)(q22;q22) translocation	Enrichment	FLT3, KIT	4.94
5	Primary hypereosinophilic syndrome	Enrichment	PDGFRA, PDGFRB	4.94
6	Hemangioma, capillary infantile	Enrichment	FLT4, KDR	4.77
7	Gastrointestinal stromal tumor	Enrichment	KIT, PDGFRA	4.62
8	Gilbert syndrome	Enrichment	SLCO1B1, UGT1A1	3.99
9	Acute myeloid leukemia with minimal differentiation	Enrichment	FLT3	3.66
10	Vitamin d-dependent rickets, type 3	Enrichment	CYP3A4	3.66
11	Tetralogy of fallot	Enrichment	FLT4, KDR	3.44
12	Acute myeloid leukemia without maturation	Enrichment	FLT3	3.35
13	Mixed phenotype acute leukemia with t(9;22)(q34.1;q11.2)	Enrichment	FLT3	3.35
14	Mixed phenotype acute leukemia with t	Enrichment	FLT3	3.18
15	Leukemia, acute myeloid	Enrichment	FLT3, KIT	3.06
16	Chronic myelomonocytic leukemia	Enrichment	FLT3	3.05
17	Premature aging syndrome, penttinen type	Enrichment	PDGFRB	2.96
18	Hypereosinophilic syndrome, idiopathic	Enrichment	PDGFRA	2.96
19	Mastocytosis, cutaneous	Enrichment	KIT	2.96
20	Colchicine resistance	Enrichment	ABCB1	2.96
21	Uric acid concentration, serum, quantitative trait locus 1	Enrichment	ABCG2	2.96
22	Myofibromatosis, infantile, 1	Enrichment	PDGFRB	2.96
23	Gist-plus syndrome	Enrichment	PDGFRA	2.96
24	Encephalopathy, acute transient	Enrichment	ABCB1	2.96
25	Myeloid and lymphoid neoplasms associated with pdgfra rearrangement	Enrichment	PDGFRA	2.96
26	Inflammatory bowel disease 13	Enrichment	ABCB1	2.96
27	Basal ganglia calcification, idiopathic, 4	Enrichment	PDGFRB	2.96
28	Myeloid and lymphoid neoplasms associated with pdgfrb rearrangement	Enrichment	PDGFRB	2.96
29	Kosaki overgrowth syndrome	Enrichment	PDGFRB	2.96
30	Blood group, junior system	Enrichment	ABCG2	2.96
31	Congenital heart defects, multiple types, 7	Enrichment	FLT4	2.96
32	Ocular pterygium-digital keloid dysplasia syndrome	Enrichment	PDGFRB	2.96
33	Chronic mast cell leukemia	Enrichment	KIT	2.96
34	Tufted angioma of skin	Enrichment	KDR	2.96
35	Isolated bone marrow mastocytosis	Enrichment	KIT	2.96
36	Smoldering systemic mastocytosis	Enrichment	KIT	2.96
37	Mastocytosis	Enrichment	KIT	2.96
38	Cutaneous mastocytoma	Enrichment	KIT	2.96
39	Typical urticaria pigmentosa	Enrichment	KIT	2.96
40	Nodular urticaria pigmentosa	Enrichment	KIT	2.96
41	Pseudoxanthomatous diffuse cutaneous mastocytosis	Enrichment	KIT	2.96
42	Telangiectasia macularis eruptiva perstans	Enrichment	KIT	2.96
43	Acute mast cell leukemia	Enrichment	KIT	2.96
44	Plaque-form urticaria pigmentosa	Enrichment	KIT	2.96
45	Bullous diffuse cutaneous mastocytosis	Enrichment	KIT	2.96
46	Testis seminoma	Enrichment	KIT	2.96
47	Drug metabolism, poor, cyp2c19-related	Enrichment	CYP2C19	2.85
48	Drug metabolism, poor, cyp2d6-related	Enrichment	CYP2D6	2.85
49	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	FLT3	2.81
50	Atypical chronic myeloid leukemia, bcr-abl1 negative	Enrichment	FLT3	2.70
51	Lymphatic malformation 1	Enrichment	FLT4	2.66
52	Myeloproliferative disorder, chronic, with eosinophilia	Enrichment	PDGFRB	2.66
53	Intracranial hypertension, idiopathic	Enrichment	FLT4	2.66
54	Piebald trait	Enrichment	KIT	2.66
55	Angioma, tufted	Enrichment	KDR	2.66
56	Infantile myofibromatosis	Enrichment	PDGFRB	2.66
57	Hereditary lymphedema i	Enrichment	FLT4	2.66
58	Chronic eosinophilic leukemia	Enrichment	PDGFRA	2.66
59	B-lymphoblastic leukemia/lymphoma with recurrent genetic abnormality	Enrichment	PDGFRA	2.66
60	B-lymphoblastic leukemia/lymphoma with t	Enrichment	KIT	2.66
61	Leukemia, acute lymphoblastic	Enrichment	FLT3	2.61
62	Testicular germ cell cancer	Enrichment	KIT	2.48
63	Hypertension, essential	Enrichment	CYP3A5	2.43
64	Coumarin resistance	Enrichment	CYP2C9	2.38
65	Systemic mastocytosis with associated hematologic neoplasm	Enrichment	KIT	2.35
66	Precursor t-cell acute lymphoblastic leukemia	Enrichment	FLT3	2.29
67	Ovarian cancer	Enrichment	KIT, PDGFRA	2.27
68	Pre-eclampsia	Enrichment	FLT1	2.26
69	Testicular germ cell tumor	Enrichment	KIT	2.18
70	Basal ganglia calcification, idiopathic, 1	Enrichment	PDGFRB	2.05
71	Inherited cancer-predisposing syndrome	Enrichment	KIT, PDGFRA	2.04
72	Epilepsy, idiopathic generalized	Enrichment	ABCB1	1.92
73	Myeloma, multiple	Enrichment	FLT3	1.91
74	Lip and oral cavity carcinoma	Enrichment	KIT	1.88
75	Crigler-najjar syndrome, type i	Enrichment	UGT1A1	1.86
76	Hyperbilirubinemia, transient familial neonatal	Enrichment	UGT1A1	1.86
77	Bilirubin, serum level of, quantitative trait locus 1	Enrichment	UGT1A1	1.86
78	Crigler-najjar syndrome, type ii	Enrichment	UGT1A1	1.86
79	Bilirubin metabolic disorder	Enrichment	UGT1A1	1.82
80	Cleft lip/palate	Enrichment	PDGFRA	1.81
81	Hydrocephalus	Enrichment	PDGFRB	1.78
82	Dandy-walker syndrome	Enrichment	PDGFRB	1.73
83	Hydrops fetalis, nonimmune	Enrichment	FLT4	1.55
84	Non-immune hydrops fetalis	Enrichment	FLT4	1.47
85	Cerebral palsy	Enrichment	PDGFRB	1.37
86	Primary ovarian insufficiency	Enrichment	KDR	1.20

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Sunitinib Pathway, Pharmacokinetics/Pharmacodynamics

Pathway Network for Sunitinib Pathway, Pharmacokinetics/Pharmacodynamics

Pathway network for the Sunitinib Pathway, Pharmacokinetics/Pharmacodynamics SuperPath

Member Pathways for Sunitinib Pathway, Pharmacokinetics/Pharmacodynamics

Pathways in the Sunitinib Pathway, Pharmacokinetics/Pharmacodynamics SuperPath

Gene overlap in member pathways for Sunitinib Pathway, Pharmacokinetics/Pharmacodynamics SuperPath

Associated Genes for Sunitinib Pathway, Pharmacokinetics/Pharmacodynamics

Associated Disorders for Sunitinib Pathway, Pharmacokinetics/Pharmacodynamics

Disorders associated with Sunitinib Pathway, Pharmacokinetics/Pharmacodynamics SuperPath

STRING Interaction Network for Sunitinib Pathway, Pharmacokinetics/Pharmacodynamics

Sources for Sunitinib Pathway, Pharmacokinetics/Pharmacodynamics