superpathway of b heme biosynthesis from glycine

Pathway network for the superpathway of b heme biosynthesis from glycine SuperPath

Sources:

PubChem
Reactome
WikiPathways

Pathways in the superpathway of b heme biosynthesis from glycine SuperPath

#	Name	Source	Genes
1	superpathway of b heme biosynthesis from glycine	PubChem	ALAD ALAS1 ALAS2 CPOX FECH HMBS PPOX UROD UROS (see all 9) (see less)
2	Metabolism of porphyrins	Reactome	ABCC1 ABCC2 ABCG2 ALAD ALAS1 ALAS2 ALB BLVRA BLVRB COX10 COX15 CPOX FABP1 FECH FLVCR1 GSTA1 HMBS HMOX1 HMOX2 PPOX SLCO1B1 SLCO1B3 SLCO2B1 UGT1A1 UGT1A4 UROD UROS (see all 27) (see less)
3	Heme degradation	Reactome	ABCC1 ABCC2 ABCG2 ALB BLVRA BLVRB FABP1 GSTA1 HMOX1 HMOX2 SLCO1B1 SLCO1B3 SLCO2B1 UGT1A1 UGT1A4 (see all 15) (see less)
4	Heme biosynthesis	Reactome	ABCG2 ALAD ALAS1 ALAS2 ALB COX10 COX15 CPOX FECH FLVCR1 HMBS PPOX UROD UROS (see all 14) (see less)
5	Heme biosynthesis	WikiPathways	ALAD ALAS1 ALAS2 CPOX FECH HMBS PPOX UROD UROS (see all 9) (see less)
6	heme biosynthesis	PubChem	ALAD ALAS1 ALAS2 CPOX FECH HMBS PPOX UROD UROS (see all 9) (see less)
7	Hemesynthesis defects and porphyrias	WikiPathways	ALAD ALAS1 ALAS2 CPOX FECH HMBS PPOX UROD UROS (see all 9) (see less)
8	tetrapyrrole biosynthesis II (from glycine)	PubChem	ALAD ALAS1 ALAS2 HMBS UROS
9	tetrapyrrole biosynthesis	PubChem	ALAD ALAS1 ALAS2 HMBS UROS
10	heme b biosynthesis I (aerobic)	PubChem	CPOX FECH PPOX UROD
11	heme biosynthesis from uroporphyrinogen-III I	PubChem	CPOX FECH PPOX UROD
12	heme degradation I	PubChem	BLVRA HMOX1 UGT1A4
13	Defective UGT1A4 causes hyperbilirubinemia	Reactome	UGT1A4
14	heme a biosynthesis	PubChem	COX10

Gene overlap in member pathways for superpathway of b heme biosynthesis from glycine SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	ALAS2	5''-Aminolevulinate Synthase 2	Protein Coding	8
2	HMBS	Hydroxymethylbilane Synthase	Protein Coding	8
3	PPOX	Protoporphyrinogen Oxidase	Protein Coding	8
4	ALAD	Aminolevulinate Dehydratase	Protein Coding	8
5	FECH	Ferrochelatase	Protein Coding	8
6	UROS	Uroporphyrinogen III Synthase	Protein Coding	8
7	CPOX	Coproporphyrinogen Oxidase	Protein Coding	8
8	UROD	Uroporphyrinogen Decarboxylase	Protein Coding	8
9	ALAS1	5''-Aminolevulinate Synthase 1	Protein Coding	8
10	UGT1A4	UDP Glucuronosyltransferase Family 1 Member A4	Protein Coding	4
11	COX10	Cytochrome C Oxidase Assembly Factor Heme A:Farnesyltransferase COX10	Protein Coding	3
12	ALB	Albumin	Protein Coding	3
13	HMOX1	Heme Oxygenase 1	Protein Coding	3
14	BLVRA	Biliverdin Reductase A	Protein Coding	3
15	ABCG2	ATP Binding Cassette Subfamily G Member 2 (JR Blood Group)	Protein Coding	3
16	SLCO1B1	Solute Carrier Organic Anion Transporter Family Member 1B1	Protein Coding	2
17	SLCO2B1	Solute Carrier Organic Anion Transporter Family Member 2B1	Protein Coding	2
18	ABCC2	ATP Binding Cassette Subfamily C Member 2	Protein Coding	2
19	COX15	Cytochrome C Oxidase Assembly Factor COX15	Protein Coding	2
20	FABP1	Fatty Acid Binding Protein 1	Protein Coding	2
21	SLCO1B3	Solute Carrier Organic Anion Transporter Family Member 1B3	Protein Coding	2
22	FLVCR1	FLVCR Choline And Heme Transporter 1	Protein Coding	2
23	GSTA1	Glutathione S-Transferase Alpha 1	Protein Coding	2
24	HMOX2	Heme Oxygenase 2	Protein Coding	2
25	ABCC1	ATP Binding Cassette Subfamily C Member 1 (ABCC1 Blood Group)	Protein Coding	2
26	UGT1A1	UDP Glucuronosyltransferase Family 1 Member A1	Protein Coding	2
27	BLVRB	Biliverdin Reductase B	Protein Coding	2

Disorders associated with superpathway of b heme biosynthesis from glycine SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Bilirubin metabolic disorder	Direct
2	Crigler-najjar syndrome, type i	Direct
3	Gilbert syndrome	Direct
4	Hyperbilirubinemia, rotor type	Enrichment	SLCO1B1, SLCO1B3	5.47
5	Hyperbilirubinemia, transient familial neonatal	Enrichment	UGT1A1, UGT1A4	4.29
6	Bilirubin, serum level of, quantitative trait locus 1	Enrichment	UGT1A1, UGT1A4	4.29
7	Crigler-najjar syndrome, type ii	Enrichment	UGT1A1, UGT1A4	4.29
8	Hyperbiliverdinemia	Enrichment	BLVRA	3.66
9	Heme oxygenase 1 deficiency	Enrichment	HMOX1	3.66
10	Coproporphyria, hereditary	Enrichment	CPOX	3.53
11	Harderoporphyria	Enrichment	CPOX	3.53
12	Variegate porphyria, childhood-onset	Enrichment	PPOX	3.53
13	Hepatoerythropoietic porphyria	Enrichment	UROD	3.53
14	Encephalopathy, porphyria-related	Enrichment	HMBS	3.43
15	Porphyria, acute hepatic	Enrichment	ALAD	3.43
16	Leukoencephalopathy, porphyria-related	Enrichment	HMBS	3.43
17	Cutaneous porphyria	Enrichment	UROS	3.43
18	Mitochondrial complex iii deficiency, nuclear type 4	Enrichment	COX10	3.43
19	Porphyria cutanea tarda, type i	Enrichment	UROD	3.23
20	Protoporphyria, erythropoietic, 1	Enrichment	FECH	3.23
21	Coproporphyria	Enrichment	CPOX	3.23
22	Autosomal erythropoietic protoporphyria	Enrichment	FECH	3.23
23	Erythropoietic protoporphyria, autosomal recessive	Enrichment	FECH	3.23
24	Porphyria, congenital erythropoietic	Enrichment	UROS	3.13
25	Porphyria, acute intermittent	Enrichment	HMBS	3.13
26	Protoporphyria, erythropoietic, x-linked	Enrichment	ALAS2	3.13
27	Acute porphyria	Enrichment	HMBS	3.13
28	X-linked protoporphyria	Enrichment	ALAS2	3.13
29	Familial porphyria cutanea tarda	Enrichment	UROD	3.05
30	Retinopathy-sensory neuropathy syndrome	Enrichment	FLVCR1	2.99
31	Uric acid concentration, serum, quantitative trait locus 1	Enrichment	ABCG2	2.99
32	Hyperthyroxinemia, familial dysalbuminemic	Enrichment	ALB	2.99
33	Hereditary sensory neuropathy	Enrichment	FLVCR1	2.99
34	Neurodevelopmental disorder with microcephaly, absent speech, and hypotonia	Enrichment	FLVCR1	2.99
35	Blood group, junior system	Enrichment	ABCG2	2.99
36	Congenital analbuminemia	Enrichment	ALB	2.99
37	Analbuminemia	Enrichment	ALB	2.99
38	Cox deficiency, benign infantile mitochondrial myopathy	Enrichment	COX10	2.99
39	Anemia, sideroblastic, 1	Enrichment	ALAS2	2.96
40	X-linked sideroblastic anemia 1	Enrichment	ALAS2	2.96
41	Deafness, autosomal dominant 77	Enrichment	ABCC1	2.96
42	Porphyria cutanea tarda	Enrichment	UROD	2.93
43	Variegate porphyria	Enrichment	PPOX	2.83
44	Mitochondrial complex iv deficiency, nuclear type 1	Enrichment	COX10	2.79
45	Mitochondrial complex iv deficiency, nuclear type 6	Enrichment	COX15	2.69
46	Anxiety	Enrichment	HMBS	2.66
47	Pulmonary disease, chronic obstructive	Enrichment	HMOX1	2.54
48	Migraine with or without aura 1	Enrichment	PPOX	2.49
49	Dubin-johnson syndrome	Enrichment	ABCC2	2.48
50	Ehlers-danlos syndrome, arthrochalasia type, 1	Enrichment	ALB	2.38
51	Cox deficiency, infantile mitochondrial myopathy	Enrichment	COX15	2.29
52	Pseudoxanthoma elasticum	Enrichment	ABCC2	2.18
53	Cystic fibrosis	Enrichment	HMOX1	2.15
54	Jeune thoracic dystrophy	Enrichment	FLVCR1	1.59
55	Asphyxiating thoracic dystrophy	Enrichment	FLVCR1	1.54
56	Stargardt disease 1	Enrichment	FLVCR1	1.52
57	Short-rib thoracic dysplasia 1 with or without polydactyly	Enrichment	FLVCR1	1.47
58	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	ABCC1	1.25
59	Leigh syndrome, nuclear	Enrichment	COX15	1.16
60	Leigh disease	Enrichment	COX15	1.12
61	Retinitis pigmentosa	Enrichment	FLVCR1	0.70
62	Hereditary retinal dystrophy	Enrichment	FLVCR1	0.58
63	Fundus dystrophy	Enrichment	FLVCR1	0.58

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

superpathway of b heme biosynthesis from glycine

Pathway Network for superpathway of b heme biosynthesis from glycine

Pathway network for the superpathway of b heme biosynthesis from glycine SuperPath

Member Pathways for superpathway of b heme biosynthesis from glycine

Pathways in the superpathway of b heme biosynthesis from glycine SuperPath

Gene overlap in member pathways for superpathway of b heme biosynthesis from glycine SuperPath

Associated Genes for superpathway of b heme biosynthesis from glycine

Associated Disorders for superpathway of b heme biosynthesis from glycine

Disorders associated with superpathway of b heme biosynthesis from glycine SuperPath

STRING Interaction Network for superpathway of b heme biosynthesis from glycine

Sources for superpathway of b heme biosynthesis from glycine