superpathway of cholesterol biosynthesis

Pathway network for the superpathway of cholesterol biosynthesis SuperPath

Sources:

PubChem
WikiPathways
Reactome

Pathways in the superpathway of cholesterol biosynthesis SuperPath

#	Name	Source	Genes
1	superpathway of cholesterol biosynthesis	PubChem	ACAT1 ACAT2 DHCR7 EBP FDFT1 FDPS GGPS1 HMGCR HMGCS1 HMGCS2 HSD17B7 IDI1 IDI2 LBR LSS MVD MVK NSDHL PMVK SC5D SQLE (see all 21) (see less)
2	Cholesterol metabolism with Bloch and Kandutsch-Russell pathways	WikiPathways	ABCA1 ABCG1 ACAT2 ACOT2 ACSL1 ACSL3 ACSL4 CH25H CYP27A1 CYP46A1 CYP51A1 DHCR24 DHCR7 EBP FASN FDFT1 FDPS GGPS1 HMGCR HMGCS1 HMGCS2 HSD17B7 IDI1 LSS MSMO1 MVD MVK MYLIP NR1H2 NR1H3 NSDHL PMVK SC5D SOAT1 SOAT2 SQLE SREBF1 SREBF2 TM7SF2 (see all 39) (see less)
3	Cholesterol biosynthesis	Reactome	ACAT2 ARV1 CYP51A1 DHCR24 DHCR7 EBP FDFT1 FDPS GGPS1 HMGCR HMGCS1 HSD17B7 IDI1 IDI2 LBR LSS MSMO1 MVD MVK NSDHL PLPP6 PMVK SC5D SQLE SREBF1 SREBF2 TM7SF2 (see all 27) (see less)
4	Cholesterol biosynthesis pathway	WikiPathways	CYP51A1 DHCR7 FDFT1 FDPS HMGCR HMGCS1 IDI1 LSS MSMO1 MVD MVK NSDHL PMVK SC5D SQLE (see all 15) (see less)
5	Mevalonate arm of cholesterol biosynthesis pathway	WikiPathways	ACAT1 ACAT2 FDFT1 FDPS GGPS1 HMGCL HMGCR HMGCS1 IDI1 IDI2 MVD MVK PMVK (see all 13) (see less)
6	superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate)	PubChem	ACAT1 ACAT2 FDPS GGPS1 HMGCR HMGCS1 HMGCS2 IDI1 IDI2 MVD MVK PMVK (see all 12) (see less)
7	mevalonate pathway I	PubChem	ACAT1 ACAT2 HMGCR HMGCS1 HMGCS2 IDI1 IDI2 MVD MVK PMVK (see all 10) (see less)
8	mevalonate pathway	PubChem	ACAT1 ACAT2 HMGCR HMGCS1 HMGCS2 IDI1 IDI2 MVD MVK PMVK (see all 10) (see less)
9	cholesterol biosynthesis III (via desmosterol)	PubChem	DHCR7 EBP FDFT1 HSD17B7 LBR LSS NSDHL SC5D SQLE (see all 9) (see less)
10	cholesterol biosynthesis I	PubChem	DHCR7 EBP FDFT1 HSD17B7 LBR LSS NSDHL SC5D SQLE (see all 9) (see less)
11	cholesterol biosynthesis II (via 24,25-dihydrolanosterol)	PubChem	DHCR7 EBP FDFT1 HSD17B7 LBR LSS NSDHL SC5D SQLE (see all 9) (see less)
12	Cholesterol biosynthesis via lathosterol	Reactome	DHCR24 DHCR7 EBP HSD17B7 MSMO1 NSDHL SC5D TM7SF2 (see all 8) (see less)
13	Cholesterol biosynthesis with skeletal dysplasias	WikiPathways	CYP51A1 DHCR24 DHCR7 EBP LBR NSDHL SC5D (see all 7) (see less)
14	Mevalonate pathway	WikiPathways	ACAT2 FDPS HMGCR HMGCS1 MVD MVK PMVK (see all 7) (see less)
15	Cholesterol biosynthesis via desmosterol	Reactome	DHCR24 DHCR7 EBP SC5D
16	trans, trans-farnesyl diphosphate biosynthesis	PubChem	FDPS GGPS1 IDI1 IDI2
17	zymosterol biosynthesis	PubChem	CYP51A1 HSD17B7 LBR NSDHL
18	Mevalonate arm of cholesterol biosynthesis pathway with inhibitors	WikiPathways	HMGCR MVD
19	epoxysqualene biosynthesis	PubChem	FDFT1 SQLE
20	lanosterol biosynthesis	PubChem	LSS

Gene overlap in member pathways for superpathway of cholesterol biosynthesis SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	DHCR7	7-Dehydrocholesterol Reductase	Protein Coding	10
2	MVD	Mevalonate Diphosphate Decarboxylase	Protein Coding	10
3	NSDHL	NAD(P) Dependent 3-Beta-Hydroxysteroid Dehydrogenase NSDHL	Protein Coding	10
4	SC5D	Sterol-C5-Desaturase	Protein Coding	10
5	HMGCR	3-Hydroxy-3-Methylglutaryl-CoA Reductase	Protein Coding	10
6	IDI1	Isopentenyl-Diphosphate Delta Isomerase 1	Protein Coding	9
7	PMVK	Phosphomevalonate Kinase	Protein Coding	9
8	MVK	Mevalonate Kinase	Protein Coding	9
9	EBP	EBP Cholestenol Delta-Isomerase	Protein Coding	9
10	HMGCS1	3-Hydroxy-3-Methylglutaryl-CoA Synthase 1	Protein Coding	9
11	FDFT1	Farnesyl-Diphosphate Farnesyltransferase 1	Protein Coding	9
12	LSS	Lanosterol Synthase	Protein Coding	8
13	FDPS	Farnesyl Diphosphate Synthase	Protein Coding	8
14	ACAT2	Acetyl-CoA Acetyltransferase 2	Protein Coding	8
15	HSD17B7	Hydroxysteroid 17-Beta Dehydrogenase 7	Protein Coding	8
16	SQLE	Squalene Epoxidase	Protein Coding	8
17	IDI2	Isopentenyl-Diphosphate Delta Isomerase 2	Protein Coding	7
18	LBR	Lamin B Receptor	Protein Coding	7
19	GGPS1	Geranylgeranyl Diphosphate Synthase 1	Protein Coding	6
20	ACAT1	Acetyl-CoA Acetyltransferase 1	Protein Coding	5
21	HMGCS2	3-Hydroxy-3-Methylglutaryl-CoA Synthase 2	Protein Coding	5
22	CYP51A1	Cytochrome P450 Family 51 Subfamily A Member 1	Protein Coding	5
23	DHCR24	24-Dehydrocholesterol Reductase	Protein Coding	5
24	MSMO1	Methylsterol Monooxygenase 1	Protein Coding	4
25	TM7SF2	Transmembrane 7 Superfamily Member 2	Protein Coding	3
26	SREBF2	Sterol Regulatory Element Binding Transcription Factor 2	Protein Coding	2
27	SREBF1	Sterol Regulatory Element Binding Transcription Factor 1	Protein Coding	2
28	CH25H	Cholesterol 25-Hydroxylase	Protein Coding	1
29	ACSL3	Acyl-CoA Synthetase Long Chain Family Member 3	Protein Coding	1
30	ABCG1	ATP Binding Cassette Subfamily G Member 1	Protein Coding	1
31	SOAT2	Sterol O-Acyltransferase 2	Protein Coding	1
32	NR1H2	Nuclear Receptor Subfamily 1 Group H Member 2	Protein Coding	1
33	SOAT1	Sterol O-Acyltransferase 1	Protein Coding	1
34	MYLIP	Myosin Regulatory Light Chain Interacting Protein	Protein Coding	1
35	FASN	Fatty Acid Synthase	Protein Coding	1
36	ACSL4	Acyl-CoA Synthetase Long Chain Family Member 4	Protein Coding	1
37	ACSL1	Acyl-CoA Synthetase Long Chain Family Member 1	Protein Coding	1
38	ABCA1	ATP Binding Cassette Subfamily A Member 1	Protein Coding	1
39	CYP27A1	Cytochrome P450 Family 27 Subfamily A Member 1	Protein Coding	1
40	ACOT2	Acyl-CoA Thioesterase 2	Protein Coding	1
41	CYP46A1	Cytochrome P450 Family 46 Subfamily A Member 1	Protein Coding	1
42	NR1H3	Nuclear Receptor Subfamily 1 Group H Member 3	Protein Coding	1
43	PLPP6	Phospholipid Phosphatase 6	Protein Coding	1
44	ARV1	ARV1 Fatty Acid Homeostasis Modulator	Protein Coding	1
45	HMGCL	3-Hydroxy-3-Methylglutaryl-CoA Lyase	Protein Coding	1

Disorders associated with superpathway of cholesterol biosynthesis SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Porokeratosis	Enrichment	FDPS, MVD, MVK	9.43
2	Porokeratosis 1, multiple types	Enrichment	MVK, PMVK	6.64
3	Alpha-methylacetoacetic aciduria	Enrichment	ACAT1, ACAT2	6.31
4	Linear porokeratosis	Enrichment	MVD, PMVK	6.16
5	Palmoplantar keratoderma and congenital alopecia 2	Enrichment	LSS	4.13
6	Hypotrichosis 14	Enrichment	LSS	4.13
7	Porokeratosis 7, multiple types	Enrichment	MVD	3.83
8	Low density lipoprotein cholesterol level quantitative trait locus 3	Enrichment	HMGCR	3.83
9	Muscular dystrophy, limb-girdle, autosomal recessive 28	Enrichment	HMGCR	3.83
10	Alopecia-intellectual disability syndrome 4	Enrichment	LSS	3.83
11	Alopecia - intellectual disability syndrome	Enrichment	LSS	3.66
12	Squalene synthase deficiency	Enrichment	FDFT1	3.53
13	Desmosterolosis	Enrichment	DHCR24	3.53
14	Chondrodysplasia punctata 2, x-linked dominant	Enrichment	EBP	3.53
15	Mend syndrome	Enrichment	EBP	3.53
16	Muscular dystrophy, congenital hearing loss, and ovarian insufficiency syndrome	Enrichment	GGPS1	3.53
17	Ck syndrome	Enrichment	NSDHL	3.53
18	Congenital hemidysplasia with ichthyosiform erythroderma and limb defects	Enrichment	NSDHL	3.53
19	Greenberg dysplasia	Enrichment	LBR	3.53
20	Pelger-huet anomaly	Enrichment	LBR	3.53
21	Rhizomelic skeletal dysplasia with or without pelger-huet anomaly	Enrichment	LBR	3.53
22	Reynolds syndrome	Enrichment	LBR	3.53
23	Congenital cataract-severe neonatal hepatopathy-global developmental delay syndrome	Enrichment	CYP51A1	3.53
24	Nsdhl-related disorders	Enrichment	NSDHL	3.53
25	Porokeratosis 3, multiple types	Enrichment	MVK	3.29
26	Mevalonic aciduria	Enrichment	MVK	3.29
27	Acetyl-coa acetyltransferase-2 deficiency	Enrichment	ACAT2	3.29
28	Lathosterolosis	Enrichment	SC5D	3.23
29	Porokeratosis 9, multiple types	Enrichment	FDPS	3.23
30	Microcephaly, congenital cataract, and psoriasiform dermatitis	Enrichment	MSMO1	3.23
31	Hypotrichosis simplex	Enrichment	LSS	3.18
32	3-hydroxy-3-methylglutaryl-coa lyase deficiency	Enrichment	HMGCL	3.02
33	Hyper-igd syndrome	Enrichment	MVK	2.99
34	Methylmalonic aciduria, cblb type	Enrichment	MVK	2.99
35	Porokeratosis 5, disseminated superficial actinic type	Enrichment	MVK	2.99
36	Smith-lemli-opitz syndrome	Enrichment	DHCR7	2.93
37	Cataract 44	Enrichment	LSS	2.90
38	Limb-girdle muscular dystrophy	Enrichment	HMGCR	2.88
39	3-hydroxy-3-methylglutaryl-coa synthase-2 deficiency	Enrichment	HMGCS2	2.83
40	Mucoepithelial dysplasia, hereditary	Enrichment	SREBF1	2.70
41	Ifap syndrome 2	Enrichment	SREBF1	2.70
42	Myopathy, tubular aggregate, 1	Enrichment	GGPS1	2.63
43	Congenital myopathy 3 with rigid spine	Enrichment	HMGCS1	2.59
44	Perrault syndrome 2	Enrichment	GGPS1	2.58
45	Long-chain 3-hydroxyacyl-coa dehydrogenase deficiency	Enrichment	HMGCL	2.54
46	Intellectual developmental disorder, x-linked 63	Enrichment	ACSL4	2.54
47	Cerebrotendinous xanthomatosis	Enrichment	CYP27A1	2.54
48	Hypoalphalipoproteinemia	Enrichment	ABCA1	2.54
49	Isolated methylmalonic acidemia	Enrichment	MVK	2.44
50	Developmental and epileptic encephalopathy 38	Enrichment	ARV1	2.40
51	Methylmalonic acidemia	Enrichment	MVK	2.38
52	Isolated congenital microcephaly	Enrichment	DHCR7	2.33
53	Perrault syndrome 1	Enrichment	GGPS1	2.33
54	Tangier disease	Enrichment	ABCA1	2.24
55	Ifap syndrome 1, with or without bresheck syndrome	Enrichment	SREBF1	2.22
56	Hepatoblastoma	Enrichment	DHCR7	2.21
57	Jeune thoracic dystrophy	Enrichment	LBR	2.13
58	Hydrops fetalis, nonimmune	Enrichment	DHCR24	2.12
59	Asphyxiating thoracic dystrophy	Enrichment	LBR	2.08
60	Hypoalphalipoproteinemia, primary, 2	Enrichment	ABCA1	2.07
61	Non-immune hydrops fetalis	Enrichment	DHCR24	2.04
62	Connective tissue disease	Enrichment	EBP	2.03
63	Short-rib thoracic dysplasia 1 with or without polydactyly	Enrichment	LBR	2.01
64	Hypoalphalipoproteinemia, primary, 1	Enrichment	ABCA1	1.94
65	Amme complex	Enrichment	ACSL4	1.94
66	Autoinflammatory disease	Enrichment	MVK	1.91
67	Coronary heart disease 5	Enrichment	ABCA1	1.59
68	Stroke, ischemic	Enrichment	ACSL4	1.55
69	Pulmonary disease, chronic obstructive	Enrichment	CYP46A1	1.43
70	Multiple sclerosis	Enrichment	NR1H3	1.40
71	Hirschsprung disease 1	Enrichment	SREBF1	1.25
72	Non-syndromic x-linked intellectual disability	Enrichment	ACSL4	1.01
73	Hereditary retinal dystrophy	Enrichment	MVK	0.85
74	Fundus dystrophy	Enrichment	MVK	0.85
75	Congenital nervous system abnormality	Enrichment	ARV1	0.72
76	Nervous system disease	Enrichment	ARV1	0.72
77	Breast cancer	Enrichment	ABCA1	0.71

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

superpathway of cholesterol biosynthesis

Pathway Network for superpathway of cholesterol biosynthesis

Pathway network for the superpathway of cholesterol biosynthesis SuperPath

Member Pathways for superpathway of cholesterol biosynthesis

Pathways in the superpathway of cholesterol biosynthesis SuperPath

Gene overlap in member pathways for superpathway of cholesterol biosynthesis SuperPath

Associated Genes for superpathway of cholesterol biosynthesis

Associated Disorders for superpathway of cholesterol biosynthesis

Disorders associated with superpathway of cholesterol biosynthesis SuperPath

STRING Interaction Network for superpathway of cholesterol biosynthesis

Sources for superpathway of cholesterol biosynthesis