superpathway of choline degradation to L-serine

Sources:

#	Name	Source	Genes
1	superpathway of choline degradation to L-serine	PubChem	ALDH7A1 BHMT CHDH DMGDH SARDH SHMT1 SHMT2 (see all 7) (see less)
2	Choline catabolism	Reactome	ALDH7A1 BHMT CHDH DMGDH SARDH SLC44A1 (see all 6) (see less)
3	glycine betaine degradation II (mammalian)	PubChem	BHMT DMGDH SARDH SHMT1 SHMT2
4	choline degradation I	PubChem	ALDH7A1 CHDH
5	choline degradation	PubChem	ALDH7A1 CHDH

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	CHDH	Choline Dehydrogenase	Protein Coding	4
2	ALDH7A1	Aldehyde Dehydrogenase 7 Family Member A1	Protein Coding	4
3	DMGDH	Dimethylglycine Dehydrogenase	Protein Coding	3
4	SARDH	Sarcosine Dehydrogenase	Protein Coding	3
5	BHMT	Betaine--Homocysteine S-Methyltransferase	Protein Coding	3
6	SHMT2	Serine Hydroxymethyltransferase 2	Protein Coding	2
7	SHMT1	Serine Hydroxymethyltransferase 1	Protein Coding	2
8	SLC44A1	Solute Carrier Family 44 Member 1	Protein Coding	1

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Epilepsy, early-onset, 4, vitamin b6-dependent	Enrichment	ALDH7A1	3.83
2	Pyridoxine-dependent-developmental and epileptic encephalopathy	Enrichment	ALDH7A1	3.53
3	Dimethylglycine dehydrogenase deficiency	Enrichment	DMGDH	3.43
4	Sarcosinemia	Enrichment	SARDH	3.43
5	Neurodevelopmental disorder with cardiomyopathy, spasticity, and brain abnormalities	Enrichment	SHMT2	3.43
6	Developmental and epileptic encephalopathy 13	Enrichment	ALDH7A1	3.35
7	Neurodegeneration, childhood-onset, with ataxia, tremor, optic atrophy, and cognitive decline	Enrichment	SLC44A1	3.35
8	Hydrocephalus, congenital, 1	Enrichment	ALDH7A1	2.63
9	Epilepsy	Enrichment	ALDH7A1	2.23
10	Congenital nervous system abnormality	Enrichment	ALDH7A1	1.81
11	Nervous system disease	Enrichment	ALDH7A1	1.81

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Pathway Network for superpathway of choline degradation to L-serine