superpathway of D-myo-inositol (1,4,5)-trisphosphate metabolism

Pathway network for the superpathway of D-myo-inositol (1,4,5)-trisphosphate metabolism SuperPath

Sources:

PubChem

Pathways in the superpathway of D-myo-inositol (1,4,5)-trisphosphate metabolism SuperPath

#	Name	Source	Genes
1	superpathway of D-myo-inositol (1,4,5)-trisphosphate metabolism	PubChem	BPNT2 IMPA1 IMPA2 INPP1 INPP5A INPP5B INPP5D INPP5J INPP5K INPPL1 IPMK ITPKA ITPKB ITPKC MINPP1 OCRL PTEN SYNJ1 SYNJ2 (see all 19) (see less)
2	3-phosphoinositide degradation	PubChem	INPP4A INPP4B INPP5B INPP5D INPP5E INPP5F INPP5J INPP5K INPPL1 MTMR14 MTMR3 OCRL PIP4P1 PIP4P2 PTEN PTPMT1 SACM1L SYNJ1 SYNJ2 (see all 19) (see less)
3	D-myo-inositol (1,3,4)-trisphosphate biosynthesis	PubChem	INPP5A INPP5B INPP5D INPP5J INPP5K INPPL1 IPMK ITPKA ITPKB ITPKC MINPP1 OCRL PTEN SYNJ1 SYNJ2 (see all 15) (see less)
4	1D-myo-inositol hexakisphosphate biosynthesis II (mammalian)	PubChem	INPP5A INPP5B INPP5D INPP5J INPP5K INPPL1 IPMK IPPK ITPK1 ITPKA ITPKB ITPKC OCRL SYNJ1 SYNJ2 (see all 15) (see less)
5	D-myo-inositol (1,4,5)-trisphosphate degradation	PubChem	BPNT2 IMPA1 IMPA2 INPP1 INPP5A INPP5B INPP5J INPP5K OCRL SYNJ1 SYNJ2 (see all 11) (see less)
6	myo-inositol biosynthesis	PubChem	BPNT2 IMPA1 IMPA2

Gene overlap in member pathways for superpathway of D-myo-inositol (1,4,5)-trisphosphate metabolism SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	INPP5K	Inositol Polyphosphate-5-Phosphatase K	Protein Coding	5
2	OCRL	OCRL Inositol Polyphosphate-5-Phosphatase	Protein Coding	5
3	SYNJ2	Synaptojanin 2	Protein Coding	5
4	INPP5B	Inositol Polyphosphate-5-Phosphatase B	Protein Coding	5
5	SYNJ1	Synaptojanin 1	Protein Coding	5
6	INPP5J	Inositol Polyphosphate-5-Phosphatase J	Protein Coding	5
7	INPP5A	Inositol Polyphosphate-5-Phosphatase A	Protein Coding	4
8	INPPL1	Inositol Polyphosphate Phosphatase Like 1	Protein Coding	4
9	INPP5D	Inositol Polyphosphate-5-Phosphatase D	Protein Coding	4
10	IMPA2	Inositol Monophosphatase 2	Protein Coding	3
11	IMPA1	Inositol Monophosphatase 1	Protein Coding	3
12	BPNT2	3''(2''), 5''-Bisphosphate Nucleotidase 2	Protein Coding	3
13	IPMK	Inositol Polyphosphate Multikinase	Protein Coding	3
14	ITPKC	Inositol-Trisphosphate 3-Kinase C	Protein Coding	3
15	ITPKB	Inositol-Trisphosphate 3-Kinase B	Protein Coding	3
16	PTEN	Phosphatase And Tensin Homolog	Protein Coding	3
17	ITPKA	Inositol-Trisphosphate 3-Kinase A	Protein Coding	3
18	INPP1	Inositol Polyphosphate-1-Phosphatase	Protein Coding	2
19	MINPP1	Multiple Inositol-Polyphosphate Phosphatase 1	Protein Coding	2
20	MTMR14	Myotubularin Related Protein 14	Protein Coding	1
21	PIP4P2	Phosphatidylinositol-4,5-Bisphosphate 4-Phosphatase 2	Protein Coding	1
22	MTMR3	Myotubularin Related Protein 3	Protein Coding	1
23	INPP4B	Inositol Polyphosphate-4-Phosphatase Type II B	Protein Coding	1
24	INPP4A	Inositol Polyphosphate-4-Phosphatase Type I A	Protein Coding	1
25	PIP4P1	Phosphatidylinositol-4,5-Bisphosphate 4-Phosphatase 1	Protein Coding	1
26	INPP5F	Inositol Polyphosphate-5-Phosphatase F	Protein Coding	1
27	SACM1L	SAC1 Like Phosphatidylinositide Phosphatase	Protein Coding	1
28	INPP5E	Inositol Polyphosphate-5-Phosphatase E	Protein Coding	1
29	PTPMT1	Protein Tyrosine Phosphatase Mitochondrial 1	Protein Coding	1
30	IPPK	Inositol-Pentakisphosphate 2-Kinase	Protein Coding	1
31	ITPK1	Inositol-Tetrakisphosphate 1-Kinase	Protein Coding	1

Disorders associated with superpathway of D-myo-inositol (1,4,5)-trisphosphate metabolism SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Dent disease 2	Enrichment	INPP5B, OCRL	6.22
2	Thyroid cancer, nonmedullary, 2	Enrichment	MINPP1, PTEN	4.62
3	Follicular thyroid carcinoma	Enrichment	MINPP1, PTEN	4.62
4	Chondrodysplasia with joint dislocations, gpapp type	Enrichment	BPNT2	3.66
5	Intellectual developmental disorder, autosomal recessive 59	Enrichment	IMPA1	3.66
6	Developmental and epileptic encephalopathy 53	Enrichment	SYNJ1	3.09
7	Lowe oculocerebrorenal syndrome	Enrichment	OCRL	3.09
8	Muscular dystrophy, congenital, with cataracts and impaired intellectual development	Enrichment	INPP5K	3.09
9	Vacterl association with hydrocephalus	Enrichment	PTEN	2.96
10	Papillary tumor of the pineal region	Enrichment	PTEN	2.96
11	Glioma susceptibility 2	Enrichment	PTEN	2.96
12	Hereditary neuroendocrine tumor of small intestine	Enrichment	IPMK	2.96
13	Segmental outgrowth-lipomatosis-arteriovenous malformation-epidermal nevus syndrome	Enrichment	PTEN	2.96
14	Neurodevelopmental disorder with growth impairment, quadriparesis, and poor or absent speech	Enrichment	INPP4A	2.85
15	Impaired intellectual development, truncal obesity, retinal dystrophy, and micropenis syndrome	Enrichment	INPP5E	2.85
16	Neurodevelopmental disorder with ataxia and brain abnormalities	Enrichment	PTPMT1	2.85
17	Parkinson disease 20, early-onset	Enrichment	SYNJ1	2.79
18	Schneckenbecken dysplasia	Enrichment	INPPL1	2.66
19	Pontocerebellar hypoplasia, type 7	Enrichment	MINPP1	2.66
20	Vacterl with hydrocephalus	Enrichment	PTEN	2.66
21	Juvenile polyposis of infancy	Enrichment	PTEN	2.66
22	Dent disease	Enrichment	OCRL	2.61
23	Atypical juvenile parkinsonism	Enrichment	SYNJ1	2.61
24	Short femur	Enrichment	INPP5E	2.55
25	Opsismodysplasia	Enrichment	INPPL1	2.48
26	Pontocerebellar hypoplasia, type 16	Enrichment	MINPP1	2.48
27	Laryngeal squamous cell carcinoma	Enrichment	PTEN	2.48
28	Familial papillary or follicular thyroid carcinoma	Enrichment	MINPP1	2.48
29	Interstitial lung disease	Enrichment	INPP5E	2.38
30	Respiratory failure	Enrichment	INPP5E	2.38
31	Glioma	Enrichment	PTEN	2.35
32	Macrocephaly/autism syndrome	Enrichment	PTEN	2.26
33	Hemangioma	Enrichment	PTEN	2.26
34	Acute megakaryocytic leukemia	Enrichment	PTEN	2.26
35	Hemimegalencephaly	Enrichment	PTEN	2.26
36	Cowden syndrome 1	Enrichment	PTEN	2.18
37	Coach syndrome 1	Enrichment	INPP5E	2.16
38	Joubert syndrome with ocular defect	Enrichment	INPP5E	2.16
39	Squamous cell carcinoma, head and neck	Enrichment	PTEN	2.11
40	Dyskeratosis congenita, autosomal dominant 1	Enrichment	INPP4A	2.08
41	Myopathy, centronuclear, 1	Enrichment	MTMR14	2.08
42	Patent ductus arteriosus	Enrichment	INPP5E	2.08
43	Early-onset parkinson's disease	Enrichment	SYNJ1	2.01
44	Dyskeratosis congenita, autosomal dominant 2	Enrichment	INPP4A	2.01
45	Cowden syndrome	Enrichment	PTEN	2.00
46	Melanoma	Enrichment	PTEN	1.96
47	Meningioma, familial	Enrichment	PTEN	1.92
48	Uterine corpus cancer	Enrichment	PTEN	1.92
49	Autosomal recessive non-syndromic intellectual disability	Enrichment	IMPA1	1.89
50	Meningioma	Enrichment	PTEN	1.88
51	Primary bone dysplasia	Enrichment	INPP5E	1.86
52	Pectus excavatum	Enrichment	INPP4A	1.82
53	Osteochondrodysplasia	Enrichment	INPP5E	1.82
54	Rhabdomyosarcoma	Enrichment	PTEN	1.76
55	Clubfoot, congenital, with or without deficiency of long bones and/or mirror-image polydactyly	Enrichment	INPP5E	1.74
56	Clubfoot	Enrichment	INPP5E	1.74
57	Pontocerebellar hypoplasia	Enrichment	MINPP1	1.70
58	Developmental and epileptic encephalopathy 1	Enrichment	SYNJ1	1.70
59	Diffuse large b-cell lymphoma	Enrichment	PTEN	1.68
60	Endometrial cancer	Enrichment	PTEN	1.64
61	Cleft palate, isolated	Enrichment	INPP5E	1.63
62	Bladder cancer	Enrichment	PTEN	1.50
63	Prostate cancer	Enrichment	PTEN	1.50
64	West syndrome	Enrichment	SYNJ1	1.45
65	Isolated joubert syndrome	Enrichment	INPP5E	1.38
66	Undetermined early-onset epileptic encephalopathy	Enrichment	SYNJ1	1.35
67	Gastric cancer	Enrichment	PTEN	1.33
68	Hereditary breast carcinoma	Enrichment	PTEN	1.32
69	Hereditary breast ovarian cancer syndrome	Enrichment	PTEN	1.23
70	Joubert syndrome 1	Enrichment	INPP5E	1.17
71	Breast cancer	Enrichment	PTEN	1.10
72	Ovarian cancer	Enrichment	PTEN	0.97
73	Congenital nervous system abnormality	Enrichment	PTEN	0.95
74	Nervous system disease	Enrichment	PTEN	0.95
75	Autism spectrum disorder	Enrichment	PTEN	0.94
76	Leber plus disease	Enrichment	INPP5E	0.90
77	Inherited cancer-predisposing syndrome	Enrichment	PTEN	0.86
78	Microcephaly	Enrichment	INPP4A	0.80
79	Retinitis pigmentosa	Enrichment	INPP5E	0.59
80	Hereditary retinal dystrophy	Enrichment	INPP5E	0.47
81	Fundus dystrophy	Enrichment	INPP5E	0.47

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

superpathway of D-myo-inositol (1,4,5)-trisphosphate metabolism

Pathway Network for superpathway of D-myo-inositol (1,4,5)-trisphosphate metabolism

Pathway network for the superpathway of D-myo-inositol (1,4,5)-trisphosphate metabolism SuperPath

Member Pathways for superpathway of D-myo-inositol (1,4,5)-trisphosphate metabolism

Pathways in the superpathway of D-myo-inositol (1,4,5)-trisphosphate metabolism SuperPath

Gene overlap in member pathways for superpathway of D-myo-inositol (1,4,5)-trisphosphate metabolism SuperPath

Associated Genes for superpathway of D-myo-inositol (1,4,5)-trisphosphate metabolism

Associated Disorders for superpathway of D-myo-inositol (1,4,5)-trisphosphate metabolism

Disorders associated with superpathway of D-myo-inositol (1,4,5)-trisphosphate metabolism SuperPath

STRING Interaction Network for superpathway of D-myo-inositol (1,4,5)-trisphosphate metabolism

Sources for superpathway of D-myo-inositol (1,4,5)-trisphosphate metabolism