superpathway of tryptophan utilization

Pathway network for the superpathway of tryptophan utilization SuperPath

Sources:

PubChem
WikiPathways

Pathways in the superpathway of tryptophan utilization SuperPath

#	Name	Source	Genes
1	superpathway of tryptophan utilization	PubChem	AANAT ACAT1 ACAT2 ACMSD ADH1B ADH6 AFMID AKR1A1 ALDH2 ALDH3A2 ASMT CYP1A2 CYP1B1 CYP2A6 CYP2C19 CYP2S1 CYP2U1 CYP4X1 DDC DHTKD1 ECHS1 GCDH HAAO IDO1 IDO2 KMO KYNU MAOA MAOB NADSYN1 NMNAT1 NMNAT2 NMNAT3 POR QPRT SULT1A1 SULT1A2 SULT1A3 SULT1A4 TDO2 TPH1 TPH2 UGT2B11 (see all 43) (see less)
2	Tryptophan metabolism	WikiPathways	AADAT AANAT ACAT1 ACMSD AFMID ALDH2 ALDH8A1 AOC1 AOX1 ASMT CAT CYP1A1 DDC DLD ECHS1 GCDH GOT2 HAAO HADH IDO1 IDO2 IL4I1 INMT KMO KYAT1 KYAT3 KYNU MAOA STAT1 TDO2 TPH1 TPH2 (see all 32) (see less)
3	tryptophan degradation	PubChem	ACAT1 ACAT2 ACMSD AFMID DHTKD1 ECHS1 GCDH HAAO IDO1 IDO2 KMO KYNU TDO2 (see all 13) (see less)
4	L-kynurenine degradation	PubChem	AADAT ACMSD AFMID DHTKD1 GOT2 HAAO IDO1 IDO2 KMO KYAT1 KYAT3 KYNU TDO2 (see all 13) (see less)
5	NAD de novo biosynthesis	PubChem	AFMID HAAO IDO1 IDO2 KMO KYNU NADSYN1 NMNAT1 NMNAT2 NMNAT3 QPRT TDO2 (see all 12) (see less)
6	L-tryptophan degradation XI (mammalian, via kynurenine)	PubChem	AADAT ACMSD DHTKD1 GOT2 HAAO IDO1 KMO KYAT1 KYAT3 KYNU TDO2 (see all 11) (see less)
7	NAD de novo biosynthesis II (from tryptophan)	PubChem	HAAO IDO1 KMO KYNU NADSYN1 NMNAT1 NMNAT2 NMNAT3 QPRT TDO2 (see all 10) (see less)
8	L-tryptophan degradation III (eukaryotic)	PubChem	ACAT1 ACAT2 ACMSD DHTKD1 HAAO IDO1 KMO KYNU TDO2 (see all 9) (see less)
9	NAD biosynthesis II (from tryptophan)	WikiPathways	AFMID HAAO KMO KYNU NADSYN1 NMNAT1 QPRT TDO2 (see all 8) (see less)
10	serotonin degradation	PubChem	ADH1B ALDH2 ALDH3A2 MAOA SULT1A2 SULT1A3 SULT1A4 (see all 7) (see less)
11	tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde	PubChem	AFMID HAAO IDO1 IDO2 KMO KYNU TDO2 (see all 7) (see less)
12	L-tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde	PubChem	HAAO IDO1 KMO KYNU TDO2
13	NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde	PubChem	NADSYN1 NMNAT1 NMNAT2 NMNAT3 QPRT
14	tryptophan degradation via tryptamine	PubChem	AKR1A1 ALDH3A2 DDC MAOB
15	2-amino-3-carboxymuconate semialdehyde degradation to glutaryl-CoA	PubChem	ACMSD DHTKD1
16	L-tryptophan degradation X (mammalian, via tryptamine)	PubChem	ALDH3A2 DDC

Gene overlap in member pathways for superpathway of tryptophan utilization SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	TDO2	Tryptophan 2,3-Dioxygenase	Protein Coding	11
2	KYNU	Kynureninase	Protein Coding	11
3	HAAO	3-Hydroxyanthranilate 3,4-Dioxygenase	Protein Coding	11
4	KMO	Kynurenine 3-Monooxygenase	Protein Coding	11
5	IDO1	Indoleamine 2,3-Dioxygenase 1	Protein Coding	10
6	AFMID	Arylformamidase	Protein Coding	7
7	ACMSD	Aminocarboxymuconate Semialdehyde Decarboxylase	Protein Coding	7
8	IDO2	Indoleamine 2,3-Dioxygenase 2	Protein Coding	6
9	DHTKD1	Dehydrogenase E1 And Transketolase Domain Containing 1	Protein Coding	6
10	QPRT	Quinolinate Phosphoribosyltransferase	Protein Coding	5
11	NADSYN1	NAD Synthetase 1	Protein Coding	5
12	NMNAT1	Nicotinamide Nucleotide Adenylyltransferase 1	Protein Coding	5
13	ALDH3A2	Aldehyde Dehydrogenase 3 Family Member A2	Protein Coding	4
14	DDC	Dopa Decarboxylase	Protein Coding	4
15	NMNAT3	Nicotinamide Nucleotide Adenylyltransferase 3	Protein Coding	4
16	ACAT1	Acetyl-CoA Acetyltransferase 1	Protein Coding	4
17	NMNAT2	Nicotinamide Nucleotide Adenylyltransferase 2	Protein Coding	4
18	ALDH2	Aldehyde Dehydrogenase 2 Family Member	Protein Coding	3
19	MAOA	Monoamine Oxidase A	Protein Coding	3
20	GCDH	Glutaryl-CoA Dehydrogenase	Protein Coding	3
21	ACAT2	Acetyl-CoA Acetyltransferase 2	Protein Coding	3
22	ECHS1	Enoyl-CoA Hydratase, Short Chain 1	Protein Coding	3
23	KYAT1	Kynurenine Aminotransferase 1	Protein Coding	3
24	AADAT	Aminoadipate Aminotransferase	Protein Coding	3
25	GOT2	Glutamic-Oxaloacetic Transaminase 2	Protein Coding	3
26	KYAT3	Kynurenine Aminotransferase 3	Protein Coding	3
27	TPH2	Tryptophan Hydroxylase 2	Protein Coding	2
28	TPH1	Tryptophan Hydroxylase 1	Protein Coding	2
29	SULT1A3	Sulfotransferase Family 1A Member 3	Protein Coding	2
30	SULT1A4	Sulfotransferase Family 1A Member 4	Protein Coding	2
31	SULT1A2	Sulfotransferase Family 1A Member 2	Protein Coding	2
32	MAOB	Monoamine Oxidase B	Protein Coding	2
33	ASMT	Acetylserotonin O-Methyltransferase	Protein Coding	2
34	AANAT	Aralkylamine N-Acetyltransferase	Protein Coding	2
35	ADH1B	Alcohol Dehydrogenase 1B (Class I), Beta Polypeptide	Protein Coding	2
36	AKR1A1	Aldo-Keto Reductase Family 1 Member A1	Protein Coding	2
37	CYP4X1	Cytochrome P450 Family 4 Subfamily X Member 1	Protein Coding	1
38	UGT2B11	UDP Glucuronosyltransferase Family 2 Member B11	Protein Coding	1
39	CYP2S1	Cytochrome P450 Family 2 Subfamily S Member 1	Protein Coding	1
40	CYP2U1	Cytochrome P450 Family 2 Subfamily U Member 1	Protein Coding	1
41	ADH6	Alcohol Dehydrogenase 6 (Class V)	Protein Coding	1
42	POR	Cytochrome P450 Oxidoreductase	Protein Coding	1
43	CYP1B1	Cytochrome P450 Family 1 Subfamily B Member 1	Protein Coding	1
44	SULT1A1	Sulfotransferase Family 1A Member 1	Protein Coding	1
45	CYP2A6	Cytochrome P450 Family 2 Subfamily A Member 6	Protein Coding	1
46	CYP1A2	Cytochrome P450 Family 1 Subfamily A Member 2	Protein Coding	1
47	CYP2C19	Cytochrome P450 Family 2 Subfamily C Member 19	Protein Coding	1
48	IL4I1	Interleukin 4 Induced 1	Protein Coding	1
49	HADH	Hydroxyacyl-CoA Dehydrogenase	Protein Coding	1
50	CAT	Catalase	Protein Coding	1
51	STAT1	Signal Transducer And Activator Of Transcription 1	Protein Coding	1
52	ALDH8A1	Aldehyde Dehydrogenase 8 Family Member A1	Protein Coding	1
53	AOX1	Aldehyde Oxidase 1	Protein Coding	1
54	AOC1	Amine Oxidase Copper Containing 1	Protein Coding	1
55	DLD	Dihydrolipoamide Dehydrogenase	Protein Coding	1
56	CYP1A1	Cytochrome P450 Family 1 Subfamily A Member 1	Protein Coding	1
57	INMT	Indolethylamine N-Methyltransferase	Protein Coding	1

Disorders associated with superpathway of tryptophan utilization SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Congenital nad deficiency disorder	Enrichment	HAAO, KYNU, NADSYN1	9.24
2	Alpha-methylacetoacetic aciduria	Enrichment	ACAT1, ACAT2	6.41
3	Alcohol dependence	Enrichment	ADH1B, ALDH2	5.47
4	Alpha-aminoadipic and alpha-ketoadipic aciduria	Enrichment	DHTKD1	3.83
5	Charcot-marie-tooth disease, axonal, type 2q	Enrichment	DHTKD1	3.83
6	Aromatic l-amino acid decarboxylase deficiency	Enrichment	DDC	3.53
7	Sjogren-larsson syndrome	Enrichment	ALDH3A2	3.53
8	Hydroxykynureninuria	Enrichment	KYNU	3.43
9	Vertebral, cardiac, renal, and limb defects syndrome 2	Enrichment	KYNU	3.43
10	Hypertryptophanemia	Enrichment	TDO2	3.43
11	Vertebral, cardiac, renal, and limb defects syndrome 3	Enrichment	NADSYN1	3.43
12	Spondyloepiphyseal dysplasia, sensorineural hearing loss, impaired intellectual development, and leber congenital amaurosis	Enrichment	NMNAT1	3.43
13	Brunner syndrome	Enrichment	MAOA	3.29
14	Alcohol sensitivity, acute	Enrichment	ALDH2	3.29
15	Acetyl-coa acetyltransferase-2 deficiency	Enrichment	ACAT2	3.18
16	Vertebral, cardiac, renal, and limb defects syndrome 1	Enrichment	HAAO	3.13
17	Catel-manzke syndrome	Enrichment	KYNU	3.13
18	Leber congenital amaurosis 9	Enrichment	NMNAT1	3.13
19	Amed syndrome, digenic	Enrichment	ALDH2	2.99
20	Developmental and epileptic encephalopathy 82	Enrichment	GOT2	2.79
21	Mitochondrial short-chain enoyl-coa hydratase 1 deficiency	Enrichment	ECHS1	2.72
22	Diarrhea	Enrichment	NMNAT1	2.66
23	3-hydroxyacyl-coa dehydrogenase deficiency	Enrichment	HADH	2.63
24	Acatalasemia	Enrichment	CAT	2.63
25	Immunodeficiency 31a	Enrichment	STAT1	2.63
26	Immunodeficiency 31b	Enrichment	STAT1	2.63
27	Leukodystrophy, hypomyelinating, 2	Enrichment	GCDH	2.54
28	Drug metabolism, poor, cyp2c19-related	Enrichment	CYP2C19	2.50
29	Brachycephaly, deafness, cataract, microstomia, and impaired intellectual development	Enrichment	POR	2.50
30	Letrozole toxicity	Enrichment	CYP2A6	2.50
31	Anemia, congenital dyserythropoietic, type iva	Enrichment	GCDH	2.42
32	Fetal hemoglobin quantitative trait locus 6	Enrichment	GCDH	2.42
33	Ciliary dyskinesia, primary, 29	Enrichment	GCDH	2.42
34	Rasopathy	Enrichment	DDC	2.42
35	Major affective disorder 1	Enrichment	TPH2	2.33
36	Dihydrolipoamide dehydrogenase deficiency	Enrichment	DLD	2.33
37	Striatonigral degeneration, infantile	Enrichment	IL4I1	2.33
38	Hyperinsulinemic hypoglycemia, familial, 4	Enrichment	HADH	2.33
39	Methemoglobinemia due to deficiency of methemoglobin reductase	Enrichment	DLD	2.33
40	Immunodeficiency 31c	Enrichment	STAT1	2.33
41	Glutaric acidemia i	Enrichment	GCDH	2.32
42	Cerebral palsy	Enrichment	ALDH3A2	2.24
43	Glaucoma 1, open angle, a	Enrichment	CYP1B1	2.20
44	Antley-bixler syndrome with genital anomalies and disordered steroidogenesis	Enrichment	POR	2.20
45	Anterior segment dysgenesis 6	Enrichment	CYP1B1	2.20
46	Antley-bixler syndrome without genital anomalies or disordered steroidogenesis	Enrichment	POR	2.20
47	Disordered steroidogenesis due to cytochrome p450 oxidoreductase deficiency	Enrichment	POR	2.20
48	Cytochrome p450 oxidoreductase deficiency	Enrichment	POR	2.20
49	Primary congenital glaucoma	Enrichment	CYP1B1	2.20
50	Hyperinsulinemic hypoglycemia	Enrichment	HADH	2.15
51	Cone dystrophy	Enrichment	NMNAT1	2.05
52	Coumarin resistance	Enrichment	CYP2A6	2.02
53	Hereditary spastic paraplegia 56	Enrichment	CYP2U1	2.02
54	Spastic paraplegia 56, autosomal recessive, with or without pseudoxanthoma elasticum	Enrichment	CYP2U1	2.02
55	Major depressive disorder	Enrichment	TPH2	1.93
56	Glaucoma 3, primary infantile, b	Enrichment	CYP1B1	1.90
57	Tobacco addiction	Enrichment	CYP2A6	1.90
58	Hyperinsulinemic hypoglycemia, familial, 1	Enrichment	HADH	1.85
59	Chronic mucocutaneous candidiasis	Enrichment	STAT1	1.85
60	Nonsyndromic genetic hyperinsulinism	Enrichment	HADH	1.85
61	Juvenile glaucoma	Enrichment	CYP1B1	1.80
62	Glaucoma, primary open angle	Enrichment	CYP1B1	1.72
63	Anterior segment dysgenesis 5	Enrichment	CYP1B1	1.72
64	Glaucoma 3, primary congenital, a	Enrichment	CYP1B1	1.66
65	Cone-rod dystrophy 2	Enrichment	NMNAT1	1.61
66	Lactic acidosis	Enrichment	DLD	1.55
67	Developmental and epileptic encephalopathy	Enrichment	GOT2	1.54
68	Peters-plus syndrome	Enrichment	CYP1B1	1.50
69	Leber plus disease	Enrichment	NMNAT1	1.46
70	Lipoid congenital adrenal hyperplasia	Enrichment	POR	1.36
71	Anterior segment dysgenesis	Enrichment	CYP1B1	1.33
72	Leigh syndrome, nuclear	Enrichment	ECHS1	1.19
73	Leigh disease	Enrichment	ECHS1	1.15
74	Lung cancer	Enrichment	CYP2A6	1.01
75	Hereditary retinal dystrophy	Enrichment	NMNAT1	0.99
76	Fundus dystrophy	Enrichment	NMNAT1	0.99
77	Hereditary spastic paraplegia	Enrichment	CYP2U1	0.90
78	Primary ovarian insufficiency	Enrichment	POR	0.77
79	Congenital nervous system abnormality	Enrichment	CYP2U1	0.54
80	Nervous system disease	Enrichment	CYP2U1	0.54

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

superpathway of tryptophan utilization

Pathway Network for superpathway of tryptophan utilization

Pathway network for the superpathway of tryptophan utilization SuperPath

Member Pathways for superpathway of tryptophan utilization

Pathways in the superpathway of tryptophan utilization SuperPath

Gene overlap in member pathways for superpathway of tryptophan utilization SuperPath

Associated Genes for superpathway of tryptophan utilization

Associated Disorders for superpathway of tryptophan utilization

Disorders associated with superpathway of tryptophan utilization SuperPath

STRING Interaction Network for superpathway of tryptophan utilization

Sources for superpathway of tryptophan utilization