Surfactant metabolism

No Pathway Network information available for Surfactant metabolism

Pathways in the Surfactant metabolism SuperPath

#	Name	Source	Genes
1	Surfactant metabolism	Reactome	ABCA3 ADA2 ADGRF5 ADORA2A ADORA2B ADRA2A ADRA2C CCDC59 CKAP4 CSF2RA CSF2RB CTSH DMBT1 GATA6 LMCD1 NAPSA P2RY2 PGA3 PGA4 PGA5 SFTPA1 SFTPA2 SFTPB SFTPC SFTPD SLC34A1 SLC34A2 TTF1 ZDHHC2 (see all 29) (see less)
2	Diseases associated with surfactant metabolism	Reactome	ABCA3 CSF2RA CSF2RB SFTPA1 SFTPA2 SFTPB SFTPC SFTPD SLC34A2 (see all 9) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	SLC34A2	Solute Carrier Family 34 Member 2	Protein Coding	2
2	CSF2RA	Colony Stimulating Factor 2 Receptor Subunit Alpha	Protein Coding	2
3	CSF2RB	Colony Stimulating Factor 2 Receptor Subunit Beta	Protein Coding	2
4	ABCA3	ATP Binding Cassette Subfamily A Member 3	Protein Coding	2
5	SFTPB	Surfactant Protein B	Protein Coding	2
6	SFTPC	Surfactant Protein C	Protein Coding	2
7	SFTPD	Surfactant Protein D	Protein Coding	2
8	SFTPA1	Surfactant Protein A1	Protein Coding	2
9	SFTPA2	Surfactant Protein A2	Protein Coding	2
10	CKAP4	Cytoskeleton Associated Protein 4	Protein Coding	1
11	ADORA2A	Adenosine A2a Receptor	Protein Coding	1
12	ADORA2B	Adenosine A2b Receptor	Protein Coding	1
13	ADRA2A	Adrenoceptor Alpha 2A	Protein Coding	1
14	CTSH	Cathepsin H	Protein Coding	1
15	ADRA2C	Adrenoceptor Alpha 2C	Protein Coding	1
16	DMBT1	Deleted In Malignant Brain Tumors 1	Protein Coding	1
17	ADGRF5	Adhesion G Protein-Coupled Receptor F5	Protein Coding	1
18	GATA6	GATA Binding Protein 6	Protein Coding	1
19	CCDC59	Coiled-Coil Domain Containing 59	Protein Coding	1
20	LMCD1	LIM And Cysteine Rich Domains 1	Protein Coding	1
21	P2RY2	Purinergic Receptor P2Y2	Protein Coding	1
22	ZDHHC2	ZDHHC Palmitoyltransferase 2	Protein Coding	1
23	ADA2	Adenosine Deaminase 2	Protein Coding	1
24	PGA5	Pepsinogen A5	Protein Coding	1
25	PGA3	Pepsinogen A3	Protein Coding	1
26	PGA4	Pepsinogen A4	Protein Coding	1
27	SLC34A1	Solute Carrier Family 34 Member 1	Protein Coding	1
28	TTF1	Transcription Termination Factor 1	Protein Coding	1
29	NAPSA	Napsin A Aspartic Peptidase	Protein Coding	1

Disorders associated with Surfactant metabolism SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Lung disease	Direct
2	Hereditary pulmonary alveolar proteinosis	Enrichment	ABCA3, CSF2RA, CSF2RB, SFTPB, SFTPC	10.79
3	Pediatric acute respiratory distress syndrome	Enrichment	ABCA3, SFTPB, SFTPC	8.06
4	Interstitial lung disease 2	Enrichment	ABCA3, SFTPA1, SFTPA2, SFTPC	7.41
5	Surfactant metabolism dysfunction, pulmonary, 1	Enrichment	ABCA3, SFTPB	5.36
6	Sneddon syndrome	Enrichment	ADA2	2.67
7	Pulmonary alveolar microlithiasis	Enrichment	SLC34A2	2.67
8	Surfactant metabolism dysfunction, pulmonary, 4	Enrichment	CSF2RA	2.67
9	Surfactant metabolism dysfunction, pulmonary, 2	Enrichment	SFTPC	2.67
10	Fanconi renotubular syndrome 2	Enrichment	SLC34A1	2.67
11	Atrioventricular septal defect 5	Enrichment	GATA6	2.67
12	Interstitial lung disease 1	Enrichment	SFTPA1	2.67
13	Hypercalcemia, infantile, 2	Enrichment	SLC34A1	2.67
14	Surfactant metabolism dysfunction, pulmonary, 5	Enrichment	CSF2RB	2.67
15	Vasculitis, autoinflammation, immunodeficiency, and hematologic defects syndrome	Enrichment	ADA2	2.67
16	Atrial septal defect 9	Enrichment	GATA6	2.67
17	Chronic respiratory distress with surfactant metabolism deficiency	Enrichment	SFTPC	2.67
18	Primary interstitial lung disease specific to childhood due to pulmonary surfactant protein anomalies	Enrichment	ABCA3	2.67
19	Lipodystrophy, familial partial, type 8	Enrichment	ADRA2A	2.67
20	Acute encephalopathy with biphasic seizures and late reduced diffusion	Enrichment	ADORA2A	2.67
21	Polyarteritis nodosa	Enrichment	ADA2	2.67
22	Carbamoyl phosphate synthetase i deficiency, hyperammonemia due to	Enrichment	ABCA3	2.37
23	Hypophosphatemic rickets with hypercalciuria, hereditary	Enrichment	SLC34A1	2.37
24	Factor xii deficiency	Enrichment	SLC34A1	2.37
25	Neutropenia, severe congenital, 8, autosomal dominant	Enrichment	GATA6	2.37
26	Nephrolithiasis/osteoporosis, hypophosphatemic, 1	Enrichment	SLC34A1	2.37
27	Surfactant metabolism dysfunction, pulmonary, 3	Enrichment	ABCA3	2.37
28	Autosomal recessive infantile hypercalcemia	Enrichment	SLC34A1	2.37
29	Dominant hypophosphatemia with nephrolithiasis or osteoporosis	Enrichment	SLC34A1	2.37
30	Heart defects, congenital, and other congenital anomalies	Enrichment	GATA6	2.19
31	Middle aortic syndrome	Enrichment	GATA6	2.07
32	Primary fanconi renotubular syndrome	Enrichment	SLC34A1	2.07
33	Congenital heart defects, multiple types, 4	Enrichment	GATA6	1.97
34	Persistent truncus arteriosus	Enrichment	GATA6	1.97
35	Conotruncal heart malformations	Enrichment	GATA6	1.89
36	Narcolepsy 1	Enrichment	CTSH	1.77
37	Loeys-dietz syndrome	Enrichment	ABCA3	1.72
38	Nephrocalcinosis	Enrichment	SLC34A1	1.67
39	Nephrolithiasis	Enrichment	SLC34A1	1.67
40	Diaphragmatic hernia, congenital	Enrichment	GATA6	1.56
41	Osteogenesis imperfecta, type iii	Enrichment	SLC34A1	1.50
42	Patent foramen ovale	Enrichment	GATA6	1.42
43	Behcet syndrome	Enrichment	ADA2	1.40
44	Familial atrial fibrillation	Enrichment	GATA6	1.30
45	Autoinflammatory disease	Enrichment	ADA2	1.30
46	Tetralogy of fallot	Enrichment	GATA6	1.27
47	Diamond-blackfan anemia	Enrichment	ADA2	1.13
48	Hereditary breast ovarian cancer syndrome	Enrichment	SLC34A2	0.95
49	Dilated cardiomyopathy	Enrichment	GATA6	0.80

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Surfactant metabolism

Pathway Network for Surfactant metabolism

Member Pathways for Surfactant metabolism

Pathways in the Surfactant metabolism SuperPath

Associated Genes for Surfactant metabolism

Associated Disorders for Surfactant metabolism

Disorders associated with Surfactant metabolism SuperPath

STRING Interaction Network for Surfactant metabolism

Sources for Surfactant metabolism