Sympathetic Nerve Pathway (Neuroeffector Junction)

No Pathway Network information available for Sympathetic Nerve Pathway (Neuroeffector Junction)

Pathways in the Sympathetic Nerve Pathway (Neuroeffector Junction) SuperPath

#	Name	Source	Genes
1	Sympathetic Nerve Pathway (Neuroeffector Junction)	PharmGKB	ACKR5 ADM ADRA1A ADRA1B ADRA1D ADRA2A ADRA2B ADRA2C ADRB1 ADRB2 CACNA1A CACNA1B CACNA1C CACNA1D DBH NPY NPY1R NPY2R PYY SLC18A1 SLC18A2 SLC22A3 SLC6A2 (see all 23) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	PYY	Peptide YY	Protein Coding	1
2	CACNA1A	Calcium Voltage-Gated Channel Subunit Alpha1 A	Protein Coding	1
3	CACNA1B	Calcium Voltage-Gated Channel Subunit Alpha1 B	Protein Coding	1
4	CACNA1C	Calcium Voltage-Gated Channel Subunit Alpha1 C	Protein Coding	1
5	CACNA1D	Calcium Voltage-Gated Channel Subunit Alpha1 D	Protein Coding	1
6	SLC6A2	Solute Carrier Family 6 Member 2	Protein Coding	1
7	SLC18A1	Solute Carrier Family 18 Member A1	Protein Coding	1
8	SLC18A2	Solute Carrier Family 18 Member A2	Protein Coding	1
9	SLC22A3	Solute Carrier Family 22 Member 3	Protein Coding	1
10	NPY	Neuropeptide Y	Protein Coding	1
11	NPY1R	Neuropeptide Y Receptor Y1	Protein Coding	1
12	NPY2R	Neuropeptide Y Receptor Y2	Protein Coding	1
13	ADM	Adrenomedullin	Protein Coding	1
14	ADRA1D	Adrenoceptor Alpha 1D	Protein Coding	1
15	ADRA1B	Adrenoceptor Alpha 1B	Protein Coding	1
16	ADRA1A	Adrenoceptor Alpha 1A	Protein Coding	1
17	ADRA2A	Adrenoceptor Alpha 2A	Protein Coding	1
18	ADRA2B	Adrenoceptor Alpha 2B	Protein Coding	1
19	ADRA2C	Adrenoceptor Alpha 2C	Protein Coding	1
20	ADRB1	Adrenoceptor Beta 1	Protein Coding	1
21	ADRB2	Adrenoceptor Beta 2	Protein Coding	1
22	DBH	Dopamine Beta-Hydroxylase	Protein Coding	1
23	ACKR5	Atypical Chemokine Receptor 5	Protein Coding	1

Disorders associated with Sympathetic Nerve Pathway (Neuroeffector Junction) SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Neurodevelopmental disorder with hypotonia, language delay, and skeletal defects with or without seizures	Enrichment	CACNA1A, CACNA1C	5.08
2	Resting heart rate, variation in	Enrichment	ADRB1	2.77
3	Primary aldosteronism, seizures, and neurologic abnormalities	Enrichment	CACNA1D	2.77
4	Brugada syndrome 3	Enrichment	CACNA1C	2.77
5	Sinoatrial node dysfunction and deafness	Enrichment	CACNA1D	2.77
6	Short sleep, familial natural, 2	Enrichment	ADRB1	2.77
7	Postural orthostatic tachycardia syndrome	Enrichment	SLC6A2	2.77
8	Lipodystrophy, familial partial, type 8	Enrichment	ADRA2A	2.77
9	Sporadic hemiplegic migraine	Enrichment	CACNA1A	2.77
10	Atypical timothy syndrome	Enrichment	CACNA1C	2.77
11	Aldosterone-producing adenoma with seizures and neurological abnormalities	Enrichment	CACNA1D	2.77
12	Timothy syndrome type 2	Enrichment	CACNA1C	2.77
13	Timothy syndrome type 1	Enrichment	CACNA1C	2.77
14	Cacna1c-related disorders	Enrichment	CACNA1C	2.77
15	Benign paroxysmal torticollis of infancy	Enrichment	CACNA1A	2.77
16	Cerebral palsy	Enrichment	CACNA1A, CACNA1C	2.71
17	N-acetylglutamate synthase deficiency	Enrichment	PYY	2.47
18	Timothy syndrome	Enrichment	CACNA1C	2.47
19	Alternating hemiplegia of childhood 1	Enrichment	CACNA1A	2.47
20	Orthostatic hypotension 1	Enrichment	DBH	2.47
21	Long qt syndrome 8	Enrichment	CACNA1C	2.47
22	Parkinsonism-dystonia 2, infantile-onset	Enrichment	SLC18A2	2.47
23	Dopamine beta-hydroxylase deficiency	Enrichment	DBH	2.47
24	Congenital disorder of glycosylation, type iw, autosomal dominant	Enrichment	CACNA1D	2.47
25	Neurodevelopmental disorder with seizures and nonepileptic hyperkinetic movements	Enrichment	CACNA1B	2.47
26	Progressive bulbar palsy	Enrichment	CACNA1A	2.47
27	Undetermined early-onset epileptic encephalopathy	Enrichment	CACNA1A, CACNA1B	2.40
28	Hereditary episodic ataxia	Enrichment	CACNA1A	2.29
29	Migraine, familial hemiplegic, 1	Enrichment	CACNA1A	2.17
30	Spinocerebellar ataxia 6	Enrichment	CACNA1A	2.17
31	Developmental and epileptic encephalopathy 2	Enrichment	CACNA1A	2.17
32	Ventricular fibrillation, paroxysmal familial, 1	Enrichment	CACNA1C	2.17
33	Developmental and epileptic encephalopathy 42	Enrichment	CACNA1A	2.17
34	Developmental and epileptic encephalopathy 52	Enrichment	CACNA1A	2.17
35	Episodic ataxia	Enrichment	CACNA1A	2.17
36	Familial or sporadic hemiplegic migraine	Enrichment	CACNA1A	2.17
37	Episodic ataxia, type 2	Enrichment	CACNA1A	2.07
38	Heart conduction disease	Enrichment	CACNA1C	2.07
39	Familial adult myoclonic epilepsy	Enrichment	ADRA2B	1.99
40	Orthostatic intolerance	Enrichment	SLC6A2	1.87
41	Lennox-gastaut syndrome	Enrichment	CACNA1A	1.87
42	Alternating hemiplegia of childhood	Enrichment	CACNA1A	1.87
43	Difference of sex development	Enrichment	CACNA1A	1.87
44	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	CACNA1C	1.82
45	Migraine with or without aura 1	Enrichment	CACNA1A	1.73
46	Cardiac conduction defect	Enrichment	CACNA1C	1.70
47	Cardiomyopathy, familial hypertrophic, 1	Enrichment	CACNA1C	1.40
48	Brugada syndrome	Enrichment	CACNA1C	1.36
49	Auditory neuropathy	Enrichment	CACNA1A	1.36
50	Strabismus	Enrichment	CACNA1A	1.35
51	Long qt syndrome 1	Enrichment	CACNA1C	1.30
52	Long qt syndrome	Enrichment	CACNA1C	1.29
53	Congenital nervous system abnormality	Enrichment	CACNA1A	0.78
54	Nervous system disease	Enrichment	CACNA1A	0.78
55	Complex neurodevelopmental disorder	Enrichment	CACNA1C	0.72

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Sympathetic Nerve Pathway (Neuroeffector Junction)

Pathway Network for Sympathetic Nerve Pathway (Neuroeffector Junction)

Member Pathways for Sympathetic Nerve Pathway (Neuroeffector Junction)

Pathways in the Sympathetic Nerve Pathway (Neuroeffector Junction) SuperPath

Associated Genes for Sympathetic Nerve Pathway (Neuroeffector Junction)

Associated Disorders for Sympathetic Nerve Pathway (Neuroeffector Junction)

Disorders associated with Sympathetic Nerve Pathway (Neuroeffector Junction) SuperPath

STRING Interaction Network for Sympathetic Nerve Pathway (Neuroeffector Junction)

Sources for Sympathetic Nerve Pathway (Neuroeffector Junction)