Sympathetic Nerve Pathway (Pre- and Post- Ganglionic Junction)

No Pathway Network information available for Sympathetic Nerve Pathway (Pre- and Post- Ganglionic Junction)

Pathways in the Sympathetic Nerve Pathway (Pre- and Post- Ganglionic Junction) SuperPath

#	Name	Source	Genes
1	Sympathetic Nerve Pathway (Pre- and Post- Ganglionic Junction)	PharmGKB	ACHE CACNA1A CACNA1B CACNA1C CACNA1D CACNA1E CHAT CHRNA7 DDC SLC18A3 SLC5A7 TH (see all 12) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	SLC5A7	Solute Carrier Family 5 Member 7	Protein Coding	1
2	TH	Tyrosine Hydroxylase	Protein Coding	1
3	CACNA1A	Calcium Voltage-Gated Channel Subunit Alpha1 A	Protein Coding	1
4	CACNA1B	Calcium Voltage-Gated Channel Subunit Alpha1 B	Protein Coding	1
5	CACNA1C	Calcium Voltage-Gated Channel Subunit Alpha1 C	Protein Coding	1
6	CACNA1D	Calcium Voltage-Gated Channel Subunit Alpha1 D	Protein Coding	1
7	CACNA1E	Calcium Voltage-Gated Channel Subunit Alpha1 E	Protein Coding	1
8	SLC18A3	Solute Carrier Family 18 Member A3	Protein Coding	1
9	CHAT	Choline O-Acetyltransferase	Protein Coding	1
10	ACHE	Acetylcholinesterase (Yt Blood Group)	Protein Coding	1
11	DDC	Dopa Decarboxylase	Protein Coding	1
12	CHRNA7	Cholinergic Receptor Nicotinic Alpha 7 Subunit	Protein Coding	1

Disorders associated with Sympathetic Nerve Pathway (Pre- and Post- Ganglionic Junction) SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Presynaptic congenital myasthenic syndromes	Enrichment	CHAT, SLC18A3, SLC5A7	7.06
2	Myasthenic syndrome, congenital, 21, presynaptic	Enrichment	CHAT, SLC18A3	6.14
3	Neurodevelopmental disorder with hypotonia, language delay, and skeletal defects with or without seizures	Enrichment	CACNA1A, CACNA1C	5.67
4	Cerebral palsy	Enrichment	CACNA1A, CACNA1C	3.28
5	Neuronopathy, distal hereditary motor, autosomal dominant 7	Enrichment	SLC5A7	3.05
6	Apnea, central sleep	Enrichment	CHAT	3.05
7	Yt blood group antigen	Enrichment	ACHE	3.05
8	Primary aldosteronism, seizures, and neurologic abnormalities	Enrichment	CACNA1D	3.05
9	Brugada syndrome 3	Enrichment	CACNA1C	3.05
10	Sinoatrial node dysfunction and deafness	Enrichment	CACNA1D	3.05
11	Developmental and epileptic encephalopathy 69	Enrichment	CACNA1E	3.05
12	Aspiration pneumonia	Enrichment	CHAT	3.05
13	Sporadic hemiplegic migraine	Enrichment	CACNA1A	3.05
14	Atypical timothy syndrome	Enrichment	CACNA1C	3.05
15	Aldosterone-producing adenoma with seizures and neurological abnormalities	Enrichment	CACNA1D	3.05
16	Timothy syndrome type 2	Enrichment	CACNA1C	3.05
17	Timothy syndrome type 1	Enrichment	CACNA1C	3.05
18	Cacna1c-related disorders	Enrichment	CACNA1C	3.05
19	Benign paroxysmal torticollis of infancy	Enrichment	CACNA1A	3.05
20	Undetermined early-onset epileptic encephalopathy	Enrichment	CACNA1A, CACNA1B	2.97
21	Timothy syndrome	Enrichment	CACNA1C	2.75
22	Alternating hemiplegia of childhood 1	Enrichment	CACNA1A	2.75
23	Segawa syndrome, autosomal recessive	Enrichment	TH	2.75
24	Aromatic l-amino acid decarboxylase deficiency	Enrichment	DDC	2.75
25	Long qt syndrome 8	Enrichment	CACNA1C	2.75
26	Myasthenic syndrome, congenital, 20, presynaptic	Enrichment	SLC5A7	2.75
27	Chromosome 15q13.3 deletion syndrome	Enrichment	CHRNA7	2.75
28	Congenital disorder of glycosylation, type iw, autosomal dominant	Enrichment	CACNA1D	2.75
29	Neurodevelopmental disorder with seizures and nonepileptic hyperkinetic movements	Enrichment	CACNA1B	2.75
30	Distal hereditary motor neuropathy type 7	Enrichment	SLC5A7	2.75
31	Progressive bulbar palsy	Enrichment	CACNA1A	2.75
32	Van der woude syndrome 1	Enrichment	CACNA1E	2.58
33	Dystonia, dopa-responsive	Enrichment	TH	2.58
34	Myasthenic syndrome, congenital, 6, presynaptic	Enrichment	CHAT	2.58
35	Bronchopulmonary dysplasia	Enrichment	CHAT	2.58
36	Hereditary episodic ataxia	Enrichment	CACNA1A	2.58
37	Migraine, familial hemiplegic, 1	Enrichment	CACNA1A	2.45
38	Spinocerebellar ataxia 6	Enrichment	CACNA1A	2.45
39	Developmental and epileptic encephalopathy 2	Enrichment	CACNA1A	2.45
40	Ventricular fibrillation, paroxysmal familial, 1	Enrichment	CACNA1C	2.45
41	Developmental and epileptic encephalopathy 42	Enrichment	CACNA1A	2.45
42	Developmental and epileptic encephalopathy 52	Enrichment	CACNA1A	2.45
43	Episodic ataxia	Enrichment	CACNA1A	2.45
44	Familial or sporadic hemiplegic migraine	Enrichment	CACNA1A	2.45
45	Episodic ataxia, type 2	Enrichment	CACNA1A	2.35
46	Heart conduction disease	Enrichment	CACNA1C	2.35
47	Gastroesophageal reflux	Enrichment	CHAT	2.15
48	Lennox-gastaut syndrome	Enrichment	CACNA1A	2.15
49	Alternating hemiplegia of childhood	Enrichment	CACNA1A	2.15
50	Difference of sex development	Enrichment	CACNA1A	2.15
51	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	CACNA1C	2.10
52	Myasthenic syndrome, congenital, 4c, associated with acetylcholine receptor deficiency	Enrichment	CHAT	2.05
53	Migraine with or without aura 1	Enrichment	CACNA1A	2.01
54	Cardiac conduction defect	Enrichment	CACNA1C	1.98
55	Lactic acidosis	Enrichment	CHAT	1.98
56	Congenital myasthenic syndrome	Enrichment	CHAT	1.91
57	Neuropathy, hereditary motor and sensory, okinawa type	Enrichment	SLC5A7	1.78
58	Cardiomyopathy, familial hypertrophic, 1	Enrichment	CACNA1C	1.68
59	Brugada syndrome	Enrichment	CACNA1C	1.64
60	Rasopathy	Enrichment	DDC	1.64
61	Auditory neuropathy	Enrichment	CACNA1A	1.64
62	Strabismus	Enrichment	CACNA1A	1.63
63	Long qt syndrome 1	Enrichment	CACNA1C	1.58
64	Long qt syndrome	Enrichment	CACNA1C	1.57
65	Dystonia	Enrichment	TH	1.52
66	Developmental and epileptic encephalopathy	Enrichment	CACNA1E	1.50
67	Fetal akinesia deformation sequence 1	Enrichment	SLC18A3	1.49
68	Congenital nervous system abnormality	Enrichment	CACNA1A	1.05
69	Nervous system disease	Enrichment	CACNA1A	1.05
70	Complex neurodevelopmental disorder	Enrichment	CACNA1C	0.98

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Sympathetic Nerve Pathway (Pre- and Post- Ganglionic Junction)

Pathway Network for Sympathetic Nerve Pathway (Pre- and Post- Ganglionic Junction)

Member Pathways for Sympathetic Nerve Pathway (Pre- and Post- Ganglionic Junction)

Pathways in the Sympathetic Nerve Pathway (Pre- and Post- Ganglionic Junction) SuperPath

Associated Genes for Sympathetic Nerve Pathway (Pre- and Post- Ganglionic Junction)

Associated Disorders for Sympathetic Nerve Pathway (Pre- and Post- Ganglionic Junction)

Disorders associated with Sympathetic Nerve Pathway (Pre- and Post- Ganglionic Junction) SuperPath

STRING Interaction Network for Sympathetic Nerve Pathway (Pre- and Post- Ganglionic Junction)

Sources for Sympathetic Nerve Pathway (Pre- and Post- Ganglionic Junction)