Synaptic Neurotransmission: GABAergic Inhibition

No Pathway Network information available for Synaptic Neurotransmission: GABAergic Inhibition

Pathways in the Synaptic Neurotransmission: GABAergic Inhibition SuperPath

#	Name	Source	Genes
1	Synaptic Neurotransmission: GABAergic Inhibition	R&D Systems	GABBR1 GABBR2 GABRA1 GABRA2 GABRA4 GABRA5 GABRA6 GABRB1 GABRB2 GABRB3 GABRD GABRG2 GAD1 GAD2 GRM3 GRM5 GRM7 (see all 17) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	GAD1	Glutamate Decarboxylase 1	Protein Coding	1
2	GAD2	Glutamate Decarboxylase 2	Protein Coding	1
3	GABRA1	Gamma-Aminobutyric Acid Type A Receptor Subunit Alpha1	Protein Coding	1
4	GABRA2	Gamma-Aminobutyric Acid Type A Receptor Subunit Alpha2	Protein Coding	1
5	GABRA4	Gamma-Aminobutyric Acid Type A Receptor Subunit Alpha4	Protein Coding	1
6	GABRA5	Gamma-Aminobutyric Acid Type A Receptor Subunit Alpha5	Protein Coding	1
7	GABRA6	Gamma-Aminobutyric Acid Type A Receptor Subunit Alpha6	Protein Coding	1
8	GABRB1	Gamma-Aminobutyric Acid Type A Receptor Subunit Beta1	Protein Coding	1
9	GABRB2	Gamma-Aminobutyric Acid Type A Receptor Subunit Beta2	Protein Coding	1
10	GABRB3	Gamma-Aminobutyric Acid Type A Receptor Subunit Beta3	Protein Coding	1
11	GABRG2	Gamma-Aminobutyric Acid Type A Receptor Subunit Gamma2	Protein Coding	1
12	GABRD	Gamma-Aminobutyric Acid Type A Receptor Subunit Delta	Protein Coding	1
13	GABBR1	Gamma-Aminobutyric Acid Type B Receptor Subunit 1	Protein Coding	1
14	GABBR2	Gamma-Aminobutyric Acid Type B Receptor Subunit 2	Protein Coding	1
15	GRM7	Glutamate Metabotropic Receptor 7	Protein Coding	1
16	GRM3	Glutamate Metabotropic Receptor 3	Protein Coding	1
17	GRM5	Glutamate Metabotropic Receptor 5	Protein Coding	1

Disorders associated with Synaptic Neurotransmission: GABAergic Inhibition SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Undetermined early-onset epileptic encephalopathy	Enrichment	GABBR2, GABRA2, GABRA5, GABRB2, GABRG2	8.22
2	Childhood absence epilepsy	Enrichment	GABRA1, GABRB3, GABRG2	7.49
3	Lennox-gastaut syndrome	Enrichment	GABRB3, GABRG2	4.39
4	Dravet syndrome	Enrichment	GABRA1, GABRG2	4.18
5	Epilepsy, myoclonic juvenile	Enrichment	GABRA1, GABRD	4.09
6	Epilepsy, idiopathic generalized	Enrichment	GABRA1, GABRD	4.09
7	Generalized epilepsy with febrile seizures plus	Enrichment	GABRD, GABRG2	3.88
8	Epilepsy	Enrichment	GABRA1, GABRB3	2.95
9	Febrile seizures, familial, 8	Enrichment	GABRG2	2.90
10	Epilepsy, idiopathic generalized 13	Enrichment	GABRA1	2.90
11	Developmental and epileptic encephalopathy 74	Enrichment	GABRG2	2.90
12	Developmental and epileptic encephalopathy 79	Enrichment	GABRA5	2.90
13	Neurodevelopmental disorder with poor language and loss of hand skills	Enrichment	GABBR2	2.90
14	Developmental and epileptic encephalopathy 59	Enrichment	GABBR2	2.90
15	Developmental and epileptic encephalopathy 89	Enrichment	GAD1	2.90
16	Epilepsy, idiopathic generalized 10	Enrichment	GABRD	2.90
17	Developmental and epileptic encephalopathy 19	Enrichment	GABRA1	2.90
18	Epilepsy, childhood absence 5	Enrichment	GABRB3	2.90
19	Developmental and epileptic encephalopathy 92	Enrichment	GABRB2	2.90
20	Developmental and epileptic encephalopathy 43	Enrichment	GABRB3	2.90
21	Developmental and epileptic encephalopathy 45	Enrichment	GABRB1	2.90
22	Neurodevelopmental disorder with seizures, hypotonia, and brain imaging abnormalities	Enrichment	GRM7	2.90
23	Neurodevelopmental disorder with language delay and variable cognitive abnormalities	Enrichment	GABBR1	2.90
24	Developmental and epileptic encephalopathy 78	Enrichment	GABRA2	2.60
25	Tobacco addiction	Enrichment	GABBR2	2.30
26	Neurodevelopmental disorder with progressive spasticity and brain white matter abnormalities	Enrichment	GAD1	2.30
27	Autosomal dominant nocturnal frontal lobe epilepsy	Enrichment	GABRG2	2.30
28	Spastic quadriplegic cerebral palsy	Enrichment	GAD1	2.30
29	Alcohol dependence	Enrichment	GABRA2	2.13
30	Epilepsy, childhood absence 1	Enrichment	GABRB3	2.13
31	Rett syndrome	Enrichment	GABBR2	2.06
32	Rett syndrome, congenital variant	Enrichment	GABBR2	2.00
33	Neurofibromatosis, type i	Enrichment	GABBR1	1.95
34	Chromosome 1p36 deletion syndrome	Enrichment	GABRD	1.79
35	Early infantile developmental and epileptic encephalopathy	Enrichment	GRM7	1.65
36	Benign epilepsy with centrotemporal spikes	Enrichment	GABRG2	1.30
37	Centralopathic epilepsy	Enrichment	GABRG2	1.28
38	Autosomal dominant non-syndromic intellectual disability	Enrichment	GABBR1	1.22
39	Autosomal recessive non-syndromic intellectual disability	Enrichment	GRM7	1.15
40	Schizophrenia	Enrichment	GABRB2	1.15
41	Microcephaly	Enrichment	GRM7	0.84

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Synaptic Neurotransmission: GABAergic Inhibition

Pathway Network for Synaptic Neurotransmission: GABAergic Inhibition

Member Pathways for Synaptic Neurotransmission: GABAergic Inhibition

Pathways in the Synaptic Neurotransmission: GABAergic Inhibition SuperPath

Associated Genes for Synaptic Neurotransmission: GABAergic Inhibition

Associated Disorders for Synaptic Neurotransmission: GABAergic Inhibition

Disorders associated with Synaptic Neurotransmission: GABAergic Inhibition SuperPath

STRING Interaction Network for Synaptic Neurotransmission: GABAergic Inhibition

Sources for Synaptic Neurotransmission: GABAergic Inhibition