Synaptic vesicle pathway

No Pathway Network information available for Synaptic vesicle pathway

Pathways in the Synaptic vesicle pathway SuperPath

#	Name	Source	Genes
1	Synaptic vesicle pathway	WikiPathways	AP2A1 AP2A2 AP2B1 AP2M1 AP2S1 ATP1A2 CACNA1A CACNA1B CLN8 CLTA CLTC CLTCL1 CPLX1 CPLX2 CPLX3 DNM1 DNM1L DNM2 DNM3 NAPA NSF PARK7 RAB3A RIMS1 SLC17A6 SLC17A7 SLC17A8 SLC18A1 SLC18A2 SLC18A3 SLC1A3 SLC22A3 SLC25A4 SLC32A1 SLC38A1 SLC6A4 SNAP25 STX1A STX1B STX2 STX3 STXBP1 SYN1 SYN2 SYN3 SYP SYT1 UNC13A UNC13B UNC13C VAMP2 (see all 51) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	NSF	N-Ethylmaleimide Sensitive Factor, Vesicle Fusing ATPase	Protein Coding	1
2	CACNA1B	Calcium Voltage-Gated Channel Subunit Alpha1 B	Protein Coding	1
3	CACNA1A	Calcium Voltage-Gated Channel Subunit Alpha1 A	Protein Coding	1
4	SYP	Synaptophysin	Protein Coding	1
5	SYN2	Synapsin II	Protein Coding	1
6	SYN1	Synapsin I	Protein Coding	1
7	STXBP1	Syntaxin Binding Protein 1	Protein Coding	1
8	STX1A	Syntaxin 1A	Protein Coding	1
9	SNAP25	Synaptosome Associated Protein 25	Protein Coding	1
10	SLC22A3	Solute Carrier Family 22 Member 3	Protein Coding	1
11	SLC18A3	Solute Carrier Family 18 Member A3	Protein Coding	1
12	SLC18A2	Solute Carrier Family 18 Member A2	Protein Coding	1
13	SLC6A4	Solute Carrier Family 6 Member 4	Protein Coding	1
14	SLC1A3	Solute Carrier Family 1 Member 3	Protein Coding	1
15	RAB3A	RAB3A, Member RAS Oncogene Family	Protein Coding	1
16	SLC17A6	Solute Carrier Family 17 Member 6	Protein Coding	1
17	SLC17A7	Solute Carrier Family 17 Member 7	Protein Coding	1
18	ATP1A2	ATPase Na+/K+ Transporting Subunit Alpha 2	Protein Coding	1
19	SLC25A4	Solute Carrier Family 25 Member 4	Protein Coding	1
20	DNM3	Dynamin 3	Protein Coding	1
21	SLC17A8	Solute Carrier Family 17 Member 8	Protein Coding	1
22	UNC13A	Unc-13 Homolog A	Protein Coding	1
23	RIMS1	Regulating Synaptic Membrane Exocytosis 1	Protein Coding	1
24	CLN8	CLN8 Transmembrane ER And ERGIC Protein	Protein Coding	1
25	STX2	Syntaxin 2	Protein Coding	1
26	DNM2	Dynamin 2	Protein Coding	1
27	DNM1	Dynamin 1	Protein Coding	1
28	CLTC	Clathrin Heavy Chain	Protein Coding	1
29	AP2S1	Adaptor Related Protein Complex 2 Subunit Sigma 1	Protein Coding	1
30	PARK7	Parkinsonism Associated Deglycase	Protein Coding	1
31	STX1B	Syntaxin 1B	Protein Coding	1
32	CPLX1	Complexin 1	Protein Coding	1
33	CPLX2	Complexin 2	Protein Coding	1
34	DNM1L	Dynamin 1 Like	Protein Coding	1
35	AP2B1	Adaptor Related Protein Complex 2 Subunit Beta 1	Protein Coding	1
36	AP2A2	Adaptor Related Protein Complex 2 Subunit Alpha 2	Protein Coding	1
37	AP2A1	Adaptor Related Protein Complex 2 Subunit Alpha 1	Protein Coding	1
38	NAPA	NSF Attachment Protein Alpha	Protein Coding	1
39	SLC32A1	Solute Carrier Family 32 Member 1	Protein Coding	1
40	CLTA	Clathrin Light Chain A	Protein Coding	1
41	AP2M1	Adaptor Related Protein Complex 2 Subunit Mu 1	Protein Coding	1
42	UNC13B	Unc-13 Homolog B	Protein Coding	1
43	SYN3	Synapsin III	Protein Coding	1
44	CLTCL1	Clathrin Heavy Chain Like 1	Protein Coding	1
45	SLC38A1	Solute Carrier Family 38 Member 1	Protein Coding	1
46	SYT1	Synaptotagmin 1	Protein Coding	1
47	VAMP2	Vesicle Associated Membrane Protein 2	Protein Coding	1
48	STX3	Syntaxin 3	Protein Coding	1
49	SLC18A1	Solute Carrier Family 18 Member A1	Protein Coding	1
50	CPLX3	Complexin 3	Protein Coding	1
51	UNC13C	Unc-13 Homolog C	Protein Coding	1

Disorders associated with Synaptic vesicle pathway SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Undetermined early-onset epileptic encephalopathy	Enrichment	ATP1A2, CACNA1A, CACNA1B, CLTC, DNM1	5.69
2	Alternating hemiplegia of childhood	Enrichment	ATP1A2, CACNA1A, SLC1A3	5.56
3	Alternating hemiplegia of childhood 1	Enrichment	ATP1A2, CACNA1A	4.86
4	Developmental and epileptic encephalopathy 2	Enrichment	CACNA1A, SNAP25	4.08
5	Familial or sporadic hemiplegic migraine	Enrichment	ATP1A2, CACNA1A	4.08
6	Lennox-gastaut syndrome	Enrichment	CACNA1A, DNM1	3.42
7	Presynaptic congenital myasthenic syndromes	Enrichment	SLC18A3, SNAP25	3.13
8	Stereotypic movement disorder	Enrichment	DNM1, SNAP25	2.98
9	Generalized epilepsy with febrile seizures plus	Enrichment	SLC32A1, STX1B	2.91
10	Autism	Enrichment	STX1A, STXBP1, UNC13A	2.60
11	Hypocalciuric hypercalcemia, familial, type iii	Enrichment	AP2S1	2.42
12	Progressive external ophthalmoplegia with mitochondrial dna deletions, autosomal dominant 2	Enrichment	SLC25A4	2.42
13	Episodic ataxia, type 6	Enrichment	SLC1A3	2.42
14	Optic atrophy 5	Enrichment	DNM1L	2.42
15	Charcot-marie-tooth disease, dominant intermediate b	Enrichment	DNM2	2.42
16	Encephalopathy due to defective mitochondrial and peroxisomal fission 1	Enrichment	DNM1L	2.42
17	Diarrhea 12, with microvillus atrophy	Enrichment	STX3	2.42
18	Mitochondrial dna depletion syndrome 12b , autosomal recessive	Enrichment	SLC25A4	2.42
19	Fetal akinesia, respiratory insufficiency, microcephaly, polymicrogyria, and dysmorphic facies	Enrichment	ATP1A2	2.42
20	Intellectual developmental disorder, x-linked 50	Enrichment	SYN1	2.42
21	Developmental and epileptic encephalopathy 117	Enrichment	SNAP25	2.42
22	Developmental and epileptic encephalopathy 63	Enrichment	CPLX1	2.42
23	Baker-gordon syndrome	Enrichment	SYT1	2.42
24	Ceroid lipofuscinosis, neuronal, 8	Enrichment	CLN8	2.42
25	Epilepsy, x-linked 1, with variable learning disabilities and behavior disorders	Enrichment	SYN1	2.42
26	Mitochondrial dna depletion syndrome 12a , autosomal dominant	Enrichment	SLC25A4	2.42
27	Ceroid lipofuscinosis, neuronal, 8, northern epilepsy variant	Enrichment	CLN8	2.42
28	Cone-rod dystrophy 7	Enrichment	RIMS1	2.42
29	Deafness, autosomal dominant 25	Enrichment	SLC17A8	2.42
30	X-linked epilepsy with variable learning disabilities and behavior disorders	Enrichment	SYN1	2.42
31	Parkinson disease 7, autosomal recessive early-onset	Enrichment	PARK7	2.42
32	Lethal congenital contracture syndrome 5	Enrichment	DNM2	2.42
33	Neurodevelopmental disorder with hypotonia and autistic features with or without hyperkinetic movements	Enrichment	VAMP2	2.42
34	Epilepsy with generalized tonic-clonic seizures	Enrichment	SNAP25	2.42
35	Generalized epilepsy with febrile seizures plus, type 12	Enrichment	SLC32A1	2.42
36	Mitochondrial metabolism disease	Enrichment	SLC25A4	2.42
37	Developmental and epileptic encephalopathy 98	Enrichment	ATP1A2	2.42
38	Retinal dystrophy and microvillus inclusion disease	Enrichment	STX3	2.42
39	Generalized epilepsy with febrile seizures plus, type 9	Enrichment	STX1B	2.42
40	Congenital insensitivity to pain with severe intellectual disability	Enrichment	CLTCL1	2.42
41	Autosomal dominant charcot-marie-tooth disease type 2m	Enrichment	DNM2	2.42
42	Developmental and epileptic encephalopathy 114	Enrichment	SLC32A1	2.42
43	Sporadic hemiplegic migraine	Enrichment	CACNA1A	2.42
44	Late infantile cln8 disease	Enrichment	CLN8	2.42
45	Encephalopathy due to mitochondrial and peroxisomal fission defect	Enrichment	DNM1L	2.42
46	Benign paroxysmal torticollis of infancy	Enrichment	CACNA1A	2.42
47	Auditory neuropathy	Enrichment	CACNA1A, SLC17A8	2.37
48	Strabismus	Enrichment	CACNA1A, STXBP1	2.34
49	Amyotrophic lateral sclerosis-parkinsonism/dementia complex 1	Enrichment	PARK7	2.12
50	Sorsby fundus dystrophy	Enrichment	SYN3	2.12
51	Migraine, familial hemiplegic, 2	Enrichment	ATP1A2	2.12
52	Obsessive-compulsive disorder	Enrichment	SLC6A4	2.12
53	Myoclonic epilepsy, familial infantile	Enrichment	CPLX1	2.12
54	Parkinsonism-dystonia 2, infantile-onset	Enrichment	SLC18A2	2.12
55	Familial hemiplegic migraine	Enrichment	ATP1A2	2.12
56	Developmental and epileptic encephalopathy 96	Enrichment	NSF	2.12
57	Intellectual developmental disorder, autosomal dominant 60, with seizures	Enrichment	AP2M1	2.12
58	Neurodevelopmental disorder with seizures and nonepileptic hyperkinetic movements	Enrichment	CACNA1B	2.12
59	9q33.3q34.11 microdeletion syndrome	Enrichment	STXBP1	2.12
60	Myasthenic syndrome, congenital, 21, presynaptic	Enrichment	SLC18A3	2.12
61	Progressive bulbar palsy	Enrichment	CACNA1A	2.12
62	Developmental and epileptic encephalopathy	Enrichment	SNAP25, STXBP1	2.09
63	Epilepsy	Enrichment	ATP1A2, SYN1	2.01
64	Sengers syndrome	Enrichment	SLC25A4	1.95
65	Intellectual developmental disorder, x-linked 96	Enrichment	SYP	1.95
66	Myopathy, centronuclear, x-linked	Enrichment	DNM2	1.95
67	Neurodevelopmental disorder with hypotonia, language delay, and skeletal defects with or without seizures	Enrichment	CACNA1A	1.95
68	Intellectual developmental disorder, autosomal dominant 56	Enrichment	CLTC	1.95
69	Developmental and epileptic encephalopathy 31b	Enrichment	DNM1	1.95
70	Gyrate atrophy of choroid and retina	Enrichment	RIMS1	1.95
71	Microvillus inclusion disease	Enrichment	STX3	1.95
72	Autosomal dominant optic atrophy, classic form	Enrichment	DNM1L	1.95
73	Hereditary episodic ataxia	Enrichment	CACNA1A	1.95
74	West syndrome	Enrichment	DNM1, STXBP1	1.93
75	Migraine, familial hemiplegic, 1	Enrichment	CACNA1A	1.83
76	Spinocerebellar ataxia 6	Enrichment	CACNA1A	1.83
77	Developmental and epileptic encephalopathy 4	Enrichment	STXBP1	1.83
78	Developmental and epileptic encephalopathy 42	Enrichment	CACNA1A	1.83
79	Developmental and epileptic encephalopathy 52	Enrichment	CACNA1A	1.83
80	Generalized epilepsy	Enrichment	STX1B	1.83
81	Neurologic, endocrine, and pancreatic disease, multisystem, infantile-onset 1	Enrichment	CLTC	1.83
82	Episodic ataxia	Enrichment	CACNA1A	1.83
83	Spastic ataxia	Enrichment	ATP1A2, STXBP1	1.77
84	Episodic ataxia, type 2	Enrichment	CACNA1A	1.73
85	Developmental and epileptic encephalopathy 31a	Enrichment	DNM1	1.73
86	Myopathy, centronuclear, 1	Enrichment	DNM2	1.65
87	Progressive external ophthalmoplegia with mitochondrial dna deletions, autosomal dominant 1	Enrichment	SLC25A4	1.65
88	Wolf-hirschhorn syndrome	Enrichment	CPLX1	1.65
89	Anxiety	Enrichment	SLC6A4	1.65
90	Parkinson disease 6, autosomal recessive early-onset	Enrichment	PARK7	1.65
91	Inflammatory myofibroblastic tumor	Enrichment	CLTC	1.65
92	Noonan syndrome 3	Enrichment	CLTC	1.58
93	Renal cell carcinoma with mit translocations	Enrichment	CLTC	1.58
94	Focal epilepsy	Enrichment	SNAP25	1.58
95	Difference of sex development	Enrichment	CACNA1A	1.53
96	Myoclonic-atonic epilepsy	Enrichment	AP2M1	1.48
97	Amyotrophic lateral sclerosis 1	Enrichment	UNC13A	1.43
98	Polymicrogyria	Enrichment	ATP1A2	1.43
99	Migraine with or without aura 1	Enrichment	CACNA1A	1.39
100	Mitochondrial myopathy	Enrichment	SLC25A4	1.39
101	Mitochondrial disease	Enrichment	DNM1L, SLC25A4	1.37
102	Early-onset parkinson's disease	Enrichment	PARK7	1.35
103	Myopia	Enrichment	SLC25A4	1.26
104	Neuronal ceroid lipofuscinosis	Enrichment	CLN8	1.26
105	Syndromic intellectual disability	Enrichment	SYT1	1.21
106	Autism spectrum disorder	Enrichment	RIMS1, STXBP1	1.20
107	Early infantile developmental and epileptic encephalopathy	Enrichment	SLC32A1	1.18
108	Arteriovenous malformations of the brain	Enrichment	SYN3	1.16
109	Williams-beuren syndrome	Enrichment	STX1A	1.14
110	Centronuclear myopathy	Enrichment	DNM2	1.12
111	Microcephaly	Enrichment	SNAP25, STXBP1	1.11
112	Cystic fibrosis	Enrichment	STX1A	0.94
113	Non-syndromic x-linked intellectual disability	Enrichment	SYP	0.90
114	Fetal akinesia deformation sequence 1	Enrichment	SLC18A3	0.89
115	Cerebral palsy	Enrichment	CACNA1A	0.86
116	Myopathy	Enrichment	DNM2	0.85
117	Charcot-marie-tooth disease	Enrichment	DNM2	0.84
118	Hypertrophic cardiomyopathy	Enrichment	SLC25A4	0.82
119	Optic atrophy plus syndrome	Enrichment	SNAP25	0.82
120	Body mass index quantitative trait locus 11	Enrichment	DNM1L	0.76
121	Autosomal dominant non-syndromic intellectual disability	Enrichment	CLTC	0.76
122	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	SLC17A8	0.75
123	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	UNC13A	0.71
124	Schizophrenia	Enrichment	SYN2	0.70
125	Cone-rod dystrophy 2	Enrichment	RIMS1	0.65
126	Congenital nervous system abnormality	Enrichment	CACNA1A	0.48
127	Nervous system disease	Enrichment	CACNA1A	0.48
128	Hereditary retinal dystrophy	Enrichment	SYN3	0.17
129	Fundus dystrophy	Enrichment	SYN3	0.17

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Synaptic vesicle pathway

Pathway Network for Synaptic vesicle pathway

Member Pathways for Synaptic vesicle pathway

Pathways in the Synaptic vesicle pathway SuperPath

Associated Genes for Synaptic vesicle pathway

Associated Disorders for Synaptic vesicle pathway

Disorders associated with Synaptic vesicle pathway SuperPath

STRING Interaction Network for Synaptic vesicle pathway

Sources for Synaptic vesicle pathway