Syndecan-1-mediated signaling events

No Pathway Network information available for Syndecan-1-mediated signaling events

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

Disorders associated with Syndecan-1-mediated signaling events SuperPath

according to GeneCards Suite gene sharing
#DisorderTypeGenesScore
1Ehlers-danlos syndrome, classic type, 1EnrichmentCOL1A1, COL1A2, COL5A1, COL5A29.50
2Classic ehlers-danlos syndromeEnrichmentCOL1A1, COL1A2, COL5A1, COL5A29.50
3Ehlers-danlos syndromeEnrichmentCOL1A1, COL1A2, COL3A1, COL5A1, COL5A29.35
4Collagen vi-related dystrophiesEnrichmentCOL6A1, COL6A2, COL6A38.01
5Intermediate collagen vi-related muscular dystrophyEnrichmentCOL6A1, COL6A2, COL6A38.01
6Bethlem muscular dystrophyEnrichmentCOL6A1, COL6A2, COL6A37.41
7Ullrich congenital muscular dystrophy 1aEnrichmentCOL6A1, COL6A2, COL6A37.01
8Bethlem myopathy 1aEnrichmentCOL6A1, COL6A2, COL6A36.47
9Osteogenesis imperfecta, type iiEnrichmentCOL1A1, COL1A2, PPIB6.47
10Connective tissue diseaseEnrichmentCOL11A1, COL2A1, COL5A1, FGFR36.17
11Primary bone dysplasiaEnrichmentCOL1A1, COL1A2, FGFR35.94
12OsteochondrodysplasiaEnrichmentCOL1A1, COL1A2, FGFR35.80
13Familial thoracic aortic aneurysm and aortic dissectionEnrichmentCOL1A1, COL3A1, COL5A1, COL5A25.61
14Osteogenesis imperfecta, type ivEnrichmentCOL1A1, COL1A2, PPIB5.56
15Osteogenesis imperfecta, type iiiEnrichmentCOL1A1, COL1A2, PPIB5.36
16Otospondylomegaepiphyseal dysplasia, autosomal recessiveEnrichmentCOL11A2, COL2A15.33
17Otospondylomegaepiphyseal dysplasia, autosomal dominantEnrichmentCOL11A2, COL2A15.33
18Ehlers-danlos syndrome, arthrochalasia type, 2EnrichmentCOL1A1, COL1A25.33
19FibrochondrogenesisEnrichmentCOL11A1, COL11A25.33
20Recessive dystrophic epidermolysis bullosaEnrichmentCOL7A1, MMP15.33
21Stickler syndrome, type iiEnrichmentCOL11A1, COL1A15.33
22Ehlers-danlos/osteogenesis imperfecta syndromeEnrichmentCOL1A1, COL1A25.33
23Crouzon syndromeEnrichmentFGFR2, FGFR34.85
24Lacrimoauriculodentodigital syndrome 1EnrichmentFGFR2, FGFR34.85
25TelecanthusEnrichmentCOL11A1, COL5A24.85
26Ehlers-danlos syndrome, classic type, 2EnrichmentCOL5A1, COL5A24.85
27High bone mass osteogenesis imperfectaEnrichmentCOL1A1, COL1A24.85
28Brittle bone disorderEnrichmentCOL1A1, COL1A2, PPIB4.78
29Ehlers-danlos syndrome, arthrochalasia type, 1EnrichmentCOL1A1, COL1A24.55
30Saethre-chotzen syndromeEnrichmentFGFR2, FGFR34.55
31Osteogenesis imperfecta with normal sclerae, dominant formEnrichmentCOL1A1, COL1A24.55
32Hemifacial hyperplasiaEnrichmentFGFR2, FGFR34.33
33Osteogenesis imperfecta, type iEnrichmentCOL1A1, COL1A24.15
34KeratoconusEnrichmentCOL1A1, COL5A24.15
35MyopathyEnrichmentCOL6A1, COL6A2, COL6A34.04
36Nevus, epidermalEnrichmentCOL7A1, FGFR34.01
37HypertelorismEnrichmentCOL11A1, COL1A1, FGFR23.70
38Stickler syndromeEnrichmentCOL11A1, COL2A13.68
39OsteoporosisEnrichmentCOL1A1, COL1A23.37
40MyopiaEnrichmentCOL11A1, COL2A13.31
41Beckwith-wiedemann syndromeEnrichmentCOL6A1, COL7A13.15
42Heart, malformation ofEnrichmentCOL11A2, COL2A13.15
43CraniosynostosisEnrichmentFGFR2, FGFR33.06
44Colorectal cancerEnrichmentFGFR2, FGFR3, MET3.04
45HepatoblastomaEnrichmentCOL7A1, FGFR33.01
46Rare autosomal recessive non-syndromic sensorineural deafness type dfnbEnrichmentCOL11A2, HGF, MET3.01
47Stickler syndrome, type iEnrichmentCOL2A12.66
48HypochondroplasiaEnrichmentFGFR32.66
49Beare-stevenson cutis gyrata syndromeEnrichmentFGFR22.66
50Epidermolysis bullosa dystrophica, pretibialEnrichmentCOL7A12.66
51Epidermolysis bullosa dystrophica, autosomal dominantEnrichmentCOL7A12.66
52Epiphyseal dysplasia, multiple, with myopia and conductive deafnessEnrichmentCOL2A12.66
53Thanatophoric dysplasia, type iEnrichmentFGFR32.66
54Ehlers-danlos syndrome, cardiac valvular typeEnrichmentCOL1A22.66
55Epidermolysis bullosa dystrophica, autosomal recessiveEnrichmentCOL7A12.66
56Spondylometaphyseal dysplasia, algerian typeEnrichmentCOL2A12.66
57Muenke syndromeEnrichmentFGFR32.66
58Deafness, autosomal recessive 53EnrichmentCOL11A22.66
59Osteoarthritis with mild chondrodysplasiaEnrichmentCOL2A12.66
60Avascular necrosis of femoral head, primary, 1EnrichmentCOL2A12.66
61Czech dysplasiaEnrichmentCOL2A12.66
62Nail disorder, nonsyndromic congenital, 8EnrichmentCOL7A12.66
63Deafness, autosomal recessive 39EnrichmentHGF2.66
64Scaphocephaly, maxillary retrusion, and impaired intellectual developmentEnrichmentFGFR22.66
65Marshall syndromeEnrichmentCOL11A12.66
66Kniest dysplasiaEnrichmentCOL2A12.66
67Apert syndromeEnrichmentFGFR22.66
68Transient bullous dermolysis of the newbornEnrichmentCOL7A12.66
69Platyspondylic lethal skeletal dysplasia, torrance typeEnrichmentCOL2A12.66
70Epidermolysis bullosa with congenital localized absence of skin and deformity of nailsEnrichmentCOL7A12.66
71Fibrochondrogenesis 1EnrichmentCOL11A12.66
72Thanatophoric dysplasia, type iiEnrichmentFGFR32.66
73Spondyloepiphyseal dysplasia, stanescu typeEnrichmentCOL2A12.66
74Camptodactyly, tall stature, and hearing loss syndromeEnrichmentFGFR32.66
75Bent bone dysplasia syndrome 1EnrichmentFGFR22.66
76Acrogeria, gottron typeEnrichmentCOL3A12.66
77Achondrogenesis, type iiEnrichmentCOL2A12.66
78Nephrotic syndrome, type 26EnrichmentLAMA52.66
79Ullrich congenital muscular dystrophy 1bEnrichmentCOL6A22.66
80Combined osteogenesis imperfecta and ehlers-danlos syndrome 2EnrichmentCOL1A22.66
81Osteofibrous dysplasiaEnrichmentMET2.66
82Spondyloperipheral dysplasiaEnrichmentCOL2A12.66
83Myosclerosis, autosomal recessiveEnrichmentCOL6A22.66
84Ullrich congenital muscular dystrophy 1cEnrichmentCOL6A32.66
85Deafness, autosomal dominant 37EnrichmentCOL11A12.66
86Deafness, autosomal dominant 13EnrichmentCOL11A22.66
87Deafness, autosomal recessive 97EnrichmentMET2.66
88Crouzon syndrome with acanthosis nigricansEnrichmentFGFR32.66
89Epidermolysis bullosa pruriginosaEnrichmentCOL7A12.66
90Autism 9EnrichmentMET2.66
91Stickler syndrome, type i, nonsyndromic ocularEnrichmentCOL2A12.66
92Fibrochondrogenesis 2EnrichmentCOL11A22.66
93Pigmented nodular adrenocortical disease, primary, 4EnrichmentPRKACA2.66
94Dystonia 27EnrichmentCOL6A32.66
95Thyroid gland diseaseEnrichmentCOL7A12.66
96Achondroplasia, severe, with developmental delay and acanthosis nigricansEnrichmentFGFR32.66
97Cardioacrofacial dysplasia 1EnrichmentPRKACA2.66
98Qualitative or quantitative defects of collagen 6EnrichmentCOL6A22.66
99Bent bone dysplasia syndrome 2EnrichmentLAMA52.66
100Vitreoretinopathy with phalangeal epiphyseal dysplasiaEnrichmentCOL2A12.66
101Recessive dystrophic epidermolysis bullosa-generalized otherEnrichmentCOL7A12.66
102Asphyxia neonatorumEnrichmentCOL1A12.66
103Bethlem myopathy 1bEnrichmentCOL6A22.66
104Arthrogryposis, distal, type 11EnrichmentMET2.66
105Lacrimoauriculodentodigital syndrome 2EnrichmentFGFR32.66
106Bethlem myopathy 1cEnrichmentCOL6A32.66
107Cask-related intellectual disabilityEnrichmentCASK2.66
108Autosomal dominant rhegmatogenous retinal detachmentEnrichmentCOL2A12.66
109Multiple epiphyseal dysplasia with myopia and deafnessEnrichmentCOL2A12.66
110HypochondrogenesisEnrichmentCOL2A12.66
111Fgfr3-related chondrodysplasiaEnrichmentFGFR32.66
112PneumothoraxEnrichmentCOL5A12.66
113Localized dystrophic epidermolysis bullosa, acral formEnrichmentCOL7A12.66
114Camptodactyly-tall stature-scoliosis-hearing loss syndromeEnrichmentFGFR32.66
115Autosomal dominant myopia-midfacial retrusion-sensorineural hearing loss-rhizomelic dysplasia syndromeEnrichmentCOL11A12.66
116DysspondyloenchondromatosisEnrichmentCOL2A12.66
117Cystic lymphangiomaEnrichmentCOL11A22.66
118Abdominal aortic aneurysmEnrichmentCOL3A12.66
119Recessive dystrophic epidermolysis bullosa inversaEnrichmentCOL7A12.66
120Type 2 collagen-related bone disorderEnrichmentCOL2A12.66
121Lama5-related multisystemic syndromeEnrichmentLAMA52.66
122Non-syndromic unicoronal craniosynostosisEnrichmentFGFR22.66
123Generalized dominant dystrophic epidermolysis bullosaEnrichmentCOL7A12.66
124Ehlers-danlos syndrome, vascular typeEnrichmentCOL3A12.35
125Epiphyseal dysplasia, multiple, 1EnrichmentCOL1A12.35
126Ehlers-danlos syndrome, hypermobility typeEnrichmentCOL3A12.35
127Camurati-engelmann disease 1EnrichmentTGFB12.35
128Spondyloepimetaphyseal dysplasia, strudwick typeEnrichmentCOL2A12.35
129Spondylometaphyseal dysplasia, corner fracture typeEnrichmentCOL2A12.35
130Osteogenesis imperfecta, type ixEnrichmentPPIB2.35
131Bruck syndrome 1EnrichmentCOL1A22.35
132Fg syndrome 4EnrichmentCASK2.35
133Dermatofibrosarcoma protuberansEnrichmentCOL1A12.35
134Cervical cancerEnrichmentFGFR32.35
135Aural atresia, congenitalEnrichmentFGFR22.35
136Legg-calve-perthes diseaseEnrichmentCOL2A12.35
137Keratosis, seborrheicEnrichmentFGFR32.35
138Pfeiffer syndromeEnrichmentFGFR22.35
139Jackson-weiss syndromeEnrichmentFGFR22.35
140Antley-bixler syndrome without genital anomalies or disordered steroidogenesisEnrichmentFGFR22.35
141Combined osteogenesis imperfecta and ehlers-danlos syndrome 1EnrichmentCOL1A12.35
142Fibromuscular dysplasia, multifocalEnrichmentCOL5A12.35
143Polymicrogyria with or without vascular-type ehlers-danlos syndromeEnrichmentCOL3A12.35
144Inflammatory bowel disease, immunodeficiency, and encephalopathyEnrichmentTGFB12.35
145Childhood hepatocellular carcinomaEnrichmentMET2.35
146Aortic dissectionEnrichmentCOL3A12.35
147Split hand-foot malformationEnrichmentFGFR22.35
148Syndromic x-linked intellectual disabilityEnrichmentCASK2.35
149Papillary renal cell carcinomaEnrichmentMET2.35
150Camurati-engelmann diseaseEnrichmentTGFB12.35
151Metaphyseal anadysplasia 2EnrichmentMMP92.35
152Fibrolamellar carcinomaEnrichmentPRKACA2.35
153Familial avascular necrosis of the femoral headEnrichmentCOL2A12.35
154Cervix carcinomaEnrichmentFGFR32.35
155Metaphyseal anadysplasiaEnrichmentMMP92.35
156Autosomal dominant nonsyndromic deafnessEnrichmentFGFR22.35
157Dentinogenesis imperfectaEnrichmentCOL1A22.35
158Epidermolysis bullosa dystrophicaEnrichmentCOL7A12.35
159Sensorineural hearing lossEnrichmentCOL11A2, HGF2.30
160Rare autosomal dominant non-syndromic sensorineural deafness type dfnaEnrichmentCOL11A1, COL11A22.23
161AchondroplasiaEnrichmentFGFR32.18
162Mccune-albright syndromeEnrichmentCOL2A12.18
163Larsen syndromeEnrichmentFGFR32.18
164Spondyloepiphyseal dysplasia congenitaEnrichmentCOL2A12.18
165MegalocorneaEnrichmentCOL11A12.18
166Nail disorder, nonsyndromic congenital, 4EnrichmentCOL7A12.18
167Hypophosphatasia, infantileEnrichmentCOL11A22.18
168Intellectual developmental disorder with microcephaly and pontine and cerebellar hypoplasiaEnrichmentCASK2.18
169Caffey diseaseEnrichmentCOL1A12.18
170Syndromic x-linked intellectual disability najm typeEnrichmentCASK2.18
171Cerebellar diseaseEnrichmentCASK2.18
172HamartomaEnrichmentFGFR32.18
173Testicular germ cell cancerEnrichmentFGFR32.18
174SpermatocytomaEnrichmentFGFR32.18
175Renal cell carcinomaEnrichmentMET2.18
176Multiple epiphyseal dysplasiaEnrichmentCOL2A12.18
177Testicular cancerEnrichmentFGFR32.18
178Hyperpigmentation of the skinEnrichmentCOL7A12.18
179PhenylketonuriaEnrichmentCOL1A12.05
180Epidermolytic hyperkeratosisEnrichmentCOL7A12.05
181Non-syndromic bicoronal craniosynostosisEnrichmentFGFR32.05
182GliomaEnrichmentFGFR22.05
183Epidermolytic hyperkeratosis 1EnrichmentCOL7A11.96
184Retinal detachmentEnrichmentCOL2A11.96
185Anemia, congenital, nonspherocytic hemolytic, 1EnrichmentCASK1.96
186Epidermolysis bullosaEnrichmentCOL7A11.96
187Familial cerebral saccular aneurysmEnrichmentCOL3A11.96
188Developmental dysplasia of the hip 1EnrichmentCOL2A11.88
189Split-hand/foot malformation 1EnrichmentFGFR21.88
190Testicular germ cell tumorEnrichmentFGFR31.88
191Inflammatory bowel disease 25, autosomal recessiveEnrichmentTGFB11.88
192Inguinal herniaEnrichmentCOL5A11.88
193Pain disorderEnrichmentCOL5A11.88
194Il10-related early-onset inflammatory bowel diseaseEnrichmentTGFB11.88
195Lung squamous cell carcinomaEnrichmentFGFR31.88
19646,xy disorder of sex developmentEnrichmentFGFR31.88
197Intervertebral disc diseaseEnrichmentCOL11A11.81
198Renal cell carcinoma, papillary, 1EnrichmentMET1.81
199Multiple enchondromatosis, maffucci typeEnrichmentCOL2A11.81
200Arthrogryposis, distal, type 1aEnrichmentMET1.76
201Gastroesophageal refluxEnrichmentCOL5A11.76
202Spastic paraplegia 4, autosomal dominantEnrichmentCOL3A11.76
203Orthostatic intoleranceEnrichmentCOL5A11.76
204Ellis-van creveld syndromeEnrichmentPRKACA1.70
205Familial thoracic aortic aneurysm and dissectionEnrichmentCOL3A11.70
206Marfan syndromeEnrichmentCOL2A11.66
207Meier-gorlin syndrome 1EnrichmentFGFR21.66
208Congenital nervous system abnormalityEnrichmentCASK, FGFR31.64
209Nervous system diseaseEnrichmentCASK, FGFR31.64
210IchthyosisEnrichmentCOL7A11.62
211Presynaptic congenital myasthenic syndromesEnrichmentLAMA51.62
212Renal hypodysplasia/aplasia 3EnrichmentFGFR31.58
213Cutis laxaEnrichmentCOL5A11.58
214Clubfoot, congenital, with or without deficiency of long bones and/or mirror-image polydactylyEnrichmentCOL5A11.55
215ClubfootEnrichmentCOL5A11.55
216MicrocephalyEnrichmentCASK, COL7A11.52
217Multiple sclerosisEnrichmentLAMA51.52
218Aortic aneurysm, familial thoracic 1EnrichmentCOL3A11.52
219CataractEnrichmentCOL5A11.52
220Renal cell carcinoma, nonpapillaryEnrichmentMET1.49
221HydrocephalusEnrichmentFGFR21.49
222Cerebellar hypoplasia/atrophy, epilepsy, and global developmental delayEnrichmentCASK1.46
223GliosarcomaEnrichmentFGFR31.46
224Isolated congenital microcephalyEnrichmentCASK1.46
225Cleft palate, isolatedEnrichmentCOL11A11.43
226Giant cell glioblastomaEnrichmentFGFR31.43
227Human immunodeficiency virus type 1EnrichmentCCL51.41
228Early infantile developmental and epileptic encephalopathyEnrichmentCASK1.41
229Endometrial cancerEnrichmentFGFR21.34
230Hepatocellular carcinomaEnrichmentMET1.32
231Skin diseaseEnrichmentCOL7A11.32
232Ear malformationEnrichmentCOL11A21.29
233ScoliosisEnrichmentCOL2A11.29
234Muscular dystrophyEnrichmentCOL6A21.29
235Bladder cancerEnrichmentFGFR31.21
236Stargardt disease 1EnrichmentCOL2A11.19
237Lung cancerEnrichmentMET1.16
238Cystic fibrosisEnrichmentTGFB11.16
239Genetic steroid-resistant nephrotic syndromeEnrichmentLAMA51.14
240DystoniaEnrichmentCASK1.13
241Non-syndromic x-linked intellectual disabilityEnrichmentCASK1.12
242Nonsyndromic hearing lossEnrichmentCOL11A21.05
243Gastric cancerEnrichmentFGFR21.04
244Nephrotic syndromeEnrichmentLAMA51.04
245Myeloma, multipleEnrichmentFGFR30.93
246Hereditary retinal dystrophyEnrichmentCOL11A2, COL2A10.87
247Fundus dystrophyEnrichmentCOL11A2, COL2A10.87
248AutismEnrichmentCOL11A10.83
249Rare genetic deafnessEnrichmentCOL11A20.79
250Ovarian cancerEnrichmentMET0.70
251Inherited cancer-predisposing syndromeEnrichmentMET0.59

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