Syndecan-2-mediated signaling events

No Pathway Network information available for Syndecan-2-mediated signaling events

Pathways in the Syndecan-2-mediated signaling events SuperPath

#	Name	Source	Genes
1	Syndecan-2-mediated signaling events	PubChem	BAX CASK CASP3 CAV2 CSF2 CXCL8 EPB41 EPHB2 EZR FGFR2 FGFR3 FN1 HRAS ITGA2 ITGB1 KNG1 LAMA1 LAMA3 MAPK3 MAPK8 MMP2 NF1 PRKACA PRKCD PRRT2 RACK1 RASA1 RHOA SDC2 SDCBP SRC TGFB1 TNFRSF13B TRAPPC4 (see all 34) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	CAV2	Caveolin 2	Protein Coding	1
2	PRRT2	Proline Rich Transmembrane Protein 2	Protein Coding	1
3	TNFRSF13B	TNF Receptor Superfamily Member 13B	Protein Coding	1
4	EPB41	Erythrocyte Membrane Protein Band 4.1	Protein Coding	1
5	CSF2	Colony Stimulating Factor 2	Protein Coding	1
6	FGFR3	Fibroblast Growth Factor Receptor 3	Protein Coding	1
7	FGFR2	Fibroblast Growth Factor Receptor 2	Protein Coding	1
8	NF1	Neurofibromin 1	Protein Coding	1
9	CXCL8	C-X-C Motif Chemokine Ligand 8	Protein Coding	1
10	MAPK8	Mitogen-Activated Protein Kinase 8	Protein Coding	1
11	PRKCD	Protein Kinase C Delta	Protein Coding	1
12	KNG1	Kininogen 1	Protein Coding	1
13	MMP2	Matrix Metallopeptidase 2	Protein Coding	1
14	FN1	Fibronectin 1	Protein Coding	1
15	CASK	Calcium/Calmodulin Dependent Serine Protein Kinase	Protein Coding	1
16	LAMA3	Laminin Subunit Alpha 3	Protein Coding	1
17	RACK1	Receptor For Activated C Kinase 1	Protein Coding	1
18	RASA1	RAS P21 Protein Activator 1	Protein Coding	1
19	SDC2	Syndecan 2	Protein Coding	1
20	ITGA2	Integrin Subunit Alpha 2	Protein Coding	1
21	LAMA1	Laminin Subunit Alpha 1	Protein Coding	1
22	SDCBP	Syndecan Binding Protein	Protein Coding	1
23	EPHB2	EPH Receptor B2	Protein Coding	1
24	EZR	Ezrin	Protein Coding	1
25	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	1
26	ITGB1	Integrin Subunit Beta 1	Protein Coding	1
27	RHOA	Ras Homolog Family Member A	Protein Coding	1
28	PRKACA	Protein Kinase CAMP-Activated Catalytic Subunit Alpha	Protein Coding	1
29	TRAPPC4	Trafficking Protein Particle Complex Subunit 4	Protein Coding	1
30	SRC	SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase	Protein Coding	1
31	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	1
32	CASP3	Caspase 3	Protein Coding	1
33	BAX	BCL2 Associated X, Apoptosis Regulator	Protein Coding	1
34	TGFB1	Transforming Growth Factor Beta 1	Protein Coding	1

Disorders associated with Syndecan-2-mediated signaling events SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Crouzon syndrome	Enrichment	FGFR2, FGFR3	4.74
2	Lacrimoauriculodentodigital syndrome 1	Enrichment	FGFR2, FGFR3	4.74
3	Spermatocytoma	Enrichment	FGFR3, HRAS	4.74
4	Saethre-chotzen syndrome	Enrichment	FGFR2, FGFR3	4.44
5	Bladder cancer	Enrichment	FGFR3, HRAS, NF1	4.30
6	Hemifacial hyperplasia	Enrichment	FGFR2, FGFR3	4.22
7	Colorectal cancer	Enrichment	BAX, FGFR2, FGFR3, SRC	4.20
8	Nevus, epidermal	Enrichment	FGFR3, HRAS	3.90
9	Arteriovenous malformation	Enrichment	HRAS, RASA1	3.66
10	Myopathy, x-linked, with excessive autophagy	Enrichment	HRAS, RASA1	3.57
11	Rhabdomyosarcoma	Enrichment	HRAS, NF1	3.15
12	Craniosynostosis	Enrichment	FGFR2, FGFR3	2.95
13	Rasopathy	Enrichment	HRAS, NF1	2.72
14	Hypochondroplasia	Enrichment	FGFR3	2.60
15	Beare-stevenson cutis gyrata syndrome	Enrichment	FGFR2	2.60
16	Immune deficiency, familial variable	Enrichment	TNFRSF13B	2.60
17	Cystic angiomatosis of bone, diffuse	Enrichment	RASA1	2.60
18	Thanatophoric dysplasia, type i	Enrichment	FGFR3	2.60
19	High molecular weight kininogen deficiency	Enrichment	KNG1	2.60
20	Muenke syndrome	Enrichment	FGFR3	2.60
21	Scaphocephaly, maxillary retrusion, and impaired intellectual development	Enrichment	FGFR2	2.60
22	Apert syndrome	Enrichment	FGFR2	2.60
23	Thanatophoric dysplasia, type ii	Enrichment	FGFR3	2.60
24	Camptodactyly, tall stature, and hearing loss syndrome	Enrichment	FGFR3	2.60
25	Elliptocytosis 1	Enrichment	EPB41	2.60
26	Autoimmune lymphoproliferative syndrome, type iii	Enrichment	PRKCD	2.60
27	Bent bone dysplasia syndrome 1	Enrichment	FGFR2	2.60
28	Angioedema, hereditary, 6	Enrichment	KNG1	2.60
29	Immunoglobulin a deficiency 2	Enrichment	TNFRSF13B	2.60
30	Prostate cancer/brain cancer susceptibility	Enrichment	EPHB2	2.60
31	Crouzon syndrome with acanthosis nigricans	Enrichment	FGFR3	2.60
32	Pigmented nodular adrenocortical disease, primary, 4	Enrichment	PRKACA	2.60
33	Achondroplasia, severe, with developmental delay and acanthosis nigricans	Enrichment	FGFR3	2.60
34	Cardioacrofacial dysplasia 1	Enrichment	PRKACA	2.60
35	Bleeding disorder, platelet-type, 22	Enrichment	EPHB2	2.60
36	Thrombocytopenia 6	Enrichment	SRC	2.60
37	Ectodermal dysplasia with facial dysmorphism and acral, ocular, and brain anomalies	Enrichment	RHOA	2.60
38	Neurodevelopmental disorder with epilepsy, spasticity, and brain atrophy	Enrichment	TRAPPC4	2.60
39	Linear hypopigmentation and craniofacial asymmetry with acral, ocular and brain anomalies	Enrichment	RHOA	2.60
40	Plexiform neurofibroma	Enrichment	NF1	2.60
41	Neurofibroma	Enrichment	NF1	2.60
42	Lacrimoauriculodentodigital syndrome 2	Enrichment	FGFR3	2.60
43	Neurofibromatosis	Enrichment	NF1	2.60
44	Chromosome 17q11.2 deletion syndrome	Enrichment	NF1	2.60
45	Cask-related intellectual disability	Enrichment	CASK	2.60
46	Optic nerve glioma	Enrichment	NF1	2.60
47	Fetomaternal alloimmune thrombocytopenia 3	Enrichment	ITGA2	2.60
48	Gorham's disease	Enrichment	RASA1	2.60
49	Fgfr3-related chondrodysplasia	Enrichment	FGFR3	2.60
50	Common variable immunodeficiency phenotype due to homozygous taci deficiency	Enrichment	TNFRSF13B	2.60
51	Camptodactyly-tall stature-scoliosis-hearing loss syndrome	Enrichment	FGFR3	2.60
52	Phakomatosis pigmentokeratotica	Enrichment	HRAS	2.60
53	Non-syndromic unicoronal craniosynostosis	Enrichment	FGFR2	2.60
54	Cafe-au-lait spots, multiple	Enrichment	NF1	2.30
55	Camurati-engelmann disease 1	Enrichment	TGFB1	2.30
56	Spondyloepimetaphyseal dysplasia, strudwick type	Enrichment	FN1	2.30
57	Costello syndrome	Enrichment	HRAS	2.30
58	Spondylometaphyseal dysplasia, corner fracture type	Enrichment	FN1	2.30
59	Epidermolysis bullosa, junctional 2c, laryngoonychocutaneous	Enrichment	LAMA3	2.30
60	Immunodeficiency, common variable, 2	Enrichment	TNFRSF13B	2.30
61	Fg syndrome 4	Enrichment	CASK	2.30
62	Cervical cancer	Enrichment	FGFR3	2.30
63	Immunodeficiency with hyper-igm, type 2	Enrichment	TNFRSF13B	2.30
64	Seizures, benign familial infantile, 2	Enrichment	PRRT2	2.30
65	Aural atresia, congenital	Enrichment	FGFR2	2.30
66	Keratosis, seborrheic	Enrichment	FGFR3	2.30
67	Pfeiffer syndrome	Enrichment	FGFR2	2.30
68	Jackson-weiss syndrome	Enrichment	FGFR2	2.30
69	Antley-bixler syndrome without genital anomalies or disordered steroidogenesis	Enrichment	FGFR2	2.30
70	Epidermolysis bullosa, junctional 2a, intermediate	Enrichment	LAMA3	2.30
71	Chromosome 17q11.2 duplication syndrome, 1.4-mb	Enrichment	NF1	2.30
72	Inflammatory bowel disease, immunodeficiency, and encephalopathy	Enrichment	TGFB1	2.30
73	Split hand-foot malformation	Enrichment	FGFR2	2.30
74	Syndromic x-linked intellectual disability	Enrichment	CASK	2.30
75	Camurati-engelmann disease	Enrichment	TGFB1	2.30
76	Fibrolamellar carcinoma	Enrichment	PRKACA	2.30
77	Bardet-biedl syndrome 9	Enrichment	NF1	2.30
78	Cervix carcinoma	Enrichment	FGFR3	2.30
79	Epidermolysis bullosa, junctional 2b, severe	Enrichment	LAMA3	2.30
80	Neurodevelopmental disorder with progressive microcephaly, spasticity, and brain anomalies	Enrichment	TRAPPC4	2.30
81	Autosomal dominant nonsyndromic deafness	Enrichment	FGFR2	2.30
82	Prrt2-related disorder	Enrichment	PRRT2	2.30
83	Pleomorphic rhabdomyosarcoma	Enrichment	NF1	2.30
84	Wooly hair nevus	Enrichment	HRAS	2.30
85	Gastric cancer	Enrichment	FGFR2, NF1	2.29
86	Achondroplasia	Enrichment	FGFR3	2.12
87	Larsen syndrome	Enrichment	FGFR3	2.12
88	Watson syndrome	Enrichment	NF1	2.12
89	Intellectual developmental disorder with microcephaly and pontine and cerebellar hypoplasia	Enrichment	CASK	2.12
90	Glomerulopathy with fibronectin deposits 2	Enrichment	FN1	2.12
91	Multicentric osteolysis, nodulosis, and arthropathy	Enrichment	MMP2	2.12
92	Glut1 deficiency syndrome 2	Enrichment	PRRT2	2.12
93	Neurofibromatosis, familial spinal	Enrichment	NF1	2.12
94	Chromosome 17q11.2 deletion syndrome, 1.4-mb	Enrichment	NF1	2.12
95	Large congenital melanocytic nevus	Enrichment	HRAS	2.12
96	Wieacker-wolff syndrome	Enrichment	RASA1	2.12
97	Poretti-boltshauser syndrome	Enrichment	LAMA1	2.12
98	Syndromic x-linked intellectual disability najm type	Enrichment	CASK	2.12
99	Cerebellar disease	Enrichment	CASK	2.12
100	Hamartoma	Enrichment	FGFR3	2.12
101	Testicular germ cell cancer	Enrichment	FGFR3	2.12
102	T-cell acute lymphoblastic leukemia	Enrichment	BAX	2.12
103	Brain cancer	Enrichment	NF1	2.12
104	Testicular cancer	Enrichment	FGFR3	2.12
105	Myeloma, multiple	Enrichment	FGFR3, NF1	2.06
106	Paroxysmal nonkinesigenic dyskinesia 1	Enrichment	PRRT2	2.00
107	Schimmelpenning-feuerstein-mims syndrome	Enrichment	HRAS	2.00
108	Episodic kinesigenic dyskinesia 1	Enrichment	PRRT2	2.00
109	Neurofibromatosis-noonan syndrome	Enrichment	NF1	2.00
110	Immunodeficiency, common variable, 1	Enrichment	TNFRSF13B	2.00
111	Embryonal rhabdomyosarcoma	Enrichment	NF1	2.00
112	Pilocytic astrocytoma	Enrichment	NF1	2.00
113	Hereditary elliptocytosis	Enrichment	EPB41	2.00
114	Epidermolytic nevus	Enrichment	HRAS	2.00
115	Familial paroxysmal nonkinesigenic dyskinesia	Enrichment	PRRT2	2.00
116	Familial or sporadic hemiplegic migraine	Enrichment	PRRT2	2.00
117	Non-syndromic bicoronal craniosynostosis	Enrichment	FGFR3	2.00
118	Glioma	Enrichment	FGFR2	2.00
119	Middle aortic syndrome	Enrichment	NF1	2.00
120	Hereditary angioedema with normal c1inh not related to f12 or plg variant	Enrichment	KNG1	2.00
121	Capillary malformations, congenital	Enrichment	RASA1	1.90
122	Anemia, congenital, nonspherocytic hemolytic, 1	Enrichment	CASK	1.90
123	Rhabdomyosarcoma 2	Enrichment	NF1	1.90
124	Convulsions, familial infantile, with paroxysmal choreoathetosis	Enrichment	PRRT2	1.90
125	Self-limited infantile epilepsy	Enrichment	PRRT2	1.90
126	Klippel-trenaunay-weber syndrome	Enrichment	RASA1	1.83
127	Telangiectasia, hereditary hemorrhagic, type 1	Enrichment	RASA1	1.83
128	Epidermolysis bullosa, junctional 1a, intermediate	Enrichment	LAMA3	1.83
129	Split-hand/foot malformation 1	Enrichment	FGFR2	1.83
130	Hemihyperplasia, isolated	Enrichment	RHOA	1.83
131	Epidermolysis bullosa, junctional 1b, severe	Enrichment	LAMA3	1.83
132	Testicular germ cell tumor	Enrichment	FGFR3	1.83
133	Hemangioma, capillary infantile	Enrichment	RASA1	1.83
134	Inflammatory bowel disease 25, autosomal recessive	Enrichment	TGFB1	1.83
135	Basal cell carcinoma 1	Enrichment	RASA1	1.83
136	Junctional epidermolysis bullosa non-herlitz type	Enrichment	LAMA3	1.83
137	Fetomaternal alloimmune thrombocytopenia 1	Enrichment	ITGA2	1.83
138	Il10-related early-onset inflammatory bowel disease	Enrichment	TGFB1	1.83
139	Lung squamous cell carcinoma	Enrichment	FGFR3	1.83
140	46,xy disorder of sex development	Enrichment	FGFR3	1.83
141	Thyroid cancer, nonmedullary, 2	Enrichment	HRAS	1.76
142	Myelofibrosis	Enrichment	SRC	1.76
143	Capillary malformation-arteriovenous malformation 1	Enrichment	RASA1	1.76
144	Noonan syndrome 3	Enrichment	HRAS	1.76
145	Hereditary hemorrhagic telangiectasia	Enrichment	RASA1	1.76
146	Common variable immunodeficiency	Enrichment	TNFRSF13B	1.76
147	Follicular thyroid carcinoma	Enrichment	HRAS	1.76
148	Melanocytic nevus syndrome, congenital	Enrichment	HRAS	1.70
149	Ewing sarcoma	Enrichment	NF1	1.70
150	Neurofibromatosis, type i	Enrichment	NF1	1.65
151	Ellis-van creveld syndrome	Enrichment	PRKACA	1.65
152	Leukemia, acute lymphoblastic 3	Enrichment	NF1	1.65
153	Junctional epidermolysis bullosa	Enrichment	LAMA3	1.65
154	Meier-gorlin syndrome 1	Enrichment	FGFR2	1.61
155	Primary bone dysplasia	Enrichment	FGFR3	1.61
156	Osteochondrodysplasia	Enrichment	FGFR3	1.56
157	Lung non-small cell carcinoma	Enrichment	HRAS	1.56
158	Congenital nervous system abnormality	Enrichment	CASK, FGFR3	1.54
159	Nervous system disease	Enrichment	CASK, FGFR3	1.54
160	Juvenile myelomonocytic leukemia	Enrichment	NF1	1.53
161	Renal hypodysplasia/aplasia 3	Enrichment	FGFR3	1.53
162	Lip and oral cavity carcinoma	Enrichment	HRAS	1.53
163	Neural tube defects	Enrichment	ITGB1	1.49
164	Osteoporosis	Enrichment	SRC	1.46
165	Pheochromocytoma	Enrichment	NF1	1.46
166	Generalized epilepsy with febrile seizures plus	Enrichment	PRRT2	1.46
167	Hydrocephalus	Enrichment	FGFR2	1.43
168	Noonan syndrome and noonan-related syndrome	Enrichment	HRAS	1.43
169	Cerebellar hypoplasia/atrophy, epilepsy, and global developmental delay	Enrichment	CASK	1.40
170	Gliosarcoma	Enrichment	FGFR3	1.40
171	Isolated congenital microcephaly	Enrichment	CASK	1.40
172	Giant cell glioblastoma	Enrichment	FGFR3	1.38
173	Early infantile developmental and epileptic encephalopathy	Enrichment	CASK	1.35
174	Endometrial cancer	Enrichment	FGFR2	1.29
175	Hepatoblastoma	Enrichment	FGFR3	1.29
176	Hereditary paraganglioma-pheochromocytoma syndromes	Enrichment	NF1	1.29
177	Skin disease	Enrichment	NF1	1.27
178	Noonan syndrome 1	Enrichment	HRAS	1.25
179	Hydrops fetalis, nonimmune	Enrichment	HRAS	1.20
180	Prostate cancer	Enrichment	EPHB2	1.15
181	Differentiated thyroid carcinoma	Enrichment	HRAS	1.15
182	Non-immune hydrops fetalis	Enrichment	HRAS	1.13
183	Cystic fibrosis	Enrichment	TGFB1	1.11
184	Connective tissue disease	Enrichment	FGFR3	1.11
185	Dystonia	Enrichment	CASK	1.07
186	Non-syndromic x-linked intellectual disability	Enrichment	CASK	1.06
187	Nephrotic syndrome	Enrichment	FN1	0.99
188	Thrombocytopenia	Enrichment	SRC	0.94
189	Hypertelorism	Enrichment	FGFR2	0.91
190	Hereditary breast ovarian cancer syndrome	Enrichment	NF1	0.89
191	Autosomal recessive non-syndromic intellectual disability	Enrichment	EZR	0.87
192	Autism spectrum disorder	Enrichment	NF1	0.62
193	Microcephaly	Enrichment	CASK	0.57
194	Complex neurodevelopmental disorder	Enrichment	TRAPPC4	0.57
195	Inherited cancer-predisposing syndrome	Enrichment	NF1	0.55
196	Hereditary retinal dystrophy	Enrichment	LAMA1	0.28
197	Fundus dystrophy	Enrichment	LAMA1	0.28

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Syndecan-2-mediated signaling events

Pathway Network for Syndecan-2-mediated signaling events

Member Pathways for Syndecan-2-mediated signaling events

Pathways in the Syndecan-2-mediated signaling events SuperPath

Associated Genes for Syndecan-2-mediated signaling events

Associated Disorders for Syndecan-2-mediated signaling events

Disorders associated with Syndecan-2-mediated signaling events SuperPath

STRING Interaction Network for Syndecan-2-mediated signaling events

Sources for Syndecan-2-mediated signaling events