Syndecan-3-mediated signaling events

No Pathway Network information available for Syndecan-3-mediated signaling events

Pathways in the Syndecan-3-mediated signaling events SuperPath

#	Name	Source	Genes
1	Syndecan-3-mediated signaling events	PubChem	AGRP APH1A APH1B CASK CTTN CXCL8 EGFR FGFR2 FGFR3 FYN MC4R NCAN NCSTN POMC PRRT2 PSEN1 PSENEN PTN SDC3 SRC (see all 20) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	SDC3	Syndecan 3	Protein Coding	1
2	APH1B	Aph-1B Gamma-Secretase Subunit	Protein Coding	1
3	APH1A	Aph-1A Gamma-Secretase Subunit	Protein Coding	1
4	PRRT2	Proline Rich Transmembrane Protein 2	Protein Coding	1
5	MC4R	Melanocortin 4 Receptor	Protein Coding	1
6	PTN	Pleiotrophin	Protein Coding	1
7	FGFR3	Fibroblast Growth Factor Receptor 3	Protein Coding	1
8	FGFR2	Fibroblast Growth Factor Receptor 2	Protein Coding	1
9	AGRP	Agouti Related Neuropeptide	Protein Coding	1
10	CTTN	Cortactin	Protein Coding	1
11	CXCL8	C-X-C Motif Chemokine Ligand 8	Protein Coding	1
12	PSEN1	Presenilin 1	Protein Coding	1
13	CASK	Calcium/Calmodulin Dependent Serine Protein Kinase	Protein Coding	1
14	PSENEN	Presenilin Enhancer, Gamma-Secretase Subunit	Protein Coding	1
15	NCSTN	Nicastrin	Protein Coding	1
16	NCAN	Neurocan	Protein Coding	1
17	FYN	FYN Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	1
18	POMC	Proopiomelanocortin	Protein Coding	1
19	SRC	SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase	Protein Coding	1
20	EGFR	Epidermal Growth Factor Receptor	Protein Coding	1

Disorders associated with Syndecan-3-mediated signaling events SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Body mass index quantitative trait locus 11	Enrichment	AGRP, MC4R, POMC, SDC3	6.12
2	Crouzon syndrome	Enrichment	FGFR2, FGFR3	5.21
3	Lacrimoauriculodentodigital syndrome 1	Enrichment	FGFR2, FGFR3	5.21
4	Saethre-chotzen syndrome	Enrichment	FGFR2, FGFR3	4.91
5	Hemifacial hyperplasia	Enrichment	FGFR2, FGFR3	4.69
6	Lung squamous cell carcinoma	Enrichment	EGFR, FGFR3	4.51
7	Gliosarcoma	Enrichment	EGFR, FGFR3	3.61
8	Colorectal cancer	Enrichment	FGFR2, FGFR3, SRC	3.57
9	Giant cell glioblastoma	Enrichment	EGFR, FGFR3	3.56
10	Craniosynostosis	Enrichment	FGFR2, FGFR3	3.41
11	Congenital nervous system abnormality	Enrichment	CASK, FGFR3, PSEN1	3.32
12	Nervous system disease	Enrichment	CASK, FGFR3, PSEN1	3.32
13	Bladder cancer	Enrichment	EGFR, FGFR3	3.09
14	Hypochondroplasia	Enrichment	FGFR3	2.83
15	Beare-stevenson cutis gyrata syndrome	Enrichment	FGFR2	2.83
16	Thanatophoric dysplasia, type i	Enrichment	FGFR3	2.83
17	Muenke syndrome	Enrichment	FGFR3	2.83
18	Scaphocephaly, maxillary retrusion, and impaired intellectual development	Enrichment	FGFR2	2.83
19	Apert syndrome	Enrichment	FGFR2	2.83
20	Acne inversa, familial, 1	Enrichment	NCSTN	2.83
21	Thanatophoric dysplasia, type ii	Enrichment	FGFR3	2.83
22	Camptodactyly, tall stature, and hearing loss syndrome	Enrichment	FGFR3	2.83
23	Bent bone dysplasia syndrome 1	Enrichment	FGFR2	2.83
24	Body mass index quantitative trait locus 20	Enrichment	MC4R	2.83
25	Crouzon syndrome with acanthosis nigricans	Enrichment	FGFR3	2.83
26	Cardiomyopathy, dilated, 1u	Enrichment	PSEN1	2.83
27	Acne inversa, familial, 2, with or without dowling-degos disease	Enrichment	PSENEN	2.83
28	Acne inversa, familial, 3	Enrichment	PSEN1	2.83
29	Achondroplasia, severe, with developmental delay and acanthosis nigricans	Enrichment	FGFR3	2.83
30	Thrombocytopenia 6	Enrichment	SRC	2.83
31	Obesity due to melanocortin 4 receptor deficiency	Enrichment	MC4R	2.83
32	Lacrimoauriculodentodigital syndrome 2	Enrichment	FGFR3	2.83
33	Cask-related intellectual disability	Enrichment	CASK	2.83
34	Fgfr3-related chondrodysplasia	Enrichment	FGFR3	2.83
35	Camptodactyly-tall stature-scoliosis-hearing loss syndrome	Enrichment	FGFR3	2.83
36	Pash syndrome	Enrichment	NCSTN	2.83
37	Non-syndromic unicoronal craniosynostosis	Enrichment	FGFR2	2.83
38	Fg syndrome 4	Enrichment	CASK	2.53
39	Alzheimer disease 3	Enrichment	PSEN1	2.53
40	Cervical cancer	Enrichment	FGFR3	2.53
41	Pick disease of brain	Enrichment	PSEN1	2.53
42	Seizures, benign familial infantile, 2	Enrichment	PRRT2	2.53
43	Aural atresia, congenital	Enrichment	FGFR2	2.53
44	Keratosis, seborrheic	Enrichment	FGFR3	2.53
45	Pfeiffer syndrome	Enrichment	FGFR2	2.53
46	Jackson-weiss syndrome	Enrichment	FGFR2	2.53
47	Antley-bixler syndrome without genital anomalies or disordered steroidogenesis	Enrichment	FGFR2	2.53
48	Split hand-foot malformation	Enrichment	FGFR2	2.53
49	Syndromic x-linked intellectual disability	Enrichment	CASK	2.53
50	Cervix carcinoma	Enrichment	FGFR3	2.53
51	Autosomal dominant nonsyndromic deafness	Enrichment	FGFR2	2.53
52	Prrt2-related disorder	Enrichment	PRRT2	2.53
53	Achondroplasia	Enrichment	FGFR3	2.35
54	Larsen syndrome	Enrichment	FGFR3	2.35
55	Intellectual developmental disorder with microcephaly and pontine and cerebellar hypoplasia	Enrichment	CASK	2.35
56	Obesity, early-onset, with adrenal insufficiency and red hair	Enrichment	POMC	2.35
57	Glut1 deficiency syndrome 2	Enrichment	PRRT2	2.35
58	Alzheimer disease 4	Enrichment	PSEN1	2.35
59	Neonatal nephrocutaneous inflammatory syndrome	Enrichment	EGFR	2.35
60	Syndromic x-linked intellectual disability najm type	Enrichment	CASK	2.35
61	Cerebellar disease	Enrichment	CASK	2.35
62	Hamartoma	Enrichment	FGFR3	2.35
63	Testicular germ cell cancer	Enrichment	FGFR3	2.35
64	Spermatocytoma	Enrichment	FGFR3	2.35
65	Neonatal inflammatory skin and bowel disease	Enrichment	EGFR	2.35
66	Testicular cancer	Enrichment	FGFR3	2.35
67	Obesity due to pro-opiomelanocortin deficiency	Enrichment	POMC	2.35
68	Paroxysmal nonkinesigenic dyskinesia 1	Enrichment	PRRT2	2.23
69	Episodic kinesigenic dyskinesia 1	Enrichment	PRRT2	2.23
70	Dowling-degos disease	Enrichment	PSENEN	2.23
71	Familial paroxysmal nonkinesigenic dyskinesia	Enrichment	PRRT2	2.23
72	Familial or sporadic hemiplegic migraine	Enrichment	PRRT2	2.23
73	Non-syndromic bicoronal craniosynostosis	Enrichment	FGFR3	2.23
74	Glioma	Enrichment	FGFR2	2.23
75	Anemia, congenital, nonspherocytic hemolytic, 1	Enrichment	CASK	2.13
76	Convulsions, familial infantile, with paroxysmal choreoathetosis	Enrichment	PRRT2	2.13
77	Dementia	Enrichment	PSEN1	2.13
78	Self-limited infantile epilepsy	Enrichment	PRRT2	2.13
79	Cowden syndrome 1	Enrichment	EGFR	2.05
80	Telangiectasia, hereditary hemorrhagic, type 1	Enrichment	PSEN1	2.05
81	Split-hand/foot malformation 1	Enrichment	FGFR2	2.05
82	Testicular germ cell tumor	Enrichment	FGFR3	2.05
83	46,xy disorder of sex development	Enrichment	FGFR3	2.05
84	Nevus, epidermal	Enrichment	FGFR3	1.99
85	Myelofibrosis	Enrichment	SRC	1.99
86	Squamous cell carcinoma, head and neck	Enrichment	EGFR	1.99
87	Semantic dementia	Enrichment	PSEN1	1.99
88	Early-onset autosomal dominant alzheimer disease	Enrichment	PSEN1	1.99
89	Progressive non-fluent aphasia	Enrichment	PSEN1	1.88
90	Behavioral variant of frontotemporal dementia	Enrichment	PSEN1	1.88
91	Meier-gorlin syndrome 1	Enrichment	FGFR2	1.83
92	Primary bone dysplasia	Enrichment	FGFR3	1.83
93	Frontotemporal dementia 1	Enrichment	PSEN1	1.79
94	Osteochondrodysplasia	Enrichment	FGFR3	1.79
95	Lung non-small cell carcinoma	Enrichment	EGFR	1.79
96	Renal hypodysplasia/aplasia 3	Enrichment	FGFR3	1.76
97	Lip and oral cavity carcinoma	Enrichment	EGFR	1.76
98	Alzheimer's disease	Enrichment	PSEN1	1.72
99	Osteoporosis	Enrichment	SRC	1.69
100	Lung cancer susceptibility 3	Enrichment	EGFR	1.69
101	Generalized epilepsy with febrile seizures plus	Enrichment	PRRT2	1.69
102	Hydrocephalus	Enrichment	FGFR2	1.66
103	Cerebellar hypoplasia/atrophy, epilepsy, and global developmental delay	Enrichment	CASK	1.63
104	Isolated congenital microcephaly	Enrichment	CASK	1.63
105	Alzheimer disease, familial, 1	Enrichment	PSEN1	1.61
106	Early infantile developmental and epileptic encephalopathy	Enrichment	CASK	1.58
107	Arteriovenous malformations of the brain	Enrichment	EGFR	1.56
108	Endometrial cancer	Enrichment	FGFR2	1.52
109	Hepatoblastoma	Enrichment	FGFR3	1.52
110	Skin disease	Enrichment	NCSTN	1.50
111	Lung cancer	Enrichment	EGFR	1.34
112	Connective tissue disease	Enrichment	FGFR3	1.34
113	Dystonia	Enrichment	CASK	1.30
114	Non-syndromic x-linked intellectual disability	Enrichment	CASK	1.29
115	Gastric cancer	Enrichment	FGFR2	1.21
116	Thrombocytopenia	Enrichment	SRC	1.16
117	Hypertelorism	Enrichment	FGFR2	1.13
118	Familial isolated dilated cardiomyopathy	Enrichment	PSEN1	1.12
119	Myeloma, multiple	Enrichment	FGFR3	1.10
120	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	PSEN1	1.09
121	Ovarian cancer	Enrichment	EGFR	0.86
122	Microcephaly	Enrichment	CASK	0.78
123	Inherited cancer-predisposing syndrome	Enrichment	EGFR	0.75

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Syndecan-3-mediated signaling events

Pathway Network for Syndecan-3-mediated signaling events

Member Pathways for Syndecan-3-mediated signaling events

Pathways in the Syndecan-3-mediated signaling events SuperPath

Associated Genes for Syndecan-3-mediated signaling events

Associated Disorders for Syndecan-3-mediated signaling events

Disorders associated with Syndecan-3-mediated signaling events SuperPath

STRING Interaction Network for Syndecan-3-mediated signaling events

Sources for Syndecan-3-mediated signaling events