Syndecan-4-mediated signaling events

No Pathway Network information available for Syndecan-4-mediated signaling events

Pathways in the Syndecan-4-mediated signaling events SuperPath

#	Name	Source	Genes
1	Syndecan-4-mediated signaling events	PubChem	ACTN1 ADAM12 CCL5 CXCL12 CXCR4 DNM2 F2 FGF2 FGFR1 FN1 FZD7 GIPC1 ITGA5 ITGB1 LAMA1 LAMA3 MDK MMP9 NUDT16L1 PLG PRKCA PRKCD PTK2 RAC1 RHOA SDC4 SDCBP TFPI THBS1 TNC TNFRSF13B (see all 31) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	TNFRSF13B	TNF Receptor Superfamily Member 13B	Protein Coding	1
2	NUDT16L1	Nudix Hydrolase 16 Like 1	Protein Coding	1
3	SDC4	Syndecan 4	Protein Coding	1
4	ADAM12	ADAM Metallopeptidase Domain 12	Protein Coding	1
5	FZD7	Frizzled Class Receptor 7	Protein Coding	1
6	MDK	Midkine	Protein Coding	1
7	CCL5	C-C Motif Chemokine Ligand 5	Protein Coding	1
8	GIPC1	GIPC PDZ Domain Containing Family Member 1	Protein Coding	1
9	PRKCD	Protein Kinase C Delta	Protein Coding	1
10	PLG	Plasminogen	Protein Coding	1
11	TFPI	Tissue Factor Pathway Inhibitor	Protein Coding	1
12	F2	Coagulation Factor II, Thrombin	Protein Coding	1
13	TNC	Tenascin C	Protein Coding	1
14	THBS1	Thrombospondin 1	Protein Coding	1
15	FN1	Fibronectin 1	Protein Coding	1
16	LAMA3	Laminin Subunit Alpha 3	Protein Coding	1
17	ACTN1	Actinin Alpha 1	Protein Coding	1
18	ITGA5	Integrin Subunit Alpha 5	Protein Coding	1
19	LAMA1	Laminin Subunit Alpha 1	Protein Coding	1
20	SDCBP	Syndecan Binding Protein	Protein Coding	1
21	PRKCA	Protein Kinase C Alpha	Protein Coding	1
22	CXCR4	C-X-C Motif Chemokine Receptor 4	Protein Coding	1
23	CXCL12	C-X-C Motif Chemokine Ligand 12	Protein Coding	1
24	PTK2	Protein Tyrosine Kinase 2	Protein Coding	1
25	ITGB1	Integrin Subunit Beta 1	Protein Coding	1
26	RHOA	Ras Homolog Family Member A	Protein Coding	1
27	RAC1	Rac Family Small GTPase 1	Protein Coding	1
28	DNM2	Dynamin 2	Protein Coding	1
29	FGF2	Fibroblast Growth Factor 2	Protein Coding	1
30	FGFR1	Fibroblast Growth Factor Receptor 1	Protein Coding	1
31	MMP9	Matrix Metallopeptidase 9	Protein Coding	1

Disorders associated with Syndecan-4-mediated signaling events SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Human immunodeficiency virus type 1	Enrichment	CCL5, CXCL12	3.12
2	Immune deficiency, familial variable	Enrichment	TNFRSF13B	2.64
3	Osteoglophonic dysplasia	Enrichment	FGFR1	2.64
4	Trigonocephaly 1	Enrichment	FGFR1	2.64
5	Prothrombin deficiency, congenital	Enrichment	F2	2.64
6	Charcot-marie-tooth disease, dominant intermediate b	Enrichment	DNM2	2.64
7	Deafness, autosomal dominant 56	Enrichment	TNC	2.64
8	Whim syndrome 1	Enrichment	CXCR4	2.64
9	Autoimmune lymphoproliferative syndrome, type iii	Enrichment	PRKCD	2.64
10	Angioedema, hereditary, 4	Enrichment	PLG	2.64
11	Immunoglobulin a deficiency 2	Enrichment	TNFRSF13B	2.64
12	Oculopharyngodistal myopathy 2	Enrichment	GIPC1	2.64
13	Lethal congenital contracture syndrome 5	Enrichment	DNM2	2.64
14	Bleeding disorder, platelet-type, 15	Enrichment	ACTN1	2.64
15	Pregnancy loss, recurrent 2	Enrichment	F2	2.64
16	Hartsfield syndrome	Enrichment	FGFR1	2.64
17	Ectodermal dysplasia with facial dysmorphism and acral, ocular, and brain anomalies	Enrichment	RHOA	2.64
18	Linear hypopigmentation and craniofacial asymmetry with acral, ocular and brain anomalies	Enrichment	RHOA	2.64
19	Autosomal dominant charcot-marie-tooth disease type 2m	Enrichment	DNM2	2.64
20	Prothrombin deficiency	Enrichment	F2	2.64
21	Common variable immunodeficiency phenotype due to homozygous taci deficiency	Enrichment	TNFRSF13B	2.64
22	Microcephaly-corpus callosum and cerebellar vermis hypoplasia-facial dysmorphism-intellectual disability syndrom	Enrichment	RAC1	2.64
23	Hartsfield-bixler-demyer syndrome	Enrichment	FGFR1	2.64
24	Spondyloepimetaphyseal dysplasia, strudwick type	Enrichment	FN1	2.34
25	Spondylometaphyseal dysplasia, corner fracture type	Enrichment	FN1	2.34
26	Epidermolysis bullosa, junctional 2c, laryngoonychocutaneous	Enrichment	LAMA3	2.34
27	Immunodeficiency, common variable, 2	Enrichment	TNFRSF13B	2.34
28	Plasminogen deficiency, type i	Enrichment	PLG	2.34
29	Immunodeficiency with hyper-igm, type 2	Enrichment	TNFRSF13B	2.34
30	Pfeiffer syndrome	Enrichment	FGFR1	2.34
31	Jackson-weiss syndrome	Enrichment	FGFR1	2.34
32	Encephalocraniocutaneous lipomatosis	Enrichment	FGFR1	2.34
33	Intellectual developmental disorder, autosomal dominant 48	Enrichment	RAC1	2.34
34	Epidermolysis bullosa, junctional 2a, intermediate	Enrichment	LAMA3	2.34
35	Rosette-forming glioneuronal tumor	Enrichment	FGFR1	2.34
36	Metaphyseal anadysplasia 2	Enrichment	MMP9	2.34
37	Hereditary angioedema	Enrichment	PLG	2.34
38	Epidermolysis bullosa, junctional 2b, severe	Enrichment	LAMA3	2.34
39	Interfrontal craniofaciosynostosis	Enrichment	FGFR1	2.34
40	Metaphyseal anadysplasia	Enrichment	MMP9	2.34
41	Hypogonadotropic hypogonadism 2 with or without anosmia	Enrichment	FGFR1	2.16
42	Angioedema, hereditary, 1	Enrichment	PLG	2.16
43	Glomerulopathy with fibronectin deposits 2	Enrichment	FN1	2.16
44	Myopathy, centronuclear, x-linked	Enrichment	DNM2	2.16
45	Chromosome 8p11 myeloproliferative syndrome	Enrichment	FGFR1	2.16
46	Poretti-boltshauser syndrome	Enrichment	LAMA1	2.16
47	Cerebral sinovenous thrombosis	Enrichment	F2	2.16
48	Immunodeficiency, common variable, 1	Enrichment	TNFRSF13B	2.04
49	Holoprosencephaly	Enrichment	FGFR1	1.94
50	Primary hypereosinophilic syndrome	Enrichment	FGFR1	1.94
51	Myopathy, centronuclear, 1	Enrichment	DNM2	1.87
52	Epidermolysis bullosa, junctional 1a, intermediate	Enrichment	LAMA3	1.87
53	Hemihyperplasia, isolated	Enrichment	RHOA	1.87
54	Epidermolysis bullosa, junctional 1b, severe	Enrichment	LAMA3	1.87
55	Holoprosencephaly 1	Enrichment	FGFR1	1.87
56	Junctional epidermolysis bullosa non-herlitz type	Enrichment	LAMA3	1.87
57	Oculopharyngodistal myopathy 1	Enrichment	GIPC1	1.80
58	Thrombophilia due to thrombin defect	Enrichment	F2	1.80
59	Pilomyxoid astrocytoma	Enrichment	FGFR1	1.80
60	Common variable immunodeficiency	Enrichment	TNFRSF13B	1.80
61	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	RAC1	1.69
62	Hypogonadotropic hypogonadism	Enrichment	FGFR1	1.69
63	Junctional epidermolysis bullosa	Enrichment	LAMA3	1.69
64	Stroke, ischemic	Enrichment	F2	1.65
65	Autosomal dominant macrothrombocytopenia	Enrichment	ACTN1	1.65
66	Septooptic dysplasia	Enrichment	FGFR1	1.57
67	Neural tube defects	Enrichment	ITGB1	1.53
68	Hypogonadotropic hypogonadism 7 with or without anosmia	Enrichment	FGFR1	1.50
69	Gliosarcoma	Enrichment	FGFR1	1.44
70	Microform holoprosencephaly	Enrichment	FGFR1	1.44
71	Lobar holoprosencephaly	Enrichment	FGFR1	1.44
72	Giant cell glioblastoma	Enrichment	FGFR1	1.42
73	Semilobar holoprosencephaly	Enrichment	FGFR1	1.39
74	Normosmic congenital hypogonadotropic hypogonadism	Enrichment	FGFR1	1.39
75	Centronuclear myopathy	Enrichment	DNM2	1.33
76	Tooth agenesis	Enrichment	FGFR1	1.31
77	Kallmann syndrome	Enrichment	FGFR1	1.29
78	Cystic fibrosis	Enrichment	PLG	1.15
79	Cerebral palsy	Enrichment	F2	1.07
80	Myopathy	Enrichment	DNM2	1.06
81	Charcot-marie-tooth disease	Enrichment	DNM2	1.05
82	Nephrotic syndrome	Enrichment	FN1	1.03
83	Thrombocytopenia	Enrichment	ACTN1	0.98
84	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	TNC	0.95
85	Primary ovarian insufficiency	Enrichment	THBS1	0.90
86	Hereditary retinal dystrophy	Enrichment	LAMA1	0.31
87	Fundus dystrophy	Enrichment	LAMA1	0.31

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Syndecan-4-mediated signaling events

Pathway Network for Syndecan-4-mediated signaling events

Member Pathways for Syndecan-4-mediated signaling events

Pathways in the Syndecan-4-mediated signaling events SuperPath

Associated Genes for Syndecan-4-mediated signaling events

Associated Disorders for Syndecan-4-mediated signaling events

Disorders associated with Syndecan-4-mediated signaling events SuperPath

STRING Interaction Network for Syndecan-4-mediated signaling events

Sources for Syndecan-4-mediated signaling events