Synthesis of substrates in N-glycan biosythesis

Pathway network for the Synthesis of substrates in N-glycan biosythesis SuperPath

Sources:
  • Reactome

Pathways in the Synthesis of substrates in N-glycan biosythesis SuperPath

#NameSourceGenes
1Synthesis of substrates in N-glycan biosythesisReactome
2Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent proteinReactome
3Sialic acid metabolismReactome
4Synthesis of UDP-N-acetyl-glucosamineReactome
5Synthesis of dolichyl-phosphateReactome
6GDP-fucose biosynthesisReactome
7Synthesis of GDP-mannoseReactome
8Defective DHDDS causes RP59Reactome
9Synthesis of dolichyl-phosphate-glucoseReactome
10Defective PMM2 causes PMM2-CDGReactome
11Defective DOLK causes DOLK-CDGReactome
12Defective MPI causes MPI-CDGReactome
13Defective SLC35C1 causes congenital disorder of glycosylation 2C (CDG2C)Reactome
14Defective SRD5A3 causes SRD5A3-CDG, KHRZReactome

Gene overlap in member pathways for Synthesis of substrates in N-glycan biosythesis SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

Disorders associated with Synthesis of substrates in N-glycan biosythesis SuperPath

according to GeneCards Suite gene sharing
#DisorderTypeGenesScore
1Retinitis pigmentosaDirect
2Developmental and epileptic encephalopathy 36Direct
3Immunodeficiency 47Direct
4Congenital disorder of glycosylation, type inEnrichmentALG1, ALG13, ALG3, DPAGT1, NUS1, PMM2, RFT1, SRD5A311.06
5Congenital myasthenic syndromes with glycosylation defectEnrichmentALG14, ALG2, DPAGT1, GFPT1, GMPPB10.41
6Muscular dystrophyEnrichmentGMPPB, PMM24.35
7Free sialic acid storage disorderEnrichmentGNE, SLC17A54.24
8Polycystic kidney disease 7EnrichmentALG53.83
9Undetermined early-onset epileptic encephalopathyEnrichmentDHDDS, NUS13.46
10Congenital disorder of glycosylation, type iicEnrichmentSLC35C13.35
11Congenital disorder of glycosylation with defective fucosylation 2EnrichmentFCSK3.35
12Anemia, congenital, nonspherocytic hemolytic, 5EnrichmentHK13.35
13Congenital disorder of glycosylation, type ibEnrichmentMPI3.35
14Congenital disorder of glycosylation, type iaEnrichmentPMM23.35
15Retinitis pigmentosa 79EnrichmentHK13.35
16Neuropathy, hereditary motor and sensory, russe typeEnrichmentHK13.35
17Neurodevelopmental disorder with visual defects and brain anomaliesEnrichmentHK13.35
18Congenital disorder of glycosylation, type imEnrichmentDOLK3.29
19Congenital disorder of glycosylation, type iaaEnrichmentNUS13.29
20Retinitis pigmentosa 59EnrichmentDHDDS3.29
21Kahrizi syndromeEnrichmentSRD5A33.29
22Porokeratosis 7, multiple typesEnrichmentMVD3.29
23Intellectual developmental disorder, autosomal dominant 55, with seizuresEnrichmentNUS13.29
24Developmental delay and seizures with or without movement abnormalitiesEnrichmentDHDDS3.29
25Rhizomelic dysplasia, ain-naz typeEnrichmentGNPNAT13.23
26Congenital disorder of glycosylation with defective fucosylation 1EnrichmentFCSK3.05
27Chromosomal instability with tissue-specific radiosensitivityEnrichmentGMPPA3.05
28Muscular dystrophy-dystroglycanopathy , type a, 14EnrichmentGMPPB3.05
29Muscular dystrophy-dystroglycanopathy , type b, 14EnrichmentGMPPB3.05
30Alacrima, achalasia, and impaired intellectual development syndromeEnrichmentGMPPA3.05
31Muscular dystrophy-dystroglycanopathy , type c, 14EnrichmentGMPPB3.05
32Syndromic x-linked intellectual disability 17EnrichmentGMPPA3.05
33Congenital muscular dystrophy-dystroglycanopathy type a14EnrichmentGMPPB3.05
34Congenital disorder of glycosylation, type 1ddEnrichmentDHRSX2.99
35Congenital disorder of glycosylation, type iqEnrichmentSRD5A32.99
36Myasthenic syndrome, congenital, 12EnrichmentGFPT12.93
37Immunodeficiency 23EnrichmentPGM32.93
38Childhood-onset epilepsy syndromeEnrichmentAMDHD22.93
39Global developmental delay, absent or hypoplastic corpus callosum, and dysmorphic faciesEnrichmentPMM12.88
40Linear porokeratosisEnrichmentMVD2.81
41Achalasia-addisonianism-alacrima syndromeEnrichmentGMPPA2.75
42Hyper ige syndromeEnrichmentPGM32.75
43Hydrops fetalis, nonimmuneEnrichmentCTSA, NEU12.75
44PorokeratosisEnrichmentMVD2.69
45Congenital muscular dystrophy with intellectual disabilityEnrichmentGMPPB2.66
46Autosomal dominant polycystic kidney diseaseEnrichmentALG52.66
47Inclusion body myositisEnrichmentGNE2.61
48Neuraminidase deficiencyEnrichmentNEU12.61
49SialuriaEnrichmentGNE2.61
50Intellectual developmental disorder, autosomal recessive 12EnrichmentST3GAL32.61
51Congenital disorder of glycosylation, type iifEnrichmentSLC35A12.61
52Thrombocytopenia 12 with or without myopathyEnrichmentGNE2.61
53Glb1-related disordersEnrichmentGLB12.61
54Cathepsin a-related arteriopathy-strokes-leukoencephalopathyEnrichmentCTSA2.61
55St3gal3-cdgEnrichmentST3GAL32.61
56Non-immune hydrops fetalisEnrichmentCTSA, NEU12.59
57Congenital muscular dystrophy with cerebellar involvementEnrichmentGMPPB2.58
58Muscular dystrophy-dystroglycanopathyEnrichmentGMPPB2.51
59Congenital muscular dystrophy due to dystroglycanopathyEnrichmentGMPPB2.51
60Polymicrogyria, bilateral perisylvian, x-linkedEnrichmentNUS12.44
61Polycystic liver diseaseEnrichmentALG8, ALG92.36
62Autosomal dominant polycystic liver diseaseEnrichmentALG8, ALG92.36
63Muscle eye brain diseaseEnrichmentGMPPB2.35
64Bilateral perisylvian polymicrogyriaEnrichmentNUS12.33
65Muscular dystrophy-dystroglycanopathy , type c, 15EnrichmentDPM32.32
66Congenital disorder of glycosylation, type iuEnrichmentDPM22.32
67Muscular dystrophy-dystroglycanopathy , type b, 15EnrichmentDPM32.32
68Diabetes mellitusEnrichmentPMM22.31
69Salt and pepper developmental regression syndromeEnrichmentST3GAL52.31
70Bleeding disorder, platelet-type, 19EnrichmentGNE2.31
71GalactosialidosisEnrichmentCTSA2.31
72Developmental and epileptic encephalopathy 15EnrichmentST3GAL32.31
73Salt and pepper syndromeEnrichmentST3GAL52.31
74GlycoproteinosisEnrichmentNEU12.31
75Combined deficiency of sialidase and beta galactosidaseEnrichmentCTSA2.31
76Optic nerve diseaseEnrichmentSRD5A32.29
77Myasthenic syndrome, congenital, 4c, associated with acetylcholine receptor deficiencyEnrichmentGFPT12.23
78Myasthenic syndrome, congenital, 14EnrichmentALG22.23
79Congenital disorder of glycosylation, type ihEnrichmentALG82.23
80Intellectual developmental disorder with epilepsy, behavioral abnormalities, and coarse faciesEnrichmentALG142.23
81Gillessen-kaesbach-nishimura syndromeEnrichmentALG92.23
82Congenital disorder of glycosylation, type icEnrichmentALG62.23
83Polycystic liver disease 3 with or without kidney cystsEnrichmentALG82.23
84Creatine phosphokinase, elevated serumEnrichmentGMPPB2.15
85Cerebellar hypoplasia/atrophy, epilepsy, and global developmental delayEnrichmentPMM22.15
86Isolated elevated serum creatine phosphokinase levelsEnrichmentGMPPB2.15
87Gm1-gangliosidosis, type iEnrichmentGLB12.14
88Mucopolysaccharidosis, type ivbEnrichmentGLB12.14
89Gm1-gangliosidosis, type iiEnrichmentGLB12.14
90Nonaka myopathyEnrichmentGNE2.14
91Spondyloepimetaphyseal dysplasia, genevieve typeEnrichmentNANS2.14
92Gm1-gangliosidosis, type iiiEnrichmentGLB12.14
93Gm1 gangliosidosisEnrichmentGLB12.14
94Congenital myasthenic syndromeEnrichmentGFPT12.08
95Focal segmental glomerulosclerosisEnrichmentPMM22.05
96Infantile sialic acid storage diseaseEnrichmentSLC17A52.01
97Salla diseaseEnrichmentSLC17A52.01
98Myopathy, autophagic vacuolar, infantile-onsetEnrichmentGNE2.01
99Congenital disorder of glycosylation, type ijEnrichmentDPAGT11.93
100Congenital disorder of glycosylation, type ifEnrichmentMPDU11.93
101Myasthenic syndrome, congenital, 13EnrichmentDPAGT11.93
102Myasthenic syndrome, congenital, 15EnrichmentALG141.93
103Congenital disorder of glycosylation, type igEnrichmentALG121.93
104Myopathy, epilepsy, and progressive cerebral atrophyEnrichmentALG141.93
105Dpagt1-congenital disorder of glycosylationEnrichmentDPAGT11.93
106Cone dystrophyEnrichmentSRD5A31.91
107Spondyloepiphyseal dysplasia with congenital joint dislocationsEnrichmentGLB11.84
108Progressive familial intrahepatic cholestasisEnrichmentGLB11.77
109Cerebral palsyEnrichmentPMM21.77
110Wilson diseaseEnrichmentALG111.75
111Congenital disorder of glycosylation, type ipEnrichmentALG111.75
112Severe combined immunodeficiencyEnrichmentPGM31.71
113Congenital disorder of glycosylation, type ikEnrichmentALG11.63
114Long qt syndrome 2EnrichmentALG10B1.63
115Primary ovarian insufficiencyEnrichmentPMM21.59
116Familial isolated dilated cardiomyopathyEnrichmentDOLK1.57
117Congenital disorder of glycosylation, type idEnrichmentALG31.54
118Congenital disorder of glycosylation, type ilEnrichmentALG91.54
119Alg9-congenital disorder of glycosylationEnrichmentALG91.54
120Lynch syndromeEnrichmentGNE1.44
121AutismEnrichmentSRD5A31.44
122Polycystic kidney disease 1 with or without polycystic liver diseaseEnrichmentALG91.39
123Polycystic kidney disease 1EnrichmentALG91.39
124Myopathy, tubular aggregate, 1EnrichmentDPAGT11.34
125Autism spectrum disorderEnrichmentHK11.33
126Nephrotic syndrome, type 1EnrichmentALG11.29
127Congenital nervous system abnormalityEnrichmentSRD5A31.27
128Nervous system diseaseEnrichmentSRD5A31.27
129Developmental and epileptic encephalopathyEnrichmentST3GAL31.08
130Rare genetic intellectual disabilityEnrichmentALG131.07
131Congenital myopathyEnrichmentALG140.97
132ThrombocytopeniaEnrichmentGNE0.96
133Spastic ataxiaEnrichmentGLB10.92
134Hereditary retinal dystrophyEnrichmentHK10.91
135Fundus dystrophyEnrichmentHK10.91
136MyopathyEnrichmentDPM30.76
137Non-syndromic x-linked intellectual disabilityEnrichmentALG130.72
138MicrocephalyEnrichmentALG130.29

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