Synthesis of substrates in N-glycan biosythesis
Pathways in the Synthesis of substrates in N-glycan biosythesis SuperPath
| # | Name | Source | Genes |
|---|---|---|---|
| 1 | Synthesis of substrates in N-glycan biosythesis | Reactome | |
| 2 | Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein | Reactome | |
| 3 | Sialic acid metabolism | Reactome | |
| 4 | Synthesis of UDP-N-acetyl-glucosamine | Reactome | |
| 5 | Synthesis of dolichyl-phosphate | Reactome | |
| 6 | GDP-fucose biosynthesis | Reactome | |
| 7 | Synthesis of GDP-mannose | Reactome | |
| 8 | Defective DHDDS causes RP59 | Reactome | |
| 9 | Synthesis of dolichyl-phosphate-glucose | Reactome | |
| 10 | Defective PMM2 causes PMM2-CDG | Reactome | |
| 11 | Defective DOLK causes DOLK-CDG | Reactome | |
| 12 | Defective MPI causes MPI-CDG | Reactome | |
| 13 | Defective SLC35C1 causes congenital disorder of glycosylation 2C (CDG2C) | Reactome | |
| 14 | Defective SRD5A3 causes SRD5A3-CDG, KHRZ | Reactome |
Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways
| # | Symbol | Description | Category | # Related Pathways |
|---|---|---|---|---|
| 1 | NUS1 | NUS1 Dehydrodolichyl Diphosphate Synthase Subunit | Protein Coding | 4 |
| 2 | DOLK | Dolichol Kinase | Protein Coding | 4 |
| 3 | MPI | Mannose Phosphate Isomerase | Protein Coding | 4 |
| 4 | PMM2 | Phosphomannomutase 2 | Protein Coding | 4 |
| 5 | SLC35C1 | Solute Carrier Family 35 Member C1 | Protein Coding | 4 |
| 6 | SRD5A3 | Steroid 5 Alpha-Reductase 3 | Protein Coding | 4 |
| 7 | DHDDS | Dehydrodolichyl Diphosphate Synthase Subunit | Protein Coding | 4 |
| 8 | GNE | Glucosamine (UDP-N-Acetyl)-2-Epimerase/N-Acetylmannosamine Kinase | Protein Coding | 3 |
| 9 | ST3GAL6 | ST3 Beta-Galactoside Alpha-2,3-Sialyltransferase 6 | Protein Coding | 3 |
| 10 | SLC35A1 | Solute Carrier Family 35 Member A1 | Protein Coding | 3 |
| 11 | ST6GALNAC2 | ST6 N-Acetylgalactosaminide Alpha-2,6-Sialyltransferase 2 | Protein Coding | 3 |
| 12 | NEU3 | Neuraminidase 3 | Protein Coding | 3 |
| 13 | NEU4 | Neuraminidase 4 | Protein Coding | 3 |
| 14 | NANP | N-Acetylneuraminic Acid Phosphatase | Protein Coding | 3 |
| 15 | FCSK | Fucose Kinase | Protein Coding | 3 |
| 16 | DHRSX | Dehydrogenase/Reductase X-Linked | Protein Coding | 3 |
| 17 | NUDT14 | Nudix Hydrolase 14 | Protein Coding | 3 |
| 18 | ST6GALNAC3 | ST6 N-Acetylgalactosaminide Alpha-2,6-Sialyltransferase 3 | Protein Coding | 3 |
| 19 | SLC17A5 | Solute Carrier Family 17 Member 5 | Protein Coding | 3 |
| 20 | GFPT1 | Glutamine--Fructose-6-Phosphate Transaminase 1 | Protein Coding | 3 |
| 21 | ST6GALNAC4 | ST6 N-Acetylgalactosaminide Alpha-2,6-Sialyltransferase 4 | Protein Coding | 3 |
| 22 | GLB1 | Galactosidase Beta 1 | Protein Coding | 3 |
| 23 | GMDS | GDP-Mannose 4,6-Dehydratase | Protein Coding | 3 |
| 24 | FUOM | Fucose Mutarotase | Protein Coding | 3 |
| 25 | ALG5 | ALG5 Dolichyl-Phosphate Beta-Glucosyltransferase | Protein Coding | 3 |
| 26 | ST8SIA5 | ST8 Alpha-N-Acetyl-Neuraminide Alpha-2,8-Sialyltransferase 5 | Protein Coding | 3 |
| 27 | GMPPB | GDP-Mannose Pyrophosphorylase B | Protein Coding | 3 |
| 28 | GMPPA | GDP-Mannose Pyrophosphorylase A | Protein Coding | 3 |
| 29 | ST6GALNAC6 | ST6 N-Acetylgalactosaminide Alpha-2,6-Sialyltransferase 6 | Protein Coding | 3 |
| 30 | HK1 | Hexokinase 1 | Protein Coding | 3 |
| 31 | ST8SIA6 | ST8 Alpha-N-Acetyl-Neuraminide Alpha-2,8-Sialyltransferase 6 | Protein Coding | 3 |
| 32 | MVD | Mevalonate Diphosphate Decarboxylase | Protein Coding | 3 |
| 33 | NEU1 | Neuraminidase 1 | Protein Coding | 3 |
| 34 | NEU2 | Neuraminidase 2 | Protein Coding | 3 |
| 35 | AMDHD2 | Amidohydrolase Domain Containing 2 | Protein Coding | 3 |
| 36 | ST8SIA3 | ST8 Alpha-N-Acetyl-Neuraminide Alpha-2,8-Sialyltransferase 3 | Protein Coding | 3 |
| 37 | PGM3 | Phosphoglucomutase 3 | Protein Coding | 3 |
| 38 | PMM1 | Phosphomannomutase 1 | Protein Coding | 3 |
| 39 | NANS | N-Acetylneuraminate Synthase | Protein Coding | 3 |
| 40 | CTSA | Cathepsin A | Protein Coding | 3 |
| 41 | NAGK | N-Acetylglucosamine Kinase | Protein Coding | 3 |
| 42 | ST6GALNAC1 | ST6 N-Acetylgalactosaminide Alpha-2,6-Sialyltransferase 1 | Protein Coding | 3 |
| 43 | CMAS | Cytidine Monophosphate N-Acetylneuraminic Acid Synthetase | Protein Coding | 3 |
| 44 | DOLPP1 | Dolichyldiphosphatase 1 | Protein Coding | 3 |
| 45 | RENBP | Renin Binding Protein | Protein Coding | 3 |
| 46 | ST6GAL1 | ST6 Beta-Galactoside Alpha-2,6-Sialyltransferase 1 | Protein Coding | 3 |
| 47 | ST3GAL1 | ST3 Beta-Galactoside Alpha-2,3-Sialyltransferase 1 | Protein Coding | 3 |
| 48 | ST3GAL2 | ST3 Beta-Galactoside Alpha-2,3-Sialyltransferase 2 | Protein Coding | 3 |
| 49 | ST3GAL4 | ST3 Beta-Galactoside Alpha-2,3-Sialyltransferase 4 | Protein Coding | 3 |
| 50 | GNPNAT1 | Glucosamine-Phosphate N-Acetyltransferase 1 | Protein Coding | 3 |
| 51 | ST3GAL3 | ST3 Beta-Galactoside Alpha-2,3-Sialyltransferase 3 | Protein Coding | 3 |
| 52 | ST8SIA1 | ST8 Alpha-N-Acetyl-Neuraminide Alpha-2,8-Sialyltransferase 1 | Protein Coding | 3 |
| 53 | UAP1 | UDP-N-Acetylglucosamine Pyrophosphorylase 1 | Protein Coding | 3 |
| 54 | GFUS | GDP-L-Fucose Synthase | Protein Coding | 3 |
| 55 | ST8SIA4 | ST8 Alpha-N-Acetyl-Neuraminide Alpha-2,8-Sialyltransferase 4 | Protein Coding | 3 |
| 56 | NPL | N-Acetylneuraminate Pyruvate Lyase | Protein Coding | 3 |
| 57 | ST8SIA2 | ST8 Alpha-N-Acetyl-Neuraminide Alpha-2,8-Sialyltransferase 2 | Protein Coding | 3 |
| 58 | ST6GALNAC5 | ST6 N-Acetylgalactosaminide Alpha-2,6-Sialyltransferase 5 | Protein Coding | 3 |
| 59 | ST6GAL2 | ST6 Beta-Galactoside Alpha-2,6-Sialyltransferase 2 | Protein Coding | 3 |
| 60 | FPGT | Fucose-1-Phosphate Guanylyltransferase | Protein Coding | 3 |
| 61 | ST3GAL5 | ST3 Beta-Galactoside Alpha-2,3-Sialyltransferase 5 | Protein Coding | 3 |
| 62 | GFPT2 | Glutamine--Fructose-6-Phosphate Transaminase 2 | Protein Coding | 3 |
| 63 | DPM3 | Dolichyl-Phosphate Mannosyltransferase Subunit 3, Regulatory | Protein Coding | 2 |
| 64 | DPM1 | Dolichyl-Phosphate Mannosyltransferase Subunit 1, Catalytic | Protein Coding | 2 |
| 65 | DPM2 | Dolichyl-Phosphate Mannosyltransferase Subunit 2, Regulatory | Protein Coding | 2 |
| 66 | ALG3 | ALG3 Alpha-1,3- Mannosyltransferase | Protein Coding | 1 |
| 67 | ALG10B | ALG10 Alpha-1,2-Glucosyltransferase B | Protein Coding | 1 |
| 68 | DPAGT1 | Dolichyl-Phosphate N-Acetylglucosaminephosphotransferase 1 | Protein Coding | 1 |
| 69 | ALG14 | ALG14 UDP-N-Acetylglucosaminyltransferase Subunit | Protein Coding | 1 |
| 70 | ALG6 | ALG6 Alpha-1,3-Glucosyltransferase | Protein Coding | 1 |
| 71 | ALG11 | ALG11 Alpha-1,2-Mannosyltransferase | Protein Coding | 1 |
| 72 | ALG1 | ALG1 Chitobiosyldiphosphodolichol Beta-Mannosyltransferase | Protein Coding | 1 |
| 73 | ALG8 | ALG8 Alpha-1,3-Glucosyltransferase | Protein Coding | 1 |
| 74 | ALG12 | ALG12 Alpha-1,6-Mannosyltransferase | Protein Coding | 1 |
| 75 | ALG9 | ALG9 Alpha-1,2-Mannosyltransferase | Protein Coding | 1 |
| 76 | ALG13 | ALG13 UDP-N-Acetylglucosaminyltransferase Subunit | Protein Coding | 1 |
| 77 | ALG10 | ALG10 Alpha-1,2-Glucosyltransferase | Protein Coding | 1 |
| 78 | ALG2 | ALG2 Alpha-1,3/1,6-Mannosyltransferase | Protein Coding | 1 |
| 79 | RFT1 | RFT1 Glycolipid Translocator Homolog | Protein Coding | 1 |
| 80 | MPDU1 | Mannose-P-Dolichol Utilization Defect 1 | Protein Coding | 1 |
Disorders associated with Synthesis of substrates in N-glycan biosythesis SuperPath
according to GeneCards Suite gene sharing