T-cell activation SARS-CoV-2

No Pathway Network information available for T-cell activation SARS-CoV-2

Pathways in the T-cell activation SARS-CoV-2 SuperPath

#	Name	Source	Genes
1	T-cell activation SARS-CoV-2	WikiPathways	AKT1 BAX BCL10 BCL2L1 CARD11 CCL19 CCL28 CCND1 CD247 CD28 CD3D CD3E CD3G CD4 CD80 CD86 CDKN1A CDKN2A CHUK CTLA4 DEPTOR FOS FOXO3 FYN GRAP2 GRB2 GSK3B HLA-DRA HLA-DRB1 HLA-DRB3 HRAS ICOS IFNAR1 IFNAR2 IFNB1 IFNG IKBKB IKBKG IL12A IL12B IL12RB1 IL12RB2 IL17A IL18R1 IL2 IL23A IL23R IL4 IRF2BPL ITPR1 JAK2 JUN LAT LCK LCP2 LTA MALT1 MAP2K1 MAP2K2 MAPK1 MAPK3 MLST8 MTOR MYD88 NFATC1 NFKB1 NFKBIA PDPK1 PIK3CD PIK3R1 PLCG1 PPP3CC PRKCQ PTEN PTPRC RAF1 RASGRP1 RELA RHEB RICTOR RPTOR SOS1 STAT4 TNF TP53 TSC1 TSC2 TYK2 ZAP70 (see all 89) (see less)
2	T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection	WikiPathways	AHSA1 AKT1 BCL10 CARD11 CBL CD28 CD3D CD4 CD40LG CD8A CDK4 CHP1 CHUK CSF2 CTLA4 DAG1 DLG1 FOS FYN GRAP2 GRB2 GSK3B ICOS IFNG IKBKB IKBKG IL10 IL2 IL4 IL5 ITK JUN LAT LCK LCP2 MALT1 MAP2K1 MAP2K2 MAP2K7 MAP3K14 MAP3K7 MAP3K8 MAPK3 MAPK9 NCK1 NFATC2 NFKB1 NFKBIA PAK1 PDCD1 PDK1 PIK3CA PLCG1 PRKCQ PTPN6 PTPRC RAF1 RRAS SOS1 TNF TRAJ10 TRBJ1-4 ZAP70 (see all 63) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	ICOS	Inducible T Cell Costimulator	Protein Coding	2
2	IL4	Interleukin 4	Protein Coding	2
3	CD3D	CD3 Delta Subunit Of T-Cell Receptor Complex	Protein Coding	2
4	CARD11	Caspase Recruitment Domain Family Member 11	Protein Coding	2
5	MALT1	MALT1 Paracaspase	Protein Coding	2
6	GRAP2	GRB2 Related Adaptor Protein 2	Protein Coding	2
7	ZAP70	Zeta Chain Of T Cell Receptor Associated Protein Kinase 70	Protein Coding	2
8	CTLA4	Cytotoxic T-Lymphocyte Associated Protein 4	Protein Coding	2
9	IFNG	Interferon Gamma	Protein Coding	2
10	IL2	Interleukin 2	Protein Coding	2
11	CD28	CD28 Molecule	Protein Coding	2
12	LCK	LCK Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	2
13	CD4	CD4 Molecule	Protein Coding	2
14	BCL10	BCL10 Immune Signaling Adaptor	Protein Coding	2
15	NFKBIA	NFKB Inhibitor Alpha	Protein Coding	2
16	IKBKB	Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Beta	Protein Coding	2
17	IKBKG	Inhibitor Of Nuclear Factor Kappa B Kinase Regulatory Subunit Gamma	Protein Coding	2
18	CHUK	Component Of Inhibitor Of Nuclear Factor Kappa B Kinase Complex	Protein Coding	2
19	FOS	Fos Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	2
20	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	2
21	LAT	Linker For Activation Of T Cells	Protein Coding	2
22	LCP2	Lymphocyte Cytosolic Protein 2	Protein Coding	2
23	JUN	Jun Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	2
24	TNF	Tumor Necrosis Factor	Protein Coding	2
25	MAP2K1	Mitogen-Activated Protein Kinase Kinase 1	Protein Coding	2
26	PRKCQ	Protein Kinase C Theta	Protein Coding	2
27	PLCG1	Phospholipase C Gamma 1	Protein Coding	2
28	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	2
29	PTPRC	Protein Tyrosine Phosphatase Receptor Type C	Protein Coding	2
30	GSK3B	Glycogen Synthase Kinase 3 Beta	Protein Coding	2
31	FYN	FYN Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	2
32	GRB2	Growth Factor Receptor Bound Protein 2	Protein Coding	2
33	SOS1	SOS Ras/Rac Guanine Nucleotide Exchange Factor 1	Protein Coding	2
34	MAP2K2	Mitogen-Activated Protein Kinase Kinase 2	Protein Coding	2
35	NFKB1	Nuclear Factor Kappa B Subunit 1	Protein Coding	2
36	RAF1	Raf-1 Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	2
37	CCL28	C-C Motif Chemokine Ligand 28	Protein Coding	1
38	IRF2BPL	Interferon Regulatory Factor 2 Binding Protein Like	Protein Coding	1
39	HLA-DRB3	Major Histocompatibility Complex, Class II, DR Beta 3	Protein Coding	1
40	HLA-DRB1	Major Histocompatibility Complex, Class II, DR Beta 1	Protein Coding	1
41	DEPTOR	DEP Domain Containing MTOR Interacting Protein	Protein Coding	1
42	HLA-DRA	Major Histocompatibility Complex, Class II, DR Alpha	Protein Coding	1
43	CD247	CD247 Molecule	Protein Coding	1
44	RASGRP1	RAS Guanyl Releasing Protein 1	Protein Coding	1
45	LTA	Lymphotoxin Alpha	Protein Coding	1
46	IL17A	Interleukin 17A	Protein Coding	1
47	IL23A	Interleukin 23 Subunit Alpha	Protein Coding	1
48	IL23R	Interleukin 23 Receptor	Protein Coding	1
49	IL12RB2	Interleukin 12 Receptor Subunit Beta 2	Protein Coding	1
50	IL12B	Interleukin 12B	Protein Coding	1
51	IL12A	Interleukin 12A	Protein Coding	1
52	STAT4	Signal Transducer And Activator Of Transcription 4	Protein Coding	1
53	IL12RB1	Interleukin 12 Receptor Subunit Beta 1	Protein Coding	1
54	IL18R1	Interleukin 18 Receptor 1	Protein Coding	1
55	CD3E	CD3 Epsilon Subunit Of T-Cell Receptor Complex	Protein Coding	1
56	CD3G	CD3 Gamma Subunit Of T-Cell Receptor Complex	Protein Coding	1
57	CD86	CD86 Molecule	Protein Coding	1
58	CD80	CD80 Molecule	Protein Coding	1
59	IFNB1	Interferon Beta 1	Protein Coding	1
60	CDKN2A	Cyclin Dependent Kinase Inhibitor 2A	Protein Coding	1
61	MYD88	MYD88 Innate Immune Signal Transduction Adaptor	Protein Coding	1
62	RPTOR	Regulatory Associated Protein Of MTOR Complex 1	Protein Coding	1
63	RHEB	Ras Homolog, MTORC1 Binding	Protein Coding	1
64	NFATC1	Nuclear Factor Of Activated T Cells 1	Protein Coding	1
65	CCND1	Cyclin D1	Protein Coding	1
66	CCL19	C-C Motif Chemokine Ligand 19	Protein Coding	1
67	MLST8	MTOR Associated Protein MLST8	Protein Coding	1
68	RICTOR	RPTOR Independent Companion Of MTOR Complex 2	Protein Coding	1
69	PPP3CC	Protein Phosphatase 3 Catalytic Subunit Gamma	Protein Coding	1
70	PTEN	Phosphatase And Tensin Homolog	Protein Coding	1
71	PDPK1	3-Phosphoinositide Dependent Protein Kinase 1	Protein Coding	1
72	RELA	RELA Proto-Oncogene, NF-KB Subunit	Protein Coding	1
73	FOXO3	Forkhead Box O3	Protein Coding	1
74	PIK3CD	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Delta	Protein Coding	1
75	TSC1	TSC Complex Subunit 1	Protein Coding	1
76	TSC2	TSC Complex Subunit 2	Protein Coding	1
77	JAK2	Janus Kinase 2	Protein Coding	1
78	ITPR1	Inositol 1,4,5-Trisphosphate Receptor Type 1	Protein Coding	1
79	IFNAR2	Interferon Alpha And Beta Receptor Subunit 2	Protein Coding	1
80	IFNAR1	Interferon Alpha And Beta Receptor Subunit 1	Protein Coding	1
81	TYK2	Tyrosine Kinase 2	Protein Coding	1
82	BCL2L1	BCL2 Like 1	Protein Coding	1
83	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	1
84	MTOR	Mechanistic Target Of Rapamycin Kinase	Protein Coding	1
85	TP53	Tumor Protein P53	Protein Coding	1
86	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	1
87	CDKN1A	Cyclin Dependent Kinase Inhibitor 1A	Protein Coding	1
88	BAX	BCL2 Associated X, Apoptosis Regulator	Protein Coding	1
89	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	1
90	CD40LG	CD40 Ligand	Protein Coding	1
91	CD8A	CD8 Subunit Alpha	Protein Coding	1
92	CBL	Cbl Proto-Oncogene	Protein Coding	1
93	MAP3K7	Mitogen-Activated Protein Kinase Kinase Kinase 7	Protein Coding	1
94	RRAS	RAS Related	Protein Coding	1
95	PTPN6	Protein Tyrosine Phosphatase Non-Receptor Type 6	Protein Coding	1
96	MAP2K7	Mitogen-Activated Protein Kinase Kinase 7	Protein Coding	1
97	MAPK9	Mitogen-Activated Protein Kinase 9	Protein Coding	1
98	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	1
99	PDCD1	Programmed Cell Death 1	Protein Coding	1
100	PAK1	P21 (RAC1) Activated Kinase 1	Protein Coding	1
101	NFATC2	Nuclear Factor Of Activated T Cells 2	Protein Coding	1
102	NCK1	NCK Adaptor Protein 1	Protein Coding	1
103	ITK	IL2 Inducible T Cell Kinase	Protein Coding	1
104	IL10	Interleukin 10	Protein Coding	1
105	IL5	Interleukin 5	Protein Coding	1
106	DLG1	Discs Large MAGUK Scaffold Protein 1	Protein Coding	1
107	DAG1	Dystroglycan 1	Protein Coding	1
108	CSF2	Colony Stimulating Factor 2	Protein Coding	1
109	MAP3K8	Mitogen-Activated Protein Kinase Kinase Kinase 8	Protein Coding	1
110	CDK4	Cyclin Dependent Kinase 4	Protein Coding	1
111	MAP3K14	Mitogen-Activated Protein Kinase Kinase Kinase 14	Protein Coding	1
112	CHP1	Calcineurin Like EF-Hand Protein 1	Protein Coding	1
113	AHSA1	Activator Of HSP90 ATPase Activity 1	Protein Coding	1
114	PDK1	Pyruvate Dehydrogenase Kinase 1	Protein Coding	1
115	TRAJ10	T Cell Receptor Alpha Joining 10	Protein Coding	1
116	TRBJ1-4	T Cell Receptor Beta Joining 1-4	Protein Coding	1

Disorders associated with T-cell activation SARS-CoV-2 SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Severe combined immunodeficiency	Enrichment	CD247, CD3D, CD3E, CD3G, IKBKB, LCK, MALT1, PTPRC, ZAP70	10.58
2	Noonan syndrome 1	Enrichment	CBL, MAP2K1, MAP2K2, RAF1, RRAS, SOS1	9.12
3	Focal cortical dysplasia, type ii	Enrichment	MTOR, RHEB, TSC1, TSC2	8.75
4	Isolated focal cortical dysplasia type ii	Enrichment	MTOR, RHEB, TSC1, TSC2	8.75
5	Noonan syndrome and noonan-related syndrome	Enrichment	CBL, MAP2K1, MAP2K2, RAF1, SOS1	8.27
6	Bladder cancer	Enrichment	CDKN1A, CDKN2A, HRAS, PTEN, TP53, TSC1	7.55
7	Rasopathy	Enrichment	CBL, MAP2K1, MAP2K2, RAF1, SOS1	6.95
8	Tuberous sclerosis 1	Enrichment	IFNG, TSC1, TSC2	6.56
9	T-b+ severe combined immunodeficiency due to cd3delta/cd3epsilon/cd3zeta	Enrichment	CD247, CD3D, CD3E	6.56
10	Hemimegalencephaly	Enrichment	MTOR, PTEN, RHEB	5.57
11	Noonan syndrome 3	Enrichment	HRAS, RAF1, SOS1	5.03
12	Ectodermal dysplasia and immune deficiency	Enrichment	IKBKG, NFKBIA	4.67
13	Colorectal cancer	Enrichment	AKT1, BAX, BCL10, CCND1, PIK3R1, TP53	4.65
14	Adult hepatocellular carcinoma	Enrichment	TP53, TSC1, TSC2	4.65
15	Systemic lupus erythematosus	Enrichment	CTLA4, IL10, PDCD1, TNF	4.51
16	Lymphangioleiomyomatosis	Enrichment	TSC1, TSC2	4.37
17	Lip and oral cavity carcinoma	Enrichment	CDKN2A, HRAS, TP53	4.24
18	Mycosis fungoides	Enrichment	CD28, CTLA4	4.20
19	Saczary syndrome	Enrichment	CD28, CTLA4	4.20
20	Cardiofaciocutaneous syndrome 1	Enrichment	MAP2K1, MAP2K2	3.90
21	Immunodeficiency, common variable, 1	Enrichment	CTLA4, ICOS	3.90
22	Cardiofaciocutaneous syndrome	Enrichment	MAP2K1, MAP2K2	3.90
23	Psoriatic arthritis	Enrichment	LTA, TNF	3.90
24	Nasopharyngeal carcinoma	Enrichment	NFKBIA, TP53	3.90
25	Tuberous sclerosis 2	Enrichment	IFNG, TSC2	3.90
26	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3CD, PIK3R1	3.90
27	Hamartoma	Enrichment	TSC1, TSC2	3.90
28	Immunodeficiency 14	Enrichment	PIK3CD, PIK3R1	3.90
29	T-cell acute lymphoblastic leukemia	Enrichment	BAX, BCL10	3.90
30	Breast cancer	Enrichment	AKT1, IL2, JUN, PTEN, TP53	3.88
31	Rhabdomyosarcoma	Enrichment	HRAS, PTEN, TP53	3.84
32	Lymphoma, mucosa-associated lymphoid type	Enrichment	BCL10, MALT1	3.68
33	Behcet syndrome	Enrichment	IL12A, IL23R, STAT4	3.61
34	Diffuse large b-cell lymphoma	Enrichment	MYD88, PTEN, TP53	3.61
35	Tuberous sclerosis	Enrichment	TSC1, TSC2	3.60
36	Breast adenocarcinoma	Enrichment	AKT1, PIK3CA	3.50
37	Follicular lymphoma	Enrichment	BCL10, HLA-DRB1	3.38
38	Acute megakaryocytic leukemia	Enrichment	PTEN, TP53	3.38
39	Capillary malformation-arteriovenous malformation 1	Enrichment	MAP2K1, PIK3CA	3.36
40	Common variable immunodeficiency	Enrichment	CD40LG, NFKB1	3.36
41	Ovarian cancer	Enrichment	AKT1, CDKN2A, PTEN, TP53, TSC2	3.28
42	Li-fraumeni syndrome	Enrichment	CDKN2A, TP53	3.20
43	Adrenocortical carcinoma	Enrichment	CDKN2A, TP53	3.20
44	Arteriovenous malformation	Enrichment	MAP2K1, PIK3CA	3.13
45	Cowden syndrome	Enrichment	AKT1, PIK3CA	3.13
46	Thyroid cancer, nonmedullary, 2	Enrichment	HRAS, PTEN	3.06
47	Squamous cell carcinoma, head and neck	Enrichment	PTEN, TP53	3.06
48	Essential thrombocythemia	Enrichment	JAK2, TP53	3.06
49	Follicular thyroid carcinoma	Enrichment	HRAS, PTEN	3.06
50	Oligoarticular juvenile idiopathic arthritis	Enrichment	CD247, STAT4	3.06
51	Overgrowth syndrome	Enrichment	MTOR, PIK3R1	3.06
52	Rheumatoid factor-negative juvenile idiopathic arthritis	Enrichment	CD247, STAT4	3.06
53	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	CDKN2A, TP53	3.06
54	Myopathy, x-linked, with excessive autophagy	Enrichment	MAP2K1, PIK3CA	3.03
55	Asthma	Enrichment	CARD11, TNF	2.94
56	Combined immunodeficiency	Enrichment	MALT1, ZAP70	2.94
57	Lung non-small cell carcinoma	Enrichment	MAP2K1, PIK3CA	2.94
58	Combined t cell and b cell immunodeficiency	Enrichment	MALT1, ZAP70	2.94
59	Combined t and b cell immunodeficiency	Enrichment	MALT1, ZAP70	2.94
60	Melanocytic nevus syndrome, congenital	Enrichment	HRAS, RAF1	2.93
61	Lymphoma, non-hodgkin, familial	Enrichment	BCL10, TP53	2.93
62	Juvenile myelomonocytic leukemia	Enrichment	CBL, RRAS	2.87
63	Meningioma	Enrichment	AKT1, PIK3CA	2.87
64	Primary biliary cholangitis	Enrichment	IL12A, IL12RB1	2.83
65	Inherited cancer-predisposing syndrome	Enrichment	CDKN2A, PTEN, TP53, TSC1, TSC2	2.76
66	Leukemia, chronic lymphocytic	Enrichment	CCND1, TP53	2.73
67	Melanoma	Enrichment	CDKN2A, PTEN	2.73
68	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3CD, PIK3R1	2.73
69	Gastric cancer	Enrichment	CDKN2A, PTEN, TP53	2.55
70	Hereditary breast carcinoma	Enrichment	AKT1, PTEN, TP53	2.53
71	Human immunodeficiency virus type 1	Enrichment	IFNG, IL10	2.51
72	Multiple sclerosis	Enrichment	HLA-DRB1, ITPR1	2.43
73	Macrodactyly	Enrichment	PIK3CA	2.33
74	Proteus syndrome	Enrichment	AKT1	2.33
75	Cardiospondylocarpofacial syndrome	Enrichment	MAP3K7	2.33
76	Incontinentia pigmenti	Enrichment	IKBKG	2.33
77	Autoinflammatory disease, systemic, x-linked	Enrichment	IKBKG	2.33
78	Noonan syndrome 5	Enrichment	RAF1	2.33
79	Noonan syndrome 4	Enrichment	SOS1	2.33
80	Melanoma, cutaneous malignant 3	Enrichment	CDK4	2.33
81	Celiac disease 3	Enrichment	CTLA4	2.33
82	Melorheostosis, isolated	Enrichment	MAP2K1	2.33
83	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	2.33
84	Cardiomyopathy, dilated, 1nn	Enrichment	RAF1	2.33
85	Cowden syndrome 5	Enrichment	PIK3CA	2.33
86	Cardiofaciocutaneous syndrome 3	Enrichment	MAP2K1	2.33
87	Muscular dystrophy-dystroglycanopathy , type a, 9	Enrichment	DAG1	2.33
88	Fetal encasement syndrome	Enrichment	CHUK	2.33
89	Immunodeficiency 116	Enrichment	CD8A	2.33
90	Frontometaphyseal dysplasia 2	Enrichment	MAP3K7	2.33
91	Cerebral cavernous malformations 4	Enrichment	PIK3CA	2.33
92	Immunodeficiency 15b	Enrichment	IKBKB	2.33
93	Immunodeficiency 69	Enrichment	IFNG	2.33
94	Immunodeficiency 81	Enrichment	LCP2	2.33
95	Immunodeficiency 15a	Enrichment	IKBKB	2.33
96	Immunodeficiency with hyper-igm, type 1	Enrichment	CD40LG	2.33
97	Immunodeficiency 48	Enrichment	ZAP70	2.33
98	Intellectual developmental disorder with macrocephaly, seizures, and speech delay	Enrichment	PAK1	2.33
99	Autoimmune disease, multisystem, infantile-onset, 4	Enrichment	PDCD1	2.33
100	Ectodermal dysplasia and immunodeficiency 1	Enrichment	IKBKG	2.33
101	Okt4 epitope deficiency	Enrichment	CD4	2.33
102	Immune dysregulation, autoimmunity, and autoinflammation	Enrichment	PLCG1	2.33
103	Graft-versus-host disease	Enrichment	IL10	2.33
104	Type 1 diabetes mellitus 12	Enrichment	CTLA4	2.33
105	Persistent polyclonal b-cell lymphocytosis	Enrichment	CARD11	2.33
106	Hemifacial myohyperplasia	Enrichment	PIK3CA	2.33
107	Systemic lupus erythematosus 2	Enrichment	PDCD1	2.33
108	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	2.33
109	Lymphoproliferative syndrome 1	Enrichment	ITK	2.33
110	Melorheostosis	Enrichment	MAP2K1	2.33
111	Leopard syndrome 2	Enrichment	RAF1	2.33
112	Cardiofaciocutaneous syndrome 4	Enrichment	MAP2K2	2.33
113	Cowden syndrome 6	Enrichment	AKT1	2.33
114	Immunodeficiency 12	Enrichment	MALT1	2.33
115	Muscular dystrophy-dystroglycanopathy , type c, 9	Enrichment	DAG1	2.33
116	Immunodeficiency 123 with hpv-related verrucosis	Enrichment	CD28	2.33
117	Immunodeficiency 105, severe combined	Enrichment	PTPRC	2.33
118	Autoimmune disease, multisystem, infantile-onset, 2	Enrichment	ZAP70	2.33
119	Immunodeficiency 22	Enrichment	LCK	2.33
120	Bartsocas-papas syndrome 2	Enrichment	CHUK	2.33
121	Spastic ataxia 9, autosomal recessive	Enrichment	CHP1	2.33
122	Immunodeficiency 79	Enrichment	CD4	2.33
123	Cd45 deficiency	Enrichment	PTPRC	2.33
124	Trigonitis	Enrichment	RAF1	2.33
125	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	2.33
126	Sezary's disease	Enrichment	BCL10	2.33
127	Immunodeficiency 19, severe combined	Enrichment	CD3D	2.33
128	Hypospadias	Enrichment	PIK3CA	2.33
129	Immunodeficiency 112	Enrichment	MAP3K14	2.33
130	Rare venous malformation	Enrichment	PIK3CA	2.33
131	Vegetative pyoderma gangrenosum	Enrichment	PTPN6	2.33
132	Bullous pyoderma gangrenosum	Enrichment	PTPN6	2.33
133	Cd40 ligand deficiency	Enrichment	CD40LG	2.33
134	Diaphragmatic eventration	Enrichment	PIK3CA	2.33
135	Pustular pyoderma gangrenosum	Enrichment	PTPN6	2.33
136	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	2.33
137	Combined immunodeficiency-hypogammaglobulinemia-skeletal anomalies syndrome due to ikbka deficiency	Enrichment	CHUK	2.33
138	Immunodeficiency 19	Enrichment	CD3D	2.33
139	Rare combined vascular malformation	Enrichment	PIK3CA	2.33
140	Cavernous lymphangioma	Enrichment	PIK3CA	2.33
141	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	2.33
142	Muscle-eye-brain disease with bilateral multicystic leucodystrophy	Enrichment	DAG1	2.33
143	Classic pyoderma gangrenosum	Enrichment	PTPN6	2.33
144	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	2.33
145	Mucosa-associated lymphoma	Enrichment	BCL10	2.33
146	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	2.33
147	Macrodactyly of toe	Enrichment	PIK3CA	2.33
148	Nik deficiency	Enrichment	MAP3K14	2.33
149	Zap70-related severe combined immunodeficiency	Enrichment	ZAP70	2.33
150	Gliosarcoma	Enrichment	NFKBIA, TP53	2.32
151	Malaria	Enrichment	IKBKG, TNF	2.30
152	Giant cell glioblastoma	Enrichment	NFKBIA, TP53	2.27
153	Autism spectrum disorder	Enrichment	IRF2BPL, MAP2K1, PTEN, TSC2	2.24
154	Vacterl association with hydrocephalus	Enrichment	PTEN	2.18
155	Immunodeficiency 35	Enrichment	TYK2	2.18
156	Immunodeficiency 68	Enrichment	MYD88	2.18
157	Leprosy 4	Enrichment	LTA	2.18
158	Macroglobulinemia, waldenstrom 1	Enrichment	MYD88	2.18
159	Immunodeficiency 30	Enrichment	IL12RB1	2.18
160	Immunodeficiency 64 with lymphoproliferation	Enrichment	RASGRP1	2.18
161	Noonan syndrome 13	Enrichment	MAPK1	2.18
162	Immunodeficiency 106 viral infections	Enrichment	IFNAR1	2.18
163	Disabling pansclerotic morphea of childhood	Enrichment	STAT4	2.18
164	Short syndrome	Enrichment	PIK3R1	2.18
165	Bone marrow failure syndrome 5	Enrichment	TP53	2.18
166	Papilloma of choroid plexus	Enrichment	TP53	2.18
167	Basal cell carcinoma 7	Enrichment	TP53	2.18
168	Anaplastic thyroid carcinoma	Enrichment	TP53	2.18
169	Immunodeficiency 18	Enrichment	CD3E	2.18
170	Systemic lupus erythematosus 11	Enrichment	STAT4	2.18
171	Papillary tumor of the pineal region	Enrichment	PTEN	2.18
172	Pulmonary alveolar proteinosis, acquired	Enrichment	HLA-DRB1	2.18
173	Immunodeficiency 25	Enrichment	CD247	2.18
174	Psoriasis 7	Enrichment	IL23R	2.18
175	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	2.18
176	Immunodeficiency 29	Enrichment	IL12B	2.18
177	Graham little-piccardi-lassueur syndrome	Enrichment	HLA-DRA	2.18
178	Immunodeficiency 14b, autosomal recessive	Enrichment	PIK3CD	2.18
179	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	2.18
180	Inflammatory bowel disease 17	Enrichment	IL23R	2.18
181	Glioma susceptibility 2	Enrichment	PTEN	2.18
182	Ductal carcinoma in situ	Enrichment	TP53	2.18
183	Thyroid gland undifferentiated carcinoma	Enrichment	TP53	2.18
184	Small-cell carcinoma of the ovary of hypercalcemic type	Enrichment	TP53	2.18
185	Cdkn2a cancer predisposition	Enrichment	CDKN2A	2.18
186	Irf2bpl-related disorder	Enrichment	IRF2BPL	2.18
187	Diffuse pediatric-type high-grade glioma, h3-wildtype and idh-wildtype	Enrichment	TP53	2.18
188	Choroid plexus cancer	Enrichment	TP53	2.18
189	Immunodeficiency 64	Enrichment	RASGRP1	2.18
190	Ebv-induced lymphoproliferative disease due to rasgrp1 deficiency	Enrichment	RASGRP1	2.18
191	Waldenstram macroglobulinemia	Enrichment	MYD88	2.18
192	Pleomorphic xanthoastrocytoma	Enrichment	TP53	2.18
193	Phakomatosis pigmentokeratotica	Enrichment	HRAS	2.18
194	Segmental outgrowth-lipomatosis-arteriovenous malformation-epidermal nevus syndrome	Enrichment	PTEN	2.18
195	Multisystem inflammatory syndrome in children	Enrichment	IFNAR2, IFNB1	2.04
196	Hashimoto thyroiditis	Enrichment	CTLA4	2.03
197	Fibromatosis, gingival, 1	Enrichment	SOS1	2.03
198	Ovarian germ cell cancer	Enrichment	CBL	2.03
199	Immunodeficiency 33	Enrichment	IKBKG	2.03
200	Pulmonic stenosis	Enrichment	SOS1	2.03
201	Ectodermal dysplasia and immunodeficiency 2	Enrichment	NFKBIA	2.03
202	Keratosis, seborrheic	Enrichment	PIK3CA	2.03
203	Immunodeficiency 11a	Enrichment	CARD11	2.03
204	Immunodeficiency 37	Enrichment	BCL10	2.03
205	Noonan syndrome 8	Enrichment	PIK3CA	2.03
206	Immunodeficiency, common variable, 12, with autoimmunity	Enrichment	NFKB1	2.03
207	Immunodeficiency 11b with atopic dermatitis	Enrichment	CARD11	2.03
208	Immunodeficiency 127	Enrichment	TNF	2.03
209	Lymphoproliferative syndrome	Enrichment	ITK	2.03
210	Rosette-forming glioneuronal tumor	Enrichment	PIK3CA	2.03
211	B-cell expansion with nfkb and t-cell anergy	Enrichment	CARD11	2.03
212	Immunodeficiency 104, severe combined	Enrichment	PTPRC	2.03
213	Glucosephosphate dehydrogenase deficiency	Enrichment	IKBKG	2.03
214	Immunodeficiency 52	Enrichment	LAT	2.03
215	Joint contractures, osteochondromas, and b-cell lymphoma	Enrichment	NFATC2	2.03
216	Malignant germ cell tumor of ovary	Enrichment	CBL	2.03
217	Common variable immunodeficiency 12	Enrichment	NFKB1	2.03
218	Tafro syndrome	Enrichment	MAP2K2	2.03
219	Lung cancer	Enrichment	MAP3K8, PIK3CA	2.02
220	Pancreatic cancer	Enrichment	CDKN2A, TP53	1.94
221	Spinocerebellar ataxia 29	Enrichment	ITPR1	1.88
222	Melanoma-astrocytoma syndrome	Enrichment	CDKN2A	1.88
223	Adrenocortical carcinoma, hereditary	Enrichment	TP53	1.88
224	Costello syndrome	Enrichment	HRAS	1.88
225	Cervical cancer	Enrichment	TP53	1.88
226	Melanoma, cutaneous malignant 2	Enrichment	CDKN2A	1.88
227	Roifman-chitayat syndrome	Enrichment	PIK3CD	1.88
228	Immunodeficiency 45	Enrichment	IFNAR2	1.88
229	Sarcoidosis 1	Enrichment	HLA-DRB1	1.88
230	Lymphoma, hodgkin, classic	Enrichment	TP53	1.88
231	Thrombocythemia 3	Enrichment	JAK2	1.88
232	Neurodevelopmental disorder with regression, abnormal movements, loss of speech, and seizures	Enrichment	IRF2BPL	1.88
233	Autoinflammatory disease, familial, behcet-like 3	Enrichment	RELA	1.88
234	Cebalid syndrome	Enrichment	MTOR	1.88
235	Rela fusion-positive ependymoma	Enrichment	RELA	1.88
236	Melanoma-pancreatic cancer syndrome	Enrichment	CDKN2A	1.88
237	Congenital fibrosarcoma	Enrichment	TP53	1.88
238	Li-fraumeni syndrome 1	Enrichment	TP53	1.88
239	Sarcoma	Enrichment	TP53	1.88
240	Immunodeficiency 17	Enrichment	CD3G	1.88
241	Bullous pemphigoid	Enrichment	HLA-DRB1	1.88
242	Cervix carcinoma	Enrichment	TP53	1.88
243	Immune system disease	Enrichment	PIK3CD	1.88
244	Hodgkin's lymphoma	Enrichment	TP53	1.88
245	Smith-kingsmore syndrome	Enrichment	MTOR	1.88
246	Polycythemia	Enrichment	JAK2	1.88
247	Lymphomatoid papulosis	Enrichment	TYK2	1.88
248	Pediatric multiple sclerosis	Enrichment	HLA-DRB1	1.88
249	Vacterl with hydrocephalus	Enrichment	PTEN	1.88
250	Hypereosinophilic syndrome	Enrichment	JAK2	1.88
251	Transient predisposition to invasive pyogenic bacterial infection	Enrichment	MYD88	1.88
252	Juvenile polyposis of infancy	Enrichment	PTEN	1.88
253	Pleomorphic rhabdomyosarcoma	Enrichment	TP53	1.88
254	Primary cutaneous anaplastic large cell lymphoma	Enrichment	TYK2	1.88
255	Wooly hair nevus	Enrichment	HRAS	1.88
256	Mesothelioma, malignant	Enrichment	BCL10	1.86
257	Pompe disease, infantile-onset	Enrichment	PIK3CA	1.86
258	Nuchal bleb, familial	Enrichment	SOS1	1.86
259	Langerhans cell histiocytosis	Enrichment	MAP2K1	1.86
260	Hepatitis c virus	Enrichment	IFNG	1.86
261	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3CA	1.86
262	Neutrophilic dermatosis, acute febrile	Enrichment	PTPN6	1.86
263	Immune dysregulation with autoimmunity, immunodeficiency, and lymphoproliferation	Enrichment	CTLA4	1.86
264	Dedifferentiated liposarcoma	Enrichment	CDK4	1.86
265	Asparagine synthetase deficiency	Enrichment	CTLA4	1.86
266	Frontometaphyseal dysplasia	Enrichment	MAP3K7	1.86
267	Migraine without aura	Enrichment	TNF	1.86
268	Congenital microcephaly - severe encephalopathy - progressive cerebral atrophy syndrome	Enrichment	CTLA4	1.86
269	Adult-onset myasthenia gravis	Enrichment	CTLA4	1.86
270	Well-differentiated liposarcoma	Enrichment	CDK4	1.86
271	Testicular cancer	Enrichment	BCL10	1.86
272	Keratoacanthoma	Enrichment	PIK3CA	1.86
273	Prostate cancer	Enrichment	PTEN, TP53	1.81
274	Neurofibromatosis-noonan syndrome	Enrichment	MAP2K2	1.73
275	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	PIK3CA	1.73
276	Congenital generalized lipodystrophy	Enrichment	FOS	1.73
277	Cerebrovascular disease	Enrichment	PIK3CA	1.73
278	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	CBL	1.73
279	Noonan syndrome with multiple lentigines	Enrichment	RAF1	1.73
280	Familial cerebral cavernous malformations	Enrichment	PIK3CA	1.73
281	Cerebral malaria	Enrichment	TNF	1.73
282	Gingival fibromatosis	Enrichment	SOS1	1.73
283	Gillespie syndrome	Enrichment	ITPR1	1.71
284	Takayasu arteritis	Enrichment	IL12B	1.71
285	Polycythemia vera	Enrichment	JAK2	1.71
286	Polycystic kidney disease, infantile severe, with tuberous sclerosis	Enrichment	TSC2	1.71
287	Osteogenic sarcoma	Enrichment	TP53	1.71
288	Large congenital melanocytic nevus	Enrichment	HRAS	1.71
289	Breast implant-associated anaplastic large cell lymphoma	Enrichment	JAK2	1.71
290	Atypical teratoid rhabdoid tumor	Enrichment	TP53	1.71
291	Anaplastic astrocytoma	Enrichment	TP53	1.71
292	Xanthinuria, type ii	Enrichment	TSC2	1.71
293	Squamous cell carcinoma	Enrichment	TP53	1.71
294	Adenocarcinoma	Enrichment	TP53	1.71
295	Immunodeficiency 44	Enrichment	IFNAR2	1.71
296	Laryngeal squamous cell carcinoma	Enrichment	PTEN	1.71
297	Bone osteosarcoma	Enrichment	TP53	1.71
298	Spermatocytoma	Enrichment	HRAS	1.71
299	Vogt-koyanagi-harada disease	Enrichment	HLA-DRB1	1.71
300	Capillary malformations, congenital	Enrichment	PIK3CA	1.64
301	Anemia, congenital, nonspherocytic hemolytic, 1	Enrichment	IKBKG	1.64
302	Myeloproliferative neoplasm	Enrichment	CBL	1.64
303	Histiocytoid hemangioma	Enrichment	FOS	1.64
304	Vascular dementia	Enrichment	TNF	1.64
305	Aggressive systemic mastocytosis	Enrichment	CBL	1.64
306	Idiopathic aplastic anemia	Enrichment	IFNG	1.64
307	Erythrocytosis, familial, 1	Enrichment	JAK2	1.59
308	Schimmelpenning-feuerstein-mims syndrome	Enrichment	HRAS	1.59
309	Small cell cancer of the lung	Enrichment	TP53	1.59
310	Temporal arteritis	Enrichment	HLA-DRB1	1.59
311	Thyroid cancer, nonmedullary, 1	Enrichment	TP53	1.59
312	Budd-chiari syndrome	Enrichment	JAK2	1.59
313	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	1.59
314	Spinocerebellar ataxia 15	Enrichment	ITPR1	1.59
315	Mantle cell lymphoma	Enrichment	CCND1	1.59
316	Lung sarcomatoid carcinoma	Enrichment	TP53	1.59
317	Hepatitis b	Enrichment	IFNAR2	1.59
318	Embryonal rhabdomyosarcoma	Enrichment	TP53	1.59
319	Epidermolytic nevus	Enrichment	HRAS	1.59
320	Pediatric systemic lupus erythematosus	Enrichment	STAT4	1.59
321	Systemic-onset juvenile idiopathic arthritis	Enrichment	HLA-DRB1	1.59
322	Glioma	Enrichment	PTEN	1.59
323	Klippel-trenaunay-weber syndrome	Enrichment	PIK3CA	1.56
324	Cowden syndrome 1	Enrichment	PIK3CA	1.56
325	Hemihyperplasia, isolated	Enrichment	PIK3CA	1.56
326	Testicular germ cell tumor	Enrichment	BCL10	1.56
327	Granulomatosis with polyangiitis	Enrichment	CTLA4	1.56
328	Il10-related early-onset inflammatory bowel disease	Enrichment	IL10	1.56
329	Lung squamous cell carcinoma	Enrichment	PIK3CA	1.56
330	Leukemia, acute myeloid	Enrichment	JAK2, TP53	1.55
331	Nevus, epidermal	Enrichment	PIK3CA	1.49
332	Gallbladder cancer	Enrichment	PIK3CA	1.49
333	Pilomyxoid astrocytoma	Enrichment	RAF1	1.49
334	Von hippel-lindau syndrome	Enrichment	CCND1	1.49
335	Rhabdomyosarcoma 2	Enrichment	TP53	1.49
336	Macrocephaly/autism syndrome	Enrichment	PTEN	1.49
337	Narcolepsy 2	Enrichment	HLA-DRB1	1.49
338	Lymphoma	Enrichment	TP53	1.49
339	Hemangioma	Enrichment	PTEN	1.49
340	Diffuse cutaneous systemic sclerosis	Enrichment	HLA-DRB1	1.49
341	Spinocerebellar ataxia, autosomal recessive 16	Enrichment	ITPR1	1.41
342	Keratoconus	Enrichment	TSC1	1.41
343	Limited scleroderma	Enrichment	HLA-DRB1	1.41
344	Rheumatoid arthritis	Enrichment	IL10	1.39
345	Inflammatory bowel disease 1	Enrichment	PRKCQ	1.39
346	Coronary heart disease 5	Enrichment	IKBKG	1.39
347	Esophageal cancer	Enrichment	TP53	1.35
348	Polycystic kidney disease 1 with or without polycystic liver disease	Enrichment	TSC2	1.35
349	Multiple endocrine neoplasia, type i	Enrichment	CDKN1A	1.35
350	Myelofibrosis	Enrichment	JAK2	1.35
351	Renal cell carcinoma, papillary, 1	Enrichment	MTOR	1.35
352	Polycystic kidney disease 1	Enrichment	TSC2	1.35
353	Ciliary dyskinesia, primary, 3	Enrichment	NFKB1	1.34
354	Aplastic anemia	Enrichment	IFNG	1.34
355	Hereditary breast ovarian cancer syndrome	Enrichment	PTEN, TP53	1.30
356	Glioma susceptibility 1	Enrichment	TP53	1.29
357	Narcolepsy 1	Enrichment	HLA-DRB1	1.29
358	Myeloma, multiple	Enrichment	CCND1, TP53	1.28
359	Primary ovarian insufficiency	Enrichment	JAK2, RICTOR	1.24
360	Leukemia, acute lymphoblastic 3	Enrichment	JAK2	1.24
361	Primary hyperaldosteronism	Enrichment	TP53	1.24
362	Aortic valve disease 1	Enrichment	SOS1	1.23
363	Alzheimer's disease	Enrichment	TNF	1.23
364	Walker-warburg syndrome	Enrichment	DAG1	1.20
365	Cleft lip/palate	Enrichment	DLG1	1.20
366	46,xy partial gonadal dysgenesis	Enrichment	SOS1	1.20
367	Familial colorectal cancer	Enrichment	TP53	1.20
368	Lynch syndrome	Enrichment	PIK3CA	1.17
369	Meningioma, familial	Enrichment	PTEN	1.16
370	Leukemia, acute lymphoblastic	Enrichment	CDKN2A	1.16
371	Myelodysplastic syndrome	Enrichment	TP53	1.16
372	Uterine corpus cancer	Enrichment	PTEN	1.16
373	Specific learning disability	Enrichment	MAPK1	1.16
374	Creatine phosphokinase, elevated serum	Enrichment	DAG1	1.14
375	Isolated elevated serum creatine phosphokinase levels	Enrichment	DAG1	1.14
376	Melanoma, cutaneous malignant 1	Enrichment	CDK4	1.12
377	Lung cancer susceptibility 3	Enrichment	TP53	1.06
378	Cardiomyopathy, dilated, 1a	Enrichment	NFATC2	1.03
379	Endometrial cancer	Enrichment	PIK3CA	1.03
380	Renal cell carcinoma, nonpapillary	Enrichment	MTOR	1.03
381	Anterior segment dysgenesis	Enrichment	ITPR1	1.03
382	Autosomal dominant polycystic kidney disease	Enrichment	TSC2	1.03
383	Kidney disease	Enrichment	TSC1	1.03
384	Rare genetic intellectual disability	Enrichment	MTOR	1.03
385	Hepatocellular carcinoma	Enrichment	PIK3CA	1.01
386	Cardiomyopathy, familial hypertrophic, 1	Enrichment	RAF1	0.98
387	Heart, malformation of	Enrichment	MAPK1	0.95
388	Hepatoblastoma	Enrichment	TP53	0.89
389	Myocardial infarction	Enrichment	LTA	0.87
390	Diamond-blackfan anemia 1	Enrichment	TP53	0.85
391	Precursor t-cell acute lymphoblastic leukemia	Enrichment	CDKN2A	0.85
392	Familial hypertrophic cardiomyopathy	Enrichment	RAF1	0.85
393	Left ventricular noncompaction	Enrichment	RAF1	0.82
394	Congenital nervous system abnormality	Enrichment	PTEN, TSC2	0.81
395	Nervous system disease	Enrichment	PTEN, TSC2	0.81
396	Hydrops fetalis, nonimmune	Enrichment	HRAS	0.80
397	Differentiated thyroid carcinoma	Enrichment	HRAS	0.76
398	Non-immune hydrops fetalis	Enrichment	HRAS	0.73
399	Diamond-blackfan anemia	Enrichment	TP53	0.68
400	Hypertelorism	Enrichment	PIK3CA	0.67
401	Familial isolated dilated cardiomyopathy	Enrichment	RAF1	0.66
402	West syndrome	Enrichment	TSC2	0.60
403	Spastic ataxia	Enrichment	ITPR1	0.53
404	Dilated cardiomyopathy	Enrichment	RAF1	0.51
405	Microcephaly	Enrichment	MAPK1	0.25

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

T-cell activation SARS-CoV-2

Pathway Network for T-cell activation SARS-CoV-2

Member Pathways for T-cell activation SARS-CoV-2

Pathways in the T-cell activation SARS-CoV-2 SuperPath

Associated Genes for T-cell activation SARS-CoV-2

Associated Disorders for T-cell activation SARS-CoV-2

Disorders associated with T-cell activation SARS-CoV-2 SuperPath

STRING Interaction Network for T-cell activation SARS-CoV-2

Sources for T-cell activation SARS-CoV-2