T cell receptor and co-stimulatory signaling

No Pathway Network information available for T cell receptor and co-stimulatory signaling

Pathways in the T cell receptor and co-stimulatory signaling SuperPath

#	Name	Source	Genes
1	T cell receptor and co-stimulatory signaling	WikiPathways	AKT1 CD28 CD8A CD8B CSNK1A1 CTLA4 DYRK1A DYRK2 FYN GSK3A GSK3B IL2 LCK NFKB1 NFKBIA PDCD1 PDK1 PLCG1 PPP3CA PRKCA PTPN6 RASA1 RASGRP1 TRA TRB ZAP70 (see all 26) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	NFKBIA	NFKB Inhibitor Alpha	Protein Coding	1
2	CD28	CD28 Molecule	Protein Coding	1
3	CD8B	CD8 Subunit Beta	Protein Coding	1
4	CD8A	CD8 Subunit Alpha	Protein Coding	1
5	DYRK2	Dual Specificity Tyrosine Phosphorylation Regulated Kinase 2	Protein Coding	1
6	ZAP70	Zeta Chain Of T Cell Receptor Associated Protein Kinase 70	Protein Coding	1
7	TRA	T Cell Receptor Alpha Locus	Protein Coding	1
8	RASA1	RAS P21 Protein Activator 1	Protein Coding	1
9	PTPN6	Protein Tyrosine Phosphatase Non-Receptor Type 6	Protein Coding	1
10	PRKCA	Protein Kinase C Alpha	Protein Coding	1
11	PPP3CA	Protein Phosphatase 3 Catalytic Subunit Alpha	Protein Coding	1
12	PLCG1	Phospholipase C Gamma 1	Protein Coding	1
13	PDCD1	Programmed Cell Death 1	Protein Coding	1
14	NFKB1	Nuclear Factor Kappa B Subunit 1	Protein Coding	1
15	LCK	LCK Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	1
16	IL2	Interleukin 2	Protein Coding	1
17	GSK3B	Glycogen Synthase Kinase 3 Beta	Protein Coding	1
18	GSK3A	Glycogen Synthase Kinase 3 Alpha	Protein Coding	1
19	FYN	FYN Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	1
20	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	1
21	DYRK1A	Dual Specificity Tyrosine Phosphorylation Regulated Kinase 1A	Protein Coding	1
22	CTLA4	Cytotoxic T-Lymphocyte Associated Protein 4	Protein Coding	1
23	CSNK1A1	Casein Kinase 1 Alpha 1	Protein Coding	1
24	RASGRP1	RAS Guanyl Releasing Protein 1	Protein Coding	1
25	TRB	T Cell Receptor Beta Locus	Protein Coding	1
26	PDK1	Pyruvate Dehydrogenase Kinase 1	Protein Coding	1

Disorders associated with T cell receptor and co-stimulatory signaling SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Mycosis fungoides	Enrichment	CD28, CTLA4	4.98
2	Saczary syndrome	Enrichment	CD28, CTLA4	4.98
3	Precursor t-cell acute lymphoblastic leukemia	Enrichment	TRA, TRB	3.06
4	Severe combined immunodeficiency	Enrichment	LCK, ZAP70	2.75
5	Proteus syndrome	Enrichment	AKT1	2.72
6	Cystic angiomatosis of bone, diffuse	Enrichment	RASA1	2.72
7	Celiac disease 3	Enrichment	CTLA4	2.72
8	Immunodeficiency 116	Enrichment	CD8A	2.72
9	Intellectual developmental disorder, autosomal dominant 7	Enrichment	DYRK1A	2.72
10	Immunodeficiency 64 with lymphoproliferation	Enrichment	RASGRP1	2.72
11	Developmental and epileptic encephalopathy 91	Enrichment	PPP3CA	2.72
12	Arthrogryposis, cleft palate, craniosynostosis, and impaired intellectual development	Enrichment	PPP3CA	2.72
13	Immunodeficiency 48	Enrichment	ZAP70	2.72
14	Autoimmune disease, multisystem, infantile-onset, 4	Enrichment	PDCD1	2.72
15	Immune dysregulation, autoimmunity, and autoinflammation	Enrichment	PLCG1	2.72
16	Type 1 diabetes mellitus 12	Enrichment	CTLA4	2.72
17	Systemic lupus erythematosus 2	Enrichment	PDCD1	2.72
18	Cowden syndrome 6	Enrichment	AKT1	2.72
19	Immunodeficiency 123 with hpv-related verrucosis	Enrichment	CD28	2.72
20	Autoimmune disease, multisystem, infantile-onset, 2	Enrichment	ZAP70	2.72
21	Immunodeficiency 22	Enrichment	LCK	2.72
22	Vegetative pyoderma gangrenosum	Enrichment	PTPN6	2.72
23	Bullous pyoderma gangrenosum	Enrichment	PTPN6	2.72
24	Immunodeficiency 64	Enrichment	RASGRP1	2.72
25	Gorham's disease	Enrichment	RASA1	2.72
26	Ebv-induced lymphoproliferative disease due to rasgrp1 deficiency	Enrichment	RASGRP1	2.72
27	Pustular pyoderma gangrenosum	Enrichment	PTPN6	2.72
28	Classic pyoderma gangrenosum	Enrichment	PTPN6	2.72
29	Zap70-related severe combined immunodeficiency	Enrichment	ZAP70	2.72
30	Systemic lupus erythematosus	Enrichment	CTLA4, PDCD1	2.60
31	Hashimoto thyroiditis	Enrichment	CTLA4	2.42
32	Ectodermal dysplasia and immunodeficiency 2	Enrichment	NFKBIA	2.42
33	Immunodeficiency, common variable, 12, with autoimmunity	Enrichment	NFKB1	2.42
34	Ectodermal dysplasia and immune deficiency	Enrichment	NFKBIA	2.42
35	Trypsinogen deficiency	Enrichment	TRB	2.42
36	Common variable immunodeficiency 12	Enrichment	NFKB1	2.42
37	Nasopharyngeal carcinoma	Enrichment	NFKBIA	2.24
38	Neutrophilic dermatosis, acute febrile	Enrichment	PTPN6	2.24
39	Immune dysregulation with autoimmunity, immunodeficiency, and lymphoproliferation	Enrichment	CTLA4	2.24
40	Wieacker-wolff syndrome	Enrichment	RASA1	2.24
41	Asparagine synthetase deficiency	Enrichment	CTLA4	2.24
42	Immunodeficiency 7	Enrichment	TRA	2.24
43	Congenital microcephaly - severe encephalopathy - progressive cerebral atrophy syndrome	Enrichment	CTLA4	2.24
44	Adult-onset myasthenia gravis	Enrichment	CTLA4	2.24
45	Immunodeficiency, common variable, 1	Enrichment	CTLA4	2.12
46	Enophthalmos	Enrichment	DYRK1A	2.12
47	Breast cancer	Enrichment	AKT1, IL2	2.05
48	Capillary malformations, congenital	Enrichment	RASA1	2.02
49	Vitamin d-dependent rickets, type 2a	Enrichment	TRB	2.02
50	Klippel-trenaunay-weber syndrome	Enrichment	RASA1	1.94
51	Telangiectasia, hereditary hemorrhagic, type 1	Enrichment	RASA1	1.94
52	Hemangioma, capillary infantile	Enrichment	RASA1	1.94
53	Basal cell carcinoma 1	Enrichment	RASA1	1.94
54	Granulomatosis with polyangiitis	Enrichment	CTLA4	1.94
55	Breast adenocarcinoma	Enrichment	AKT1	1.94
56	Capillary malformation-arteriovenous malformation 1	Enrichment	RASA1	1.87
57	Hereditary hemorrhagic telangiectasia	Enrichment	RASA1	1.87
58	Common variable immunodeficiency	Enrichment	NFKB1	1.87
59	Arteriovenous malformation	Enrichment	RASA1	1.77
60	Cowden syndrome	Enrichment	AKT1	1.77
61	Myopathy, x-linked, with excessive autophagy	Enrichment	RASA1	1.72
62	Ciliary dyskinesia, primary, 3	Enrichment	NFKB1	1.72
63	Combined immunodeficiency	Enrichment	ZAP70	1.68
64	Combined t cell and b cell immunodeficiency	Enrichment	ZAP70	1.68
65	Combined t and b cell immunodeficiency	Enrichment	ZAP70	1.68
66	Meningioma	Enrichment	AKT1	1.64
67	Hereditary chronic pancreatitis	Enrichment	TRB	1.58
68	Male infertility with spermatogenesis disorder	Enrichment	DYRK1A	1.55
69	Gliosarcoma	Enrichment	NFKBIA	1.52
70	Pancreatitis, hereditary	Enrichment	TRB	1.49
71	Giant cell glioblastoma	Enrichment	NFKBIA	1.49
72	Microphthalmia	Enrichment	DYRK1A	1.38
73	Hereditary breast carcinoma	Enrichment	AKT1	1.09
74	Autosomal dominant non-syndromic intellectual disability	Enrichment	PPP3CA	1.04
75	Undetermined early-onset epileptic encephalopathy	Enrichment	PPP3CA	0.99
76	Colorectal cancer	Enrichment	AKT1	0.81
77	Ovarian cancer	Enrichment	AKT1	0.75
78	Autism spectrum disorder	Enrichment	DYRK1A	0.72
79	Microcephaly	Enrichment	DYRK1A	0.68
80	Complex neurodevelopmental disorder	Enrichment	DYRK1A	0.67

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

T cell receptor and co-stimulatory signaling

Pathway Network for T cell receptor and co-stimulatory signaling

Member Pathways for T cell receptor and co-stimulatory signaling

Pathways in the T cell receptor and co-stimulatory signaling SuperPath

Associated Genes for T cell receptor and co-stimulatory signaling

Associated Disorders for T cell receptor and co-stimulatory signaling

Disorders associated with T cell receptor and co-stimulatory signaling SuperPath

STRING Interaction Network for T cell receptor and co-stimulatory signaling

Sources for T cell receptor and co-stimulatory signaling