Tacrolimus/Cyclosporine Pathway, Pharmacodynamics

No Pathway Network information available for Tacrolimus/Cyclosporine Pathway, Pharmacodynamics

Pathways in the Tacrolimus/Cyclosporine Pathway, Pharmacodynamics SuperPath

#	Name	Source	Genes
1	Tacrolimus/Cyclosporine Pathway, Pharmacodynamics	PharmGKB	ATF2 ATF3 BATF FKBP1A FOS FOSB FOSL1 FOSL2 IL2 JDP2 JUN JUNB JUND MAF MAFA MAFB MAFF MAFG MAFK MAP2K3 MAP2K4 MAP2K6 MAP2K7 MAP3K1 MAP3K11 MAP3K7 MAPK14 MAPK8 NFATC1 NFATC2 NFATC4 NFKB1 NFKB2 NRL PPIA PPP3CA PPP3CB PPP3CC PPP3R1 PPP3R2 REL RELA RELB TGFB1 (see all 44) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	MAP2K4	Mitogen-Activated Protein Kinase Kinase 4	Protein Coding	1
2	REL	REL Proto-Oncogene, NF-KB Subunit	Protein Coding	1
3	RELA	RELA Proto-Oncogene, NF-KB Subunit	Protein Coding	1
4	RELB	RELB Proto-Oncogene, NF-KB Subunit	Protein Coding	1
5	TGFB1	Transforming Growth Factor Beta 1	Protein Coding	1
6	FKBP1A	FKBP Prolyl Isomerase 1A	Protein Coding	1
7	MAFK	MAF BZIP Transcription Factor K	Protein Coding	1
8	FOSL1	FOS Like 1, AP-1 Transcription Factor Subunit	Protein Coding	1
9	MAP3K7	Mitogen-Activated Protein Kinase Kinase Kinase 7	Protein Coding	1
10	MAP3K1	Mitogen-Activated Protein Kinase Kinase Kinase 1	Protein Coding	1
11	MAP3K11	Mitogen-Activated Protein Kinase Kinase Kinase 11	Protein Coding	1
12	MAF	MAF BZIP Transcription Factor	Protein Coding	1
13	MAFG	MAF BZIP Transcription Factor G	Protein Coding	1
14	JUN	Jun Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
15	JUNB	JunB Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
16	JUND	JunD Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
17	NFATC1	Nuclear Factor Of Activated T Cells 1	Protein Coding	1
18	NFATC2	Nuclear Factor Of Activated T Cells 2	Protein Coding	1
19	NFATC4	Nuclear Factor Of Activated T Cells 4	Protein Coding	1
20	NFKB1	Nuclear Factor Kappa B Subunit 1	Protein Coding	1
21	NFKB2	Nuclear Factor Kappa B Subunit 2	Protein Coding	1
22	NRL	Neural Retina Leucine Zipper	Protein Coding	1
23	FOS	Fos Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
24	FOSB	FosB Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
25	FOSL2	FOS Like 2, AP-1 Transcription Factor Subunit	Protein Coding	1
26	MAFF	MAF BZIP Transcription Factor F	Protein Coding	1
27	IL2	Interleukin 2	Protein Coding	1
28	ATF2	Activating Transcription Factor 2	Protein Coding	1
29	MAPK8	Mitogen-Activated Protein Kinase 8	Protein Coding	1
30	MAP2K3	Mitogen-Activated Protein Kinase Kinase 3	Protein Coding	1
31	MAP2K6	Mitogen-Activated Protein Kinase Kinase 6	Protein Coding	1
32	MAP2K7	Mitogen-Activated Protein Kinase Kinase 7	Protein Coding	1
33	MAPK14	Mitogen-Activated Protein Kinase 14	Protein Coding	1
34	BATF	Basic Leucine Zipper ATF-Like Transcription Factor	Protein Coding	1
35	PPIA	Peptidylprolyl Isomerase A	Protein Coding	1
36	ATF3	Activating Transcription Factor 3	Protein Coding	1
37	MAFB	MAF BZIP Transcription Factor B	Protein Coding	1
38	PPP3CA	Protein Phosphatase 3 Catalytic Subunit Alpha	Protein Coding	1
39	PPP3CB	Protein Phosphatase 3 Catalytic Subunit Beta	Protein Coding	1
40	PPP3CC	Protein Phosphatase 3 Catalytic Subunit Gamma	Protein Coding	1
41	PPP3R1	Protein Phosphatase 3 Regulatory Subunit B, Alpha	Protein Coding	1
42	PPP3R2	Protein Phosphatase 3 Regulatory Subunit B, Beta	Protein Coding	1
43	MAFA	MAF BZIP Transcription Factor A	Protein Coding	1
44	JDP2	Jun Dimerization Protein 2	Protein Coding	1

Disorders associated with Tacrolimus/Cyclosporine Pathway, Pharmacodynamics SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Histiocytoid hemangioma	Enrichment	FOS, FOSB	3.99
2	Common variable immunodeficiency	Enrichment	NFKB1, NFKB2	3.67
3	Multicentric carpotarsal osteolysis syndrome	Enrichment	MAFB	2.49
4	Insulinomatosis and diabetes mellitus	Enrichment	MAFA	2.49
5	Cardiospondylocarpofacial syndrome	Enrichment	MAP3K7	2.49
6	Cataract 21, multiple types	Enrichment	MAF	2.49
7	46,xy sex reversal 6	Enrichment	MAP3K1	2.49
8	Frontometaphyseal dysplasia 2	Enrichment	MAP3K7	2.49
9	Immunodeficiency 92	Enrichment	REL	2.49
10	Developmental and epileptic encephalopathy 91	Enrichment	PPP3CA	2.49
11	Arthrogryposis, cleft palate, craniosynostosis, and impaired intellectual development	Enrichment	PPP3CA	2.49
12	Enhanced s-cone syndrome 2	Enrichment	NRL	2.49
13	Ayme-gripp syndrome	Enrichment	MAF	2.49
14	Duane retraction syndrome 3 with or without deafness	Enrichment	MAFB	2.49
15	Deficiency in anterior pituitary function - variable immunodeficiency syndrome	Enrichment	NFKB2	2.49
16	Immunodeficiency 53	Enrichment	RELB	2.49
17	Duane retraction syndrome 3	Enrichment	MAFB	2.49
18	Aplasia cutis-enamel dysplasia syndrome	Enrichment	FOSL2	2.49
19	Duane retraction syndrome with congenital deafness	Enrichment	MAFB	2.49
20	Duane retraction syndrome 1	Enrichment	MAFB	2.19
21	Camurati-engelmann disease 1	Enrichment	TGFB1	2.19
22	Phosphoenolpyruvate carboxykinase deficiency, mitochondrial	Enrichment	NRL	2.19
23	Enhanced s-cone syndrome 1	Enrichment	NRL	2.19
24	Developmental and epileptic encephalopathy 28	Enrichment	MAF	2.19
25	Duane retraction syndrome 2	Enrichment	MAFB	2.19
26	Immunodeficiency, common variable, 12, with autoimmunity	Enrichment	NFKB1	2.19
27	Immunodeficiency, common variable, 10	Enrichment	NFKB2	2.19
28	Spinocerebellar ataxia, autosomal recessive 12	Enrichment	MAF	2.19
29	Autoinflammatory disease, familial, behcet-like 3	Enrichment	RELA	2.19
30	Inflammatory bowel disease, immunodeficiency, and encephalopathy	Enrichment	TGFB1	2.19
31	Rela fusion-positive ependymoma	Enrichment	RELA	2.19
32	Camurati-engelmann disease	Enrichment	TGFB1	2.19
33	Enhanced s-cone syndrome	Enrichment	NRL	2.19
34	Retinitis pigmentosa 27	Enrichment	NRL	2.19
35	Joint contractures, osteochondromas, and b-cell lymphoma	Enrichment	NFATC2	2.19
36	Common variable immunodeficiency 12	Enrichment	NFKB1	2.19
37	Frontometaphyseal dysplasia	Enrichment	MAP3K7	2.01
38	Duane retraction syndrome	Enrichment	MAFB	2.01
39	Phosphoenolpyruvate carboxykinase deficiency	Enrichment	NRL	2.01
40	Immunodeficiency, common variable, 1	Enrichment	NFKB2	1.89
41	Congenital generalized lipodystrophy	Enrichment	FOS	1.89
42	Congenital blue dot cataract	Enrichment	MAF	1.89
43	Pseudomyogenic hemangioendothelioma	Enrichment	FOSB	1.89
44	Inflammatory bowel disease 25, autosomal recessive	Enrichment	TGFB1	1.71
45	Il10-related early-onset inflammatory bowel disease	Enrichment	TGFB1	1.71
46	Breast cancer	Enrichment	IL2, JUN	1.61
47	Cataract - microcornea syndrome	Enrichment	MAF	1.59
48	Orofacial cleft 1	Enrichment	MAFB	1.54
49	Cataract 30, multiple types	Enrichment	MAF	1.50
50	Ciliary dyskinesia, primary, 3	Enrichment	NFKB1	1.50
51	46,xy complete gonadal dysgenesis	Enrichment	MAP3K1	1.45
52	46,xy partial gonadal dysgenesis	Enrichment	MAP3K1	1.35
53	Cardiomyopathy, dilated, 1a	Enrichment	NFATC2	1.18
54	Developmental and epileptic encephalopathy 1	Enrichment	MAF	1.11
55	Cystic fibrosis	Enrichment	TGFB1	1.01
56	Benign epilepsy with centrotemporal spikes	Enrichment	MAF	0.90
57	Centralopathic epilepsy	Enrichment	MAF	0.88
58	West syndrome	Enrichment	MAF	0.87
59	Autosomal dominant non-syndromic intellectual disability	Enrichment	PPP3CA	0.82
60	Undetermined early-onset epileptic encephalopathy	Enrichment	PPP3CA	0.78
61	Ovarian cancer	Enrichment	MAP3K1	0.55
62	Retinitis pigmentosa	Enrichment	NRL	0.30
63	Hereditary retinal dystrophy	Enrichment	NRL	0.21
64	Fundus dystrophy	Enrichment	NRL	0.21

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Tacrolimus/Cyclosporine Pathway, Pharmacodynamics

Pathway Network for Tacrolimus/Cyclosporine Pathway, Pharmacodynamics

Member Pathways for Tacrolimus/Cyclosporine Pathway, Pharmacodynamics

Pathways in the Tacrolimus/Cyclosporine Pathway, Pharmacodynamics SuperPath

Associated Genes for Tacrolimus/Cyclosporine Pathway, Pharmacodynamics

Associated Disorders for Tacrolimus/Cyclosporine Pathway, Pharmacodynamics

Disorders associated with Tacrolimus/Cyclosporine Pathway, Pharmacodynamics SuperPath

STRING Interaction Network for Tacrolimus/Cyclosporine Pathway, Pharmacodynamics

Sources for Tacrolimus/Cyclosporine Pathway, Pharmacodynamics